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| Number | Title | Issue Date |
| 8017318 | Method for detecting and/or quantifying a known function from a nucleic acid sample The invention concerns a method for detecting a known function, from nucleic acids present in a sample, characterized in that it comprises the following steps: (a) preparing, from the nucleic acids of the sample, nucleic acid molecules comprising the gene(s) coding ... | 09/13/2011 |
| 7897336 | Molecular lymphatic mapping of sentinel lymph nodes The present invention describes a method for identification and labeling of sentinel lymph nodes (SLNs) and the presence or absence of lymph node metastases as an important diagnostic and prognostic factor in early stage cancers of all types. The method, know as Mol... | 03/01/2011 |
| 7803528 | Fluorescence energy transfer by competitive hybridization A method is provided for detecting the presence of nucleotides or monitoring nucleotide amplification. It utilizes fluorescence energy transfer by competitive hybridization. Competitive hybridization is achieved by using unequal length complementary probes which hav... | 09/28/2010 |
| 7709192 | Nucleic acid ligand diagnostic biochip A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule conta... | 05/04/2010 |
| 7456273 | Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions relating to same Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating ilie oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detectin... | 11/25/2008 |
| 7449297 | Methods of copying the methylation pattern of DNA during isothermal amplification and microarrays A method for copying the methylation patterns of molecules of genomic DNA (MGD) during isothermal amplification of the MGD comprising obtaining MGD, copying the methylation patterns of the MGD using a DNA methylation-maintenance enzyme, while isothermally amplifying... | 11/11/2008 |
| 7442782 | Intron associated with myotonic dystrophy type 2 and methods of use The present invention provides methods for identifying individuals not at risk for developing myotonic dystrophy type 2 (DM2), and individuals that have or at risk for developing DM2. The present invention also provides isolated polynucleotides that include a repeat... | 10/28/2008 |
| 7435572 | Methods and compositions for DNA manipulation Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a casset... | 10/14/2008 |
| 7435794 | Methods and compositions for selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, and nuclease compositions for use in practicing the same Methods of selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, as well as nuclease containing compositions for use therein, are provided. In the subject methods, a nuclease or composition thereof is employed to provide for sel... | 10/14/2008 |
| 7429376 | Methods of screening for compounds that improve engraftment The invention provides for methods of screening for compounds that increase the expression of P-selectin, SDF-1, and/or CXCR4 on facilitatory cells (FCs). The invention also provides for methods of screening for compounds that increase the level of p-predendritic ce... | 09/30/2008 |
| 7393644 | Method for real-time detection of polymerase chain reaction A method for real-time detection of polymerase chain reaction (PCR) is provided. The method includes: manufacturing a reactor having a plurality of electrodes; immobilizing a PCR primer to surfaces of electrodes; injecting a mixture for a PCR into the reactor to per... | 07/01/2008 |
| 7387876 | Amplification of trace amounts of nucleic acids Methods of reducing background during amplification of small amounts of nucleic acids employ careful analysis of sources of low level contamination. Ultraviolet light can be used to reduce nucleic acid contaminants in reagents and equipment. “Primer-dimer” backg... | 06/17/2008 |
| 7374914 | Method of detection of alterations in MSH5 We have now discovered that mammals have a DNA gene analogous to that existing in bacteria. MSH5 defects or alterations in this mismatch repair pathway in a mammal, such as a human, can be diagnostic of a predisposition to cancer, and prognostic for a particular can... | 05/20/2008 |
| 7368243 | Detection of nucleic acids to assess risk for bovine spongiform encephalopathy The present invention provides a method of detecting abnormal serum nucleic acid profiles to assess the risk of a transmissible spongiform encephalopathy, e.g., BSE. ... | 05/06/2008 |
| 7364851 | Nucleic acid sequencing by Raman monitoring of uptake of precursors during molecular replication The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DN... | 04/29/2008 |
| 7364844 | Use of the gene in the field of angiogenesis The invention concerns a method for diagnosing cavernous angiomas for detecting mutations in the Krit1 gene. More particularly, said detection is performed by using nucleotide sequences. The invention further concerns the use of the Krit1 gene for therapeutic purpos... | 04/29/2008 |
| 7361469 | Dual labeled fluorescent probes The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present invention include an interactive pair of labels, as well as a hairpin sequenc... | 04/22/2008 |
| 7361460 | Approach to molecular diagnosis of human papillomavirus-related diseases The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the method improves the accuracy and reliability of diagnostic and prognost... | 04/22/2008 |
| 7348410 | Flea head, nerve cord, hindgut and malpighian tubule proteins The present invention relates to flea head, nerve cord, hindgut and Malpighian tubule proteins; to flea head, nerve cord, hindgut and Malpighian tubule nucleic acid molecules, including those that encode such flea head, nerve cord, hindgut and Malpighian tubule prot... | 03/25/2008 |
| 7341833 | Compositions and methods relating to nucleic acid reference standards The invention relates to novel nucleic acid reference standards comprising a nucleic acid comprising a known target sequence bound with a microparticulate binding agent where the binding agent includes liposomes, polyamines (e.g., nylon), siliceous compounds (e.g., ... | 03/11/2008 |
| 7332274 | Process of quality examining for microarray of biological material The present invention relates a process of quality examining for microarray of biological material. More particularly, the present invention is directed to a process of quality examining for microarray of biological material, which comprises 1) a step for mixing pro... | 02/19/2008 |
