Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 6294377 | Adenoviral vectors of canine origin The present invention resides in use of a recombinant adenovirus of animal origin containing a heterologous DNA sequence for the preparation of a pharmaceutical composition intended for the therapeutic and/or surgical treatment of the human body.... | 09/25/2001 |
| 6203977 | Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization This disclosure relates to a method of specifically decorating selected mammalian chromosomes and of detecting, identifying and and/or quantitating selected individual chromosomes, by means of chromosomal in situ suppression (CISS) hybridization. The meth... | 03/20/2001 |
| 6040174 | Defective adenoviruses and corresponding complementation lines Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the process for the preparation of these novel defective adenovir... | 03/21/2000 |
| 6008022 | Human cytokine polypeptide The invention relates to human cytokine polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention furth... | 12/28/1999 |
| 6004746 | Interaction trap systems for detecting protein interactions Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first... | 12/21/1999 |
| 5958671 | Methods and compositions for regulating T cell subsets by modulating transcription factor activity Methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of a transcription factor, in particular the proto-oncoprotein c-Maf, that regulates expression of the Th2-associated... | 09/28/1999 |
| 5935816 | Chlamydia trachomatis lysS polynucleotides The invention provides lysS polypeptides and DNA (RNA) encoding lysS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lysS polypeptides to screen for antibacterial compounds.... | 08/10/1999 |
| 5932446 | HMVAB41 HMVAB41 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HMVAB41 polypeptides and polynucleotides in the design of protocols for the treatment of... | 08/03/1999 |
| 5932432 | Expression library screen by prenylation of expressed proteins Described is a novel in vitro method for obtaining and identifying proteins which, in their natural in vivo setting, are covalently modified after translation. To identify novel isoprenylated proteins for subsequent biochemical study, colony blots of a Gl... | 08/03/1999 |
| 5932435 | Screening antisense and ribozyme nucleic acids in schizosaccharomyces pombe The present invention relates generally to an in vivo system for gene expression and, more particularly, to the use of the system to screen for molecules which are capable of inhibiting, reducing, altering or otherwise modulating expression of a target nu... | 08/03/1999 |
| 5929045 | Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae The invention provides MurD polypeptides and DNA (RNA) encoding MurD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurD polypeptides to screen for antibacterial compounds.... | 07/27/1999 |
| 5925346 | Antisense strategy for the production of species specific viral insecticides A novel type of insect control agent and methods for controlling insect pests are described. The agent consists of a vector, such as a baculovirus of the polyhedral inclusion body type, containing in an antisense orientation cDNA sequence which has been d... | 07/20/1999 |
| 5919667 | Modular assembly retroviral vectors and uses thereof In accordance with the present invention, novel retroviral vectors containing modified long terminal repeats (LTRS) which enable high level and ligand-modulatable expression of a desired gene product, even after prolonged periods of cellular quiescence, h... | 07/06/1999 |
| 5916745 | Method and kit for detecting bovine acetyl coenzyme a synthetase nucleic acids A method and test kit for determining milk production in bovines is described. The acetyl coenzyme A synthetase (ACS) production is determined and related to milk production. The method is useful in selection and/or breeding to enhance milk production. Re... | 06/29/1999 |
| 5916810 | Method for producing tagged genes transcripts and proteins The invention described here is a method whereby a molecular tag is put on a gene, transcript and protein in a single recombinational event. The protein tag takes the form of a unique peptide that can be recognized by an antibody or other specific reagent... | 06/29/1999 |
| 5916554 | Use of pouch for implantation of living cells A biocompatable and biostable flexible pouch for use e.g., in implanting cell bodies producing therapeutic agents, featuring, in various aspects, either encapsulated or unencapsulated cell bodies contained within the pouch; and a means for attaching the o... | 06/29/1999 |
| 5914246 | Multiple drug resistance gene of Aspergillus fumigatus The invention provides isolated nucleic acid compounds encoding a multiple drug resistance protein of Aspergillus fumigatus. Vectors and transformed host cells comprising the multiple drug resistance-encoding DNA of Aspergillus fumigatus AfuMDR1 are also ... | 06/22/1999 |
| 5910414 | Topoisomerase I of streptococcus pneumoniae topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment... | 06/08/1999 |
| 5888765 | Endothelial-cell specific promoter A substantially pure DNA comprising an endothelial cell-specific promoter sequence capable of directing endothelial cell-specific transcription of a polypeptide-encoding sequence or an antisense template to which it is operably linked.... | 03/30/1999 |
| 5885777 | Cloning, expression and characterization of a novel form of phosphatidylinositol-3-kinase The present invention concerns a new phosphatidyl-inositol-3-kinase (PI3Kγ), a nucleic acid coding for it, an antibody directed against the protein as well as the diagnostic and therapeutic use of the protein, the nucleic acid and the antibody.... | 03/23/1999 |
| 5882924 | Vectors for the genetic selection of ligand binding proteins in microorganisms by means of signal transduction The invention relates to a process for the genetic selection in microorganisms of proteins which are capable of ligand binding, in which process a protein which is capable of ligand binding is presented extracytoplasmically and the signal of the ligand bi... | 03/16/1999 |
