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| Number | Title | Issue Date |
| 8005623 | Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease p... | 08/23/2011 |
| 7983850 | Diagnosis, prognosis, identification, and classification of multiple myeloma based on gene expression profiling Provided herein is a method for gene expression profiling multiple myeloma patients into distinct subgroups via DNA hybridization and hierarchical clustering analysis of the hybridization data where the results may further be used to identify therapeutic gene target... | 07/19/2011 |
| 7974788 | Gene discovery through comparisons of networks of structural and functional relationships among known genes and proteins The present invention also relates to natural language processing and extraction of relational information associated with genes and proteins that are found in genomics journal articles. To enable access to information in textual form, the natural language processin... | 07/05/2011 |
| 7970548 | AFLP-based method for integrating physical and genetic maps The invention pertains to a method for the integration of physical and genetic maps and markers. The method is based on the use of AFLP fingerprinting with primers of varying selectivity on a library of artificial chromosomes such as a BAC library. The fingerprintin... | 06/28/2011 |
| 7957912 | Methods for identifying and producing polypeptides In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. One disclosed method involves identifying and producing a polypeptide. The method may involve (a) rec... | 06/07/2011 |
| 7957910 | Method for predicting effectiveness of chemotherapy A method for predicting an effectiveness of chemotherapy is described. The method comprises a comparing step and a predicting step. The comparing step is a step of comparing a threshold value with a parameter of a cyclin dependent kinase (CDK) included in a sample c... | 06/07/2011 |
| 7941275 | Method and system for automated detection of immunohistochemical (IHC) patterns A method and system for automated detection of immunohistochemical (IHC) patterns. The method and system is able to automatically differentiate an epithelial cell part from a non-epithelial cell part of a digital image of a tissue sample to which an IHC compound has... | 05/10/2011 |
| 7939646 | Compositions and methods for the therapy and diagnosis of prostate cancer Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides,... | 05/10/2011 |
| 7935679 | Gene expression profiling based identification of CKS1B as a potential therapeutic target in multiple myeloma Gene expression profiling is a powerful tool that has varied utility. It enables classification of multiple myeloma into subtypes and identifing genes directly involved in disease pathogensis and clinical manifestation. The present invention used gene expression pro... | 05/03/2011 |
| 7930104 | Predicting response to chemotherapy using gene expression markers The present invention provides gene expression information useful for predicting whether a cancer patient is likely to have a beneficial response to treatment with chemotherapy, comprising measuring, in a biological sample comprising a breast tumor sample obtained f... | 04/19/2011 |
| 7930107 | Methods of generating variant proteins with increased host string content The present invention relates to novel methods for generating variant proteins with increased host string content, and proteins that are engineered using these methods. ... | 04/19/2011 |
| 7925445 | Read-write assay system A read-write assay system includes providing an assay device; and writing assay device information to the assay device for subsequent reading of the assay device information from the assay device; or performing an assay with the assay device and subsequent writing o... | 04/12/2011 |
| 7923546 | Base sequence for control probe and method of designing the same There are provided a sequence for a control probe having a sequence rarely forming a secondary structure and rarely hybridizing with an undesired target and a method of designing thereof. There is further provided a probe carrier employing a control probe designed b... | 04/12/2011 |
| 7923542 | Libraries of regulatory sequences, methods of making and using same Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. In particular, libraries of regulatory sequences are provided, in which each member of the library comprises a polynucleot... | 04/12/2011 |
| 7912652 | System and method for mutation detection and identification using mixed-base frequencies The present teachings disclose methods for evaluation of sequence information to characterize putative heterozygous indel mutations. The mutation analysis methods utilize sequence and trace information to identify mixed-base presence resulting from allelic differenc... | 03/22/2011 |
| 7910353 | Methods and apparatuses for achieving precision genetic diagnoses Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or inef... | 03/22/2011 |
| 7904249 | Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedures In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators are used to identify sets of oligonucleotides for in vitro recombination. In certain embodiments, the methods involve inputting amino acid sequence character strings... | 03/08/2011 |
| 7904285 | Method, system and apparatus for accessing, modulating, evoking, and entraining global bio-network influences for optimized self-organizing adaptive capacities The invention interacts with subjects to query, challenge, and identify aspects and multidimensional influences providing access to, modulation and entrainment of, state-specific global bio-regulatory self-organizing controllers and evocable triggers. Modulating sta... | 03/08/2011 |
| 7899623 | Methods and computer program products for analysis and optimization of marker candidates for cancer prognosis Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of fe... | 03/01/2011 |
