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| Number | Title | Issue Date |
| 7442525 | Method for expressing HIV polypeptides Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 10/28/2008 |
| 7425428 | Recombinant DNA construct for HIV envelope polypeptides and polypeptides produced thereby Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 09/16/2008 |
| 7415359 | Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents Systems and methods are presented for cell simulation and cell state prediction. For example, a cellular biochemical network intrinsic to a phenotype of a cell can be simulated by specifying its components and their interrelationships. The various interrelationships... | 08/19/2008 |
| 7409297 | Methods and systems for providing a nutraceutical program specific to an individual animal The present invention relates to methods and systems for providing an animal with a nutraceutical program that is specifically tailored to address the deficiencies and/or needs of the particular animal. Blood is drawn from the animal and analyzed at a lab to obtain ... | 08/05/2008 |
| 7408053 | Recombinant DNA constructs for GAG polypeptides and polypeptides produced thereby Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 08/05/2008 |
| 7393949 | Human immunodeficiency virus (HIV) nucleotide sequences Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 07/01/2008 |
| 7384735 | Retinoblastoma nucleic acids This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients. ... | 06/10/2008 |
| 7373255 | Method and system for determination of molecular interaction parameters A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the imm... | 05/13/2008 |
| 7363168 | Adaptive baseline algorithm for quantitative PCR The invention relates to baseline subtraction algorithms developed to reduce tube-to-tube and cycle-to-cycle variabilities during real time PCR amplification. Particularly, the invention relates to algorithms for determining the threshold cycle for the first reliabl... | 04/22/2008 |
| 7353116 | Chemical array with test dependent signal reading or processing A method in which an array identifier for a chemical array with probes at multiple feature locations is retrieved from a memory or read. The array identifier, a request for a test which requires an instruction on reading or processing the signal data read from the a... | 04/01/2008 |
| 7349810 | Safety test support system, method and program A safety test support system comprises application storage 5, an application activating means 7, check program storage 17 and an inspection conducting means 19. The application storage 5 stores applications for safety tests, which ... | 03/25/2008 |
| 7349808 | System and method for tracking and controlling infections The present invention is a system and method for performing real-time infection control over a computer network. The method comprises obtaining a sample of a microorganism at a health care facility, sequencing a first region of a nucleic acid from the microorganism ... | 03/25/2008 |
| 7340349 | Method and system for identifying splice variants of a gene A method and system for identifying mRNA present in a sample. A splice variant technique selects a set of possible exon-exon junctions based on exons of expected mRNA transcripts. The splice variant technique then selects indicator polynucleotides for the exon-exon ... | 03/04/2008 |
| 7337071 | Information processing system using base sequence-related information This invention constructs a highly safe system for processing information for providing semantic information and/or information associated with the semantic information useful for each individual organism through effective utilization of differences in nucleotide se... | 02/26/2008 |
| 7332290 | Dectection of AMACR cancer markers in urine The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provid... | 02/19/2008 |
| 7333894 | Methods for the diagnosis of hemodialysis patients and utilization of such methods to improve the administration of intravenous levocarnitine treatments to hemodialysis patients The disclosed invention pertains to methods for diagnosing clinical conditions that are common in hemodialysis patients and that may be related to abnormal carnitine metabolism resulting from hemodialysis. Further, the present invention pertains to methods for monit... | 02/19/2008 |
| 7328110 | System for cellular storage and genetic information retrieval A system for storage of cellular material and retrieval of genetic information comprises a cell bank comprising a plurality of cell storage units for storage of cellular material from individual depositors. Cryo-preservation of the material is contemplated. Genetic ... | 02/05/2008 |
| 7302347 | Method for creating specific, high affinity nuclear receptor pharmaceuticals This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are inclu... | 11/27/2007 |
| 7285271 | Antigenic composition comprising an HIV gag or env polypeptide Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 10/23/2007 |
| 7273695 | HIV immunoassays using synthetic envelope polypeptides Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 09/25/2007 |
| 7272508 | Small molecule mimetics of erythropoietin The invention features computer-assisted methods for identifying molecules which will bind to the EPO receptor and act as an erythropoietin (EPO) mimetic. Preferred EPO mimetics identified using the method of the invention act as agonists of the EPO receptor in one ... | 09/18/2007 |
