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| Number | Title | Issue Date |
| 7459480 | Benzodioxepine derivatives This invention relates to compounds of the formula wherein B, X, Y, Z, R1 and R2 are as defined in the description, and pharmaceutically acceptable salts thereof. The invention further relates to pharm... | 12/02/2008 |
| 7459464 | Triple monoamine reuptake inhibitors for the treatment of chronic pain The present invention relates to the use of triple monoamine reuptake inhibitors for the treatment of chronic pain. ... | 12/02/2008 |
| 7459561 | N-substituted carbamoyloxyalkyl-azolium derivatives N-substituted carbamoyloxyalkyl-azolium derivatives which have antifungal activity and are useful for the treatment of fungal diseases. ... | 12/02/2008 |
| 7456285 | Use of metal complex compounds as oxidation catalysts Use of metal complex compounds of formula [LnMemXp]zYq, (1) wherein Me is manganese, titanium, iron, cobalt, nickel or copper, X is a coordinating or bridging radical, ... | 11/25/2008 |
| 7456205 | Benzopyran compounds, process for preparing the same and their use The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R1 represents a hydrogen atom or a C1-6 alkyl that can be substituted; R2 | 11/25/2008 |
| 7452909 | Imidazole derivatives The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3, R4, X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. Th... | 11/18/2008 |
| 7452911 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds The present invention relates to alkyne compounds of general formula I wherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relat... | 11/18/2008 |
| 7452998 | Process for preparing optically pure active compounds The invention relates to a novel process for preparing an optically pure PPI having a sulfinyl structure using a chiral zirconium complex or a chiral hafnium complex. ... | 11/18/2008 |
| 7449484 | Compounds The present invention is directed to novel compounds of Formula (I) for use in the treatment of diseases in a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred and/or where excessive Tie2 receptor activity has occurred. ... | 11/11/2008 |
| D580499 | Chess game piece | 11/11/2008 |
| 7449584 | N-(2((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1 N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed. ... | 11/11/2008 |
| 7446205 | Method for making nicotine hapten A high yielding and short process for preparing the 3′-aminomethylnicotine hapten of general formula I permits the isolation of the hapten in very pure quantities. The process can be adapted for the synthesis of a single ... | 11/04/2008 |
| 7446200 | Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer o... | 11/04/2008 |
| 7446206 | N-((2Z)-2-((4-hydroxyphenyl) amino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide crystalline form 2 N-((2Z)-2-((4-Hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide Crystalline Form 2, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed. ... | 11/04/2008 |
| 7446117 | Cox-2 inhibiting pyridine derivatives Compounds of formula (I) or pharmaceutically acceptable salts thereof are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever and inflammation of a variety of conditions and diseases.... | 11/04/2008 |
| D579500 | Multiplayer gaming machine | 10/28/2008 |
| 7439368 | Process for producing 3-acylaminobenzofuran-2-carboxylic acid derivative The present invention provides a process of preparing a compound of the formula [I]: wherein X is a group of the formula: —N═ or —CH═; R1 is a hydrogen atom, a halogen atom, a lower alkyl group, a lower a... | 10/21/2008 |
| 7439367 | Pharmaceutical process and compounds prepared thereby The present invention relates to an improved process for the preparation of a sulfinyl compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof, from a sulfide compound of formula (II), wherein in both formulae (I) and (II) R1 ... | 10/21/2008 |
| 7435826 | Substituted sulfoxides The present invention relates to a process for preparing substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, racemic omeprazole is reacted with (S)-camphorsulfonyl chloride to form a diastereomeric mixture and the dias... | 10/14/2008 |
| 7435821 | Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors. ... | 10/14/2008 |
