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| Number | Title | Issue Date |
| 5877004 | Human cytomegalovirus containing a ଲ-glucuronidase marker gene This invention relates to a method for identifying non-essential genes of the human cytomegalovirus (HCMV) genome through the insertion of a ଲ-glucuronidase marker gene into a specified HCMV gene, such that, if the product of the HCMV gene is not ex... | 03/02/1999 |
| 5871909 | Human cellular retinoic acid binding protein I and II DNA and methods of use The sequences encoding two isoforms of human cellular retinoid acid binding proteins, CRABP-I and CRABP-II, have been cloned and sequenced and are set forth with their corresponding amino acid sequences. The identification of human CRABP nucleic and amino... | 02/16/1999 |
| 5858651 | Nucleotide sequences of human immunodeficiency virus type 2 (HIV-2), probes of HIV-2, and methods of using these probes A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probe... | 01/12/1999 |
| 5854037 | Recombinant negative strand RNA virus expression systems and vaccines Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. Th... | 12/29/1998 |
| 5849523 | Aedes aegypti densovirus expression system The present invention is directed to use of Aedes aegypti densonucleosis virus (Aedes DNV or AeDNV) as a heterologous gene expression system. The invention described herein provides promoters from the Aedes aegypti genome such as the p.05, p7 and p61 prom... | 12/15/1998 |
| 5849580 | Nucleic acid encoding a NF-.kappa.B activation regulatory protein, I.kappa.Bଲ The present invention provides a novel polypeptide, I.kappa.B-ଲ, which binds to and affects NF-.kappa.B gene activation. Also provided is the nucleotide sequence encoding I.kappa.B-ଲ and methods of identifying compositions which affect I.kappa... | 12/15/1998 |
| 5849500 | Phagemid for antibody screening A phagemid has been constructed that expresses an antibody fused to coliphage pIII protein. The phagemid is suitable for selecting specific antibodies from large gene libraries with small quantities of antigen. The antibody-pIII gene can be strongly repre... | 12/15/1998 |
| 5846806 | Identification of a human cytomegalovirus gene region involved in down-regulation of MHC class I heavy chain expression Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including ope... | 12/08/1998 |
| 5847077 | Fungal multisubunit protein complex critical for expression of fungal proteins The present invention provides a complex of fungal polypeptides, termed TAFs, that are necessary for activated transcription in fungi such as S. cerevisiae. The complex comprises at least nine associated subunit polypeptides, having molecular masses of ab... | 12/08/1998 |
| 5840543 | Fermentation process Processes for preparing polypeptides, such as G-CSF or analogues thereof, in which fermentation is carried out in the presence of at least one amino acid which is present in an amount sufficient to give improved accumulation of the polypeptide. The amino ... | 11/24/1998 |
| 5840528 | Transformation of phaffia rhodozyma The present invention discloses a transformed Phaffia strain. Also disclosed are specific vectors for transforming Phaffia, preferably such vectors contain expression regulating sequences obtained from Phaffia. The present invention also discloses the use... | 11/24/1998 |
| 5834236 | AATT repeat transcription enhancer element A novel transcription enhancer element, (AATT)n, that increases the activity of cis-elements in heterologous promoter constructs without altering their intrinsic specificity is provided. Also provided is a transcription factor, PABF, which spec... | 11/10/1998 |
| 5830643 | Partially double-stranded oligonucleotide and method for forming oligonucleotide A method for forming an oligonucleotide comprises the steps of synthesizing a pair of oligonucleotides, one oligonucleotide having a base sequence portion comlementary to that of the other at a part of the terminal end region thereof; binding the pair of ... | 11/03/1998 |
| 5830707 | Method for site-specific integration of nucleic acids and related products Chimeric proteins are provided comprising a first domain that attaches said chimeric protein to a target nucleic acid, and a second domain that integrates donor nucleic acid into a target nucleic acid. Also provided are nucleic acid constructs, recombinan... | 11/03/1998 |
