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| Number | Title | Issue Date |
| 6323328 | Human citrate synthase homolog The invention provides a human citrate synthase homolog (HUCS) and polynucleotides which identify and encode HUCS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for tr... | 11/27/2001 |
| 6310185 | Recombinant human anti-Lewis Y antibodies The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by murine atibodies specific for the Lewis Y antigen. The Lewis Y antigen is expressed in normal tissues but the level o... | 10/30/2001 |
| 6270978 | Immunomethods for isolating and indentifying human influx peptide transporter Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide transporter and in immunoassays to identify agents taken up... | 08/07/2001 |
| 6268470 | Composition and methods for the diagnosis, prevention, and treatment of neoplastic cell growth and proliferation The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers (e.g., colon cancer) in mammals, e.g., humans. The invention is based on the discovery of genes that are differentially expressed ... | 07/31/2001 |
| 6184013 | Catalytic antibodies against cocaine and methods of using and producing same This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmace... | 02/06/2001 |
| 6156877 | Compounds for diagnosis and/or therapy of tumours Compounds are provided for use in the diagnosis and/or therapy of tumors and/or as immunosuppressive agent. The compounds are antibodies which bind to IL-4 receptors and IL-4 receptor-binding fragments thereof. A preferred compound is monoclonal antibody ... | 12/05/2000 |
| 6150500 | Activators of endothelial nitric oxide synthase The regulatory peptides for constitutive nitric oxide synthase enzymes, and a peptide specific to inducible nitric oxide synthase, as well as derivatives of the peptides, homologous peptides, nucleic acids encoding the peptides, derivatives, and homologou... | 11/21/2000 |
| 6140464 | Nonapeptides that bind a HLA-A2.1 molecule The invention described methods for identifying a molecule of interest, as well as nucleic acid molecules which encode it, and binding partners for it. A cDNA library from a cell expressing the target is prepared, and expressed in host cells. Lysates of t... | 10/31/2000 |
| 6129914 | Bispecific antibody effective to treat B-cell lymphoma and cell line The invention provides bispecific antibodies with selective cytotoxicity against malignant B-cells. The bispecific antibodies bind to an effector cell antigen and to a 28/32 kDa heterodimeric protein on the surface of malignant B-cells. The invention also... | 10/10/2000 |
| 6124436 | Purified mammalian monocyte antigens and related reagents Cell surface antigens from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.... | 09/26/2000 |
| 6103525 | Hybridoma cell lines producing monoclonal antibodies that bind to human plasma hyaluronidase The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invent... | 08/15/2000 |
| 6103873 | Isolated renal cancer specific antigen The invention described methods for identifying a molecule of interest, as well as nucleic acid molecules which encode it, and binding partners for it. A cDNA library from a cell expressing the target is prepared, and expressed in host cells. Lysates of t... | 08/15/2000 |
| 6103235 | Methods of inducing immune tolerance using immunotoxins Provided is a method of treating an immune system disorder not involving T cell proliferation, comprising administering to the animal an immunotoxin comprising a mutant diphtheria toxin moiety linked to an antibody moiety which routes by the anti-CD3 path... | 08/15/2000 |
| 6096311 | Methods for use of monoclonal antibodies specific for the high affinity Fc receptor for immunoglobulin G Monoclonal antibodies which react specifically to Fc receptor of human effector cells are disclosed. Binding of the antibodies to the receptor is not blocked by human immunoglobulin G. The antibodies are useful for targeting human effector cells (e.g. mac... | 08/01/2000 |
| 6087125 | Polynucleotide encoding a novel human nm23-like protein The present invention provides polynucleotides which identify and encode a novel human nm23-like protein (H-nm23). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding H-nm23 and... | 07/11/2000 |
| 6075004 | Peptide compositions which induce immune tolerance and methods of use Peptide compositions which inhibit the binding of one protein to another protein, and corresponding methods of use are disclosed. These peptide compositions include at least one peptide which binds to one protein, and at least one peptide which binds to t... | 06/13/2000 |
| 6074833 | Osteoblast and fibroblast antigen and antibodies recognizing it Monoclonal antibodies (MAb) are provided which have binding specificity to an antigen expressed on osteogenic and fibroblastic cells (OFA) and are capable of binding to osteogenic and fibroblastic cells at a substantially higher extent as compared to thei... | 06/13/2000 |
| 6071515 | Dimer and multimer forms of single chain polypeptides The present invention discloses novel proteins which are dimers and multimers of single chain polypeptides. The single chain polypeptides having two domains derived from the immunoglobulin superfamily which are joined by a peptide linker. The dimers and m... | 06/06/2000 |
| 6063379 | Anti-idiotypic monoclonal antibodies and compositions including the anti-idiotypic monoclonal antibodies An anti-idiotypic monoclonal antibody that is specific against the N-glycolyl residues of gangliosides, particularly those expressed by cancer cells. The monoclonal antibody is useful as an immunomodulator for cancer treatment. Specifically, the anti-idio... | 05/16/2000 |
| 6036950 | Method for improving utilisation of nutrients by ruminant or ruminant-like animals A method for improving the nutrient uptake of a ruminant or ruminant-like animal comprising inoculating the animal with an immunogenic preparation effective in inhibiting the activity in the gastrointestinal tract of at least one species or strain of Arch... | 03/14/2000 |
