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| Number | Title | Issue Date |
| 5354659 | Method for detecting pathological pregnancy A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in th... | 10/11/1994 |
| 5324668 | Method for detecting trisomy 13 and Down syndrome by non-invasive maternal blood screening A method and apparatus for determining if a pregnant woman is at significant risk of carrying a fetus with Down syndrome, The method comprises measuring the pregnant woman's maternal blood levels of the free beta subunit of human chorionic gonadotropin. T... | 06/28/1994 |
| 5316943 | Racemic conversion of using a transaminase Recombinant cells and an improved method utilizing them is disclosed for the preparation of an optically pure, L-amino acid from its D and D,L isomer forms. The process utilizes cell cultures that possess high aminotransferase activity that exhibits moder... | 05/31/1994 |
| 5316911 | Method of determining the presence of endotoxin in a sample In a method of determining the presence of an endotoxin or endotoxin-like material in a sample, a) a sample is incubated with a component of horseshoe crab amoebocytes lysate or haemolymph or a synthetic analogue thereof, b) the incubated mixture of the s... | 05/31/1994 |
| 5316953 | Screening method for detecting fetal chromosal abnormalities A screening method for fetal Down syndrome using free beta (HCG) as a marker. The maternal blood level of free beta (HCG) is measured and compared to reference data, at a similar gestational age, of the level of free beta (HCG) in pregnant women carrying ... | 05/31/1994 |
| 5310655 | Process for the detection of kidney tubule functioning In the case of a process for the detection of the functionability of the kidney tubules, one specifically determines the content of THP in the urine as measure of the function of the kidney tubules. One uses this process for the control of the transplant ... | 05/10/1994 |
| 5298397 | Method of assaying d-vanillylmandelic acid The present invention is concerned with a method of assaying D-vanillylmandelic acid (D-VMA) contained in a specimen of a living organism through the following steps (A) to (D), and a reagent and a kit used for the assay, wherein a racemic mixture of VMA ... | 03/29/1994 |
| 5296352 | Monoclonal antibodies directed against complexes formed by thrombin and hirudin The invention concerns monoclonal antibodies which are directed against the thrombin/hirudin-complex and derivatives thereof, processes for their preparation, hybridoma cell lines secreting said monoclonal antibodies, and processes for the preparation of ... | 03/22/1994 |
| 5290679 | Method of predicting threatened premature delivery in a pregnant woman Even when the specimen contains human granulocyte elastase in the form of a mixture of free elastase with an elastase-inhibitor complex or complexes, the present invention enables the total quantity of elastase in that specimen to be precisely detected. T... | 03/01/1994 |
| 5290680 | Monoclonal antibody, method of production thereof and use thereof The present invention relates to a monoclonal antibody which specifically recognizes 6,15-diketo-13,14-dihydro-prostaglandin F1 with high sensitivity, a hybridoma producing said monoclonal antibody, a method of establishing said hybrido... | 03/01/1994 |
| 5286749 | Control of sheep ectoparasites A topical liquid formulation for treating lice or head infection is disclosed. The formulation contains active ingredients such as deltamethrin or permethrin in a lower alkyl ether of glycol.... | 02/15/1994 |
| 5284750 | Serum proteins related to autoimmune disease A method for diagnosing a patient with an autoimmune disease using monoclonal antibodies to quantitate the amount of 680 kd, 54 kd, 44 kd or 14 kd present, wherein an elevated amount of protein compared to a patient without the disease indicates the prese... | 02/08/1994 |
| 5284778 | Sensitive bioassay using monoclonal antibodies which bind to hormone-receptor complexes This invention provides a quantitative assay for determining the amount of a biologically active ligand selected from the group consisting of human chorionic gonadotropin and luetinizing hormone present in a sample comprising contacting the sample with bo... | 02/08/1994 |
| 5283060 | Bacillus-containing pesticide granules Pesticide granules especially for delivering a biological pesticide in aquatic applications have a wax core and the pesticide secured to the core in a water dispersible or water soluble matrix. More specifically the pesticide composition is free flowing a... | 02/01/1994 |
