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| Number | Title | Issue Date |
| 8188147 | Therapeutic methods employing nitric oxide precursors Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymor... | 05/29/2012 |
| 8183259 | Heterocyclic compounds and their uses Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psorias... | 05/22/2012 |
| 8183292 | Chiral cyclic β-amino acids and their derivatives, pharmaceutical compositions containing them and the use of such compounds The invention relates to chiral cyclic β-amino acids of Formula (I) and their salts formed with pharmaceutically acceptable acids or bases, wherein the main meanings of the substituents are as follows: R stands for C1-4 Alk; X stands for —COOH, —CONH... | 05/22/2012 |
| 8183258 | Heterocyclic compounds and their uses Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psorias... | 05/22/2012 |
| 8173626 | Methods, dosing regimens and medications using anti-progestational agents for the treatment of disorders The present invention relates to the treatment of disorders using anti-progestational agents. More specifically, the present invention relates to the treatment of disorders using low doses of anti-progestational agents. Compared to dosages and lengths of treatment t... | 05/08/2012 |
| 8163722 | Pharmaceutical formulation for contraception and hormone-replacement therapy The present invention provides slow release estradiol-progesterone formulations that can be used in either contraception or hormone replacement therapies. The formulations comprise shaped particles of estradiol that is in a hemicrystalline form that exhibits especia... | 04/24/2012 |
| 8163805 | Small molecule antagonists of Bcl-2 family proteins The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds (e.g., isomers, enantiomers, racemic compounds, metabolites, derivat... | 04/24/2012 |
| 8163313 | Compositions containing amines and use thereof The present invention features compositions comprising at least one compound of the formula I or formula II: wherein R1, R2, R3, R4, and R5 independently, are selected from the group consisting of hydrogen, C1-C | 04/24/2012 |
| 8158638 | Pyrazolopyrimidine derivative Problem to be Solved To provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity. Solution The present invention provides a pyra... | 04/17/2012 |
| 8158138 | Urea compositions and their methods of manufacture Urea compositions useful for treatment of dermatological conditions. The compositions, which are free from perceptible solids, may include at least about 50 wt-% urea, zinc pyrithione, and lactic acid, and may be formulated as a topical gel. ... | 04/17/2012 |
| 8158613 | Topical pharmaceutical formulations and methods of treatment In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium the... | 04/17/2012 |
| 8153616 | Combination preparation for oral contraception and oral therapy of dysfunctional uterine bleeding containing estradiol valerate and dienogest and method of using same The multiphase combination preparation for oral therapy of dysfunctional uterine bleeding and for oral contraception contains a first phase consisting of 2 daily dosage units, each containing 3 mg of estradiol valerate or | 04/10/2012 |
| 8153694 | Cyclopropanecarboxylic acid compound A compound of the formula (I): wherein each symbol is as defined in the description, a salt thereof, and a prodrug thereof of the present invention unexpectedly have a superior GPR40 receptor agonist activity and superior p... | 04/10/2012 |
| 8148388 | 2,4 (4,6) pyrimidine derivatives The present invention is drawn to 2,4 (4,6) pyrimidine derived macrocyclcs, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell pro... | 04/03/2012 |
| 8138198 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, X and Y have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them a... | 03/20/2012 |
| 8138164 | HCV NS3 protease inhibitors The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. ... | 03/20/2012 |
| 8138187 | Substituted heteroaryl derivatives The invention relates to substituted heteroaryl derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted heteroaryl derivatives for producing medicaments. ... | 03/20/2012 |
| 8133906 | Method of treating amblyopia The present invention relates to a method of treating or alleviating the symptoms of amblyopia. It is based on the discovery that repeated administration of a specific drug, which is known to be clinically active to treat depression in humans, results in improved vi... | 03/13/2012 |
| 8129414 | Non-competitive NMDA receptor antagonists Disclosed herein are non-competitive NMDA receptor antagonists having chemical structures similar to that of phencyclidine (PCP). These antagonists contain a polycyclic ring structure in place of the cycloalkyl ring of PCP. The antagonists also differ from PCP in th... | 03/06/2012 |
| 8119693 | Tissue non-specific alkaline phosphatase inhibitors and uses thereof for treating vascular calcification Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate vascular calcification, arterial calcification and other cardiovascular diseases. ... | 02/21/2012 |
| 8110565 | Enhanced drug delivery in transdermal systems A composition for transdermal administration resulting from an admixture includes: a therapeutically effective amount of a drug that includes a parent drug and a prodrug; and a pharmaceutically acceptable carrier, wherein the parent drug and prodrug are individually... | 02/07/2012 |
| 8106097 | Composition based on substituted 1,3-diphenylprop-2-en-1-one derivatives, preparation and uses thereof The invention concerns compositions comprising substituted 1,3-diphenylprop-2-en-1-one derivatives designed for therapeutic use. The inventive compositions are useful in particular for preventing or treating cardiovascular diseases, syndrome X, Ia restenosis, diabet... | 01/31/2012 |