| 5879926 | Yeast strains for the production of mature heterologous proteins, especially hirudin The present invention relates to an improved system for producing mature heterologous proteins, and especially hirudin, by means of yeasts comprising an expression vector containing a sequence coding for the heterologous protein. This improvement is chara... | 03/09/1999 |
| 5876988 | Selection marker gene free recombinant strains: method for obtaining them and the use of these strains The present invention discloses a selection marker free system which can be used to introduce genetic modifications in bacteria, yeasts and fungi. The system can be employed to introduce or delete desired genes or DNA fragments in the genome of the indica... | 03/02/1999 |
| 5869037 | Adenoviral-mediated gene transfer to adipocytes The present invention provides for in vivo gene transfer to adipocytes mediated by adenovirus and, in particular, the in vivo transfer of toxic genes as a means of reducing adiposity, as well as the transfer of genes encoding angiogenic substances to indu... | 02/09/1999 |
| 5869239 | Library screening method Materials and methods for homologous-recombination screening of DNA libraries constructed in a eukaryotic host and methods for homologous-recombination chromosome walking for isolating overlapping DNA sequences for building an extended physical map of a c... | 02/09/1999 |
| 5869644 | Synthesis of diverse and useful collections of oligonucleotidies A new technique for generating mixtures of oligonucleotides in a single automated synthesis is taught. The method can be used to prepare mixed oligonucleotides ideally suited for creation of useful mixtures of oligo- or polypeptides or proteins. Additiona... | 02/09/1999 |
| 5866331 | Single molecule detection by in situ hybridization Disclosed are methods for accurately determining the total emission intensity of a single fluorochrome, under imaging conditions, using a digital imaging fluorescence microscopy system. Also disclosed are methods for detecting and localizing probe-target ... | 02/02/1999 |
| 5866382 | Xylose utilization by recombinant yeasts This invention relates to recombinant-DNA-technology. Specifically, this invention relates to new recombinant yeast strains transformed with xylose reductase and/or xylitol dehydrogenase enzyme genes. A yeast strain transformed with the xylose reductase g... | 02/02/1999 |
| 5863722 | Method of sorting polynucleotides The invention provides a method and materials for sorting polynucleotides with oligonucleotide tags. Oligonucleotide tags of the invention are capable of hybridizing to complementary oligomeric compounds consisting of subunits having enhanced binding stre... | 01/26/1999 |
| 5861246 | Multiple selection process for binding sites of DNA-binding proteins Methods are provided for isolating binding sites of DNA-binding proteins. An extract, such as a nuclear extract, containing DNA-binding proteins is mixed with oligonucleotide duplexes comprising a random sequence. Bound duplexes are isolated and amplified... | 01/19/1999 |
| 5856090 | DNA-methylase linking reaction The activity of sequence-specific DNA binder proteins, such as DNA methylases, provides a method of obtaining a covalent linkage between a nucleic acid segment and a polypeptide determinant encoded by the nucleic acid segment. The polypeptide determinant ... | 01/05/1999 |
| 5851762 | Genomic mapping method by direct haplotyping using intron sequence analysis The present invention is an improved genomic mapping method which is able to generate highly informative polymorphic sites throughout the genome. In addition to being highly polymorphic, the sites can be used to generate patterns that identify allelic and... | 12/22/1998 |
| 5851804 | Chimeric kanamycin resistance gene Chimeric kanamycin resistance genes are disclosed. The chimeric genes comprise a nucleotide sequence that encodes ANT(4')-IA enzyme operably linked to a heterologous promoter and a heterologous termination sequence. Plasmids that comprise the chimeric kan... | 12/22/1998 |
| 5851521 | Viral vectors and their use for treating hyperproliferative disorders, in particular restenosis The present invention relates to replication defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angi... | 12/22/1998 |
| 5846719 | Oligonucleotide tags for sorting and identification The invention provides a method of tracking, identifying, and/or sorting classes or subpopulations of molecules by the use of oligonucleotide tags. Oligonucleotide tags of the invention comprise oligonucleotides selected from a minimally cross-hybridizing... | 12/08/1998 |
| 5840570 | Aspartic proteinase deficient filamentous fungi This invention relates to novel mutant filamentous fungi which are deficient in the gene for the corresponding aspartic proteinase. These organisms are useful production hosts in the production of heterologous polypeptides such as chymosin.... | 11/24/1998 |
| 5837835 | Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties Modified oligonucleotides 3'-NHP(O)(O-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation e... | 11/17/1998 |
| 5830649 | Human galactokinase gene This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the... | 11/03/1998 |
| 5827552 | Production of fermented food products This invention discloses novel methods of making fermented food products such as yogurt. It also discloses novel Lactobacillus bulgaricus organisms for making fermented food products which are conditionally sensitive, that is, operate to metabolize a desi... | 10/27/1998 |
| 5824469 | Method for producing novel DNA sequences with biological activity A method of obtaining an oligonucleotide capable of carrying out a predetermined biological function. A heterogeneous pool of oligonucleotides, x+y+z nucleotides in length, is first generated. Each oligonucleotide has a 5' randomized sequence, x nucleotid... | 10/20/1998 |
