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| Number | Title | Issue Date |
| 7368527 | HADDE71 polypeptides The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind thes... | 05/06/2008 |
| 7344736 | Extraction of pharmaceutically active components from plant materials The invention relates to the extraction of pharmaceutically active components from plant materials, and more particularly to the preparation of a botanical drug substance (BDS) for incorporation in to a medicament. It also relates to a BDS of given purity, for use i... | 03/18/2008 |
| 7314762 | Apolipoprotein biopolymer markers indicative of insulin resistance The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 01/01/2008 |
| 7262019 | System and methods for detection of related analytes in biological fluids The invention provides a heterogeneous immunoassay for detection of antibodies and antigens based on specific antigen-antibody immune complex formation with multiple antigen-bearing conjugate components. The invention further provides means for optimizing the assay ... | 08/28/2007 |
| 7169613 | Method for avoiding the contamination of negative sampling material by samples containing analytes during the use of automatic pipette machines The invention relates to a method for reducing the contamination of reaction containers which are empty or already fitted with analyte-free sampling material or sampling material having a low analyte concentration, inside a configuration of reaction containers which... | 01/30/2007 |
| 7105187 | Method for obtaining taxanes A method for obtaining a taxane by which a taxane is isolated from a growth medium, such as soil, in which a taxane-producing plant has grown. ... | 09/12/2006 |
| 7105343 | Methods and compositions for transposition using minimal segments of the eukaryotic transformation vector Piggybac The present invention provides efficient transfer of genes into host cells or embryos to transform the cells or embryos by transposition vectors using the minimal amount of nucleotide sequences in the transposon piggyBac required for gene transfer. The transformed c... | 09/12/2006 |
| 7101710 | Two-stage culture protocol for isolating mesenchymal stem cells from amniotic fluid A method of harvesting mesenchymal stem cells from human amniotic fluid uses a two-stage culture protocol comprising culturing human amniocytes and then culturing mesenchymal stem cells. For culturing human amniocytes, primary amniocyte cultures are set up using rou... | 09/05/2006 |
| 7090997 | Diagnostic agent and test method for colon cancer using tannase as index A diagnostic agent for colon cancer, which comprises a reagent for detecting a tannase high-producing bacterium or measuring an amount of tannase contained in an intracolonic microflora sample, and a test method for colon cancer, which comprises the step of detectin... | 08/15/2006 |
| 7087711 | Transcriptional activator comprising a short hydrophobic activation peptide The present invention describes novel transcriptional activators and activation systems. The activators of the present invention comprise a DNA binding moiety linked to a short peptide of novel sequence. Preferably, the peptide is substantially hydrophobic. Preferre... | 08/08/2006 |
| RE39229 | Binding proteins for recognition of DNA Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polyp... | 08/08/2006 |
| RE39220 | Peptide-mediated gene transfer A methodology that allows for highly efficient transfer and stable integration of DNA into both established eukaryotic cell lines and primary cells, including non-dividing cells such as human peripheral blood monocytes and macrophages, entails the use of a synthetic... | 08/01/2006 |
| 7070980 | Midecamycin biosynthetic genes The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid sequence selected from SEQ ID NOs: 2 to 10, 13, 14, 16, 19, 20, 22 to... | 07/04/2006 |
| 7067617 | Zinc finger binding domains for nucleotide sequence ANN Polypeptides that contain from 2 to 12 zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula (ANN)2–12 are provided. Polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides an... | 06/27/2006 |
| 7063962 | DNA sequences for regulating transcription The invention relates to a DNA sequences for regulating transcription of a structural gene encoding a polypeptide in a eukaryotic host cell comprising (a) a first DNA sequence to which RNA polymerase binds which DNA sequence comprises a mRNA initiation site; and fur... | 06/20/2006 |
| 7056672 | Method of identifying an open reading frame using a nucleic acid molecule encoding multiple start codons and histidine tags Compositions and methods for identifying nucleotide fragments that contain an open reading frame are provided. Compositions comprise a nucleotide sequence that encodes, in each of the three possible reading frames, an ATG start codon and a histidine tag, and vectors... | 06/06/2006 |
| 7052896 | Lactobacillus rhamnosus polynucleotides, polypeptides and methods for using them Novel polynucleotides isolated from Lactobacillus rhamnosus, as well as probes and primers, genetic constructs comprising the polynucleotides, biological materials, including plants, microorganisms and multicellular organisms incorporating the polynucleotides... | 05/30/2006 |
| 7053052 | Therapies involving mutated heat shock transcription factor The present invention relates to exogenous mutant HSF (mutHSF encoded by exogenous DNA) alters expression or synthesis of endogenous heat shock protein (hsp) genes in eukaryotic cells, tissues and organisms (e.g., mammalian, particularly human, cells, tissues and or... | 05/30/2006 |
| 7053265 | Application of bi-directional promoters for modification of gene expression The present invention provides a novel bi-directional promoter. The present invention further provides methods of producing proteins of interest and methods of controlling gene expression using the bi-directional promoter. The present invention also provides methods... | 05/30/2006 |
