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| Number | Title | Issue Date |
| 4970144 | Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use Peptide fragments of certain apolipoproteins have been found to be both immunogenic and capable of eliciting antibodies with highly apolipoprotein-specific immunoreactivity. These antibodies, in labeled and unlabeled form, as well as the labeled synthetic... | 11/13/1990 |
| 4883579 | Photoresponsive redox detection and discrimination Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independentl... | 11/28/1989 |
| 4879249 | Linker compounds, linker-compound-ligands and linker-compound-receptors Novel immunoassay which utilizes an enzyme linked ligand or receptor wherein the enzyme is bacterial luciferase; mercantile kit useful in performing said immunoassay; and compounds utilized in performing said assay.... | 11/07/1989 |
| 4849330 | Photoresponsive redox detection and discrimination Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independentl... | 07/18/1989 |
| 4843020 | Method for detecting tetrahydrocannabinol in human urine involving melanin precipitation An improved method for the detection of tetrahydrocannabinol in human urine wherein the pigment melanin is precipitated out of the urine prior to analysis with a solution of nitroferricyanide so that the melanin does not interfere with the analysis. The v... | 06/27/1989 |
| 4840894 | Method for detecting a marker for essential hypertension and diagnostic use thereof A method for detecting the presence in a human of an integral membrane calcium-binding protein associated with essential hypertension which comprises isolating tissue from a human, treating the tissue to obtain integral membrane proteins, contacting the p... | 06/20/1989 |
| 4839297 | Test carrier and method for the analytical determination of a component of a body fluid The present invention provides a test carrier (1) for the analytical determination of a component of a body fluid with a base layer (2) and at least two planar test layers which, in the initial state of the test carrier, before carrying out the determinat... | 06/13/1989 |
| 4837162 | Non-fluorescing, non-reflective polyamide for use in diagnostic testing A polyamide dyed with a reactive dye capable of absorbing incident light of the excitation waveband of a fluorophore or light of the emission waveband of the polyamide is provided for use in assays in which the presence or quantity of an analyte is being ... | 06/06/1989 |
| 4837170 | Monoclonal antibody, measuring method of glucosylated protein by utilizing the monoclonal antibody, and kit therefor For the diagnosis of diabetes, a glucosylated protein in a sample is measured by subjecting the sample to a reducing treatment and then detecting a compound, which contains one or more reduced glucosylated lysine residual groups, in accordance with an imm... | 06/06/1989 |
| 4835110 | Method for enhancing analysis timing in kinetic nephelometry The peak verify time for kinetic nephelometric measurements of reactions between antigens and antibodies is adjusted as a function of the magnitude of the peak rate order to reduce the time required for peak verification. The scatter signal is zeroed foll... | 05/30/1989 |
| 4832916 | Chromatographic column for immunological determining methods The invention relates to a chromatographic column for separating antigen-antibody complexes from the free antigens not bonded to the antibodies and/or for complete bonding of all marked substances in the immunological determination of antigens or haptens ... | 05/23/1989 |
| 4833092 | Method for determining mimotopes A method of detecting or determining the sequence of monomers which is a topographical equivalent of the ligand which is complementary to a particular receptor of interest, the method comprising the steps of: 1. synthesizing a plurality of catamers, each said ... | 05/23/1989 |
| 4833090 | Preservation of glucose in blood Inclusion in a blood sample of an isomer of glucose which is capable of replacing glucose in blood cell metabolism ensures accuracy of glucose assay.... | 05/23/1989 |
| 4829010 | Immunoassay device enclosing matrixes of antibody spots for cell determinations An immunoassay device comprising a support which has a substantially planar surface 14 on which is located an array of small, closely-spaced, discrete, antibody coated areas (spots) 17. A cover 16 is spaced from the support surface 14 and is positioned ov... | 05/09/1989 |
| 4829011 | Agglutination assay A method of detecting the presence and/or amount (concentration) of an analyte in a sample is provided by forming a reaction medium containing (1) a sample; (2) a plurality of particles having a binding pair member bound to their surfaces; and (3) a monov... | 05/09/1989 |
| 4828980 | Membrane structure coated with low pI protein or carbohydrate and methods of making and use A membrane structure useful in filtration and diagnostic tests includes a microporous membrane formed from a biologically inert material, such as a polyamide, and has a coating comprising one or more water-soluble proteins or carbohydrates. None of the pr... | 05/09/1989 |
| 4828978 | Agglutination reagent and method of preparing same An agglutination reagent is prepared by covalently attaching an immunoreactive species to polymeric particles through reactive groups in the species. After attachment, the species is chemically modified with an acylating, alkylating or sulfonylating agent... | 05/09/1989 |
| 4829009 | Noise controlled immunoassays A method for reducing false positives and to assay background noise in solid phase immunoassays utilizes a matrix coated on a solid support, which matrix contains an effective amount of a noise reduction component and an effective amount of noise balancin... | 05/09/1989 |
| 4828984 | Composition, synthesis and use of simulated cells The synthesis, composition and use of particles exemplified by microbeads of uniform size and character, with covalently bound biological molecules for biological simulation is disclosed.... | 05/09/1989 |
| 4826776 | Method for determining hyaluronic acid, and a reagent kit for said method Method in determining hyaluronic acid by means of inhibition technique where in addition to the hyaluronic acid of the sample (analyte) a first reactant possessing hyaluronic acid structure (reactant (1), derivatized hyaluronic acid) and a second reactant... | 05/02/1989 |
| 4826767 | Enzymatic synthesis of waxes Process for generating an about 98% ester yield from fatty acids and fatty alcohols comprising esterifying the acid and alcohol in liquid phase under a vacuum of at least 0.5 bar in the presence of an immobilized lipase.... | 05/02/1989 |
