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| Number | Title | Issue Date |
| 5024943 | Regulatory region cloning and analysis plasmid for bacillus Novel constructs in plasmids are provided for evaluating the efficiency of expression and secretion of structural genes. The constructs provide for transcriptional and translational regulatory regions, a signal sequence and structural gene, which also may... | 06/18/1991 |
| 4990446 | Promoters for the expression of foreign genes in yeast, plasmids comprising them, and use thereof for the production of polypeptides Promoters capable of ensuring expression in yeast of genes coding for heterologous polypeptides are disclosed, which comprise a DNA fragment or mutants or sub-fragments thereof, said promoter comprising a definite nucleotide sequence commencing with an Ec... | 02/05/1991 |
| 4965195 | Interleukin-7 Mammalian Interleukin-7 proteins (IL-7s), DNAs and expression vectors encoding mammalian IL-7s, and processes for producing mammalian IL-7s as products of cell culture, including recombinant systems, are disclosed.... | 10/23/1990 |
| 4956280 | Biphasic shuttle vectors This invention provides a biphasic shuttle vector capable replication and expression of foreign genetic information in Escherichia coli and Agmenellum quadruplicatum comprising an E. coli replicon, an A. quadruplicatum replicon, at least two selectable ma... | 09/11/1990 |
| 4952499 | Genes and their encoded proteins which regulate gene expression of the interleukin-2 receptor and of human lymphotropic retroviruses The present invention is directed to genes, termed Rpt-1 (regulatory protein T lymphocyte-1), which are expressed at higher levels by resting CD4+ helper/inducer T cells relative to activated CD4+ cells. The invention also relates to... | 08/28/1990 |
| 4952500 | Cloning systems for Rhodococcus and related bacteria A plasmid transformation system for Rhodococcus was developed using an Escherichia coli-Rhodococcus shuttle plasmid. Rhodococcus sp. H13-A contains three cryptic indigenous plasmids, designated pMVS100, pMVS200 and pMVS300, of 75, 19.5 and 13.4 kilobases ... | 08/28/1990 |
| 4950740 | Recombinant diphtheria vaccines Recombinant diphtheria toxin A fragment muteins which are enzymatically inactive but immunologically crossreactive with diphtheria toxin are disclosed. Intermediates and methods for preparing such proteins using recombinant techniques are also described.... | 08/21/1990 |
| 4945059 | Method of proliferating vesicular-arbuscular mycorrhizal fungi A method of proliferating vesicular arbuscular mycorrhizal fungi (i.e., VAM fungi) is disclosed which comprises inoculating VAM fungi in a soil medium containing a potato and a porous amphoteric ion exchanger, an accelerator and, optionally, in the presen... | 07/31/1990 |
| 4940781 | Peptides comprising an immunogenic side of poliovirus and DNAs containing nucleotide sequences coding for these peptides Peptides which can be recognized by antibodies acting both against the "C" and "D" particles of the same poliovirus and against the VP-1 structural polypeptides of this capsid of the poliovirus. These peptides comprise the amino acid sequence: Asp Asn Pro... | 07/10/1990 |
| 4935367 | Novel restriction endonuclease A new restriction enzyme, Mfe I, has been discovered. Mfe I recognizes the sequence CAATTG and cuts at the recognition sequence C'AATTG and generates compatible cohesive ends with EcoRI cleaved fragments. Various utilities of the enzyme have been describe... | 06/19/1990 |
| 4935366 | Method of obtaining cellulase deficient strains of white-rot fungi A method is described of obtaining cellulase deficient strains which have great ability to degrade lignin at the same time. The method comprises crossing a homokaryotic cellulase deficient mutant of a white-rot fungus having a full sexual cycle with a hom... | 06/19/1990 |
| 4935368 | Process for producing tissue plasminogen activator This invention discloses a process for producing tissue plasminogen activator. The process comprises cultivating Escherichia coli, yeast, or mammalian cells into which the vector having the gene for human tissue plasminogen activator (tPA) has been introd... | 06/19/1990 |
| 4935353 | Preparation of strains of Bacillus thuringiensis having an improved activity against certain lepidopterous pests and novel strain produced thereby The invention relates to a strain of Bacillus thuringiensis, GC 91, a sample of which has been deposited under the accession number NCTC 11821, or a derivative or mutant thereof having entomocidal activity against lepidopterous pests. The invention also r... | 06/19/1990 |