| 7435825 | Hydrates of optionally substituted 2-(2-pyridinyl) methylthio-1H-benzimidazoles and process for the production thereof The invention relates to crystals from optionally substituted 2-(2-pyridinyl)methylthio-1H-benzimidazole hydrates and to a method for the production thereof. ... | 10/14/2008 |
| 7432270 | N-aroyl cyclic amines This invention relates to N-aroyl cyclic amine derivatives and their use as orexin antagonists wherein: Y represents a bond, oxygen, or a group (CH2)n, wherein n represents 1, 2 or 3;... | 10/07/2008 |
| 7432288 | Pyrrole-2,5-dione derivatives as Liver X receptor modulators The present invention relates to certain novel compounds of the Formula I to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR)α(NR1H3) and/or β(... | 10/07/2008 |
| 7429605 | Phenylpyridine derivatives The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical comp... | 09/30/2008 |
| 7425568 | Compounds, which are potent inhibitors of Na /Ca exchange mechanism and are useful in the treatment of arrhythmias Therapeutically active compounds of formula (I): wherein the variables shown in formula (I) are defined in the disclosure; and pharmaceutically acceptable salts and esters thereof. The compounds are potent inhibitors of the... | 09/16/2008 |
| 7425566 | 1,3-dihydro-2H-indol-2-one derivatives, process for preparing them and pharmaceutical compositions containing them The invention relates to compounds of formula: and to solvates and/or hydrates thereof, with affinity for and selectivity towards the V1b receptors or both the V1b and V1a receptors of argin... | 09/16/2008 |
| 7425634 | Benzimidazole compound An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitor... | 09/16/2008 |
| 7423052 | Piperidine compounds for use as orexin receptor antagoinst A invention relates to N aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists. ... | 09/09/2008 |
| 7420001 | Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. ... | 09/02/2008 |
| 7414136 | Method for producing 3-substituted 2-chloro-5-fluoro-pyridine or its salt To provide a method for producing a 3-substituted 2-chloro-5-fluoro-pyridine or its salt in high yield from a readily available material through a short process under mild reaction conditions using a reagent which is easy for handling and simple in the reaction oper... | 08/19/2008 |
| 7414066 | Amide compounds and medications containing the same technical field The present invention provides to a novel compound having an ACAT inhibiting activity. The present invention relates to compounds represented by formula (I) wherein represents an op... | 08/19/2008 |
| 7410981 | Prodrugs of imidazole derivatives, for use as proton pump inhibitors in the treatment of e.g. peptic ulcers An imidazole compound represented by the formula (I), a salt thereof and a compound of the formula (V), which is one of the intermediates thereof. wherein each symbol is as defined in the present specification. The compound of the present invention shows a superior ... | 08/12/2008 |
| 7410980 | Crystals of taxane derivative and process for their production A crystal of (1S,2S,3R,4S,5R,8R,9S,10R,13S)-4-acetoxy-2-benzoyloxy-9,10-[(1S)-2-(dimethylamino)ethylidenedioxy]-5,20-epoxy-1-hydroxytax-11-en-13-yl (2R,3S)-3-(tert-butoxycarbonylamino)-3-(3-fluoro-2-pyridyl)-2-hydroxypropionate, which has characteristic peaks at dif... | 08/12/2008 |
| 7410985 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones The present invention provides an cycloalkyl derivative of 3-hydroxy-4-pyridinone which is useful for the chelation of metal ions such as iron. Its preparation and use is described. In particular, the invention concerns the removal of iron in chemical and biological... | 08/12/2008 |
| 7405228 | Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoprotein sites The present invention provides agents having high antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel cyano-(substituted)-methylenepiperidinophenyl oxazolidinone derivatives, processes for making the com... | 07/29/2008 |
| D573667 | Stuffed toy animals | 07/22/2008 |
| 7402687 | Dihydrobenzofuran derivatives and uses thereof Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, ... | 07/22/2008 |
| D573206 | Bear | 07/15/2008 |
| D572319 | Toy robot dog | 07/01/2008 |
| D572314 | Dual wide-screen gaming machine | 07/01/2008 |