| 7264963 | Protein(poly)peptide libraries The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of ... | 09/04/2007 |
| 7251568 | Methods and compositions for regulating bone and cartilage formation The invention provides methods and compositions for diagnostic assays for detecting bone and cartilage formation and therapeutic methods and compositions for treating disease and disorders related to bone and cartilage formation or resorption, such as osteoporosis a... | 07/31/2007 |
| 7248970 | Forensic and genealogical test A method is provided for determining the probable surname of a male from a sample of his tissue or DNA, wherein the haplotype of his sample is compared with a database, the database containing information which correlates Y chromosome haplotypes to given surnames. | 07/24/2007 |
| 7241876 | Compositions and methods for the therapy and diagnosis of breast cancer Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antige... | 07/10/2007 |
| 7223842 | Detection of proteins whose absence is associated with a neoplasm This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients. ... | 05/29/2007 |
| RE39586 | Human monoclonal antibody against Hepatitis B virus surface antigen (HBVSAG) Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatme... | 04/24/2007 |
| 7205101 | Human immunodeficiency virus (HIV) nucleotide sequences, recombinant polypeptides, and applications thereof Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare... | 04/17/2007 |
| 7202334 | Compositions and methods for the therapy and diagnosis of ovarian cancer Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune... | 04/10/2007 |
| 7184893 | Method for selecting an optimally diverse library of small molecules based on validated molecular structural descriptors The use for biological screening purposes of a subset (library) of a large combinatorially accessible chemical universe increases the efficiency of the screening process only if the subset contains members representative of the total diversity of the universe. In or... | 02/27/2007 |
| 7162372 | Least-square deconvolution (LSD): a method to resolve DNA mixtures Least Square Deconvolution (LSD) uses quantitative allele peak data derived obtained from a sample containing the DNA of more than one contributor to resolve the best-fit genotype profile of each contributor. The resolution is based on finding the least square fit o... | 01/09/2007 |
| 7157089 | Immune responses using compositions containing stress proteins The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a portion of a protein having an amino acid sequence sufficiently homolog... | 01/02/2007 |
| 7158891 | Method and system to build optimal models of 3-dimensional molecular structures The present invention relates to a method to build 3-dimensional models of molecular structures corresponding to the lowest value of the potential energy function from knowledge of their chemical structures. The system uses Mutually Orthogonal Latin Squares to searc... | 01/02/2007 |
| 7155345 | System for regulating the handling of milk during the milking process and a method for regulating said milking process The present invention concerns a system and a method for regulating the handling of milk during the milking process in order to separate mastitis infected milk from milk for human consumption and apt to be applied in an automated milking process. ... | 12/26/2006 |
| 7136758 | Virtual library searchable for possible combinatorially derived product molecules having desired properties without the necessity of generating product structures The problem of how to select out of a large chemically accessible universe molecules representative of the diversity of that universe is resolved by the discovery of a method to validate molecular structural descriptors. Using the validated descriptors, optimally di... | 11/14/2006 |
| 7129337 | Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents The present invention relates to new genomic nucleotide sequences and amino acid sequences corresponding to the coding region of these genomes. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes se... | 10/31/2006 |
| 7117095 | Methods for selecting nucleic acid probes Methods and computer software products are provided for selecting nucleic acid probes. In one embodiment, dynamic programming is employed to select a set of k probes from n probes so that the selected probes have a maximum aggregate adjusted quality score. ... | 10/03/2006 |
| 7113870 | Prediction of molecular polar surface area and bioabsorption The polar surface area of molecules is computed without reference to three dimensional molecular structures using a linear equation incorporating counts of nitrogens, oxygens, and related atom clusters. Methods and systems for predicting intestinal absorption and bl... | 09/26/2006 |
| 7096162 | Computer-implemented method of merging libraries of molecules using validated molecular structural descriptors and neighborhood distances to maximize diversity and minimize redundancy The use for biological screening purposes of a subset (library) of a large combinatorially accessible chemical universe increases the efficiency of the screening process only if the subset contains members representative of the total diversity of the universe. In or... | 08/22/2006 |
| 7087435 | Biopolymer marker indicative of disease state having a molecular weight of 2753 daltons The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopoly... | 08/08/2006 |
