Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 7118907 | Single molecule detection systems and methods A microfluidic system is provided that includes a substrate, a first microchannel disposed in the substrate for providing a reactant to a reaction zone, a second microchannel disposed in the substrate, and a third microchannel disposed in the substrate, the third mi... | 10/10/2006 |
| 7056716 | High fidelity reverse transcriptases and uses thereof The invention relates to reverse transcriptases which have increased fidelity (or reduced misincorporation rate) and/or terminal deoxynucleotidyl transferase activity. In particular, the invention relates to a method of making such reverse transcriptases by modifyin... | 06/06/2006 |
| 7037653 | Molecular methods for detecting guar gum additions to locust bean gum The invention concerns methods for detecting guar gum alone or in mixtures of guar gum and locust bean gum. The invention also concerns methods for extracting, amplifying, and detecting DNA of guar and locust bean gums and the mixtures thereof. DNAs of plants from w... | 05/02/2006 |
| 7033760 | Metallic solid supports modified with nucleic acids The present invention is directed to solid supports having metallic surfaces comprising blocking moieties and modified nucleic acids, which exhibit excellent characteristics in hybridization assays, in a stable, reproducible, rapid manner. In an additional aspect, t... | 04/25/2006 |
| 7022478 | Methods for evaluating stroke or cardiac ischemia by nucleic acid detection This invention relates to the use of a blood sample from a patient for evaluating stroke or cardiac ischemia in the patient. ... | 04/04/2006 |
| 7015372 | Plant artificial chromosome compositions and methods The present invention provides for the identification and cloning of functional plant centromeres in Arabidopsis. This will permit construction of stably inherited plant artificial chromosomes (PLACs) which can serve as vectors for the construction of transge... | 03/21/2006 |
| 6994962 | Methods of identifying point mutations in a genome The invention relates to a method for identifying inherited point mutations in a targeted region of the genome in a large population of individuals and determining which inherited point mutations are deleterious, harmful or beneficial. Deleterious mutation are ident... | 02/07/2006 |
| 6982146 | High speed parallel molecular nucleic acid sequencing A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. ... | 01/03/2006 |
| 6972197 | Plant chromosome compositions and methods The present invention provides for the identification and cloning of functional plant centromeres in Arabidopsis. This will permit construction of stably inherited minichromosomes which can serve as vectors for the construction of transgenic plant and animal ... | 12/06/2005 |
| 6951726 | Real-time PCR assay of the bacterium Edwardsiella ictaluri in channel catfish A rapid and sensitive PCR-based assay is provided to facilitate early detection of Edwardsiella ictaluri in channel catfish. This bacteria is the causative agent in the disease, Enteric septicemia of catfish (ESC). Also provided is a method of selecting breed... | 10/04/2005 |
| 6951714 | High-throughput microbial culturing Methods for isolating microbial species, particularly previously uncultured species, from non-laboratory source environments (such as soil, freshwater, seawater, etc.) are disclosed. These methods can include the use of cultures in arrays, and cells deposited on sol... | 10/04/2005 |
| 6936415 | Diagnostic compositions, elements, methods and test kits for amplification and detection of two or more DNA's using primers having matched melting temperatures An aqueous composition containing primers for opposing strands of two or more target nucleic acids can be used in polymerase chain reaction to provide simultaneously rapid and efficient amplification and detection of those nucleic acids. The primers for each target ... | 08/30/2005 |
| 6936443 | Detection and typing of human papillomavirus using PNA probes The invention provides materials and methods for detection and typing of HPV infection using PNA probes. More specifically, methods are provided for detecting high-risk types of HPV infection with minimal numbers of PNA probes or using PNA probes to selectively ampl... | 08/30/2005 |
| 6933117 | Reagents and methods for automated hybridization The invention provides novel reagents, reagent kits, and methods for automated hybridization. More particularly, the invention provides reagents, reagent kits, and methods for automated in situ hybridization and automated hybridization on a microarray. The use of au... | 08/23/2005 |
| 6929915 | Methods for nucleic acid manipulation A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The... | 08/16/2005 |
| 6916632 | Methods and reagents for molecular cloning The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful for performing such methods. For example, a method of covalently linkin... | 07/12/2005 |
| 6908735 | Polynucleotide quantitation method Methods useful for improving results obtained with enzyme-based polynucleotide amplification reactions. More particularly, the invented methods are useful for: (1) promoting amplification of template-specific products such that the amount of amplicon produced reflec... | 06/21/2005 |
| 6892139 | Determining the functions and interactions of proteins by comparative analysis The invention provides novel methods for characterizing the function of nucleic acids and polypeptides. The invention provides a novel method for identifying a nucleic acid or a polypeptide sequence that may be a target for a drug. The invention provides a novel met... | 05/10/2005 |
| 6884587 | Metallization of nucleic acids via metal nanoparticles produced ex-situ The invention relates to a process for the metallization of nucleic acids, comprising providing tris(hydroxymethyl)phosphine-Au (THP-Au) particles or derivatives thereof, binding said THP-Au particles to a nucleic acid to produce a metal nanoparticle-nucleic acid co... | 04/26/2005 |
| 6869764 | Nucleic acid sequencing using charge-switch nucleotides The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In opera... | 03/22/2005 |