| 6025191 | Isolated nucleic acid molecules which encode a melanoma specific antigen and uses thereof The invention involves the isolation of a nucleic acid molecule which encodes a melanoma associated antigen. Cell lines and expression vectors which include this and related sequences, as well as uses of these molecules, are described.... | 02/15/2000 |
| 6020134 | Method for diagnosing cancer via DNA hybridization The invention described methods for identifying a molecule of interest, as well as nucleic acid molecules which encode it, and binding partners for it. A cDNA library from a cell expressing the target is prepared, and expressed in host cells. Lysates of t... | 02/01/2000 |
| 6017716 | Methods for screening for possibility or melanoma in a subject This invention involves screening for possibility of melanoma. The screening method relies on the binding of antibodies to protein encoded by a nucleic acid molecule defined by the nuclotide sequence of SEQ ID NO:2.... | 01/25/2000 |
| 6018031 | Binding agents specific for IgA receptor Binding agents which bind specifically to a receptor for human IgA, including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting human ... | 01/25/2000 |
| 6010865 | Process for detecting a variant CD44 gene product The invention relates to a process for diagnosing and analysing tumours which is based on detecting the expression of certain variant exons of the CD44-gene. Detection may be carried out at the protein or nucleic acid level. In a preferred embodiment the ... | 01/04/2000 |
| 6010861 | Target specific screens and their use for discovering small organic molecular pharmacophores The invention relates to a general process by which recombinantly derived variable domains of antibodies encompassing either or both light and heavy variable regions with or without respective constant regions are engineered and selected for identificatio... | 01/04/2000 |
| 6010844 | Methods of preparing and recovering proteins There is disclosed the preparation and recovery of proteins, in particular of enzymes, by controlled proteolytic cleavage of pro-proteins, in particular pro-enzymes, in a single method step, wherein a pro-protein-containing solution is contacted with a pr... | 01/04/2000 |
| 6004554 | Methods for targeting the vasculature of solid tumors The present invention relates generally to methods and compositions for targeting the vasulature of solid tumors using immunologcially-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculat... | 12/21/1999 |
| 6001359 | Diagnosis of colon carcinoma using monoclonal antibodies to human influx peptide transporter Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide transporter and in immunoassays to identify agents taken up... | 12/14/1999 |
| 5998151 | Methods for predicting the efficacy of a chemotherapeutic regimen for gastrointestinal cancers using antibodies specific for thymidylate synthase Methods for determining whether a chemotherapeutic treatment is appropriate for patients afflicted with gastrointestinal cancers, comprising; (a) obtaining a solid tumor tissue sample from the patient; (b) measuring a thymidylate synthase expression level in the ti... | 12/07/1999 |
| 5990285 | Catalytic antibodies against cocaine This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmace... | 11/23/1999 |
| 5990275 | Linker and linked fusion polypeptides The invention is directed to a novel peptide linker useful for connecting polypeptide constituents into a novel linked fusion polypeptide. The peptide linker of the invention provides greater stability and is less susceptible to aggregation than previousl... | 11/23/1999 |
| 5989830 | Bifunctional or bivalent antibody fragment analogue A bispecific or bivalent double head antibody fragment, which is composed of a binding complex containing two polypeptide chains, whereby one polypeptide chain has two times a variable domain of a heavy chain (VH) in series and the other polype... | 11/23/1999 |
| 5977314 | Catalytic antibodies against cocaine This invention provides compounds which are analogs to the hydrolysis transition-state of a cocaine benzoyl ester group. This invention also provides such analogs linked to carrier proteins, and antibodies thereto. This invention further provides pharmace... | 11/02/1999 |
| 5972649 | Polynucleotide sequence encoding human multiple endocrine neoplasia type 1 protein The invention provides a human multiple endocrine neoplasia type 1 protein (MEND1) and polynucleotides which identify and encode MEND1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also pr... | 10/26/1999 |
| 5973116 | Compounds for targeting Fusion compounds comprising a target cell-specific portion fused to an oligomeric rival nuclease are disclosed. The inventive compounds are useful as anti-cancer agents. Methods of preparation and use of the inventive compounds are disclosed.... | 10/26/1999 |
| 5969109 | Chimeric antibodies comprising antigen binding sites and B and T cell epitopes The present invention relates to chimeric antibodies which comprise a B cell epitope, a T cell epitope, and/or an antigen binding site. The chimeric antibodies may be produced by replacing at least a portion of an immunoglobulin molecule with the desired ... | 10/19/1999 |
| 5969107 | Anti-idiotypic antibodies which induce an immune response against epidermal growth factor receptor The present invention relates to anti-idiotypic antibodies which induce an immune response against tumors, bearing as antigen the epidermal growth factor receptor (EGFR). The antibodies of the invention may mimic said antigen. As preferred embodiment the ... | 10/19/1999 |
| 5958412 | Methods of treating colon cancer utilizing tumor-specific antibodies This invention relates to methods of reducing the effects of colon cancer tumors. Various agents are conjugated to monoclonal antibodies which are specific for colon cancer cells. The conjugates are administered to patients having colon cancer such that t... | 09/28/1999 |
| 5955302 | Polynucleotide sequence encoding human dosage compensation-associated protein The present invention provides a human dosage compensation-associated protein (HDCAP) and polynucleotides which encode HDCAP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encodi... | 09/21/1999 |
