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| Number | Title | Issue Date |
| 7053078 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardi... | 05/30/2006 |
| 6965027 | Crystalline 3-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile citrate This invention relates to novel amorphous and crystallline forms of 3-{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile mono citrate salt, useful as inhibitors of protein kinases, and to their methods of prepara... | 11/15/2005 |
| 6958331 | Bradykinin receptor antagonists The invention relates to sulfonyl amine derivatives of formula IA wherein R5A, X1, X2, R9 and R10 are as defined herein, which derivatives are useful as bradykinin... | 10/25/2005 |
| 6953800 | Use of selective antagonists of the α1B-adrenergic receptor for improvement of sexual dysfunction Described is the use in the treatment of either male or female sexual dysfunction of selective antagonists of the α1B-adrenergic receptor and the pharmaceutical compositions containing them as compounds capable of helping the sexual act avoiding at the s... | 10/11/2005 |
| 6943159 | Compounds and their use as positive AMPA receptor modulators The invention provides novel compounds represented by general formula (I) wherein the bond represented by the broken line may be a single, double bond or absent; and if the bond is absent, then the nitrogen is substitu... | 09/13/2005 |
| 6919474 | Cracking of neo-C9 and neo-C13 carboxylic acids to either pivalic acid or methyl pivalate A method for production of pivalic acid comprising the steps of: (a) reacting isobutylene, carbon monoxide, and a first catalyst to produce a reaction mixture; (b) contacting the reaction mixture with water, thereby producing a crude acid product having pivalic acid... | 07/19/2005 |
| 6911452 | Spiroazacyclic compounds as monoamine receptor modulators The present invention relates to 1-oxa-3,8-diaza-spiro[4.5]decan-2-one compounds as monoamine receptor modulators; compositions comprising the same; methods of inhibiting an activity of a monoamine receptor with said compounds; methods of treating a disease conditio... | 06/28/2005 |
| 6908923 | Compositions and methods for treating heart failure Certain substituted benzamide derivatives of Formula I: selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including conges... | 06/21/2005 |
| 6908922 | Linear cyclic ureas Compound of formula (I): wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each repr... | 06/21/2005 |
| 6903087 | Pyrido cyclohexenyl phenyl carboxamides tocolytic oxytocin receptor antagonists The present invention provides novel tricyclic pyridyl carboxamides as well as methods and pharmaceutical compositions utilizing them compounds for the treatment and/or prevention and/or suppression of disorders which may be remedied or alleviated by oxytocin antago... | 06/07/2005 |
| 6903103 | Linear cyclic ureas Compound of formula (I): wherein: V represents a single bond or an alkylene chain, M represents a single bond or an alkylene chain, A and E each repr... | 06/07/2005 |
| 6903110 | Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-6H-5-oxa-1-aza-phenanthrene Compounds of the formula useful for the treatment of such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disor... | 06/07/2005 |
| 6903224 | Substituted 1,3-oxathiolanes Substituted 1,3-oxathiolanes, such as cis- and trans-2-ethoxycarbonyl-5-hydroxy-1,3-oxathiolane and cis- and trans-2-ethoxycarbonyl-5-acetoxy-1,3-oxathiolane, are suitable as intermediates for the production of substituted 1,3-oxathiolanes nucleoside analogs having ... | 06/07/2005 |
| 6900344 | Method of preparing alkylated salicylamides via a dicarboxylate intermediate The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for ... | 05/31/2005 |
| 6900194 | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors for the treatment of respiratory diseases Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of Respiratory Diseases, pharmaceutical compositions containing them, and a... | 05/31/2005 |
| 6897214 | Quinazoline derivatives The invention concerns quinazoline derivatives of the formula I wherein X1 is a direct link or a group such as CO, C(R2)2 and CH(OR2); | 05/24/2005 |
| 6887866 | Short-acting sedative hypnotic agents for anesthesia and sedation The invention provides compounds compositions and methods useful for inducing or maintaining general anesthesia or sedation in mammals. ... | 05/03/2005 |
| 6867300 | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein R1 through R6 and Z are as described in th... | 03/15/2005 |
| 6858603 | Acetindine derivatives, their preparation and medicaments containing them Disclosed are azetidine derivatives of formula: their optical isomers, their salts, their preparation and medicaments containing them. ... | 02/22/2005 |
| 6858600 | Proteomimetic compounds and methods The present invention relates to compounds and pharmaceutical compositions which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are m... | 02/22/2005 |
