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| Number | Title | Issue Date |
| 8084200 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 12/27/2011 |
| 8071732 | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T c... | 12/06/2011 |
| 8057799 | ErbB interface peptidomimetics and methods of use thereof Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are discl... | 11/15/2011 |
| 7999088 | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or ... | 08/16/2011 |
| 7981621 | In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC The present invention relates to the use of matrix metalloproteinase 7 (MMP-7) and/or its precursors and fragments with MMP-7 immunoreactivity, or of circulating anti-MMP-7 antibodies, as humoral biomarkers in diagnostic in vitro methods for the detection, early det... | 07/19/2011 |
| 7982004 | Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P5C5 provides a ... | 07/19/2011 |
| 7977463 | Polypeptide compounds for inhibiting angiogenesis and tumor growth In certain embodiments, this present invention provides polypeptide compositions (e.g., antibodies and antigen binding portions thereof that bind to EphB4), and methods for inhibiting EphB4 activity. In other embodiments, the present invention provides methods and c... | 07/12/2011 |
| 7973137 | Cell compositions comprising molecular complexes that modify immune responses Compositions comprising a cell in which a molecular complex with high affinity for its cognate ligand is bound to the surface of the cell are provided. To form the molecular complexes, extracellular domains of transmembrane heterodimeric proteins, particularly T cel... | 07/05/2011 |
| 7968090 | Nucleic acids and corresponding proteins entitled 191P4D12(b) useful in treatment and detection of cancer A novel gene 191P4D12(b) and its encoded protein, and variants thereof, are described wherein 191P4D12(b) exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 191P4D12(b) provides a d... | 06/28/2011 |
| 7960110 | Detection of chromosomal region copy number changes to diagnose melanoma This invention provides methods of detecting melanoma. The methods comprises detecting a gain or loss of certain chromosomal regions that undergo copy number changes in melanoma. ... | 06/14/2011 |
| 7951546 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 05/31/2011 |
| 7943306 | Gene expression signature for prediction of human cancer progression Methods are provided for classification of cancers by the expression of a set of genes referred to as the core serum response (CSR), or a subset thereof. The expression pattern of the CSR in normal tissues correlates with that seen in quiescent fibroblasts cultured ... | 05/17/2011 |
| 7939254 | Breast cancer related gene ZNFN3A1 Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. Also described are methods of treating and preventing breast cancer and breast cancer metastasis as well as methods of assessing the prognosis of a breast cancer subject and the... | 05/10/2011 |
| 7939272 | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R ki... | 05/10/2011 |
| 7939268 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 05/10/2011 |
| 7939263 | Compositions and methods for treating and diagnosing cancer The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell ca... | 05/10/2011 |
| 7935491 | Nucleic acid and corresponding protein entitled 24P4C12 useful in treatment and detection of cancer A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C... | 05/03/2011 |
| 7928196 | Nucleic acid and corresponding protein entitled 125P5C8 useful in treatment and detection of cancer A novel gene (designated 125P5C8) and its encoded protein, and variants thereof, are described wherein 125P5C8 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 125P5C8 provides a ... | 04/19/2011 |
| 7923429 | Treatment for CD5 B cell lymphoma The present invention provides methods for increasing expression of cell surface molecules of CD5+ B cell lymphoma cells by contacting cells with immune response modifiers. The invention also provides methods for the treatment of CD5+ B cell ly... | 04/12/2011 |
| 7919261 | Methods for predicting treatment response based on the expression profiles of protein and transcription biomarkers The invention disclosed herein describes novel biomarkers useful for risk assessment, screening, prognosis and selection and monitoring of therapy for HDAC mediated cell proliferative disorders. In particular, the invention provides the identities of three particula... | 04/05/2011 |
| 7919085 | Means for the diagnosis and therapy of CTCL The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and therapy of CTCL. ... | 04/05/2011 |
