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Griffin, Ronald W.


Primary examiner statistics: 5371 patents; average approval time: 634 days
Assistant examiner statistics: 2 patents; average approval time: 727 days

Patents as Primary Examiner

1                      
NumberTitleIssue Date
5637575Methods of inhibiting restenosis
Disclosed are compositions and methods effective for inhibiting restenosis. In particular, the present invention provides compositions for inhibiting undesired smooth muscle cell growth or proliferation following angioplasty in mammals, said composition c...
06/10/1997
5583215Crystalline mixture solid containing maltitol and a process for preparing it
The crystalline mixture solid containing maltitol of the present invention has a crushed and relatively tight crystal structure which can be observed at 1,000 magnifications by a scanning electron microscope, an apparent specific gravity in the range of 0...
12/10/1996
5567812Polysaccharide products derived from lesquerella fendleri and methods of their production
Previously unrecognized polysaccharide products are extracted from either whole Lesquerella fendleri seed or commercially processed and oil-extracted seed meal or presscake or other seed material. Processes used include the steps of: (1) combining the see...
10/22/1996
5534244Methods and compositions for mineralizing and/or fluoridating calcified tissues with amorphous strontium compounds
This invention involves new compositions and methods of use and delivery of amorphous strontium compounds such as: amorphous strontium phosphate (ASP), amorphous strontium phosphate fluoride (ASPF), amorphous strontium calcium phosphate (ASCP), amorphous ...
07/09/1996
5525593Medicinal use of IFG-II
The use of IGF-II for preparing a medicament for the regeneration of muscle tissue; and methods for medical treatment for the purpose of regenerating muscle tissue, for minimizing scar formation during healing of a wound or for preventing undesired tissue...
06/11/1996
5516766Cyclodextrin polymers and cyclodextrins immobilized on a solid surface
Polyionic derivatives of cyclodextrin polymers and cyclodextrins immobilized on a solid surface are disclosed. Compositions and methods for separating a molecular species, including but not limited to a biologically active protein, from a mixture, for the...
05/14/1996
5514665Method of preventing or reducing the risk of infection by bacterial pathogens utilizing simple and conjugated dextrans
Methods for reducing the risk of or preventing infections by bacterial pathogens in vivo. In particular, a method for reducing the risk of P. aeruginosa infection in vivo in compromised hosts such as cystic fibrosis patients. The methods involve the use o...
05/07/1996
5514673Pharmaceutical composition containing lipophilic drugs
A pharmaceutical composition having a form suitable for transmucosal administration containing progesterone and/or 17-ଲ-estradiol as an active ingredient....
05/07/1996
5514661Immunological activity of rhamnolipids
Methods for treating various autoimmune diseases and for providing immunorestoration, by administering, to a subject in need thereof, an effective amount of a composition having, as active ingredient, one or more rhamnolipids of formula (I) ##STR1## ...
05/07/1996
5512200Low pH Acidic Compositions
Low pH acidic compositions for uses related generally to chemical, pharmaceutical and cosmetic agents and more particularly, but not limited to, used as bactericides, fungicides, germicides and virucides; all having pH values of less than about 2.0 in the...
04/30/1996
5510337Agents for suppression or lowering of blood lipids
The present invention relates to an agent for the suppression or lowering of blood lipids, cholesterol and neutral fats, which is derived from a plant and comprises, as an effective ingredient, an edible dietary fiber which contains cellulose and lignin a...
04/23/1996
5510335Exercise hydration regimen to enhance exercise endurance and performance
An exercise regimen which enhances exercise endurance and performance. The regimen includes pre-exercise hydration with a glycerol solution combined with hydration during exercise with a glycerol based solution to prolong hydration effects. The first pre-...
04/23/1996
5508392Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D analog glycosides and vitamin D analog orthoester glycosides for the treatment of osteoporosis
The present invention relates to methods for the treatment of prevention of osteoporosis by the administration of a vitamin D glycoside or vitamin D orthoester glycoside, or an analog thereof....
