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| Number | Title | Issue Date |
| 6280721 | Production of Bacillus thuringiensis integrants The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.... | 08/28/2001 |
| 6242177 | Methods and compositions for secretion of heterologous polypeptides The instant invention discloses the unexpected result that mutant signal sequences with reduced translational strength provided essentially complete processing and high levels of expression of a polypeptide of interest as compared to wild type signal sequ... | 06/05/2001 |
| 6218357 | Fibroin fluid and process for the production thereof A fibroin fluid obtained by adding carbon dioxide to a fibroin aqueous solution and then completely removing the carbon dioxide by pressure reduction or heating has fibroin microstructures which are dispersed in a dispersing medium, the fibroin fluid, unl... | 04/17/2001 |
| 6184372 | Antisense interleukin 10 and methods of use The present invention pertains to a method for treating a patient with a disease in which the levels of interleukin-10 need to be down-regulated which comprises adminstering to the patient a therapeutically effective amount of an antisense oligodeoxynucle... | 02/06/2001 |
| 6159729 | Synthetic HPV6/11 hybrid L1 DNA encoding human papillomavirus type 11 L1 protein The present invention is directed to a synthetic DNA molecule encoding purified human papillomavirus type 11 L1 protein and derivatives thereof.... | 12/12/2000 |
| 6150169 | Expression of the heterologous genes according to a targeted expression profile This invention relates to DNA constructs for inserting heterologous gene sequences into a host genome so as to obtain expression of the heterologous gene, to methods of inserting heterologous gene sequences into a host genome, and to organisms carrying mo... | 11/21/2000 |
| 6150141 | Intron-mediated recombinant techniques and reagents The present invention makes available methods and reagents for novel manipulation of nucleic acids. As described herein, the present invention makes use of the ability of intronic sequences, such as derived from group I, group II, or nuclear pre-mRNA intr... | 11/21/2000 |
| 6140306 | Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bact... | 10/31/2000 |
| 6140120 | Regulated transcription of targeted genes and other biological events Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We... | 10/31/2000 |
| 6140074 | SH3 protein, gene, chimeric cells, vectors and expression method for producing the novel protein, and uses The invention is a protein having the amino acid sequence of Seq. I.D. No. 1 or an allelic variation retaining the biological activity of the protein having the amino acid sequence of Seq. I.D. No. 1, a DNA segment coding for a protein according to claim ... | 10/31/2000 |
| 6110666 | Locus control subregions conferring integration-site independent transgene expression abstract of the disclosure The invention encompasses a locus control subregion that possesses chromatin opening domain activity, the activity conferring reproducible activation of tissue-specific expression on a linked transgene to a non-physiological level when the transgene is in... | 08/29/2000 |
| 6110459 | Transplants for myocardial scars and methods and cellular preparations A method is provided for forming a graft in heart tissue which comprises the transplantation of cells chosen from cardiomyocytes, fibroblasts, smooth muscle cells, endothelial cells and skeletal myoblasts. The grafts are especially useful in treating scar... | 08/29/2000 |
| 6107078 | Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof This invention is directed to improved catalytic compounds, hammerhead ribozymes, capable of hybridizing with a target RNA to be cleaved. These improved compounds have optimized stems (X)m*(X)m', loops (X)b and hybridizing arms. The invention is also dire... | 08/22/2000 |
| 6100043 | Recombinant clone selection system Cloning systems useful for the isolation of recombinant nucleic acid are disclosed in which the recombination of cloning-system nucleic acid and foreign nucleic acid is linked to the expression of a moiety on the surface of a host organism, the moiety bei... | 08/08/2000 |
| 6090791 | Method for inducing mucosal immunity By injecting plasmid DNAs or oligonucleotides with DNA sequence containing a 2 base sequence of unmethylated cytosine and guanine adjacent thereto into mamalian mucosal cells, mucosal immunity and CD4 positive T cells capable of producing interleukin 10 a... | 07/18/2000 |
| 6090925 | Macromolecular microparticles and methods of production and use Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of ho... | 07/18/2000 |
| 6087094 | Compositions and methods for detecting viral infection The present invention generally relates to the field of diagnostic virology. More particularly, the present invention is directed to methods and compositions useful for the detection and differentiation of viral particles and/or virions in specimens. The ... | 07/11/2000 |
| 6087095 | DNA sequencing method The invention is drawn to a method of DNA sequencing using labeled nucleotides that do not act as chain elongation inhibitors where the label is removed or neutralized for the sequential addition of non-labeled nucleotides.... | 07/11/2000 |
| 6087171 | Method for inducing DNA synthesis in neurons A method is provided for inducing DNA synthesis in differentiated neurons. According to certain embodiments of the invention, a method for inducing DNA synthesis in a differentiated neuron is provided that includes obtaining a vector comprising nucleic ac... | 07/11/2000 |