| 7894992 | Diagnosis and classification of multiple myeloma Gene expression profiling between normal B cells/plasma cells and multiple myeloma cells revealed four distinct subgroups of multiple myeloma plasma cells that have significant correlation with clinical characteristics known to be associated with poor prognosis. Dia... | 02/22/2011 |
| 7888477 | Ovarian cancer-associated antibodies and kits Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, anti... | 02/15/2011 |
| 7885767 | Method, an installation, and a computer program for estimating the initial size of a population of nucleic acids, in particular by PCR In order to estimate the size of an initial population of nucleic acids in a sample of interest, in particular by PCR, the following steps are performed: a) providing a model of the effectiveness (En) of the PCR, the mod... | 02/08/2011 |
| 7873502 | Creation and maintenance of a history list in a method and apparatus for integrated modeling, simulation and analysis of chemical and biological systems A system for modeling, simulating and analyzing chemical and biochemical reactions includes a modeling environment for constructing a model of a chemical or biochemical system comprising a plurality of chemical reactions. The system also includes a simulation engine... | 01/18/2011 |
| 7873499 | Methods of populating data structures for use in evolutionary simulations In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two... | 01/18/2011 |
| 7869959 | Optimized probe selection method The present invention provides methods for optimizing oligonucleotide hybridization probes for use in basic and clinical research. Specifically, the invention involves hybridizing serially diluted genomic sample to the oligonucleotide probes on the array, such that ... | 01/11/2011 |
| 7868149 | Plant genome sequence and uses thereof The present invention is in the field of plant biochemistry and genetics. More specifically the invention relates to nucleic acid molecules from plant cells, in particular, genomic DNA sequences from rice plants and nucleic acid molecules that contain markers, in pa... | 01/11/2011 |
| 7862995 | Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor The present invention relates to a panel of targeted therapy markers that can be used in assessing a particular subject's sensitivity to various therapeutic agents and cancer treatments as a means of prognosticating whether a treatment or use of a particular therape... | 01/04/2011 |
| 7856320 | Systems for gene expression array analysis Disclosed are methods and systems for applying independent component analysis (ICA) and other advanced signal processing techniques to automatically identify an optimal number of independent gene clusters and to efficiently separate gene expression data into biologi... | 12/21/2010 |
| 7853410 | Method for making polynucleotides having desired characteristics In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. ... | 12/14/2010 |
| 7846412 | Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a quantum dot and a hydrophobic protection structur... | 12/07/2010 |
| 7848888 | Method for identification of biologically active agents The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, cr... | 12/07/2010 |
| 7844431 | Method and apparatus for integrated modeling, simulation and analysis of chemical and biochemical reactions An integrated system for modeling, simulating and analyzing chemical and biochemical reactions includes a modeling environment for constructing a model of a chemical or biochemical reaction. The system also includes a simulation engine accepting as input the constru... | 11/30/2010 |
| 7834146 | Recombinant polypeptides associated with plants Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved properties. | 11/16/2010 |
| 7835868 | Process for selecting shaped particles for use in a packed bed A process for selecting shaped particles for use in a tube which is capable of being packed with shaped particles to form a packed bed in the tube. A desired value of one or more properties of the packed bed is defined. The dimensions of the shaped particles are cal... | 11/16/2010 |
| 7831392 | System and process for validating, aligning and reordering one or more genetic sequence maps using at least one ordered restriction map A method and system are provided for comparing ordered segments of a first DNA restriction map with ordered segments of a second DNA restriction map to determine a level of accuracy the first DNA map and/or the second DNA map. In particular, the first and second DNA... | 11/09/2010 |
| 7826979 | Method of modeling complex formation between a query ligan and a target molecule Computer-based methods for modeling complex formation between a query ligand and a target macromolecule are described herein. The methods can include, for example, providing a structural model of a query ligand and a structural model of a target macromolecule; ident... | 11/02/2010 |
| 7816123 | Methods and apparatuses for achieving precision genetic diagnoses Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or inef... | 10/19/2010 |
| 7813880 | Apparatus and method for providing optimal concentrations for medication infusions Optimum concentrations for a drug administered as a medical infusion to a patient, particularly a pediatric patient, are determined. The determination is made using inputs regarding (1) the drug to be administered; (2) the patient; and (3) the infusion process. The ... | 10/12/2010 |
| 7809509 | Comparative mapping and assembly of nucleic acid sequences A method for assembling nucleic acid sequence fragments is disclosed. The fragments are assembled using information about their relative position inferred by comparison of the fragments against a known sequence of a related nucleic acid (FIG. 3). Additionally... | 10/05/2010 |
| 7801683 | Hierarchical optimization for procedural effectiveness in diagnosing mutations that relate to disease A method for determining the optimal test order for diagnosing mutations that relate to a disease. The method includes receiving data, creating a database, receiving new data, applying at least one decision tree algorithm to score each possible test order, and gener... | 09/21/2010 |