| 5281579 | Purified virus-free hemoglobin solutions and method for making same An aqueous solution of cross-linked hemoglobin free of active virus and having a P50 under physiologic conditions of at least 26 mm. Hg. are disclosed.... | 01/25/1994 |
| 5281522 | Reagents and kits for determination of fetal fibronectin in a vaginal sample This invention relates to methods, reagents and kits for detection of normal or ectopic pregnancy, the termination of pregnancy, or increased risk of preterm labor and rupture of membranes. Each embodiment involves sampling from the vaginal cavity, and de... | 01/25/1994 |
| 5274300 | Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion This invention relates to a method for the production of (2R,3S)-3-(4-methoxyphenyl)glycidic acids and esters thereof, which are synthetic intermediates for the production of the calcium antagonist diltiazem. The method involves the stereoselective enzyma... | 12/28/1993 |
| 5273888 | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals A chemical test kit for determining the presence of occult blood in a stool specimen is disclosed which includes an improved monitor system for verifying the effectiveness of the chemicals used in the test. A method of testing for occult blood is also dis... | 12/28/1993 |
| 5273908 | Stabilizing method for immuno active substances immobilized on insoluble carrier and its use in preparation of reagent for measuring physiologically active substances An immuno active substance immobilized on a carrier and stabilized by immersing the carrier in a solution of at least one of sugars and proteins can be used for measuring a physiologically active substance even after stored for a long period of time. A pr... | 12/28/1993 |
| 5272059 | Monoclonal antibodies specific for hirudin The invention concerns a process for the preparation of hybridoma cells which secrete monoclonal antibodies specific for hirudin, the hybridoma cells themselves, the monoclonal antibodies specific for hirudin secreted by these hybridoma cells, derivatives... | 12/21/1993 |
| 5270168 | Method for diagnosing non-healing ulcers The present invention provides methods for the diagnosis of non-healing ulcers in humans. Provided are methods for detecting the presence of non-healing ulcers by assaying for certain cell adhesion-related proteins or their degradation products in ulcer e... | 12/14/1993 |
| 5270206 | Enzymatic resolution of endo-bicyclo[2.2.1]heptan-2-ol and derived pharmaceutical agents Process for the pancreatic lipase mediated transesterification method for the optical resolution of endo-norborneol; derived optically active 5-(3-(exo-bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphenyl)-3,4,5,6-tetrahydrop yrimidin-2(1H)-ones; and stepwise proce... | 12/14/1993 |
| 5266464 | Method of screening for protein inhibitors and activators Inhibitors and activators of a protein whose expression affects a phenotypic characteristic of the cell, especially a cultural or morphological characteristic, are identified by their more pronounced effect on cells producing higher, usually non-naturally... | 11/30/1993 |
| 5266499 | Method for detection of antibodies for metallic elements An apparatus and method for detecting antibodies specific to non-protein antigens. The apparatus is an immunological plate containing a plurality of plastic projections coated with a non-protein material. Assays utilizing the plate are capable of stabiliz... | 11/30/1993 |
| 5266461 | Method for determining (1-3)-ଲ-D-glucan The present invention provides a reagent for determining (1.fwdarw.3)-ଲ-D-glucan comprising limulus amebocyte lysate and an antibody to an endotoxin-sensitive factor, or comprising endotoxin-sensitive factor-free lysate, which enables highly sensiti... | 11/30/1993 |
| 5264370 | Detection of basement membrane components as diagnostic of cancer and other diseases Methods for the diagnosis of diseases that result in the release of fragments of basement membrane, including fragments, intact molecules and/or complexes of basement membrane components, are disclosed. Detection of basement membrane fragments, intact mol... | 11/23/1993 |
| 5262302 | Method for screening white blood cells A method and apparatus for automatically and rapidly, retrieving, counting and/or analyzing at least one selected white blood cell population and/or subset thereof of an aged whole blood sample or portion thereof. A volume of a biological sample containin... | 11/16/1993 |
