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| Number | Title | Issue Date |
| 7407801 | Truncated CMV promoters and vectors containing same The present invention relates to nucleic acid molecules comprising certain truncated forms of the human cytomegalovirus (CMV) immediate-early enhancer-promoter, either alone or operably linked to transgenes of interest, including those encoding partially-deleted CFT... | 08/05/2008 |
| 7351697 | Tumor-specific vector for gene therapy The invention relates to a vector for the gene therapeutic treatment of tumors, especially in connection with radiotherapy. Said vector is provided with a therapeutic gene in the DNA sequence thereof. The gene is controlled by the promoter for the catalytic subunit ... | 04/01/2008 |
| 7344711 | Use of adenoviruses mutated in the VA genes for cancer treatment This invention refers to the use of an adenovirus for cancer treatment, being this adenovirus defective in its virus-associated (VA) RNAs. Said adenovirus has a mutation in the VAI or VAII gene sequence or both. This adenovirus may also have mutations in the sequenc... | 03/18/2008 |
| 7341718 | Neuronal gene transfer of adenovirus and herpes virus vectors The present invention is related to compositions and methods for the delivery of nucleic acids to neurons in a mammal, and uses thereof. The present invention specifically discloses the use of compounds that cause synaptic nerve sprouting to increase neuron retrogra... | 03/11/2008 |
| 7341871 | Nucleotide sequences for gene regulation and methods of use thereof The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or ... | 03/11/2008 |
| 7341710 | Method of identifying molecules that home to a selected organ in vivo The present invention provides methods for in vivo panning of a library to identify molecules that specifically home to a selected organ. ... | 03/11/2008 |
| 7318919 | Adenovirus vectors for gene therapy Gene Therapy vectors, which are especially useful for cystic fibrosis, and methods for using the vectors are disclosed. ... | 01/15/2008 |
| 7316924 | Twin-arginine translocation in Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a Bacillus. In another preferred embodiment, the host cell is a gram-negative microorganism. Preferably t... | 01/08/2008 |
| 7306794 | Methods and compositions for the treatment of defects in lipoprotein metabolism The invention provides a recombinant viral vector comprising the DNA of, or corresponding to, at least a portion of the genome of an adenovirus, which portion is capable of infecting a hepatic cell; and a human VLDL receptor gene operatively linked to regulatory seq... | 12/11/2007 |
| 7297540 | Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs Methods of generating, and isolating adult stem cells and utilizing such cells and/or embryonic stem cells in generating tissue of a specific function and micro-architecture are provided. ... | 11/20/2007 |
| 7285542 | Hyperthermic inducible expression vectors for gene therapy and methods of use thereof Methods and compositions are provided for transgene expression in target cells. Expression constructs using an inducible amplification system to drive expression of a therapeutic gene or other gene of interest in mammalian host cells are provided, as well as methods... | 10/23/2007 |
| 7273932 | Antisense oligonucleotides for fertility and menstrual cycle regulation and for chemopreventive and chemotherapeutic use The invention relates to antisense oligonucleotides, in particular to antisense oligonucleotides to receptor genes, and the use of such oligonucleotides to regulate reproductive function and as chemopreventive or as a chemotherapeutic for various cancers, especially... | 09/25/2007 |
| 7261887 | as carriers for the delivery of proteins and peptides Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. T... | 08/28/2007 |
| 7261886 | Insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides An insect larva aerosol infection method for producing recombinant proteins and baculovirus bio-insecticides is disclosed. A liquid spray of budded form baculoviruses are employed to infect insect larvae in order to reduce the manpower for manual injections and the ... | 08/28/2007 |
| 7261885 | Adenoviral vector with replication-dependent transgene expression The invention provides an adenoviral vector comprising (a) at least a portion of an adenoviral genome comprising a major late transcription unit containing a terminal exon, wherein the terminal exon comprises a 5′ splice acceptor DNA sequence element and a 3′ po... | 08/28/2007 |
| 7262062 | Diagnostic for scleroderma As anti-RNA polymerase (RNAP) antibodies are detected with high frequency in patients suffering from cutaneous scleroderma where skin sclerosis progresses rapidly, supervenes scleroderma renal crisis at a high rate, and associates with clinical entities whose progno... | 08/28/2007 |
| 7259255 | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast The promoter regions associated with the Yarrowia lipolytica glyceraldehyde-3-phosphate dehydrogenase (gpd) and phosphoglycerate mutase (gpm) genes have been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The ... | 08/21/2007 |
| 7256036 | Modified adenoviral fiber and target adenoviruses The invention relates to an adenovirus fiber modified by the mutation of one or more residues. The residues are directed towards the natural cell receptor in the three-dimensional structure of said adenovirus. The invention further relates to a DNA fragment, and exp... | 08/14/2007 |
| 7250404 | Lipid-mediated polynucleotide administration to deliver a biologically active peptide and to induce a cellular immune response A method for delivering an isolated polynucleotide to the interior of a cell in a vertebrate, comprising the interstitial introduction of an isolated polynucleotide into a tissue of the vertebrate where the polynucleotide is taken up by the cells of the tissue and e... | 07/31/2007 |