| 4935363 | Sterol regulatory elements Disclosed are discreet functionally translocatable DNA segments, termined Sterol Regulatory Elements (SRE's), which are fused to heterologous structural genes to provided sterol regulatory capability to the thus formed hybrid gene. The hybrid genes respon... | 06/19/1990 |
| 4935356 | Production of interleukin-2 The present invention provides an improvement in a method for producing interleukin-2 by cultivating a transformant of Escherichia coli capable of producing interleukin-2 into a medium, which comprises inoculating said Escherichia coli into the medium of ... | 06/19/1990 |
| 4935357 | Universal restriction endonuclease A universal restriction endonuclease for cleaving a target DNA at a predetermined site. The universal restriction endonuclease utilizes a tailored oligodeoxynucleotide adapter in conjunction with a restriction enzyme which cuts DNA at a known distance fro... | 06/19/1990 |
| 4933288 | Use of a modified soluble Pseudomonas exotoxin A in immunoconjugates DNA sequences encoding proteins processable by secretion leaders in recombinant hosts are described. The DNA sequences encode the NH2 -terminal region of proteins that are cleaved from a secretion leader and may be secreted through the cell mem... | 06/12/1990 |
| 4933286 | Purification of apase-11 and retrieval of the nematode resistance gene An isoenzyme from tomato, acid phosphatase-1 isoenzyme (Apase-11), has ben purified to homogeneity and is subjected to amino acid sequencing and used to prepare anti-Apase-1 antibodies. The amino acid sequence permits design of probes to recove... | 06/12/1990 |
| 4931392 | Process for stabilizing kinase The present invention provides a process for stabilizing creatine kinase by disulphide modification, wherein creatine kinase is reacted in any desired sequence (a) with a molar excess of disulphide and/or thiosulphonate and (b) with a molar excess of water-sol... | 06/05/1990 |
| 4929553 | Protease for specific processing of secreted proteins This invention is concerned with the specific processing of secreted proteins in genetically modified yeast cells. The yeast KEX1 gene was cloned and the KEX1 product was shown to be a serine protease, evidently a carboxypeptidase B-like protease. A proba... | 05/29/1990 |
| 4929604 | Lipopolysaccharides of reduced toxicity and the production thereof An acyloxyacyl hydrolase from the human promyelocyte cell line HL-60 has been found to specifically hydrolyze fatty acids form their ester linkages to hydroxy groups of 3-hydroxyfatty acids, the latter being bound in turn to LPS glycosaminyl residues. The... | 05/29/1990 |
| 4929547 | Antitumor protein gene of streptococcus pyogenes Su, plasmids containing the gene, transformant cells harboring the plasmids, and process for producing the antitumor protein Amino acid sequence of N-terminal region of streptococcal acid glycoprotein (SAGP), and antitumor glycoprotein produced by Streptococcus pyogenes Su, was determined, and DNA probes which are complementary to SAGP gene were synthesized. Chromosomal DNA fra... | 05/29/1990 |
| 4927751 | Processes for obtaining exoenzymes by culture Exoenzymes, such as proteases, xylanases and amylases, are obtained continuously by cultivation of exoenzyme-producing microorganisms in one step in a fermenter which is operated with continuous flow and in which a deficiency state corresponding to maxima... | 05/22/1990 |
| 4925794 | Hybrid plasmids and microorganisms containing them New hybrid plasmids which are useful as vectors in recombinant DNA in which Acremonium chrysogenum or Saccharomyces cerevisiae is used as a host, and microorganisms bearing the hybrid plasmids, are disclosed. The disclosure herein is based on the cloning ... | 05/15/1990 |
| 4925792 | Process for producing proteins correlated with the diphtheric toxin Process for the production of a protein correlated with the diphtheric toxin which comprises culturing in a liquid nutrient medium having a concentration of iron ions of from 0.05 μg/ml to 0.5 μg/ml, at a temperature of from 30° C. to 40° C., in a neu... | 05/15/1990 |
| 4921841 | Immunoaffinity purification of phytolaccin proteins and their use in treating Herpes Simplex virus type II Antiviral proteins phytolaccin1 and phytolaccin2 were isolated from the higher plant Phytolaccin americana using the technique of immunoaffinity chromatography. Phytolaccin proteins were purified to apparent homogeneity in a rapid an... | 05/01/1990 |
| 4921795 | Method for producing high solids dextrin adhesives The present invention relates to an improvement in the alpha-amylase method of hydrolyzing a heated slurry of raw starch into starch fragments, the improvement comprising adding a hydrolytically effective amount of the enzyme, glucoamylase, to the reactio... | 05/01/1990 |
