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| Number | Title | Issue Date |
| 7153999 | Production of dimethylolcarboxylic acid In the method of the present invention, a dimethylolcarboxylic acid is produced by reacting a trimethylolalkane and formaldehyde to prepare a cyclic formal having a formal protecting group, followed by the oxidation of the cyclic formal by using nitric acid as an ox... | 12/26/2006 |
| 7119210 | Dual function UV-absorbers for ophthalmic lens materials Disclosed are UV absorbers that contain a labile functional group capable of initiating free radical polymerization. ... | 10/10/2006 |
| 7071352 | Processes for preparation of 2-alkyl-2-adamantyl esters A magnesium halide salt of a 2-alkyl-2-adamantanol is reacted with a carboxylic acid halide such as acrylic chloride or the like in the presence of a tertiary amine to produce a 2-alkyl-2-adamantyl ester (the first invention). A 2-alkyl-2-adamantanol is react... | 07/04/2006 |
| 7071360 | Method for evaporating cyclohexanone oxime A method is provided for evaporating cyclohexanone oxime in which cyclohexanone oxime is evaporated using a falling-film evaporator with wetting the evaporation surface of the evaporator well with the cyclohexanone oxime at a pressure of less than about 1060 Torr wi... | 07/04/2006 |
| 6974878 | Catalyst ligands, catalytic metal complexes and processes using same A new ligands that include a benzene ring in the backbone can be combined with a metal or metal precursor compound or formed into a metal-ligand complex catalyze a number of different chemical transformations, including olefin polymerization reactions. The ligands, ... | 12/13/2005 |
| 6965029 | Method for producing enantiomer-free 6,8 dihydroxy octanoic acid esters by means of asymmetric, catalytic hydrogenation The invention relates to a process for the preparation of compounds of the general formula I in which R1 represents a C1-C20-alkyl group, a C3-C12-cycloalkyl group... | 11/15/2005 |
| 6958420 | Synthesis of aminoarylboronic esters and substituted anilines from arenes via catalytic C-H activation/borylation/amination and uses thereof A process is described for synthesizing aminoarylboronic esters of the general formula wherein R, R2, and R3 are each an alkyl, aryl, vinyl, alkoxy, carboxylic esters, amides, or halogen; Ar is an... | 10/25/2005 |
| 6953813 | 2-Aminotetralin derivatives for the therapy of glaucoma The use of racemic or optically active compounds represented by formula (I) and the salts thereof wherein R is H or CH3 for the preparation of pharmaceutical compositions for the therapy of ophthalmic disorders. ... | 10/11/2005 |
| 6946485 | Treatment of post-angioplasty restenosis and atherosclerosis with Ras antagonists Disclosed are methods for inhibiting Ras activity such as cell proliferation associated with vascular injury such as post-angioplasty restenosis and atherosclerosis. Preferred Ras antagonists are S-trans-trans farnesylthiosalicylic acid (FTS) and structurally relate... | 09/20/2005 |
| 6926887 | Photostabilizers, UV absorbers, and methods of photostabilizing a sunscreen composition Derivatives of fluorene, including diesters and polyesters of diphenylmethylenemalonic acid and derivatives of cyano(9H-fluoren-9-ylidene) acetic acid; and sunscreen compositions including a mixture of a photoactive compound and any one of the foregoing derivatives ... | 08/09/2005 |
| 6927306 | Process for producing hydrogenated aromatic polycarboxylic acid and process for producing hydrogenated aromatic polycarboxylic anhydride Disclosed are processes for industrially advantageously producing at a good yield respectively, a hydrogenated aromatic polycarboxylic acid and an acid anhydride thereof each having a high purity. The present invention provides processes for producing a hydrogenated... | 08/09/2005 |
| 6927302 | Process for the arylation of olefins The present invention encompasses a process for preparing arylolefins by reacting one or more arylamines with one or more organic nitrites, in the presence of one or more olefins which bear at least one hydrogen atom on the double bond and in the presence of acid an... | 08/09/2005 |
| 6909012 | Diflunisal esters and related compounds O-medium alkyl esters of diflunisal and related compounds are disclosed having anti-platelet activity, hydroxy radical scavenging properties, enhanced hepatic clearance and low ulcerogenic potential. These compounds have general formula (I) wherein n equals 3-13. | 06/21/2005 |
| 6903236 | Process for producing fluorocarboxylic anhydride A method of producing (RfCO)2O by reacting RfCOCl with MmCO3 can efficiently synthesize a fluorocarboxylic anhydride in a one-step reaction, wherein Rf is a saturated hydrocarbon group having 1... | 06/07/2005 |
| 6900336 | 8-aza-11-deoxy prostaglandin analogues This invention relates to compounds which are generally EP4 receptor agonists and which are represented by Formula I: wherein A is a —CH2—CH2—, or —CH═CH—; B is absent, an a... | 05/31/2005 |
| 6900345 | Pleuromutilin derivatives Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy. ... | 05/31/2005 |
| 6900347 | Impurity inhibition in olefin metathesis reactions Reaction mixtures and methods using catalysts and reaction conditions to produce significantly improved yields (and thereby higher purity) of olefin metathesis products, with greatly reduced amounts of impurities. These techniques include in one instance reduction i... | 05/31/2005 |
| 6897236 | Aminobenzophenones as inhibitors of IL-1β and TNF-α The present invention relates to compounds of formula (I) wherein R1, R2 and R3 independently represent one or more, same or different substituents selected from the group consisting of hydrogen, halogen, hydroxy, mercapto, trifluoro... | 05/24/2005 |
| 6897337 | Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor Site-specific isotopically-labeled valine, leucine, and isoleucine and biosynthetic precursors for these amino acids are provided. The amino acids are labeled with 13C or 14C at the methyl group carbon atom(s) most remote from the carboxyl grou... | 05/24/2005 |
