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| Number | Title | Issue Date |
| 7574304 | Chromatin segmentation A method of segmenting chromatin particles in a nucleus of a cell by locating regional minima in an image, computing a zone of influence (ZOI) around each regional minimum, and segmenting a single chromatin blob within each ZOI using a region growing procedure. The ... | 08/11/2009 |
| 7191068 | Proteomic analysis of biological fluids The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth ... | 03/13/2007 |
| 7171311 | Methods of assigning treatment to breast cancer patients The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as... | 01/30/2007 |
| 7101963 | polypeptides and uses thereof The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication pr... | 09/05/2006 |
| 7091315 | Protein HDPBQ71 The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted prote... | 08/15/2006 |
| 7078169 | Methods for the identification of inhibitors of an isoprenoid metabolic pathway The present invention relates to methods of identifying genes whose expression is indicative of activation of a particular biochemical or metabolic pathway or a common set of biological reactions or functions in a cell (“regulon indicator genes”) The present inv... | 07/18/2006 |
| 7074898 | Compositions and methods for therapy and diagnosis of prostate cancer Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a t... | 07/11/2006 |
| 7065450 | Process for production of new catalysts using an evolutionary process This invention relates to a process wherein improved production of catalysts is made possible according to an evolutionary method. The principles of mutation and crossing of catalyst components and determination of performance parameters of the mixed catalysts used ... | 06/20/2006 |
| 7058515 | Methods for making character strings, polynucleotides and polypeptides having desired characteristics “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. ... | 06/06/2006 |
| 7053205 | Cassava vein mosaic virus promoter nucleic acid sequences and expression vectors The invention relates to compositions useful for the production of transgenic plants. In particular, the invention relates to Cassava vein mosaic virus (CsVMV) promoter sequences and expression cassettes containing CsVMV promoter sequences. The invention describes n... | 05/30/2006 |
| 7048901 | Electrical connection structure, production method thereof, and electric wiring method An electrical connection structure that is able to electrically connect wiring to a biopolymer, a production method of the electrical connection structure, and an electric wiring method which is able to perform wiring on a nanometer-scale. A first aspect of the prod... | 05/23/2006 |
| 7048931 | Compositions and methods for the therapy and diagnosis of prostate cancer Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a t... | 05/23/2006 |
| 7041465 | Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus ... | 05/09/2006 |
| 7033827 | Prostate-specific polynucleotide compositions Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides,... | 04/25/2006 |
| 7035740 | Artificial intelligence and global normalization methods for genotyping Described herein are systems and methods for normalizing data without the use of external controls. Also described herein are systems and methods for analyzing cluster data, such as genotyping data, using an artificial neural network. ... | 04/25/2006 |
| 7024312 | Methods for making character strings, polynucleotides and polypeptides having desired characteristics “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. ... | 04/04/2006 |
| 7010431 | Method for effecting computer implemented decision-support in the selection of the drug therapy of patients having a viral disease A method is described for effecting computer-implemented decision-support in the selection of a drug therapy of patients having a viral disease. A rules database is provided and patient data is entered including genotype data on the viral genome of the viral disease... | 03/07/2006 |
| 7002004 | Biomolecule and/or cellular arrays on metal surfaces Disclosed is a process to construct multi-component biomolecule or cellular arrays suitable for use in SPR imaging studies of large molecule, cellular/molecular, and cell/cell interactions. Also disclosed are the resulting arrays. The success of the procedure hinges... | 02/21/2006 |
| 6996476 | Methods and systems for gene expression array analysis Disclosed are methods and systems for applying independent component analysis (ICA) and other advanced signal processing techniques to automatically identify an optimal number of independent gene clusters and to efficiently separate gene expression data into biologi... | 02/07/2006 |
| 6991928 | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of ident... | 01/31/2006 |
| 6980974 | Method for processing expression data of genes The expression data of specimen genes are processed using the SWEEP operator method and the parameter increasing method, and genes are selected. A FNN model is constructed by making the expression data of the selected genes as input variables. ... | 12/27/2005 |