| 4826771 | Procedure to be performed in conjunction with protein blotting or nucleic acid blotting Procedure to be performed in conjunction with protein blotting or nucleic acid blotting wherein the matrix to which said components have been transferred is contacted with reagent and wash solutions in a rotary drum.... | 05/02/1989 |
| 4826661 | Solid block chemical dispenser for cleaning systems A dispenser for and method of dispensing a concentrated cleaning solution from a solid block of a cleaning composition wherein the concentrated cleaning solution is dispensed at a substantially constant concentration during the entire useful life of the s... | 05/02/1989 |
| 4824785 | Canine corona virus vaccine An efficacious parenterally administered modified live Canine Corona virus vaccine which provides systemic, humoral protection and also protection of the intestinal tract in dogs from infection by virulent Canine Corona virus is produced. A method for pro... | 04/25/1989 |
| 4822747 | Polyacrylamide gel particles having hapten moieties bound thereto as immunoassay reagent An immobilized hapten reagent for use in a specific binding assay for the determination of a hapten or binding analog thereof in a liquid test sample and methods for preparing and using the immobilized hapten reagent. The immobilized hapten reagent compri... | 04/18/1989 |
| 4822732 | Method of concentrating and detecting biomolecules and cells A method of detecting biological substances having affinity properties by passing the substance to be detected in a flow over a solid surface to which surface a second substance, to which the substance to be detected shows affinity, is attached, so that t... | 04/18/1989 |
| 4820649 | Method and kit having layered device for detecting biological component by interference color A method for detecting a component of a biological system, which comprises contacting a biological component detecting device composed of a light reflecting substrate (I) substantially free from diffused reflection, a light interference layer (II) formed ... | 04/11/1989 |
| 4820633 | Process for production of an immune reactive, porous carrier material for heterogeneous immunological analysis Process for the production of an immune-reactive, porous carrier material for heterogeneous immunological analysis by application to a carrier material of a solution of a receptor and of a component precipitating this immunologically, incubation of the ca... | 04/11/1989 |
| 4820637 | Detection of fungi and/or algae with stilbene having at least 4 sulpho groups The invention relates to a method for the detection of fungi and algae in animal or human tissues and body fluids, to preparations containing an optical whitening agent suitable for the method, and to a test pack for performing the method. The tissue sect... | 04/11/1989 |
| 4820490 | Device and method for chemical analysis of fluids with a reagent coated light source A device for measuring transmittance of light comprises a light source, photodetector and signal processor. The concentration of a substance in a fluid sample can be accurately determined by coating the light source with a reagent that is chemically react... | 04/11/1989 |
| 4818685 | Method and kit for diagnosing bloom's syndrome A method and kit for diagnosing Bloom's syndrome are provided relying on specific monoclonal antibodies, such as ATCC HB-9311, which recognize the base excision repair pathway enzyme uracil DNA glycosylase from normal healthy individuals and individuals a... | 04/04/1989 |
| 4818710 | Method for optically ascertaining parameters of species in a liquid analyte An optical waveguide with one or more coatings of reactants specific to species to be analyzed in a liquid analyte immersed therein. A light signal carried by the waveguide undergoes interaction either with the bulk analyte whereby a first signal in conne... | 04/04/1989 |
| 4818677 | Membrane assay using focused sample application Methods and kits are described for performing immunoassays. The kit includes a reaction cell having a microporous membrane and an absorbent capable of drawing liquid sample through the membrane. An applicator is provided for applying a small volume of the... | 04/04/1989 |
| 4818678 | Diagnostic system for the detection of cytomegalovirus A mammalian monoclonal receptor is produced by a hybridoma formed by fusion of cells from a myeloma cell line and lymphocytes that produce antibodies that react with a viral antigen from a mammal immunized with cytomegalovirus-infected cells. The monoclon... | 04/04/1989 |
| 4818684 | Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof A competitive immunoassay for a steroid receptor has been developed in which monoclonal antibodies capable of binding to the steroid receptor are competitively bound by anti-steroid antibodies capable of binding to the steroid. The presence or amount of m... | 04/04/1989 |
| 4818707 | Device and mixture for testing for immune responses to food A device for the detecting of an individual's Gell-Coombs Types I, II, III and IV immune response reactions to edible substances includes a mixture of an edible substance and a solution of non-toxic aprotic solvent, such as DMSO and water. The solvent act... | 04/04/1989 |
| 4816400 | Basement membrane collagen degrading enzyme and method of purifying same Basement membrane collagen degrading enzymes are provided which are useful for the detection of malignant cells with metastatic activity. Means for detecting such cells are also provided.... | 03/28/1989 |
| 4816250 | Preparing vaccine against Herpes simplex virus A vaccine against a DNA virus, for exmaple, Herpes simplex virus, is prepared by incubating a cell sample which has been infected with the virus, releasing the nuclei in the infected cell material from the cytoplasmic fraction of that material, chemically... | 03/28/1989 |
| 4816409 | Method of eliminating tumor cells and device therefor Bone marrow or blood containing tumor cells can be freed from the tumor cells by bringing it into contact with an water-insoluble antitumor monoclonal antibody which is prepared according to the enzyme insolubilizing method and thereby combining the tumor... | 03/28/1989 |
| 4816417 | Assay for 1,25-dihydroxy vitamin D in sample containing vitamin D transport protein An assay for 1,25-dihydroxy vitamin D is disclosed. One aspect of the invention involves adding pig receptor protein, radiolabeled, 1,25-dihydroxy vitamin D and biotinylated antibody capable of binding to the receptor to untreated blood serum. In performi... | 03/28/1989 |