| 6894190 | Process for producing optically active 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid, and salt thereof There are disclosed imine compounds of formula (7) and (11), and processes for preparing the same: ... | 05/17/2005 |
| 6891062 | Pharmaceutical composition for treatment of diseases associated with decrease in bone mass A pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising an EP4 agonist as an active ingredient. An EP4 agonist, in which includes a compound possessing prostaglandin skeleton as a represent... | 05/10/2005 |
| 6891060 | Preparation of 3-acyloxy-2-methylbenzoic acids The invention relates to an improved process for preparing 3-acyloxy-2-methylbenzoic acids by heating substituted naphthalenes in the presence of alkali metal hydroxides and subsequently acylating. ... | 05/10/2005 |
| 6888022 | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or i... | 05/03/2005 |
| 6888001 | Pyridyl ethers and thioethers as ligands for nicotinic acetylcholine receptor and its therapeutic application The present invention provides compounds of the formula: wherein m is 0, 1 or 2; p is 0 or 1; Y is O, S, S(O) or S(O)2 and R1 to R7 are various substituents as selective modulators of t... | 05/03/2005 |
| 6887902 | Anti-inflammatory method using gamma-aminobutyric acid (GABA) analogs GABA analogs such as gabapentin and pregabalin are useful to prevent and treat inflammatory diseases. ... | 05/03/2005 |
| 6888027 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: —S(═O)... | 05/03/2005 |
| 6884819 | Neuropathy remedies The present invention provides a neurodegenerative disease therapeutic agent containing as its active ingredient a (15R)-isocarbacycline derivative indicated by the following formula [I] or a 15-deoxy-isocarbacycline derivative indicated by the following formula [II... | 04/26/2005 |
| 6881860 | Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholest... | 04/19/2005 |
| 6878842 | Process for the enantioselective synthesis of propargyl alcohol derivatives of R configuration from the racemic mixtures thereof The invention relates to a novel process for synthesizing organic compounds of general formula (I): said process may be carried out on an industrial scale and makes it possible to obtain from a... | 04/12/2005 |
| 6875886 | Modified PSMA ligands and uses related thereto The instant invention provides reagents and methods for diagnosis, detection and treatment of cancers (for example, prostate cancers). In particular, the invention provides methods to generate various functionalized PSMA ligands, and their uses in diagnosis, detecti... | 04/05/2005 |
| 6872846 | Process for preparation of tertiary alcohol esters The production process of the present invention comprises a step of allowing a carboxylic acid derivative represented by the formula (1): wherein ring Z is a monocyclic or polycyclic non-aromatic or aromatic ring, and ... | 03/29/2005 |
| 6867327 | Preparation and purification of hydroxylamine stabilizers The invention relates to the preparation of ultra-high purity 1,2-diaminocyclohexanetetraacetic acid being essentially free of unwanted metal and metal ion contaminants and its use as a stabilizer for ultra-high purity hydroxylamine compounds used extensively in the... | 03/15/2005 |
| 6867320 | Substituted phenylalkanoic acid derivatives and use thereof A compound represented by the formula (I) or a salt thereof: wherein n represents an integer of 1 to 3, R represents an alkyl group having 3 to 8 carbon atoms, a group represented by the following formula: R1 | 03/15/2005 |
| 6861555 | Calcium dicarboxylate ethers, methods of making same, and treatment of vascular disease and diabetes therewith Alcohol and water solvates of 6-(5-carboxy-5-methyl-hexyloxy)-2,2-dimethylhexanoic acid monocalcium salt are crystalline and have the formula (I), wherein R1 is H or lower alkyl, and x is a number from 0 to 10, and are useful for treating dyslipidemia. | 03/01/2005 |
| 6861558 | Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or i... | 03/01/2005 |
| 6861551 | Processes for the preparation of macrocyclic ketones Disclosed are a process of subjecting a diester of a long-chain dicarboxylic acid having 18 to 21 carbon atoms to intramolecular condensation in the presence of titanium tetrachloride or zirconium tetrachloride and a trialkylamine to form an α-alkoxycarbonylated ma... | 03/01/2005 |
| 6861550 | Polyhydroxyalkanoate containing 3-hydroxybenzoylalkanoic acid as monomer unit, and method for producing the same Microorganisms capable of producing novel polyalkanoates having 3-hydroxybenzoylalkanoic acids as monomer units by utilizing benzoylalkanoic acids as starting materials are cultured in media containing benzoylalkanoic acids and saccharides, and the polyhydroxyalkano... | 03/01/2005 |
| 6858764 | Method for preparing bromofluorenes A method for preparing bromofluorenes includes a step of dispersing a compound selected from the group consisting of fluorene, fluorenone, and derivatives of fluorene and fluorenone in water to prepare a disperse system. Bromination is initiated by adding bromine Br... | 02/22/2005 |
| 6858751 | Process for preparing aliphatic fluorofomates A method for the production of aliphatic fluoroformates, wherein carbonyl fluoride is made to react with aliphatic alcohol in the presence of sodium fluoride in ether at a temperature of −20° to 50° C. The method is carried out using carbonyl fluoride obtained b... | 02/22/2005 |
| 6858747 | Process to prepare, 1,4-dihydropyridine intermediates and derivatives thereof An improved catalyst is disclosed for a process involving the preparation of benzylidene intermediates useful in the preparation of 1,4-dihydropyridine compounds and derivatives thereof useful as medicines such as for example felodipine. This is accomplished by the ... | 02/22/2005 |
