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| Number | Title | Issue Date |
| 6706705 | Quinazoline derivatives The present invention provides a new compound which shows slow and continuous blood pressure reducing action and is useful as an antihypertensive agent. The invention resides in a quinazoline derivative of the following formula (I) and its pharmaceutically ac... | 03/16/2004 |
| 6080745 | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands A class of fused tricyclic heteroaromatic compounds of formula (I) as defined in claim 1 or a salt thereof or a prodrug thereof, containing a fused pyrazole, oxazole or pyrimidine ring are ligands for dopamine receptor subtypes within the body and are the... | 06/27/2000 |
| 6051588 | Nitroso esters of ଲ-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositi... | 04/18/2000 |
| 5955463 | Quinazoline thymidylate synthase inhibitors The invention relates to quinazoline derivatives or pharceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them. The invention provides a quinazoline of... | 09/21/1999 |
| 5939268 | Combinatorial libraries of molecules and methods for producing same This invention features methods of synthesizing combinatorial libraries of chemical compounds, and combinatorial libraries of chemical compounds formed by the methods of this invention. Specifically, Diels-Alder chemistry is utilized to generate libraries... | 08/17/1999 |
| 5939415 | A!-annellated pyrrole derivatives and their use in pharmacology The present invention relates to heterocyclic compounds with the formula ##STR1## in which R1 to R7, B, a, and X have the meanings indicated in the specification. These compounds can be used for the treatment of diseases of the ... | 08/17/1999 |
| 5932592 | Quinoline or quinazoline derivatives, their production and use A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C-G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted for; ... | 08/03/1999 |
| 5932521 | Herbicidal 1,3-oxazin-4-one derivatives and intermediates thereto Novel 1,3-oxazin-4-one derivatives of the formula ##STR1## wherein R1 to R5 are hydrocarbyl radicals which are optionally substituted, and herbicidal compositions comprising the same as active ingredients and their use in contro... | 08/03/1999 |
| 5922711 | 8-substituted quinazolines, quinoxalines and benzopyridazines A compound of the formula: ##STR1## wherein --X3 .dbd.X2 --X1 .dbd.N-- is a group of the formula: ##STR2## R1 is hydrogen or halogen, R2 is halogen, R3 is hydrogen, nitro, amino o... | 07/13/1999 |
| 5922706 | Morpholine and thiomorpholine tachykinin receptor antagonists Substituted heterocycles of the general structural formula: ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis, and calcium channel blockers useful in the treatment of ca... | 07/13/1999 |
| 5919778 | Cyclic amide derivatives The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is ##STR1## R2 being an ... | 07/06/1999 |
| 5902493 | Method for forming micro patterns of semiconductor devices A method for forming accurate micro patterns having a micro dimension smaller than the resolution of a stepper used on a semiconductor substrate, thereby achieving an improvement in the integration degree of the semiconductor device which is ultimately pr... | 05/11/1999 |
| 5893983 | Technique for removing defects from a layer of metal A technique for polishing an exposed surface of metal on a substrate to remove defects from mechanical working of metals, such as burrs and pigtails resulting from drilling, and defects from plating, such as nodules and depressions, is provided. The subst... | 04/13/1999 |
| 5889018 | Heterocyclic compounds, pharmaceutical compositions comprising them and process for the preparation thereof The invention relates to anxiolytic pharmaceutical compositions comprising as active ingredient 1-sytrylisoquinoline derivatives of general formula (I), wherein n is 1, 2, 3 or 4; R may be the same or different and represent(s) hydrogen, lower alkyl, lowe... | 03/30/1999 |
| 5889006 | Muscarinic antagonists Di-N-substituted piperazine or 1,4 di-substituted piperadine compounds in accordance with formula I (including all isomers, salts, esters, and solvates) ##STR1## wherein R, R1, R2, R3, R4, R21, R... | 03/30/1999 |
| 5889002 | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use 1,2,4-Thiadiazine and 1,4-thiazine derivatives represented by the formula ##STR1## wherein A, B, D, R1, R2, R3 and R4 are defined in the description, compositions thereof and methods for preparing the compounds ... | 03/30/1999 |
| 5885996 | Antiproliferative quinazolines Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the gro... | 03/23/1999 |
| 5882537 | Metallic precipitate monitoring method Disclosed is a method of etching which makes the quantitative analysis possible and easier. In the prior art, chemical plasma etching is mainly by ion bombardment, and the tool used to observe the metal bulk is transmission electron microscopy (TEM), so i... | 03/16/1999 |
| 5883094 | Benzimidazolone derivatives with central dopaminergic activity This invention relates to novel, pharmaceutically active benzimidazolone derivatives of the formula ##STR1## wherein the dashed line, R0 through R6 and X1 through X3 are defined as in the specification. The... | 03/16/1999 |
| 5874579 | Insecticidal substituted-2.4-diaminoquinazolines related applications An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 2,4-diaminoquinazoline compound of the formula: ##STR1## wherein R1, R2, R6, R | 02/23/1999 |
| 5874397 | Granular detergent builder The invention relates to a granular detergent builder in the form of cogranules of a mixture of sodium bicarbonate and crystalline sheet silicates of the formula NaMSix O2x+1 *yH2 O, where M is sodium or hydrogen, x is a n... | 02/23/1999 |