| 6950753 | Methods for extracting information on interactions between biological entities from natural language text data The present invention relates to methods for identifying novel genes comprising: (i) generating one and/or more specialized databases containing information on gene/protein structure, function and/or regulatory interactions; and (ii) searching the specialized databa... | 09/27/2005 |
| 6943236 | Compositions and methods for the therapy and diagnosis of prostate cancer Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides,... | 09/13/2005 |
| 6917882 | Methods for making character strings, polynucleotides and polypeptides having desired characteristics “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. ... | 07/12/2005 |
| 6914131 | Neisserial antigens The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae, including amino acid sequences, the corresponding nucleotide sequences, expression data, and serological data. The proteins are useful antigens ... | 07/05/2005 |
| 6904369 | Conjugated ligands for the stimulation of blood cell proliferation by effecting dimerization of the receptor for stem cell factor This invention provides a computer based method for preparing a stem cell factor (SCF) analog comprising the steps of: (a) providing computer expression of the three dimensional structure of an SCF molecule using its crystal structure; (b) selecting from the compute... | 06/07/2005 |
| 6892140 | Immunogenic cancer peptides and uses thereof This invention relates to novel general methods and compositions that provide cancer-specific or highly cancer-associated antigens useful for diagnosis and treatment of cancer. ... | 05/10/2005 |
| 6859736 | Method for protein structure alignment This invention provides a method for protein structure alignment. More particularly, the present invention provides a method for identification, classification and prediction of protein structures. The present invention involves two key ingredients. First, an energy... | 02/22/2005 |
| 6858710 | Compositions and methods for the therapy and diagnosis of ovarian cancer Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, anti... | 02/22/2005 |
| 6839634 | Method for predicting reaction characteristics of molecules A molecule surrounding surface (20) is set so as to be reflected in the spatial dimension of a molecule. A molecule surrounding space surrounded by the molecule surrounding surface is divided into a plurality of component spaces (22), by which the reac... | 01/04/2005 |
| 6821724 | Methods of genetic analysis using nucleic acid arrays The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of murine genes. The invention provides the sequences in such a way as to make them available for a variety of analyses. As such, the invention related to div... | 11/23/2004 |
| 6822072 | Expressed sequence tags and encoded human proteins The sequences of 5′ ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs may be to obtain cDNAs and genomic DNAs corresponding to the 5′ ESTs. The 5′ ESTs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping... | 11/23/2004 |
| 6818754 | Methods and materials relating to semaphorin-like polynucleotides The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from c... | 11/16/2004 |
| 6820011 | Three-dimensional structure of complement receptor type 2 and uses thereof Disclosed is a crystalline human CR2 protein in complex with C3d, and the three dimensional structure of the crystalline complex. Also disclosed are methods of use of the structure, particularly for structure-based identification of compounds that bind to CR2 and in... | 11/16/2004 |
| 6800744 | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumonia that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypep... | 10/05/2004 |
| 6800746 | Compositions and methods for the therapy and diagnosis of prostate cancer Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides,... | 10/05/2004 |
| 6799119 | Method for detection of biological related materials using biomarkers The present invention relates to a method for the detection of biological agents and, in particular, biological agents that may present a health hazard. In one embodiment, the invention identifies the unidentified biological agent, assesses the reliability of the id... | 09/28/2004 |
| 6774222 | Molecular computing elements, gates and flip-flops This invention relates to novel molecular constructs that act as various logic elements, i.e., gates and flip-flops. The constructs are useful in a wide variety of contexts including, but not limited to, computation and control systems. The basic functional unit of ... | 08/10/2004 |
| 6772069 | Determining protein function and interaction from genome analysis A computational method system, and computer program are provided for inferring functional links from genome sequences. One method is based on the observation that some pairs of proteins A′ and B′ have homologs in another organism fused into a single protein chai... | 08/03/2004 |
| 6737514 | Compositions and methods for the therapy and diagnosis of lung cancer Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic ... | 05/18/2004 |
