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| Number | Title | Issue Date |
| 5804430 | Bovine ovary cell line (FROV) for virus replication A bovine ovary cell line (FROv), a process for its preparation, and its use for replicating viruses, are described.... | 09/08/1998 |
| 5753236 | Antigenic composition obtained by V8 proteolysis of a protein from S. mansoni An antigenic composition against S. mansoni comprising an 8 kD peptidic fragment associated with a suitable vehicle, the 8 kD peptidic fragment being obtained by controlled proteolysis using V8 protease of a 28 kD protein obtained from S. mansoni is descr... | 05/19/1998 |
| 5717065 | Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen Antigens, immunogens, inocula, antibodies, and particularly diagnostic methods and systems relating to Epstein-Barr virus nuclear antigen (EBNA) are disclosed. The diagnostic methods and systems utilize a synthetic, random copolymer polypeptide containing... | 02/10/1998 |
| 5712118 | Vaccine for branhamella catarrhalis Compositions comprising outer membrane protein "CD", and peptides and oligopeptides thereof, of Branhamella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide or oligopeptide are disclosed, as well as recombinant v... | 01/27/1998 |
| 5695761 | Suppression of nitric oxide production by osteopontin The present invention relates to compositions and methods for inhibition of the vasoactive and signal transduction agent nitric oxide (NO), and to therapeutic treatment of diseases or disorders that involve inappropriate or detrimental NO activity. The in... | 12/09/1997 |
| 5681568 | Device for delivery of substances and methods of use thereof This invention comprises devices and methods for producing a composite microporous membrane specifically tailored to be useful for optimizing the delivery of macromolecules to a therapeutic target.... | 10/28/1997 |
| 5679321 | Sialic acid/fucose based medicaments Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs o... | 10/21/1997 |
| 5672488 | Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides The present invention relates to contraceptive vaccines based on cloned zona pellucida genes and the strategy of alloimmunization with zona pellucida polypeptides. In particular, the present invention relates to a contraceptive vaccine for use in a mammal... | 09/30/1997 |
| 5660992 | Sialic acid/fucose based assay reagents and assay methods Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs o... | 08/26/1997 |
| 5650152 | Liposome immunoadjuvants containing IL-2 The present invention provides a liposome comprising an effective immunoadjuvant amount of a lymphokine such as IL-2. Also provided is an effective antineoplastic amount of IL-2 liposomes in combination with adoptively transferred cells stimulated with an... | 07/22/1997 |
| 5650318 | Process and culture medium for the production of cells infected by a multiple sclerosis-associated virus Process for in vitro production of a culture or cell line infected by a viral strain associated with multiple sclerosis (MS), according to which a body sample is taken from an individual suffering from MS, said sample is cultivated in a culture medium whi... | 07/22/1997 |
| 5643771 | Non-reverting live bacterial vaccines Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification in a gene involved in at least one, normally at least two, ... | 07/01/1997 |
| 5643574 | Protein- or peptide-cochleate vaccines and methods of immunizing using the same A method is described of immunizing a host by administering a biologically effective amount of a protein- or peptide-cochleate comprising at least a protein or peptide to which an immune response is elicited, a negatively charged lipid, and a divalent cat... | 07/01/1997 |
| 5641487 | Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides The present invention relates to contraceptive vaccines based on cloned zona pellucida genes and the strategy of alloimmunization with zona pellucida polypeptides. In particular, the present invention relates to a contraceptive vaccine for use in a mammal... | 06/24/1997 |
| 5632988 | Polypeptide inhibitors of gamma interferon Novel synthetic polypeptides comprising the amino acid subsequence Arg-Arg-Lys-Trp-Gln are provided by this invention. Also provided are methods for the use of such polypeptides, other known polypeptides containing such subsequence and a variety of acidic... | 05/27/1997 |
| 5631009 | Porcine adipocyte antigens and their use in the immunological control of fat Antigens present in the plasma membrane of mature porcine white adipocytes, which are not present in porcine liver, kidney, spleen, brain, cardiac muscle, skeletal muscle or lung or in porcine erythrocytes, which react with antisera raised against said ad... | 05/20/1997 |
| 5629198 | Anti-HIV agent The invention relates to an anti-HIV agent comprising, as an active ingredient, at least one porphyrin derivative selected from the following derivatives (A) and (B): (A) porphyrins modified with a compound selected from carbodiimides, alkylenediamines an... | 05/13/1997 |
| 5629001 | Oral administration of therapeutic proteins for treatment of infectious disease An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating compositio... | 05/13/1997 |
| 5626846 | Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides The present invention relates to contraceptive vaccines based on cloned zona pellucida genes and the strategy of alloimmunization with zona pellucida polypeptides. In particular, the present invention relates to a contraceptive vaccine for use in a mammal... | 05/06/1997 |