| 5824546 | Regulation of a sigma factor from Mycobacterium tuberculosis Two genes, orfX and orfY, regulate sigF expression and sigF activity in M. tuberculosis. M. tuberculosis sigF, orfX, and orfY are used in screening methods for potential therapeutic agents which regulate the growth of M. tuberculosis.... | 10/20/1998 |
| 5820871 | Recombinant negative strand RNA virus expression systems and vaccines Recombinant negative-strand viral RNA templates are described which may be sed with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. The ... | 10/13/1998 |
| 5817501 | DNA encoding suppressin protein and uses thereof A unique gene sequence encoding a suppressin protein has been isolated. Using recombinant DNA techniques, the suppressin protein may be produced in useful quantities. Methods for preparing the gene sequence and the gene product are disclosed. Also provide... | 10/06/1998 |
| 5804372 | Method of distinguishing an IBRV-vaccinated bovine from a bovine infected with a wild type virus The present invention provides recombinant infectious bovine rhinotracheitis (IBR) viruses useful in vaccines to protect bovines from infectious bovine rhinotracheitis and other bovine diseases. The present invention further provides methods for distingui... | 09/08/1998 |
| 5800986 | Assay methods for tat cell lines Assays screened for compounds that inhibit tat transactivation of the HIV (HTLV-III) LTR are taught. The assay involves tranfecting a cell line containing the tat gene by a vector containing a gene under the control of an HIV-1 LTR, adding the compound to... | 09/01/1998 |
| 5795755 | Method of implanting living cells by laser poration at selected sites A method and apparatus for operating on living cells in order to transfer material to the interior of selectively targeted cells is disclosed. The operation may take place in a reaction chamber in which a group of cells are disposed, only some of which ar... | 08/18/1998 |
| 5792634 | RNA polymerase transcription factor A new RNA polymerase transcription factor has been discovered. The enzyme significantly increases the rate of transcription elongation by RNA polymerase II.... | 08/11/1998 |
| 5786199 | Recombinant negative strand RNA virus expression systems and vaccines Recombinant negative-strand viral RNA templates are described which may be used with purified RNA-directed RNA polymerase complex to express heterologous gene products in appropriate host cells and/or to rescue the heterologous gene in virus particles. He... | 07/28/1998 |
| 5783195 | Recombinant infectious bovine rhinotracheitis virus S-IBR-052 and uses thereof The present invention provides a recombinant infectious bovine rhinotracheitis virus designated S-IBR-052 (ATCC Accession No. VR 2443). A vaccine is provided which comprises an effective immunizing amount of S-IBR-052 and a suitable carrier. A method of i... | 07/21/1998 |
| 5776776 | DTEF-1 isoforms and uses thereof Transcription enhancer factor 1 (TEF-1) gene family polypeptides are described. In particular, DTEF-1 isoforms are provided. The isoforms may be used for the differential regulation of genes which contain upstream TEF-1 binding sites. Thus, TEF-1 family p... | 07/07/1998 |
| 5773009 | Rotavirus strain G9P11 Provided is an isolated rotavirus of the strain G9P11, an isolated nucleic acid encoding the rotavirus of strain G9P11 and a purified antigen specific for the rotavirus. An isolated nucleic acid encoding the antigen of the rotavirus is also provided, as i... | 06/30/1998 |
| 5770374 | Methods for identifying oncogenes and anti-oncogenes Episomal plasmids containing a papovavirus origin of replication and a papovavirus large T antigen mutant form are shown to replicate episomally in human cells, and yield levels of gene expression proportional to their episomal copy number. Candidate onco... | 06/23/1998 |
| 5766586 | Gram-positive bacteria replicon A recombinant vector capable of replicating in Gram positive bacteria and containing: a) a nucleotide concatenation I of Bacillus thuringiensis with a size of about 2.6 kb between sites BalI-HpaI, or any fragment included in said concatenation as long as ... | 06/16/1998 |
