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| Number | Title | Issue Date |
| 6593367 | Treatment of addiction and addiction-related behavior The present invention provides a method for changing addiction-related behavior of a mammal suffering from addiction to a combination of abused drugs. The method includes administering to the mammal an effective amount of gamma vinylGABA (GVG) or a pharma... | 07/15/2003 |
| 6541000 | Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response A method for generating antigen-sensitized Ig-A-producing lymphoblasts in a mammal, using an immunogen comprising an antigen or antigen mixture in association with hydroxylated calcium phosphate (hydroxy apatite) is administered to a mucosal surface of th... | 04/01/2003 |
| 6267969 | Unit-of-use reagent composition for specific binding assays Unit-of-use reagent compositions and methods for preparing such reagent compositions are disclosed. The reagent composition comprises one or more reagents which are necessary for a specific binding assay and which are incorporated in a porous material whi... | 07/31/2001 |
| 6258552 | Estimation of change in bone mineral density and diagnosis of osteoporosis A method for estimation of change in bone mineral density or a method for diagnosis of osteoporosis, comprising the step of measuring change in a concentration of soluble interleukin-6 receptor in a blood sample, by for example, sandwich assay or competit... | 07/10/2001 |
| 6251581 | Assay method utilizing induced luminescence Methods are disclosed for determining an analyte in a medium suspected of containing the analyte. One method comprises treating a medium suspected of containing an analyte under conditions such that the analyte, if present, causes a photosensitizer and a ... | 06/26/2001 |
| 6251687 | Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds The invention describes the particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stokes shif... | 06/26/2001 |
| 6232060 | Assay system for anti-stress agents Methods and compositions are provided for screening compounds for anti-stress activity. A rat hepatoma-derived cell line is employed, which is particularly responsive to mitochondrial function inhibiting agents, demonstrated by the extracellular release o... | 05/15/2001 |
| 6225050 | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods Cyanine and related dyes, such as merocyanine, styryl and oxonol dyes, are strongly light-absorbing and highly luminescent. Cyanine and related dyes having functional groups make them reactive with amine, hydroxy and sulfhydryl groups are covalently attac... | 05/01/2001 |
| 6214613 | Expression screening vector An expression vector for preparing a library of an antibody variable region, which can express comprising polypeptides containing the H-chain and/or L-chain variable regions of antibodies in the membrane-bound form on the surfaces of eukaryotic cells, whi... | 04/10/2001 |
| 6210899 | Use of a BMP protein receptor complex for screening bone metabolism actives and cells co-transfected with a type II BMP receptor and type I BMP receptor The present invention relates to a method for determining whether a compound is capable of binding to a BMP receptor kinase protein complex. The invention further relates to a method for determining the concentration of a BMP receptor ligand in a clinical... | 04/03/2001 |
| 6207396 | Immunoassay reagents and methods for determination of LSD and LSD metabolites To improve the detection of LSD in biological samples, antibodies are raised to LSD conjugated to a protein carrier, preferably through the indole ring. Selected antibodies are matched with an immunoassay reagent in which the LSD is conjugated in the same... | 03/27/2001 |
| 6197299 | Antibody conjugates A soluble antibody conjugate comprising an antibody linked to a structure which is recognized by T-cells and has the ability to direct T-cells to lyse the target cell, which is recognized by the antibody. The conjugate is characterized by the structure be... | 03/06/2001 |
| 6190855 | Systems and methods for removing viral agents from blood System and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellu... | 02/20/2001 |
| 6190856 | Methods of detection utilizing modified bacteriophage Viruses expressing ligands on their surfaces are used as a detection means for the related polypeptide which binds the ligand. Multiple copies of the ligand can be expressed on the viral surface. These viruses may be used to detect polypeptides, cells, re... | 02/20/2001 |
| 6183772 | Doped colorimetric assay liposomes The present invention provides compositions comprising colorimetric assay liposomes. The present invention also provides methods for producing colorimetric liposomes and calorimetric liposome assay systems. In preferred embodiments, these calorimetric lip... | 02/06/2001 |
| 6184030 | Biologically-active polymers This invention relates to biologically-active polymers that are useful for analyte detection and isolation and delivery of substances. The biologically-active polymers are capable of specifically and reversibly binding to analytes, including molecules and... | 02/06/2001 |
| 6180135 | Three-dimensional colorimetric assay assemblies A direct assay is described using novel three-dimensional polymeric assemblies which change from a blue to red color when exposed to an analyte, in one case a flue virus. The assemblies are typically in the form of liposomes which can be maintained in a s... | 01/30/2001 |
| 6177089 | Use of at least one sulphonic acid for stimulating renewal and/or epidermal repair and for combatting cutaneous aging and conditions The use of specific sulphonic acids or hydrates thereof in or for the preparation of a cosmetic or dermatological composition for achieving various effects on the skin, such as promoting desquamation of the skin, stimulating epidermal renewal, combatting ... | 01/23/2001 |
| 6172197 | Methods for producing members of specific binding pairs A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recomb... | 01/09/2001 |