| 7250502 | Formaldehyde dehydrogenase genes from methylotrophic yeasts The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable marker in methylotrophic yeasts. The FLD promoter sequences are stro... | 07/31/2007 |
| 7250293 | Complementing cell lines A packaging cell line capable of complementing recombinant adenoviruses based on serotypes from subgroup B, preferably adenovirus type 35. The cell line is preferably derived from primary diploid human cells transformed by adenovirus E1 sequences either operatively ... | 07/31/2007 |
| 7247472 | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use A recombinant vector comprising capsid proteins derived from simian adenovirus Pan5, Pan6, Pan7, SV1, SV25 or SV39 sequences are described. These vectors contain a heterologous gene under the control of regulatory sequences packaged in the capsid. A cell line which ... | 07/24/2007 |
| 7247716 | Recombinant sequence, its preparation and use An isolated, purified or recombinant nucleic acid sequence is disclosed, comprising: (a) a sequence that encodes both an angiogenic factor antagonist and a vascular endothelial structure regulator; (b) a sequence substantially homologous to or that hybridizes to seq... | 07/24/2007 |
| 7244434 | Replicons of pestviruses that do not express C and or E1 protein and infectious viral particles containing same, that can be used in vaccines The present invention provides new Pestiviral RNA genomes (replicons) that are able to replicate, and can be packaged into infectious viral particles in cells that complement the missing protein(s), but do not produce infectious progeny virus. Such replicons can be ... | 07/17/2007 |
| 7241591 | Adenovirus comprising a gene coding for glutathione peroxidase The present invention relates to a defective adenovirus comprising at least a DNA sequence coding for all or an active part of glutathione peroxidase or a derivative thereof. It also relates to their utilization in therapy and to the corresponding pharmaceutical com... | 07/10/2007 |
| 7238347 | Suicidal mutant vaccine The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal cytolysis. The mutant can be selected from natural Leishmani... | 07/03/2007 |
| 7238346 | High capacity recombinant adenoviral vector for treatment of hemophilia A The invention relates to adenoviral vectors. More particularly, this invention relates to recombinant high capacity adenoviral vectors which can be employed in the treatment of hemophilia A, as well as methods and process for their creation and use. ... | 07/03/2007 |
| 7235652 | Artificial bidirectional promoter for activation of gene expression A bidirectional module for activation of gene expression and regulation of transcription in both directions is disclosed. The bidirectional module comprises multiple cis regulatory DNA sequence elements, strategically arranged to give a ‘Transcription Activating M... | 06/26/2007 |
| 7235638 | Coagulation factor VII derivatives The present invention relates to novel human coagulation Factor VII polypeptides, Factor VII derivatives as well as polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions... | 06/26/2007 |
| 7232940 | Polynucleotide sequences from rice The present invention provides polynucleotides isolated from eucaryotic organisms which are structural genes or promoters. Such isolated polynucleotides are particularly useful in the modification of gene expression in plants. This invention also relates to composit... | 06/19/2007 |
| 7229825 | Double-transfected cell line useful for the identification of transport inhibitors Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates,... | 06/12/2007 |
| 7220849 | Enhanced gamma-carboxylation of recombinant vitamin K-dependent clotting factor The invention relates to methods of optimizing gamma carboxylation of a vitamin K-dependent protein, methods of generating fully gamma carboxylated vitamin K-dependent protein, and compositions comprising chimeric nucleic acids and proteins for use in treatment of v... | 05/22/2007 |
| 7220578 | Single LTR lentivirus vector The present invention provides an isolated nucleic acid comprising a single retroviral LTR, a polypurine tract, a packaging signal, a primer binding site and a rev responsive element. Further provided is an isolated nucleic acid comprising a heterologous nucleotide ... | 05/22/2007 |
| 7217411 | CeSERT genes, proteins, and modulatory compounds The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin reuptake transporter (SERT) polypeptides, as well as the polypeptides themselves. The invention also features methods for identifying modulators of the biological... | 05/15/2007 |
| 7217699 | Compositions comprising genome segments and methods of using the same Methods of treating an individual who has a disease or disorder associated with one or more genetic mutations or undesirable alleles in genomic DNA of the individual, or preventing an individual from developing a disease or disorder associated with one or more genet... | 05/15/2007 |
| 7205103 | Method of regulating transcription in a cell The present invention provides methods and compounds for altering remodeling of chromatin in a cell. ... | 04/17/2007 |
| 7201911 | Cloned genomes of infectious hepatitis C viruses and uses thereof The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the developme... | 04/10/2007 |
| 7202055 | Process for the production of proteins and the production of arrays of proteins Described is a novel process for the production of at least one protein of interest by secretion of the protein of interest from a pro- or eukaryotic host cell in a compartment system, which host cell is stably expressing a secretion system and capable of heterologo... | 04/10/2007 |
| 7198951 | Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor Sequences of a serotype 9 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. AAV9-mediated delivery of therapeutic and immunogeni... | 04/03/2007 |
| 7195915 | Vectors for animal cells and use thereof Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated ... | 03/27/2007 |