| 4921797 | C-terminal alpha-amidating enzyme and process for production and use thereof C-terminal -amidating enzyme preparations, including preparations AE-I, AE-II, AE-IIa and AE-IIb, from the skin of Xenopus laevis, wherein all components can convert a peptide having a glycine residue at its C-terminal to a C-terminal amidated pept... | 05/01/1990 |
| 4918015 | Gentamicin-resistance genes and their use as markers S. ghanaensis DSM 2932 is resistant to gentamicin at up to 20 μg/ml. Total digestion of the genomic DNA with BglII, incorporation of the restriction fragments into a suitable plasmid, and selection using gentamicin results in gentamicin-resistant clones ... | 04/17/1990 |
| 4918006 | Gene coding for insecticidal crystal protein Recombinant plasmids containing the larvicidal delta-endotoxin gene were constructed by inserting HindIII fragments of the Bacillus thuringiensis var. israelensis 72-75 Md plasmid into the Escherichia coli vector pUC12. Two recombinants producing a 27-kda... | 04/17/1990 |
| 4918012 | Method for producing carnitine, L-carnitinamide hydrolase and method for producing same This invention relates to a method for producing carnitine comprising contacting, in a reaction medium, carnitinamide with (A) an amidase capable of hydrolyzing carnitinamide to form carnitine or (B) a microorganism containing said amidase, carnitinamide ... | 04/17/1990 |
| 4918018 | Microorganism for use in industrial processes A purified culture of Ferroxifunis bagdadii capable of extracting metals from mining heaps, liquefying and desulfurizing coal, and decolorizing textile mill wastewaters.... | 04/17/1990 |
| 4918014 | Method for producing mucoid and phage resistant group N streptococcus strains from non-mucoid and phage sensitive parent strains A method for imparting phage resistance to phage sensitive strands of Streptococcus group N is described. The method involves transferring plasmid encoding for production of a mucoid substance (Muc+) into the phage sensitive strain. Even if the... | 04/17/1990 |
| 4916212 | DNA-sequence encoding biosynthetic insulin precursors and process for preparing the insulin precursors and human insulin Human insulin precursors containing the peptide chain B(1-29)-A(1-21) of human insulin and derivatives thereof with a bridging chain connecting the carboxyl terminus of the B(1-29)-chain with the amino terminus of the A(1-21)-chain are prepared by culturi... | 04/10/1990 |
| 4914030 | Carbomycin resistance-conferring gene, designated carb, for use in streptomyces and other organisms The carB gene is a novel carbomycin resistance-conferring gene isolated from Streptomyces thermotolerans and used to construct a number of cloning vectors for use in Streptomyces and related organisms. One such coloning vector, plasmid pOJ159, can be obta... | 04/03/1990 |
| 4912044 | Preparation of mesophilic microorganisms which contain a D-hydantoinase which is active at elevated temperature A description is given of a genertic engineering process for the preparation of mesophilic microorganisms which contain a hydantoinase active at elevated temperature, and of DNA sequences which code for this enzyme.... | 03/27/1990 |
| 4904602 | Thioredoxin shufflease and use thereof The subject invention concerns a novel enzyme named thioredoxin shufflease, means for preparing the same, and procedures for using thioredoxin shufflease to fold proteins containing disulfide crosslinks. Thioredoxin shufflease is a generic term to define ... | 02/27/1990 |
| 4904597 | Method for cultivation of bacteria of the genus campylobacter Disclosed is a simple method for cultivation of bacteria of the genus Campylobacter with good growth of bacteria which comprises carrying out the cultivation in a sealed container of gas barrier type in which are enclosed a medium inoculated with bacteria... | 02/27/1990 |
| 4904591 | Carbomycin resistance-conferring gene, designated cara, for use in streptomyces and other organisms The carA gene is a novel carbomycin resistance-conferring gene isolated from Streptomyces thermotolerans and used to construct a number of cloning vectors for use in Streptomyces and related organisms. One such cloning vector, plasmid pOJ158, can be obtai... | 02/27/1990 |
| 4904593 | Novel microorganism, a novel esterase and method for preparing the same A novel esterase (molecular weight 54,000&#b1;2,000) derived from a microorganism belonging to genus Bacilus is extensively utilizable for organic synthetic reaction, especially for asymmetric hydrolysis of ethyl 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopro... | 02/27/1990 |