| 6165470 | Albumin derivatives with therapeutic functions Utilization of albumin as a stable plasma transporter with a therapeutic function that is derived from a membrane receptor. The present invention is exemplified by the description of new therapeutic agents that can be used in the treatment of Acquired Imm... | 12/26/2000 |
| 6140099 | Method of delaying fetal membrane rupture by inhibiting matrix metalloproteinase-9 activity The invention relates to compositions and methods for delaying the onset of fetal membrane rupture in a human. The method comprises administering to the human a metalloproteinase-9 inhibitor in an amount effective to delay the onset of fetal membrane rupt... | 10/31/2000 |
| 6136984 | Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate... | 10/24/2000 |
| 6127133 | Automated analysis equipment and assay method for detecting cell surface protein function using same Automated drug screening method and a method of studying receptor and ion-channel activity are provided.... | 10/03/2000 |
| 6120777 | High fluorescence specific immune enhancing factor and methods of use for same The present invention relates to a malondialdehyde-acetaldehyde adduct which acts as a specific immune-enhancing factor. In addition to its highly specific and immunogenic properties, the factor is highly fluorescent. It has an excitation frequency of abo... | 09/19/2000 |
| 6114508 | Cocaethylene immunogens and antibodies The ethyl ester of derivatives of benzoyl ecgonine are provided having a linking group at the para position of the benzoyl group. The derivatives are used to bond to immunogenic polypeptides for production of antisera and monoclonal antibodies. The antise... | 09/05/2000 |
| 6103236 | Toxin conjugates The present invention relates to a toxin conjugate in which a residue derived from a compound having an affinity for a target cell is bound to a toxin through a spacer comprising polyalkylene glycol and dipeptide.... | 08/15/2000 |
| 6103217 | Polymeric assemblies for sensitive colorimetric assays The presently claimed invention relates to polymeric assemblies which visibly change color in the presence of analyte. In particular, the presently claimed invention relates to liposomes comprising a plurality of lipid monomers, which comprises a polymeri... | 08/15/2000 |
| 6099834 | Method for modulating eicosanoid mediated immune responses in arthropods The invention is directed to compositions which alter the health of invertebrate organisms by affecting eicosanoid-mediated immune responses, and methods of using the compositions. The invention provides pharmaceutical compositions and biopesticide compos... | 08/08/2000 |
| 6093564 | Methods and compositions for the selective modification of nucleic acids Methods and compositions for selectively modifying nucleic acid molecules in biological compositions, including contacting the composition with an inactivating agent having the formula: ##STR1## where each of R1, R2, R3 | 07/25/2000 |
| 6083505 | 1H-imidazo[4,5-C]quinolin-4-amines as vaccine adjuvants An immunogen/vaccine adjuvant composition containing an immunogen in an amount effective to stimulate an immune response and as a vaccine adjuvant a 1H-imidazo[4,5-c]quinolin-4-amine in an amount effective to increase the immune response to the immunogen.... | 07/04/2000 |
| 6077940 | Free solution ligand interaction molecular separation method The present invention is directed to novel methods for enhancing the ability to separate a species of interest from other different species present in a free solution mixture thereof which takes advantage of interactions that occur between soluble, small ... | 06/20/2000 |
| 6071707 | Phosphotyrosine mimics and method for identifying and using same This invention relates to phosphotyrosine mimics which, when incorporated into an appropriate molecular structure, are capable of inhibiting the binding of tyrosine kinase-dependent regulatory proteins to the native phosphotyrosine-containing receptors. T... | 06/06/2000 |
| 6072040 | Stabilized conjugates of uncomplexed subunits of multimeric proteins The present invention provides methods for preparing, and compositions comprising, stabilized protein-polymer conjugates. More particularly, the present invention relates to the stabilization of individual subunits of multisubunit protein complexes by con... | 06/06/2000 |
| 6063616 | Matrix mill for DNA extraction The device and methods herein disclosed were developed to allow a large number of small samples of organic tissue to be processed. The goal was to allow for the capture of these intracellular contents for study, use, and/or amplification. Though the devic... | 05/16/2000 |
| 6060256 | Optical diffraction biosensor The present invention provides an inexpensive and sensitive device and method for detecting and quantifying analytes present in a medium. The device comprises a metalized film upon which is printed a specific, predetermined pattern of analyte-specific rec... | 05/09/2000 |
| 6054127 | Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are disclosed. Methods of preparing the hapten-carrier conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition... | 04/25/2000 |
| 6054431 | Anti-gram-positive bacterial methods and materials The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on sel... | 04/25/2000 |
| 6054114 | Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzheimer's disease in... | 04/25/2000 |
| 6051553 | Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products The present invention provides methods of potentiating the gram-negative bactericidal activity of BPI protein products by means of administering LBP protein products.... | 04/18/2000 |
| 6051372 | Template induced patterning of surfaces and their reversible stabilization using phase transitions of the patterned material A two-dimensional patterning of a three-dimensional surface by a template molecule (or object) involving non-covalent interactions between the template and the surface and the reversible fixation of the pattern by undergoing a phase transition in the patt... | 04/18/2000 |