| 8106065 | Antitussive agent An antitussive, which can be used for therapy or prophylaxis of coughing, is disclosed. The antitussive comprises as an effective ingredient a morphinan derivative having a nitrogen-containing cyclic substituent or a pharmaceutically acceptable acid addition salt th... | 01/31/2012 |
| 8093258 | Use of urokinase inhibitors for the treatment and/or prevention of neuropathological diseases The present invention relates to methods and compositions for the treatment and/or prevention of neuropathological and/or neurodegenerative diseases. In particular, the invention delivers novel uses of inhibitors of Urokinase-type Plasminogen activator in the treatm... | 01/10/2012 |
| 8093243 | Hepatitis C virus inhibitors The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infec... | 01/10/2012 |
| 8093262 | Use of huperzine for disorders Methods and compositions containing huperzine are used to prevent and alleviate neuropathic pain. The invention is also directed to methods and compositions for using huperzine for the prevention and/or treatment of neuropathic pain and orthostatic hypotension. ... | 01/10/2012 |
| 8088927 | Fungicide N-cycloalkyl-benzyl-amide derivatives The present invention relates to N-cycloalkyl-benzyl-amide derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and meth... | 01/03/2012 |
| 8088786 | Layered pharmaceutical formulations In one embodiment a layered pharmaceutical formulation includes two or more pharmaceutical layers and an intermediate layer disposed between at least two of the two or more pharmaceutical layers, the intermediate layer configured to dissolve in vivo to thereby leave... | 01/03/2012 |
| 8084488 | Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium Novel forms of atorvastatin magnesium salt designated Form A, Form B, Form C, Form D, Form E, and Form F, pharmaceutical compositions containing such compounds, methods for their preparation and methods utilizing the compounds for treatment of hyperlipidemia, hyperc... | 12/27/2011 |
| 8084446 | Use of DHEA derivatives for enhancing physical performance A method is disclosed for administering a DHEA derivative or a physiologically acceptable salt, ester or ether thereof for one of decreasing body weight, reducing adipose tissue, increasing endurance, as an anti-aging compound and generating production of red blood ... | 12/27/2011 |
| 8076352 | Administration of carboline derivatives useful in the treatment of cancer and other diseases In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds ... | 12/13/2011 |
| 8076325 | 1,2,4,5-tetrahydro-3H-benzazepine compounds, a process for their preparation and pharmaceutical compositions containing them Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group selected from cycloalkyl, benzyl and optionally substituted alkyl, R2, R | 12/13/2011 |
| 8076353 | Inhibition of VEGF translation In accordance with the present invention, methods for inhibiting the translation of VEGF and methods for decreasing VEGF level by inhibiting VEGF translation are provided. In another aspect of the invention, compounds that inhibit the 5′-UTR-dependent translation ... | 12/13/2011 |
| 8076328 | Use of fungicides for the treatment of fish mycoses Process for the protection of fish and invertebrates and all their stages of development against or for the treatment of mycoses caused by fungi of the genera Saprolegnia, Aphanomyces, Achlyaflagellata and other species important in aquacultures by use of 2-[... | 12/13/2011 |
| 8076317 | Contraception process and administration form for the same Process for hormonal contraception, in which in a plurality of substantially time-unlimited, linked taking periods and optionally having a sequence lasting several years and which in each case comprise at least one taking cycle with a duration-constant taking phase ... | 12/13/2011 |
| 8071577 | Multi-phase contraceptive preparation based on a natural estrogen The multiphase preparation having higher contraceptive safety and reduced side effects is based on a combination of a natural oestrogen with dienogest or drospirenone. The multiphase preparation is characterized by a first phase consisting of 2 daily dose units of 3... | 12/06/2011 |
| 8071122 | Compositions and methods for increasing lean muscle mass and/or reducing fat gain Compositions and methods for increasing lean muscle mass and/or reducing fat gain in growing animals by feeding the animals a composition having a total lysine to metabolizable energy ratio of from about 2.5 to about 6 g/Mcal and comprising (a) arginine in a total a... | 12/06/2011 |
| 8071649 | Method for treatment of nocturia A method for treatment of nocturia by administering to a mammal, such as a human, in need of such treatment, a therapeutically effective amount of loxoprofen or a pharmacologically acceptable salt thereof. ... | 12/06/2011 |
| 8071630 | Treatment of effect of chemicals with their ultradilute stereoisomers A method of treating an effect of a chemical agent, which agent is characterized by one or more chiral centres, by administering a dilution or an ultra-high dilution or potentised preparation of a stereoisomer of said chemical agent. ... | 12/06/2011 |
| 8067399 | Method and apparatus for transdermal or transmucosal application of testosterone Methods, formulations, and devices for providing transdermal or transmucosal delivery of active agents to subjects in need thereof. The formulations and methods treat symptoms of hormonal disorders including hypogonadism, female sexual desire disorder, female menopa... | 11/29/2011 |