| 6852712 | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases This invention is directed to quinoline/quinoxaline compounds which inhibit platelet-derived growth factor or p56lck tyrosine kinase activity, to pharmaceutical compositions comprising these compounds, and to the use of these compounds for treating a pati... | 02/08/2005 |
| 6846818 | Selective inhibitors of cyclooxygenase-2 The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the inventio... | 01/25/2005 |
| 6844340 | Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors The present invention relates to tricyclic 2-pyrimidone compounds of formula (I): or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of H... | 01/18/2005 |
| 6844338 | Piperidyindoles as serotonin receptor ligands A pharmaceutical compound of the formula (I) in which R1 and R2 are each hydrogen or C1-6 alkyl, R3 is —SR10, —SOR10, —SO2R10, —COR10, —CH2OH or ... | 01/18/2005 |
| 6841668 | Polyoxometalate catalysts for the preparation of sterically hindered N-substituted aryloxyamines Sterically hindered N-substituted aryloxyamines are prepared by the Keggin polyoxometalate or the transition metal substituted polyoxometalate (TMS-POM) catalyzed decomposition of diazonium salts in the presence of a sterically hindered nitoxyl radical. These compou... | 01/11/2005 |
| 6821978 | Xanthine phosphodiesterase V inhibitors A xanthine phosphodiesterase V inhibitor having the formula (I), with the variables defined herein, which is especially useful for treating male (erectile) and female sexual dysfunction and other physiological disorders: | 11/23/2004 |
| 6818450 | Use of infrared spectroscopy for on-line process control and endpoint detection The present invention is directed to an analytical method for measuring the concentration of an N-(phosphonomethyl)iminodiacetic acid (“NPMIDA”) substrate, an N-(phosphonomethyl)glycine product, formaldehyde, formic acid, N-methyl-N-(phosphonomethyl)glycine (“... | 11/16/2004 |
| 6809097 | Quinoline derivatives inhibiting the effect of growth factors such as VEGF Compounds of the formula (I): wherein: R2 represents hydroxy, halogeno, C1-3alkyl, C1-3alkoxy, C1-3alkanoyloxy, trifluoromethyl, cyano, amino or nitro; n is an integer from 0... | 10/26/2004 |
| 6809098 | Compounds The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicam... | 10/26/2004 |
| 6806391 | Process for the carbonylation of ethylenically unsaturated compounds and bidentate diphosphine composition used in this process Process for the carbonylation of optionally substituted ethylenically unsaturated compounds by reaction with carbon monoxide and a coreactant in the presence of a catalyst system. The catalyst system includes (a) a source of Pt gro... | 10/19/2004 |
| 6800633 | Pyrrolo[2,3d]pyrimidine compositions and their use This invention pertains to compounds having the structure: wherein R1 and R2 are each independently a hydrogen atom, substituted alkyl, or a substituted or unsubstituted aryl, or alkylaryl mo... | 10/05/2004 |
| 6797706 | Heterocyclecarboxamide derivative A nitrogen-containing six-membered heterocyclic compound having substituents —X—A—R3, —N(R1)-(Ph substituted by R2), and —CONH2, a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an ac... | 09/28/2004 |
| 6794381 | Succinoylamino lactams as inhibitors of aβ protein This invention relates to novel lactams having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-pe... | 09/21/2004 |
| 6790844 | Certain 1,3-disubstituted isoquinoline derivatives Condensed pyridine compounds represented by formula (I): wherein: R1 and R3 are, independently, hydrogen, halogen, lower alkyl, or lower alkoxy; R2 represents an amino substituent; ring A... | 09/14/2004 |
| 6787542 | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents The present invention relates to novel heterocyclyl-containing diaryl sulfide compounds that are useful for treating inflammatory and immune diseases, to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing... | 09/07/2004 |
| 6787545 | Pyrrolotriazine derivatives having spla2-inhibitory activities The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, c... | 09/07/2004 |
| 6787535 | Indole derivatives with 5HT6 receptor affinity This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: wherein one of R5, R6 or R7 is a group of general Formula B, where... | 09/07/2004 |
| 6787541 | Thieno-and furopyrimidine derivatives as A2A-receptor antagonists Compounds of formula (I): wherein X is S. Compounds can be used for treating a disorder in which the blocking of purine receptors is beneficial. ... | 09/07/2004 |
| 6787653 | Preparation process of biphenylcarboxylic acid amide derivatives A process for preparing a biphenylcarboxylic acid amide derivative represented by the following formula (1): wherein, R1, R2 and R3 each independently represents a hydrogen atom or a subs... | 09/07/2004 |
| 6784182 | Serine protease inhibitors Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, factor Xa and are useful in the treatment of cardiov... | 08/31/2004 |