04/16/1996
5506216Cyclodextrin-biocide complex
The invention concerns a complex of cyclodextrin and an organic biocide, wherein the organic biocide has a maximum water-solubility of 0.15% (w/v) at a temperature of 25° C., a process for the production of the complex as well as the use of the complex f...
04/09/1996
5506353Particulate hydrogenated starch hydrolysate based flavoring materials and use of same
Particulate flavor composition comprising a flavor oil fixed in a particulate low cariogenic matrix of hydrogenated starch hydrolysate and a maltodextrin having a dextrose equivalent value of less than 20. A process for the encapsulation of a flavor oil compri...
04/09/1996
5504202Sucrose polyester useful as fat subtitute and preparation process
A process for preparing a sucrose fatty acid polyester comprising mixing a sucrose ether having an average degree of etherification of from about 4 to about 8 with a basic catalyst and an excess of a fatty acid lower alkyl ester, heating the resultant mix...
04/02/1996
5502180Inulin derivatives, process for their preparation and their use
The present invention relates to inulin derivatives of the general formula I ##STR1## in which R=--CH2 OH, --CHOH--(CH2)m --CH3, m is an integer from 0 to 10, n is on average a number from 10 to 50, a and b is a...
03/26/1996
5502039O-derivatized alginic acid antigens
O-derivatized alginic acid antigens capable of eliciting opsonizing antibodies in vivo are described. The O-derivatized antigens show enhanced antigenicity and immunogenicity relative to native, non-O-derivatized alginic acid antigens, particularly the ME...
03/26/1996
5502043Use of hydroxyethyl starch for improvement of microcirculation
The use of a hydroxyethyl starch specification with a molecular weight MW of 110,000 to 150,000, a substitution level MS of 0.38 to 0.5, a substitution level DS of 0.32 to 0.45, and a C2 /C6 ratio from 8 to 20 for improvem...
03/26/1996
5502076Dispersing agents for use with hydrofluoroalkane propellants
Vitamin E acetate, C3 -linked triesters, glycerin, t-butanol, and transesterified oil/polyethylene glycol are effective dispersing agents for use with hydrofluoroalkanes. Effective amounts of the above are effective in suspending medicaments wh...
03/26/1996
5500206Oral compositions comprising actinomyces viscosus fimbriae
The present invention relates to compositions and methods for inhibiting or preventing growth of dental plaque on tissues within the human oral cavity comprising topical administration, to tissues of a human oral cavity, of a composition comprising a safe...
03/19/1996
5498709Production of sucralose without intermediate isolation of crystalline sucralose-6-ester
There is disclosed a process for producing sucralose from sucralose-6-ester whereby the sucralose-6-ester is deacylated directly either prior to or after removal of the tertiary amide reaction vehicle from the neutralized chlorination reaction mixture, to...
03/12/1996
5498613Dipyridamole and analogs thereof in preventing adhesion formation
Compositions and methods for prevention of adhesion formation, whereby an effective amount of at least one compound selected from dipyridamole and analogs thereof is administered as active agent for a period of time sufficient to permit tissue repair. The...
03/12/1996
5496541Tasteful toothpaste and other dental products
Dental products employing a ternary surfactant system of poloxamers, anionic polysaccharides, and nonionic cellulose ethers. This ternary surfactant system has greatly enhanced foaming power relative to poloxamers alone or to poloxamers plus anionic polys...
03/05/1996
5496930Unsaturatd sugar compounds
A process for highly regioselective esterification and ester cleavage on unsaturated sugar compounds with the aid of lipases and esterases, and products which can be prepared by this process. Highly regioselective esterifications and ester cleavages can be car...
03/05/1996
5496937Polysaccharide substances, process for producing them and use of them
A polysaccharide substance having the following formula is provided: ##STR1## Also provided is a method of producing the polysaccharide substance in which an oligosaccharide having a degree of polymerization from 3 to 10 is chemically bonded to a sil...