| 7919246 | SEMA4D in cancer diagnosis, detection and treatment This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the SEM A4D gene or proteins encoded by this gene. The invention also provides ... | 04/05/2011 |
| 7910318 | Methods of diagnosing ovarian cancer and kits therefor A method comprising: providing a biological sample from a subject (subject sample); and detecting the expression level of each of the markers FGF-2 and CA125 in the subject sample. A kit comprising means for detection of an expression level of each of markers CA125 ... | 03/22/2011 |
| 7910316 | Kit and method for detecting urothelial cancer This invention relates to a method for detecting in vitro a urothelial cancer, comprising measuring CXCL1 protein, or expression of a gene encoding the protein, in a biological sample from a subject, and to a kit for diagnosing a urothelial cancer comprising an anti... | 03/22/2011 |
| 7910295 | Detection of micro metastasis of melanoma and breast cancer in paraffin-embedded tumor draining lymph nodes by multimarker quantitative RT-PCR The invention provides a quantitative realtime RT-PCR assay for detection of metastatic breast, gastric, pancreas or colon cancer cells or metastatic melanoma. The assay allows to predict disease recurrence and survival in patients with AJCC stage I and II, and III ... | 03/22/2011 |
| 7906621 | Anti-tumor drug, medicament, composition, and use thereof An active polypeptide includes the amino acid sequence of SEQ ID NO:3, or having at least 50%, preferably 70%, more preferably 90% identity with the amino acid sequence of SEQ ID NO:3, or fragments thereof having at least 20 contiguous amino acids, or peptides havin... | 03/15/2011 |
| 7906635 | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in ... | 03/15/2011 |
| 7901881 | Diagnostic tool for diagnosing benign versus malignant thyroid lesions The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer. ... | 03/08/2011 |
| 7901878 | Screening assays for antioxidants and antiproliferative compounds Provided are screening assays for identifying and evaluating compounds with antioxidant and/or antiproliferative activities. ... | 03/08/2011 |
| 7897740 | Secreted protein called 36P6D5 characteristic of tumors Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, b... | 03/01/2011 |
| 7897356 | Methods and systems of using exosomes for determining phenotypes Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physio... | 03/01/2011 |
| 7897741 | Cell cycle phase markers The present invention relates to polypeptide and nucleic acids constructs which are useful for determining the cell cycle status of a mammalian cell. Host cells transfected with these nucleic acid constructs can be used to determine the effects that test agents have... | 03/01/2011 |
| 7892738 | Pot1 alternative splicing variants The present invention provides methods an compositions for diagnosis and treatment of carcinomas with aberrant expression patterns of POT 1. The invention also provides methods of identifying compounds that may modulate the cellular expression of POT 1. The inventio... | 02/22/2011 |
| 7892760 | Lung cancer markers, and uses thereof Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and ot... | 02/22/2011 |
| 7892761 | Protein markers for diagnosing stomach cancer and the diagnostic kit using them The present invention relates to protein markers for diagnosing stomach cancer and a diagnostic kit using the same, more precisely protein markers screened by two-dimensional gel electrophoresis and bioinformatics and a diagnostic kit using the same. The markers of ... | 02/22/2011 |
| 7892740 | Prognosis and therapy predictive markers and methods of use Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for char... | 02/22/2011 |
| 7892758 | Use of N-myristoyltransferase on non-tumor tissue for cancer diagnosis A diagnostic method and kit are disclosed for detection of cancer. Detection of elevated levels of N-myristoyltransferase (NMT) or NMT activity in blood or bone marrow, and specifically in peripheral blood mononuclear cells, can be used as a marker for cancer. The u... | 02/22/2011 |
| 7888480 | Reagents for the detection of protein phosphorylation in leukemia signaling pathways The invention discloses nearly 288 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selecti... | 02/15/2011 |
| 7888044 | Melanoma biomarker and methods of uses The present invention relates to the use of TROY, also called tumor necrosis factor receptor superfamily, member 19 (TNFRSF 19) also called toxicity and JNK inducer (TAJ), in diagnosis and therapy of non-epithelial cancers, such as melanoma. Accordingly, the inventi... | 02/15/2011 |
| 7884179 | Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer A novel gene 08P1D4 (also designated STEAP-1) and its encoded protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1... | 02/08/2011 |