| 6083923 | Liposomal oligonucleotide compositions for modulating RAS gene expression Pharmaceutical compositions comprising sterically stabilized liposomes containing antisense oligonucleotides are provided for the modulation of expression of the human ras gene in both the normal (wildtype) and activated (mutant) forms.... | 07/04/2000 |
| 6083699 | Method for bi-directional sequencing of nucleic acid polymers A method is provided for simultaneously determining the positions of a selected nucleotide base in a target region of both strands of a denatured duplex nucleic acid polymer. The nucleic acid polymer is combined with a reactant mixture comprising first an... | 07/04/2000 |
| 6074819 | DNA replication-regulating genes The invention pertains to novel genes which function in the regulation of DNA replication and/or entry of a cell into mitosis. The invention also pertains to novel proteins encoded by the genes described herein, antibodies which bind the encoded protein, ... | 06/13/2000 |
| 6071743 | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes The present invention relates to the identification of several human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus (HIV) infection. These genes encode intracellular products which appear to be ... | 06/06/2000 |
| 6066473 | Introduction of DNA into bacillus strains by conjugation The present invention relates to methods of constructing recombinant Bacillus strains encoding a polypeptide of interest, in which method a DNA construct comprising a DNA sequence encoding the polypeptide of interest is introduced into a recipient Bacillu... | 05/23/2000 |
| 6063590 | Membrane filter agar medium containing two enzyme substrates used for the simultaneous detection of total coliforms and E. coli. An improved method for detection of total coliforms and E. coli comprising placing the target sample in a broth containing an ingredient that will encourage growth and repair of injured coliforms, at least one agent that suppresses growth of gram positive... | 05/16/2000 |
| 6057156 | Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors Enzymatic nucleic acid molecules which cleave EGFR RNA.... | 05/02/2000 |
| 6046384 | Papaya ringspot virus NIa protease gene NIa protease genes of papaya ringspot virus strains FLA83 and USA P-type (HA-attenuated strain) are provided.... | 04/04/2000 |
| 6046047 | Regulated transcription of targeted genes and other biological events Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We... | 04/04/2000 |
| 6045798 | Membrane-associated immunogens of mycobacteria Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA,... | 04/04/2000 |
| 6046307 | Modulation of mammalian telomerase by peptide nucleic acids The invention relates to peptide nucleic acids that inhibit telomerase activity in mammalian cells.... | 04/04/2000 |
| 6040181 | Regulation of bcl-2 gene expression The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.... | 03/21/2000 |
| 6040424 | Protein and gene for antioxidant response A set of seven nuclear proteins were identified which bind to the antioxidant responsive element (ARE), a DNA sequence present in the promoters of inducible chemoprotective enzymes. One of these ARE binding proteins, here designated ARE-BP-1, has been fou... | 03/21/2000 |
| 6037173 | Isolated nucleic acid encoding TRBP The invention provides nucleic acids encoding a TRBP polypeptide, fragments thereof and homologs thereof The invention also provides TRBP polypeptides, fragments thereof and homologs thereof, and TRBP binding proteins. Methods for treating diseases or con... | 03/14/2000 |
| 6037457 | Method for recombinant fibrinogen production The present invention provides methods of producing recombinant fibrinogen in a long-term mammalian cell culture system. Disclosed is a method for the production of recombinant fibrinogen, comprising: growing mammalian cells that express recombinant fibri... | 03/14/2000 |
| 6033848 | Human ice homolog The present invention provides a polynucleotide (icel) which identifies and encodes a human ice homolog (ICEL) expressed in lung cells and tissues. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequ... | 03/07/2000 |
| 6030791 | Antibody for a homolog of rat elastase IV derived from human pancreas The present invention provides nucleotide and amino acid sequences that identify and encode a human homolog of rat elastase IV (HEIV) expressed in pancreas tissue. The present invention also provides for antisense molecules to the nucleotide sequences whi... | 02/29/2000 |
| 6024953 | Vaccine against rabies and process for preparation thereof The present invention relates to a vaccinia virus, characterised in that it contains all or part of a DNA sequence (I) coding for an antigenic glycoprotein of rabies.... | 02/15/2000 |
| 6025137 | Compositions and methods for the diagnosis, prevention and treatment of tumor progression The present invention relates to methods and compositions for the diagnosis, prevention, and treatment of tumor progression in cells involved in human tumors such as melanomas, breast, gastrointestinal, lung, and bone tumors, various types of skin cancers... | 02/15/2000 |
| 6025190 | Temperature-sensitive plasmid A bacterial vector plasmid of the type having an efficient replication origin in Gram-positive bacteria. The plasmid is characterized by having at least one marker gene which expresses itself in a bacterial host strain, an efficient replication system whi... | 02/15/2000 |
| 6025192 | Modified retroviral vectors The present invention relates to methods and compositions for the elucidation of mammalian gene function. Specifically, the present invention relates to methods and compositions for improved mammalian complementation screening, functional inactivation of ... | 02/15/2000 |
