Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 7521195 | Lung disease targets and uses thereof The present invention provides a method for diagnosing and detecting diseases associated with lung. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in lung diseases (LCAT) and anti... | 04/21/2009 |
| 7442777 | Cytotoxicity mediation of cells evidencing surface expression of CD63 This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more ... | 10/28/2008 |
| 7439320 | Cripto tumour polypeptide Compositions and methods for the therapy and diagnosis of cancer, particularly lung, colon, colorectal and breast cancer, are disclosed. Illustrative compositions comprise one or more Cripto tumor polypeptides, immunogenic portions thereof, polynucleotides that enco... | 10/21/2008 |
| 7431923 | Cytotoxicity mediation of cells evidencing surface expression of CD63 This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more ... | 10/07/2008 |
| 7432066 | Non-invasive enzyme screen for tissue remodeling associated conditions Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence... | 10/07/2008 |
| 7429451 | Nucleic acids isolated from stage 4 neuroblastoma Diagnostic agent or kit for the prognosis of neuroblastoma is used to diagnose the prognosis of neuroblastoma (particularly, classifying its progress and determining stage 4s neuroblastoma), which agent or kit comprising a nucleic acid probe, nucleic acid primers, o... | 09/30/2008 |
| 7422859 | Method for discrimination of metaplasias from neoplastic or preneoplastic lesions The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.... | 09/09/2008 |
| 7407763 | Systems and methods for detecting and regulating metastasis The present invention relates to compositions and methods for cancer diagnostics and therapeutics, including but not limited to, RKIP cancer markers and RKIP pathway modulators. In particular, the present invention provides compositions and methods of using RKIP in ... | 08/05/2008 |
| 7407762 | Diagnosis of gynecological neoplasms by detecting the levels of oviduct-specific glycoprotein The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample... | 08/05/2008 |
| 7405283 | Screening methods and sequences relating thereto A screening method for identifying an individual having a pre-disposition towards having a cancer is disclosed, which screening method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence comprised in a gene in a gene in a base excisi... | 07/29/2008 |
| 7402389 | Compositions and methods for prognosis of cancers The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, pros... | 07/22/2008 |
| 7399595 | Means for the diagnosis and therapy of CTCL A means for the diagnosis and therapy of T lymphomas, in particular Cutaneous T Cell Lymphomas (“CTCL”) are provided. Tumor markers which are universal for CTCL are described. More particularly, a molecule, termed SC5 by the inventors, an allelic form of p140, a... | 07/15/2008 |
| 7399834 | Anti-PRO1558 antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 07/15/2008 |
| 7385023 | Cancer immunotherapy and diagnosis using cytochrome P450 1B1 The invention provides methods for conducting cancer immunotherapy and diagnosis using cytochrome P450 1B1 and peptide fragments thereof. ... | 06/10/2008 |
| 7381410 | Polypeptide compounds for inhibiting angiogenesis and tumor growth In certain embodiments, this present invention provides polypeptide compositions, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-a... | 06/03/2008 |
| 7381809 | Compositions and methods for the treatment of immune related diseases The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. ... | 06/03/2008 |
| 7378092 | Immunogenic compositions for induction of anti-tumor immunity The invention relates to methods of inducing an anti-tumor immunity and/or inducing an immune responses to p53 in mammals. The methods comprise administering to a mammal an effective amount of at least one immunogen selected from the group consisting of: | 05/27/2008 |
| 7378249 | Treatment of cancer using TLR3 agonists The present invention relates generally to the fields of genetics and medicine. More specifically, the present invention relates to improved methods of treating cancers using a TLR3 agonist, by assessing the expression of a TLR3 receptor by cancer cells. ... | 05/27/2008 |
| 7371834 | Apoptosis-inducing factor The present invention related generally novel mammalian apoptosis-inducing factors, polynucleotides encoding such factors and methods related thereto. ... | 05/13/2008 |
| 7371527 | Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expr... | 05/13/2008 |