| 5260188 | Method of testing a donor liver for transplant A method for determining the suitability of an organ for transplant by performing one or more tests on the endothelial cells lining the blood vessels in the organ prior to the transplant operation. Specifically hyaluronic acid is used as the measure to de... | 11/09/1993 |
| 5258312 | Serum proteins used to detect autoimmune disease A method for diagnosing a patient with an autoimmune disease comprising assaying a blood sample from a patient for increased levels of the carbohydrate moieties of one or more proteins, said increased level of one or more of said proteins indicating the p... | 11/02/1993 |
| 5256411 | Immune cell proliferation inhibitors A method for treating an immune system disorder in a human by administering to the human a therapeutically effective amount of an active substance selected from the group consisting of PP14, derivatives of PP14, muteins of PP14, fragments of PP14, and sub... | 10/26/1993 |
| 5256538 | Detection of early platelet activation and prediagnosis of thrombotic events The present invention relates to a highly sensitive diagnostic/prediagnostic test to identify persons at risk of a thrombotic event. Thrombotic events include myocardial infarction, deep venous thrombosis, pulmonary embolism, thromboembolic stroke pulmona... | 10/26/1993 |
| 5256539 | Method of screening for infertility of sperm A method for detecting the presence of infertility in mammalian male animals based upon failure of sperm to undergo successful capacitation. Sperm samples are given the opportunity to undergo capacitation and subsequently contacted with antibodies to fibr... | 10/26/1993 |
| 5254329 | Method for improving visualization of serotonergic structures in nonhuman vertebrates A method for the visualization of serotonergic cells in the dorsal raphe of living nonhuman vertebrates by pretreatment with L-tryptophan significantly less than one hour prior to sacrifice reveals numerous structures and cell types hitherto unidentified ... | 10/19/1993 |
| 5254339 | Process for preparing immune complexes A process is provided for preparing an immunogenic complex containing antigenic proteins and peptides with hydrophobic domains, whereby proteins or peptides from viruses, mycoplasmas, bacteria, parasites, animal cells with hydrophobic domains are mixed wi... | 10/19/1993 |
| 5252489 | Down syndrome screening method utilizing dried blood samples The present invention relates to a method for detecting fetal Down syndrome (Trisomy 21), trisomy 13, trisomy 18 and other chromosomal anomalies during prenatal screening by analyzing a dried blood sample from a pregnant woman. More particularly the prese... | 10/12/1993 |
| 5250303 | Procedure for storing red cells with prolonged maintenance of cellular concentrations of ATP and 2,3 DPG This invention provides an improved method for prolonging the shelf life of transfusible red blood cells by decreasing the effective osmolality of the suspending solution and increasing the intracellular pH of the cells prior to storage thereof. This inve... | 10/05/1993 |
| 5250413 | Sublethal bioassay for environmental quality A sublethal assay is conducted to determine the presence of a stressor in the environment. An organism exposed to the environment is assayed for the presence of shock proteins, produced in response to environmental stress. The amount of stress protein can... | 10/05/1993 |
| 5248506 | Synthetic, plasma-free, transfusible storage medium for red blood cells and platelets The invention is a sterile, plasma-free storage medium for blood components including red blood cells and for platelets processed separately or together. The red cell storage medium includes a physiologically compatible, aqueous electrolyte solution. In o... | 09/28/1993 |
| 5248593 | Process and reagent for the determination of the luteinizing hormone and monoclonal antibodies suitable thereof The present invention provides an immunological process for the determination of the luteinizing hormone (LH), wherein at least one monoclonal antibody is used which is directed against LH and cross-reacts with other glycoprotein hormones to an extent of ... | 09/28/1993 |
| 5246834 | Enzyme immunoassay method employing acetate kinase The present invention is intended to provide an EIA method utilizing bioluminescence using a firefly luciferase. The EIA method of the present invention is characterized by using an ATP-generating enzyme as a labeling enzyme, subjecting ATP generated to b... | 09/21/1993 |