03/05/1996
5496801Parathyroid hormone formulation
Described herein are preparations containing parathyroid hormone that has been stablized with an excipient and buffering agent. Preferred preparations incorporate human PTH(1-84), mannitol as excipient and citrate as buffering agent, and are incorporated ...
03/05/1996
5494901Topical compositions for the eye comprising a ଲ-cyclodextrin derivative and a therapeutic agent
A topical composition comprising an amount of a carbonic anhydrase inhibitor and an amount of ଲ-cyclodextrin derivative effective in increasing the bioavailability of the carbonic anhydrase inhibitor when coadministered topically to the eye....
02/27/1996
5492911Linsidomine for the treatment for erectile dysfunctions
The treatment of erectile dysfunctions in mammals, including humans, comprises administering to a host in need thereof an effective dose of linsidomine or a pharmacologically compatible salt thereof, alone or in combination with adenosine, vitamins, prost...
02/20/1996
5493015Method for reducing contaminative live bacteria in xanthan gum
A method for reducing the number of contaminative live bacteria in xanthan gum which comprises the step of washing a mixture of 100 parts by weight of water-containing isopropanol having an isopropanol concentration of 50 to 100% by weight and 1 to 100 pa...
02/20/1996
5489577Semi-solid pharmaceutical agent and process for producing the same
Disclosed is a semi-solid pharmaceutical agent containing a stabilized proteinaceous bioactive substance prepared by successively mixing an oligosaccharide and an aqueous solution of a proteinaceous bioactive substance, and kneading the resultant solids w...
02/06/1996
5489674Guar gum composition and process for making it
Guar gum which demonstrates greater than 75% light transmission at a wavelength of from about 500-600 nanometers when dispersed in water in the amount of 0.5 parts per 100 parts water and the process for producing such guar gum is disclosed....
02/06/1996
5488104Process for comminuting cellulose ethers
This invention is a process for comminuting a cellulose ether which comprises extruding a hydrated cellulose ether through a plurality of orifices, each orifice having a cross-sectional area of from about 7.5×10-9 m2 to about 1×10
01/30/1996
5484801Pharmaceutical composition for inhibiting HIV protease
A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a mixture of (1) (a) a solvent selected from propylene glycol and polyethylene glycol o...
01/16/1996
5484581Process for the production of precipitated silica
Precipitated silica which has a BET surface area of 10-130 m2 /g, a CTAB surface area of 10-70 m2 /g , an average particle diameter of 5-20 μm, a Cu abrasion value in a 10% glycerol dispersion of 4-50 mg and thickening behavior in a...
01/16/1996
5484608Sustained-release drug delivery system
A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a hydrophobic matrix. A hydrophilic microenvironment is created ...
01/16/1996
5484609Therapeutic compositions and methods
Compositions comprising (i) granules comprising a biologically active material in association with a weak base and partially coated with a delayed release material soluble in intestinal juice, (ii) an acidifying agent having a pH between 1.5 to 6, and (ii...
01/16/1996
5484773Treatment of antibiotic associated diarrhea
This invention relates to treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD) and pseudomembranous colitis (PMC), using oligosaccharide compositions which bind C. difficile toxin A. More specifically, th...
01/16/1996
5484816External skin treatment composition
An external skin treatment composition containing (I) vitamin A (retinol) and (II) as a stabilizer, a chelating agent/a polysaccharide, an oil, polyethylene (propylene) glycol, a hydroxy carboxylate, a neutral amino acid salt, an oil-soluble antioxidant/E...
01/16/1996
5484776Process for the production of stable liquid form of beta-blocker-containing medicaments with controlled release of the active constituent for oral administration
This invention relates to a process for the production of optimally stable orally administrable solution forms of medicaments containing high-molecular polysaccharides, with controlled release of drugs having beta-blocking action, this process consisting ...
01/16/1996
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