| 5756708 | DNA sequences of banana bunchy top virus The invention provides DNA molecules consisting essentially of a nucleotide sequence or part thereof which are asosciated with the genome of banana bunchy top virus (BBTV) as illustrated in FIGS. 1 through 8 (SEQ ID NOS: 49-54, 27-37, 55-60, 38-48, and 9-... | 05/26/1998 |
| 5756668 | Hypermethylated in cancer polypeptide, HIC-1 Polynucleotide and polypeptide sequences encoding a novel tumor suppressor, HIC-1, are provided. Also included is a method for detecting a cell proliferative disorder associated, with HIC-1. HIC-1 is a marker which can be used diagnostically, prognostical... | 05/26/1998 |
| 5753476 | Identification of a human cytomegalovirus gene region involved in down regulation of MHC class I heavy chain expression Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including ope... | 05/19/1998 |
| 5739007 | Hybrid GAL10/pgk yeast promoter A hybrid yeast promoter comprising constituents of the 5' non-coding PGK region and, as an upstream activation sequence, the upstream activitation sequence of the GAL10 gene of Saccharomyces cerevisiae, and which does not contain the endogenous PGK upstre... | 04/14/1998 |
| 5739010 | Human transcription factor The present invention provides a human transcription factor (HTRAN) and polynucleotides which identify and encode HTRAN. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods fo... | 04/14/1998 |
| 5733555 | Modified live BRSV vaccine The invention provides an improved BRSV vaccine composition, which advantageously provides immunity from infection after a single administration. The composition comprises a modified live BRS virus and an adjuvant, which in combination provide immunity fr... | 03/31/1998 |
| 5726043 | Process for the production of protease inhibitors A novel process for the production of recombinant desulphatohirudin by transformed yeast strains is provided. The process makes use of an expression cassette comprising the yeast CUP1 promoter. The invention concerns also said transformed yeast strains, n... | 03/10/1998 |
| 5720957 | Recombinant human cytomegalovirus vaccine Infection of human fibroblast cells with human cytomegalovirus (HCMV) causes down regulation of cell surface expression of MHC class I. The present invention is directed to a mutant with a 9-kb deletion in the S component of the HCMV genome (including ope... | 02/24/1998 |
| 5712113 | Signal sequences for secretion of heterologous proteins from yeast Secretion signal peptides of inulinases derived from Kluyveromyces marxianus, which makes a heterologous protein produced in a yeast cell be secreted almost completely into the extracellular medium; nucleotide sequences encoding said secretion signal pept... | 01/27/1998 |
| 5708158 | Nuclear factors and binding assays The invention provides methods and compositions for identifying pharmacological agents useful in the diagnosis or treatment of disease associated with the expression of a gene modulated by a transcription complex containing at least a human nuclear factor... | 01/13/1998 |
| 5702921 | Expression of biologically active human C-reactive protein in escherichia coli The present invention relates to a plasmid possessing the restriction enzyme map shown in FIG. 1 , and this plasmid is largely characterized in that the kil gene is linked downstream from the human CRP (C-reactive protein) gene. Using this plasmid, it is ... | 12/30/1997 |
| 5702908 | Interruption of binding of MDM2 and p53 protein and therapeutic application thereof A method of identifying a compound which interferes with the binding of MDM2 to human p53 has been determined. This method comprises forming a mixture between MDM2 and a fragment of human p53 consisting of 6 to 28 amino acids comprising TFSDLW (SEQ ID NO:... | 12/30/1997 |
| 5693759 | Human T-cell leukemia virus transcription modulators and screening assays The invention provides methods and compositions relating to the Tax-response Complex-1 (TRC-1) a transcription complex associated with disease, particularly HTLV infection. TRC-1 is composed of novel forms of JunB and a member of a novel protein family ca... | 12/02/1997 |