| 5622702 | Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric ... | 04/22/1997 |
| 5620691 | Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid... | 04/15/1997 |
| 5620690 | Immunogenic complexes The invention relates to immunogenic complexes such as two-dimensional lamellae having a honeycomb structure and in particular three-dimensional iscoms, which immunogenic complexes are composed of at least one sterol, one saponin and, in the case of iscom... | 04/15/1997 |
| 5618533 | Flagellin-based polypeptides for the diagnosis of lyme disease Diagnostic means and methods for Lyme disease comprising B. burgdorferi flagellin polypeptides and antibodies. Compositions and methods comprising neuroborreliosis-associated antigens useful for the detection, treatment and prevention of neuroborreliosis,... | 04/08/1997 |
| 5616328 | Method of preparing gram-negative bacterial vaccines There is provided by this invention a novel method of preparing Gram-negative bacterial vaccines. The method comprises providing a concentrated Gram-negative bacterial antigenic preparation,adsorbing the preparation with a mineral carrier capable of bindi... | 04/01/1997 |
| 5612042 | Vaccine against streptococcus suis infection The present invention relates to a polypeptide of the bacterium Streptococcus suis with a molecular weight of about 54 kD, capable of inducing neutralising antibodies against Streptococcus suis. The invention also relates to a vaccine against Streptococcu... | 03/18/1997 |
| 5609870 | Methods for the preparation of immunogens against gastrin Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormo... | 03/11/1997 |
| 5609871 | Oral administration of therapeutic proteins for treatment of infectious disease An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating compositio... | 03/11/1997 |
| 5607676 | Immunogenic compositions against gastrin peptides Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormo... | 03/04/1997 |
| 5595738 | CTAA 81AV78, the antigen recognized by human monoclonal antibody 81AV78 A lipid antigen found in colon, breast, lung, ovarian and pancreatic human adenocarcinomas identified by reactivity with human monoclonal antibody 81AV78, and the use of the antigen in vaccines.... | 01/21/1997 |
| 5595744 | Respiratory disease vaccine for cats The present invention is concerned with the use of Bordetella bronchiseptica antigens for the prevention of upper respiratory disease in cats. These antigens may also be combined with Feline herpes virus, Feline calici and/or Chamydia antigens.... | 01/21/1997 |
| 5591433 | Oral administration of immunologically active biomolecules and other therapeutic proteins An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating compositio... | 01/07/1997 |
| 5587164 | Porcine reproductive and respiratory syndrome virus antigen and processes for the preparation and use of said antigen in vaccines and diagnostics A process for growing a PRRSV in a tissue culture which is susceptible to infection to replicate the virus to an amount sufficient to protect animals against PRRS or be used in diagnosing PRRS or identifying the molecular structure of PRRSV for developmen... | 12/24/1996 |
| 5582831 | Anti-tumor vaccines An immunogen derived from modified tumor cells and capable of inducing an anti-tumor immune response is prepared in accordance with the invention by exposing tumor cells to a crosslinking agent, which is a 2',3'-nucleoside or nucleotide dialdehyde at a co... | 12/10/1996 |
| 5583112 | Saponin-antigen conjugates and the use thereof Saponin/antigen conjugates and the use thereof for enhancing immune responses in individuals are disclosed. The saponins may be substantially pure or mixtures of saponins.... | 12/10/1996 |
| 5565319 | Assay and apparatus for detecting feline immunodeficiency virus Compositions derived from a novel viral isolate designated feline T-lymphotropic lentivirus (FTLV) include the whole virus; proteins, polypeptides and, polynucleotide sequences derived from the virus; and antibodies to antigenic sites on the virus. These ... | 10/15/1996 |
| 5565204 | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections Immunogenic polysaccharide-protein conjugates are generated which have an oxidized polysaccharide derived from the capsular polysaccharide of Streptococcal pneumniae and the pneumolysin protein of S. pneumoniae which is expressed recombinantly. The pneumo... | 10/15/1996 |
| 5565198 | Zona pellucida as a growth stimulant Zona pellucida is useful for growth stimulation in animals and especially in female ruminants such as heifers. Immunization of heifers with Zona pellucida obtained from young pig ovaries leads to increased weight gains that are comparable to, or exceed th... | 10/15/1996 |
| 5541102 | Bovine cell line resistant to in vitro infection by bovine viral diarrhea virus and all other known pestiviruses Bovine cell line resistant to infection by the pestiviruses Bovine Viral Diarrhea Virus (BVDV), Hog Cholera Virus (HCV) and Border Disease Virus (BDV) and all progeny and mutants thereof. A bovine cell line (CRIB) that is resistant to infection by cytopat... | 07/30/1996 |
| 5534258 | Polypeptides to prevent atherosclerotic plaque A vaccine is disclosed for the prophylaxis against pathogenic development of atherosclerotic plaque in a mammalian subject susceptible thereto which comprises: (a) 10 to 30% by weight of the compound ##STR1## (b) 10 to 30% by weight of the compound ... | 07/09/1996 |
| 5529777 | Hydrogel microencapsulated vaccines Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen, and, optionally, the polymer is crosslinked to form a stabl... | 06/25/1996 |