| 7320863 | Thyroid sodium/iodide symporter and nucleic acid encoding same The present invention provides a purified and isolated nucleic acid encoding a sodium/iodide symporter. The present invention also provides purified sodium/iodide symporter, a vector comprising nucleic acid encoding sodium/iodide symporter, a host cell transformed w... | 01/22/2008 |
| 7314746 | Apparatus and method for preparative scale purification of nucleic acids Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to... | 01/01/2008 |
| 7306906 | Engineered templates and their use in single primer amplification Methods of amplifying nucleic acid have now been discovered which include the steps of: a) annealing a primer to a template nucleic acid sequence, the primer having a first portion which anneals to the template and a second portion of predetermined sequence; b) synt... | 12/11/2007 |
| 7303869 | Solid-phase reactions The present invention relates to systems, compositions, and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for attaching nucleic acids to solid supports and ... | 12/04/2007 |
| 7303870 | Method of detecting microorganisms The present invention relates generally to a method for detecting, enumerating and/or identifying microorganisms in a sample. More particularly, the present invention provides a method for determining total microbial content in a sample by detecting the presence of ... | 12/04/2007 |
| 7297780 | Reactive functional groups for preparation of modified nucleic acid The present invention relates to compositions and methods for the preparation of modified nucleic acids. In particular, the present invention provides novel reagents and chemistries for the generation of linkers and modified phosphoramidates. ... | 11/20/2007 |
| 7297483 | Isolated luciferases and the use thereof This invention relates to an isolated nucleic acid molecule which is a) a nucleic acid molecule comprising SEQ ID No. 3, or b) a nucleic acid molecule which exhibits at least 90% sequence identity to the nucleic acid molecule of SEQ ID No. 3, and the claimed nucleic... | 11/20/2007 |
| 7294461 | Methods and compositions for transcription-based nucleic acid amplification Methods for isothermal exponential amplification of a target polynucleotide are disclosed. The methods employ two transcription modules, the first module providing linear amplification resulting in RNA transcripts, and a second module providing for further (generall... | 11/13/2007 |
| 7291465 | Method for direct detection of fungal pathogens The present invention relates to a method and diagnostic kit for directly detecting the presence of a specific species of mold/fungi in a sample, particularly a species which is toxic to humans or animals including pets and livestock. The method involves releasing a... | 11/06/2007 |
| 7291488 | Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification The present invention relates to a method of detecting the presence or absence of herpes simplex virus (HSV) in a sample based on amplifying a portion of the Glycoprotein G (US4) gene of HSV and detecting the presence of the amplified nucleic acid using primers and ... | 11/06/2007 |
| 7282328 | Helicase dependent amplification of nucleic acids Methods and a kit are provided for selectively and exponentially amplifying nucleic acids and include the use of a helicase preparation and a DNA polymerase such that the amplification can be performed isothermally. ... | 10/16/2007 |
| 7276340 | Age determination from biological stains using messenger RNA profiling analysis Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays, systems, methods and kits for the age determination of an individual from bloodstains or samples of unknown origin. The methodology is based on gene expression profiling analysis in which... | 10/02/2007 |
| 7276358 | Rapid quantification of butyric acid-producing bacteria using real-time PCR A set of primer pairs for amplifying a nucleic acid of a butyric acid-producing bacteria, each primer containing an oligonucleotide selected from the buk gene region of the butyric acid-producing bacteria. The primers are particularly suitable for amplifying the nuc... | 10/02/2007 |
| 7270951 | Method for direct nucleic acid sequencing The present invention provides a novel sequencing apparatus and the methods employed to determine the nucleotide sequence of many single nucleic acid molecules simultaneously, in parallel. The methods and apparatus of the present invention offer a rapid, cost effect... | 09/18/2007 |
| 7267986 | Method of detecting inorganic phosphoric acid, pyrophosphate and nucleic acid, and method of typing SNP sequence of DNA According to the present invention, an inorganic phosphoric acid is detected by a method which includes: subjecting a sample to a measurement system containing glyceraldehyde-3-phosphate, oxidized nicotinamide adenine dinucleotide or oxidized nicotinamide adenine di... | 09/11/2007 |
| 7264927 | Isolation and purification of nucleic acids A method for the isolation and purification of nucleic acids such as DNA, RNA, and PNA from various sources using cellulose particles or cellulose paper. Adjusting the concentrations of the salt and polyalkylene glycol to the levels that result in binding of nucleic... | 09/04/2007 |
| 7259251 | 3′ UTR of the human prohibitin gene The 3′ untranslated region of the human prohibitin gene has been isolated for use in a cancer susceptibility screen and as a therapeutic agent for the treatment of cancer. ... | 08/21/2007 |
| 7259256 | Primers useful in polymerase chain reaction for the identification of subtypes C1, C2 and C3 of staphylococcal enterotoxin type C The invention provides primers designed on base of the difference of sequences among staphylococcal enterotoxin subtypes, i.e., C1, C2 and C3. The invention also provides a PCR method for detecting subtypes of staphylococcal enteroto... | 08/21/2007 |
| 7252976 | Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample The present invention involves the use of quantitative RT-PCR to identify AC133 as a marker. AC133 is prevalent on endothelial progenitor cells (EPCs), which are important cells in angiogenesis. Therefore, the invention is applied to ascertain the quantity of EPCs i... | 08/07/2007 |