| 6864058 | Vaccinia topoisomerases I-based assays for detection of specific DNA breaks Several types of DNA cuts are used as markers of apoptosis for detection of apoptotic cells in situ. The present invention includes a method to detect DNase II type DNA damage, bearing 5′OH using vaccinia topoisomerase I. The present invention also includes a meth... | 03/08/2005 |
| 6858412 | Direct multiplex characterization of genomic DNA The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids,... | 02/22/2005 |
| 6858382 | Detection systems for registering protein interactions and functional relationships Disclosed herein are methods for detecting complex protein interactions and protein functional relationships, and reagents for carrying out those methods. ... | 02/22/2005 |
| 6858431 | Bone mineralization proteins, DNA, vectors expression systems The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising nucleotide sequences that encode LMP, as well as host cells comprising those vectors. Moreover, the... | 02/22/2005 |
| 6855497 | DNA test for SCA-10 Included is a method for detecting spinocerebellar ataxia type 10 (SCA10) by measuring the presence or absence of a DNA expansion in a gene locus associated with spinocerebellar ataxia type 10. The method employs extracting DNA from a sample to be tested, amplifying... | 02/15/2005 |
| 6855498 | In-situ hybridization probes for the detection of microsporidial species The present invention provides in situ hybridization probes which include a marker and a nucleic acid molecule able to hybridize exclusively with only one species of Encephalitozoon. The nucleic acid molecule may be, for example, complimentary to segment 878-... | 02/15/2005 |
| 6852492 | Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication The methods, compositions and apparatus disclosed herein are of use for nucleic acid sequence determination. The methods involve isolation of one or more nucleic acid template molecules and polymerization of a nascent complementary strand of nucleic acid, using a DN... | 02/08/2005 |
| 6849410 | Method for detecting DNA polymorphism applying triple strand DNA formation technique An objective of this invention is to provide a method for detecting DNA polymorphism that has high sensitivity and efficiency and does not need long DNA searching region. A homologous recombination protein RecA makes partial triple strand DNA from target doub... | 02/01/2005 |
| 6846638 | Method and system for rapid biomolecular recognition of amino acids and protein sequencing Methods, compositions, kits, and apparatus are provided wherein the aminoacyl-tRNA synthetase system is used to analyze amino acids. The method allows very small devices for quantitative or semi-quantitative analysis of the amino acids in samples or in sequential or... | 01/25/2005 |
| 6844158 | Direct RT-PCR on oligonucleotide-immobilized PCR microplates The entire process of reverse transcription-polymerase chain reaction (RT-PCR) is simplified by using oligonucleotide-immobilized microplates made of, e.g., polypropylene, to which oligonucleotides are securely immobilized and which can be subjected to thermal cycle... | 01/18/2005 |
| 6841349 | Methods for the reduction of stutter in microsatellite amplification The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a G+C content of 50% or less; contacting the sample with at least one enzyme having nucleic ac... | 01/11/2005 |
| 6824977 | Assays for human T cell lymphotrophic virus types I and II Blood or other body fluid is screened for infection of an individual with HTLV-I and/or HTLV-II by subjecting each sample from the individual to a test for the presence of the Tax protein, DNA which encodes the Tax protein, or antibodies specific to the Tax protein,... | 11/30/2004 |
| 6818762 | Compositions and methods relating to nucleic acid reference standards The invention relates to novel nucleic acid reference standards comprising a nucleic acid comprising a known target sequence bound with a microparticulate binding agent where the binding agent includes liposomes, polyamines (e.g., nylon), siliceous compounds (e.g., ... | 11/16/2004 |
| 6815164 | Methods and probes for detection and/or quantification of nucleic acid sequences The present invention discloses nucleic acid detector probes for specific detection and/or quantification of target nucleic acid sequences and detection and/or quantification methods using these probes. In the absence of target nucleic acid sequence, a first oligonu... | 11/09/2004 |
| 6811974 | Primer-specific and mispair extension assay for identifying gene variation The invention relates to primer-specific and mispair extension assays for identifying gene variations, such as in different genotypes or subtypes of a given genotype. The assay includes extending a nucleic acid sequence from a patient sample with extension products ... | 11/02/2004 |
| 6803200 | Compositions and methods for the release of nucleic acid molecules from solid matrices The present invention relates to compositions and methods for releasing nucleic acid molecules from solid matrices. The invention further relates to compositions and methods for purifying and isolating nucleic acid molecules from biological materials such as animal ... | 10/12/2004 |
| 6800453 | Nucleic-acid programmable protein arrays Arrays of polypeptides are generated by translation of nucleic acid sequences encoding the polypeptides at a plurality of addresses on the array. ... | 10/05/2004 |
| 6794139 | Breast carcinoma-associated gene A pharmaceutical composition is disclosed, as well as its use in tumour diagnosis, therapy and prevention, methods for diagnosing, treating and preventing tumours, and antibodies and their use. ... | 09/21/2004 |
| 6790454 | Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained A composite product is disclosed as a collagen support comprising at least one porous collagen layer covered on at least one side with an essentially compact collagen membrane consisting either of a collagen film prepared by drying a collagen gel, preferably in air ... | 09/14/2004 |
| 6787316 | DNA cloning method The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecu... | 09/07/2004 |