| 7368548 | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as oppose... | 05/06/2008 |
| 7358348 | β-catenin nuclear localized protein The present invention provides a novel β-catenin nuclear localizing protein and DNA encoding the protein. Furthermore, the use of the β-catenin nuclear localizing protein and the DNA encoding the protein provides a diagnostic agent and therapeutic agent for diseas... | 04/15/2008 |
| 7345142 | Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of thes... | 03/18/2008 |
| 7342107 | Cynomolgus prostate specific antigen Isolated polynucleotides encoding Cynomolgus monkey prostate specific antigen and polypeptides obtainable from the polynucleotides and uses are disclosed. ... | 03/11/2008 |
| 7341721 | β-microglobulin (βm) and anti-βm binding agents as anti-cancer therapeutics The present invention describes the use of agents that interact with major histocompatibility complex (MHC) HLA class I molecules, such as β2-microglobulin, or antibodies that bind to β2-microglobulin, for the treatment and prevention of mult... | 03/11/2008 |
| 7339042 | Gene delivery to tumors Disclosed are methods and compositions for gene therapy for tumors. Cytotoxic agents are selectively expressed in endothelial cells of tumor blood vessels, and delivered to tumor cells adjacent to the blood vessels, producing a bystander effect such that all the cel... | 03/04/2008 |
| 7339026 | mda-9 protein This invention provides a method for producing a temporally spaced subtracted cDNA library comprising: a) isolating temporally spaced RNAs from cells; b) generating cDNA inserts from the RNAs isolated from step (a); c) producing a temporally spaced cDNA library havi... | 03/04/2008 |
| 7335738 | Heregulin-like factor The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant ... | 02/26/2008 |
| 7332584 | Antibodies that specifically bind PMS2 Antibodies against PMS2 and PMS2-134 and cells that produce the anti-PMS2 and anti-PMS2-134 antibodies are provided. The antibodies of the invention may be used in methods for detecting a PMS2 protein, including a truncated PMS2, and in methods for detecting an abno... | 02/19/2008 |
| 7329495 | Mutations in KIT confer imatinib resistance in gastrointestinal stromal tumors The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, s... | 02/12/2008 |
| 7323548 | Modulators of the function of FAS/APO1 receptors Proteins capable of modulating the function of FAS/APO1 are provided. The proteins may be prepared by culturing a host cell transformed with a vector containing the DNA encoding such a protein under suitable conditions and isolating the protein. ... | 01/29/2008 |
| 7323302 | Molecular markers The present invention relates generally to genetic sequences exhibiting differential expression patterns in cancer tissue relative to normal tissue. The identification of differentially expressed genetic sequences permits their use as molecular markers for cancer, a... | 01/29/2008 |
| 7317085 | Human apoptosis-associated genes and human apoptosis-associated proteins produced thereby As novel human apoptosis-related protein inducing apoptosis, a protein comprising the amino acid sequence of SEQ ID No. 2, 4 or 6 is provided. Moreover, a polynucleotide encoding the protein, an antibody against the protein, etc. are provided. These protein, polynuc... | 01/08/2008 |
| 7316907 | 14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, incl... | 01/08/2008 |
| 7288383 | Eosinophil-derived neurotoxin as a marker for ovarian cancer The present invention is directed to methods of identifying women at increased risk of having ovarian cancer. Identification is based upon the extent to which biological samples derived from the women exhibit elevated levels of eosinophil-derived neurotoxin (EDN). | 10/30/2007 |
| 7282562 | Compositions and methods for the treatment of immune related diseases The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases. ... | 10/16/2007 |
| 7258991 | Antibody to bladder cancer nuclear matrix protein and its use Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also... | 08/21/2007 |
| 7258983 | Cardiotrophin-1 compositions and methods for the treatment of tumor The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. S... | 08/21/2007 |
| 7253272 | Gene BRCC-2 and diagnostic and therapeutic uses thereof A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and treating cancers that involve expression of BRCC2 such as breast canc... | 08/07/2007 |
| 7250497 | Large deletions in human BRCA1 gene and use thereof Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to canc... | 07/31/2007 |