| 5872125 | Polymorphs of lesopitron dihydrochloride and its hydrated forms, preparation processes and compositions containing it It comprises the new polymorphs I and II of Lesopitron dihydrochloride, characterized by their infrared spectra and their X-ray diffraction patterns. They are obtained by crystallization of Lesopitron dihydrochloride. It also comprises the forms I-hydrate... | 02/16/1999 |
| 5869486 | Fused pyrimidines and pyriazines as pharmaceutical compounds The compounds of the formula: ##STR1## wherein ring ##STR2## is a hetero ring containing nitrogen atom, optionally selected from ##STR3## n is 0-2; Y is bond or alkylene; Z is bond, alkylene or vinylene; E is (i) 4-15 membered, unsaturated,... | 02/09/1999 |
| 5869665 | Quinazolinone derivatives as cholecystokinin (CCK) ligands Novel quinazolinone derivatives with good binding affinity for the CCK-A and CCK-B receptors, pharmaceutical compositions containing them, methods of using them and a novel process for their preparation are taught. The compounds are useful agents to suppr... | 02/09/1999 |
| 5869655 | Diamine compounds, methods of making same, method of use of same and intermediates A diamine useful as a catalyst for the polymerization of urethane. A method of making the catalyst comprises reacting a spiro quaternary amine with a secondary amine. The spiro quaternary amine is also useful as an antimicrobial agent.... | 02/09/1999 |
| 5863916 | 8-aza, 6-aza and 6,8-diaza-1,4-dihydroquinoxaline-2,3-diones and the use thereof as antagonists for the glycine/NMDA receptor Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof; wherein n is zero or 1; R4, R5, R6 are independently hydrogen, nitro, amino, halo, haloalkyl, cyano, alkyl, cycloalkyl, al... | 01/26/1999 |
| 5863232 | Fabrication method of micro tip for field emission display device A method for making a micro tip of an FED device includes the steps converting impurity layer regions into porous semiconductor layer regions by performing an anodic reaction using an HF aqueous solution as an electrolytic solution, oxidizing the porous s... | 01/26/1999 |
| 5861392 | Therapeutic heterocycles Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of ... | 01/19/1999 |
| 5861395 | Compounds useful for inhibition of farnesyl proteins transferase Novel compounds of the formula: ##STR1## are disclosed. Compounds of Formula 1.0 are represented by the compounds of formulas: ##STR2## wherein R1, R3 and R4 are each independently selected from halo. Also d... | 01/19/1999 |
| 5856503 | Aminoalkyl-substituted benzo-heterocyclic compounds Aminoalkyl-substituted benzo-heterocyclic compounds of the formula ##STR1## wherein M, Q, R and T are as defined in the specification, as well as acid addition salts thereof. These compounds are useful as cholesterol level lowering agents and as anti... | 01/05/1999 |
| 5854227 | Therapeutic derivatives of diphosphonates Novel chemotherapeutic agents having utility in treating infectious diseases such as periodontal disease, certain urinary tract infections, infectious urinary tract stones, and bone cancer, are obtained by combining chemically a diphosphonate compound wit... | 12/29/1998 |
| 5852006 | N-aminoalkyl-substituted nitrogen-containing six membered heterocyclic compounds Disclosed are new alkylenediamine derivatives of the following formula which are effective for treatment of dysuria are disclosed: ##STR1## wherein R1 is hydrogen, alkyl, or a substituted or unsubstituted phenyl, naphthyl or aromatic heter... | 12/22/1998 |
| 5849216 | Compounds for use in liquid-crystal mixtures Compounds of the formula (I) R1 --(A1)a (--M1)b --(--A2)c (--M2)d (--A3)e (--M3)f (--A4)g --H(I... | 12/15/1998 |
| 5849742 | Compounds for the treament of disorders related to vasculogenesis and/or angiogenesis The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction and particularly KDR/FLK-1 receptor signal transduction in order to regulate and/or modulate vasculogenesis and angiogenesis. The invention is bas... | 12/15/1998 |
| 5837711 | Substituted quinuclidines as substance P antagonists Certain novel substituted quinuclidine compounds having the ability to antagonize substance P and having the following formula: ##STR1## wherein Ar1 and Ar2 are each, independently, thienyl, phenyl, fluorophenyl, chlorophenyl or... | 11/17/1998 |
| 5834468 | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists This invention relates to substituted and unsubstituted (aryl- and heteroaryl-) alkyl-, alkyloxy-, alkylthio-, oxo-, thio-, and alkylamino!- heteroaryl and aryl!- alkylamino-, aminoalkyl-, alkyloxy-, and alkylthio!- aryl and heteroaryl compounds of ... | 11/10/1998 |
| 5834456 | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents Polyazamacrocyclofluoromonoalkylphosphonic acid compounds are disclosed which form inert complexes with Gd, Mn, Fe or La ions. The complexes are useful as contrast agents for diagnostic purposes.... | 11/10/1998 |
| 5834469 | Endothelin receptor antagonists The invention concerns compounds of the following formulae: ##STR1## wherein the variables are defined in the specification. The compounds are useful as endothelin receptor antagonists.... | 11/10/1998 |
| 5831090 | Process for the preparation of photochromic compounds of the annelated spiroindoline2,3'! benzoxazine!type The present disclosure relates to a process for the preparation of photochromic compounds of the annelated spiroindoline2,3'!benzoxazine! type comprising the reaction of a Fisher base (I) having a 2-alkylidene indoline structure with a condensed ortho... | 11/03/1998 |
| 5830835 | Dryer-activated fabric conditioning and antistatic compositions with improved perfume longevity The present invention relates to dryer-activated fabric softening compositions comprising: (A) fabric softening compounds; (B) a non-allylic perfume alcohol ester; and (C) optionally, (1) a carboxylic acid salt of a tertiary amine and/or a tertiary amine ... | 11/03/1998 |