| 7049090 | Modulation of hedgehog-mediated signaling pathway The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provi... | 05/23/2006 |
| 7049071 | Detection of DNA damaging agents Recombinant DNA molecules comprising a regulatory element that activates gene expression in response to DNA damage operatively linked to a DNA sequence that encodes a light emitting reporter protein, recombinant vectors containing such DNA molecules and cells contai... | 05/23/2006 |
| 7045312 | Method of monitoring a biological system by labeling with an apo metal binding protein The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo ... | 05/16/2006 |
| 7045315 | Methods for modulating expression of exogenous genes in mammalian systems In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as we... | 05/16/2006 |
| 7041483 | Expression modulating sequences The present invention provides a method for modulating expression of a genetic sequence by introducing, creating or deleting one or more pseudo-translation initiation sites in the nucleotide sequence of an mRNA, upstream of the authentic translation initiation site ... | 05/09/2006 |
| 7034142 | Method to improve translation of polypeptides by using untranslated regions from heat-shock proteins Untranslated regions associated with the heat shock response can be used to obtain increased efficiency of translation of polypeptides that are not necessarily normally associated with the heat shock response. This allows the development of greatly improved expressi... | 04/25/2006 |
| 7033749 | Ribonuclease resistant RNA preparation and utilization The present invention relates to nuclease resistant nucleic acids in general and ribonuclease resistant RNAs in particular. Methods of making and using such nucleic acids are disclosed. ... | 04/25/2006 |
| 7029868 | Cell fusion assays using fluorescence resonance energy transfer Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying subst... | 04/18/2006 |
| 7026122 | Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay The present application provides methods of assaying for compounds that inhibit premature translation termination and nonsense mediated RNA decay in cells. ... | 04/11/2006 |
| 7022501 | Ligation of double-stranded DNAs The present invention relates to a DNA ligation method. Specifically, a DNA complex comprising a three-stranded structure in each of the ends of double-stranded DNAs, one of which has single-stranded regions at the end, and the other of which does not have single-st... | 04/04/2006 |
| 7015012 | Methods of identifying agents that mediate polypeptide aggregation The present invention is based, in part, on the discovery of methods for identifying compounds that mediate (by promoting or inhibiting) protein-protein interaction (e.g., aggregation, dimerization, or other physiologically significant association). Compounds that m... | 03/21/2006 |
| 6998478 | Isolation and characterization of a fiber-specific β-tubulin promoter from cotton The present invention relates to a cotton β-tubulin gene CFTUB2, and active fragments thereof. These promoters show strong fiber-specific activity. ... | 02/14/2006 |
| 6998383 | Inhibitors of receptor activator of NF-κB and uses thereof The present invention provides a RANK (receptor activator of NF-κB) inhibitor consisted of a TRAF-6 (TNF receptor-associated factor-6) binding domain attached to a leader sequence. The peptide inhibitor inhibits RANKL (RANK ligand)-mediated osteoclast differentiati... | 02/14/2006 |
| 6994975 | Expression and purification of ATM protein using vaccinia virus The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM protein. In particular, a method is disclosed for using a vaccinia virus vec... | 02/07/2006 |
| 6994999 | Isolated DNA molecule comprising the promoter sequence of a bovine myostatin gene The present invention relates to a novel promoter sequence which encodes an isolated DNA molecule comprising the polynucleotide sequence of SEQ ID NO: 1 and which encodes the promoter region of the myostatin gene, or a fragment thereof, or variant thereof which has ... | 02/07/2006 |
| 6991900 | Methods for identifying an essential gene in a prokaryotic microorganism Methods are provided for the rapid identification of essential or conditionally essential DNA segments in any species of haploid cell (one copy chromosome per cell) that is capable of being transformed by artificial means and is capable of undergoing DNA recombinati... | 01/31/2006 |
| 6989265 | Bacteria with reduced genome The present invention provides a bacterium having a genome that is genetically engineered to be at least 2 to 14% smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present in... | 01/24/2006 |
| 6982317 | C21 polypeptide that modulates the stability of transcriptional regulatory complexes regulating nuclear hormone receptor activity A gene in humans and mice, designated C21, encodes a family of proteins that play a role in transcriptional regulation. Two isoforms (α and β) produced by alternative splicing has been identified in humans. A transgenic model was created that shows that over-expre... | 01/03/2006 |
| 6977157 | Clock gene promoter The present invention discloses a Period2 gene promoter, a construct containing the promoter and a reporter gene, a cell containing the construct, a transgenic animal harboring the construct, and a method for screening a substance which controls expression or oscill... | 12/20/2005 |
| 6974694 | Adenoviruses for control of gene expression The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprisi... | 12/13/2005 |
| 6972193 | Regulated transcription of targeted genes and other biological events Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have devel... | 12/06/2005 |
