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| Number | Title | Issue Date |
| 7364911 | Methods for isolating and labeling sample molecules The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more functional groups, and a reactive group for the sample molecule, under condit... | 04/29/2008 |
| 7229782 | Antibodies specific to multiple beta blockers and methods for their use The present invention is directed antibodies specific to multiple beta blockers, as well as immunogens used to produce the antibodies and immunoassay kits and methods for using the antibodies. ... | 06/12/2007 |
| RE39663 | Electron-deficient nitrogen heterocycle-substituted fluorescein dyes The invention provides compositions electron-deficient nitrogen heterocycle-substituted fluorescein dyes and methods in which the dyes are conjugated to substrates and used as detection labels in molecular biology experiments. The electron-deficient nitrogen heteroc... | 05/29/2007 |
| 7220842 | Immunoassays for buprenorphine and norbuprenorphine Methods, compositions and kits are disclosed directed at haptens, immunogens and immunoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) o... | 05/22/2007 |
| 7217575 | Avidin derivatives and uses thereof A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or —CH═CH—, wherein n is an intege... | 05/15/2007 |
| 7214546 | Dendritic chemiluminescent substrates Chemiluminescent substrate delivery systems comprising a conjugate of a dendrimer and at least one chemiluminescent substrate are provided. The substrate delivery systems can also include a chemiluminescence enhancer. The dendrimer/chemiluminescent substrate conjuga... | 05/08/2007 |
| 7211445 | Conjugation of biomolecules using diels-alder cycloaddition A method is provided for covalently linking carbohydrates, proteins, nucleic acids, and other biomolecules under neutral conditions, using a Diels-Alder cycloaddition reaction. In an example, activated carbon-carbon double bonds were attached to free amino sites of ... | 05/01/2007 |
| 7208322 | Sensor surfaces for detecting analytes The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises an organic compound having a boronic acid complexing moiety. The mat... | 04/24/2007 |
| 7208299 | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces The present invention is directed to a composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces and hydrophobic coated surfaces. The composition is a biomolecule conjugated end-group activated polymer (EGAP). The biomolecu... | 04/24/2007 |
| 7205161 | Polymer brushes for immobilizing molecules to a surface or substrate having improved stability Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersib... | 04/17/2007 |
| 7205162 | Artificial antibodies, method of producing the same and use thereof Artificial antibodies or antibody mimics are described. They consist of polymers that carry specific binding sites mimicking the properties of antibodies. There is also described a method for producing artificial antibodies, in which polymerisable monomers carrying ... | 04/17/2007 |
| 7202348 | Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.... | 04/10/2007 |
| 7202092 | Indinavir derivatives useful in immunoassay Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Al... | 04/10/2007 |
| 7198958 | Method for increasing hydrophilicity of fluorescent label compounds A fluorescent label compound of formula where Z is a reactive group that can be used for covalent coupling of the fluorescent label compound to other molecule. Either the fluorophore is a dipyrrometheneboron difl... | 04/03/2007 |
| 7195882 | Monoclonal antibodies specific for buprenorphine and metabolites thereof The present invention relates to monoclonal antibodies that specifically bind buprenorphine and/or at least one metabolic product thereof. The present invention further relates to buprenorphine metabolite conjugates for the production of monoclonal antibodies that s... | 03/27/2007 |
| 7193065 | Protease inhibitor conjugates and antibodies useful in immunoassay Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for HIV protease inhibitors. The novel haptens feature ... | 03/20/2007 |
| 7192719 | Antibodies specific for papillary fibroblasts as markers for skin quality Whether or not a sample of skin or of a skin equivalent contains such amount of a papillary fibroblast population as to be considered a normal skin is determined by labelling said skin or skin equivalent with at least one antibody specific for papillary fibroblasts ... | 03/20/2007 |
| 7186518 | Method and composition useful for determining FK 506 New derivatives of FK 506 are disclosed. These new derivatives and other derivatives that are useful for determining the levels of FK 506 in a sample are also provided as are assay procedures and kits for use in determining the levels of FK 506 or other macrophilin ... | 03/06/2007 |
| 7183116 | Methods for isolation and labeling of sample molecules The invention provides methods for labeling a molecule by contacting a sample molecule with a solid support coupled to a chemical group comprising a cleavable functional group, one or more functional groups, and a reactive group for the sample molecule, under condit... | 02/27/2007 |
| 7183392 | Site-specific, covalent bioconjugation of proteins Heterofunctional crosslinking groups are provided having the formula: wherein W is a covalent core component; L1, L2 and L3 are independently linking groups; X is a non-covalent o... | 02/27/2007 |
| 7179616 | Method for detecting phosphatidylserine on the surface of cells The present invention relates generally to a method and compound for sensing the presence of anionic phospholipids, especially phosphatidylserine, on the surface of vesicles and cells. Upon introducing a compound having the structure below to a sample of cells or ve... | 02/20/2007 |
| 7179659 | Sensor surfaces for detecting analytes and methods of use The present invention provides a method for detecting an analyte, comprising providing a sensor comprising a substrate coated with a free electron metal, a matrix layer disposed on the free electron metal, the matrix layer comprising an organic compound, wherein the... | 02/20/2007 |
| 7172905 | Polypeptide immobilization A substrate comprises a surface, and a plurality of moieties, on at least a portion of the surface. The moieties are moieties of formula: Surf-L—Q—T, where —T comprises a reactant ligand, and Surf- designates where the moiety attaches to th... | 02/06/2007 |
| 7173130 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 02/06/2007 |
| 7172907 | Cyanine dye labelling reagents with -substitution Disclosed are cyanine dyes having meso-substituents in the polymethine chain linking the heterocyclic ring systems. The dyes are of formula (1): in which groups R3 and R4 are attached to the... | 02/06/2007 |
| 7169907 | Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs Compounds including haptens, intermediates, and immunogens that are useful in the production of antibodies specific for the methylenedioxy class of amphetamine derivatives are described. Antibodies specific for the methylenedioxy class of amphetamine derivatives, re... | 01/30/2007 |
| 7166440 | 2,4,5-trichlorophenoxyalkyl carboxylic acid and a method for determining dioxins using the same An immunoassay of dioxins using 2,4,5-trichlorophenoxyalkyl amide derivative represented by the following formula (II) as an antigen for a competitive immunoassay is provided: where n is ... | 01/23/2007 |
| 7160733 | Ligand specific to β-glycoprotein I and use thereof The cholesterol derivative, represented by the following formula (1): wherein R represents a C3–C23 saturated or unsaturated aliphatic hydrocarbon residue having an optional substituent, and, to the cholesterol backbone, ... | 01/09/2007 |
| 7160732 | Fluorescein-based metal sensors, and methods of making and using the same The present invention is directed, in part, to fluorescein-based ligands for detection of metal ions, and methods of making and using the same. ... | 01/09/2007 |
| 7157561 | Methods of inhibiting transmission of a costimulatory signal of lymphocytes Activated haptens useful for generating immunogens to the HIV protease inhibitor atazanavir, immunogens useful for producing antibodies to atazanavir, and antibodies and labeled conjugates useful in immunoassays for determination of atazanavir. The haptens feature a... | 01/02/2007 |
| 7157560 | Immunoassay for LSD and 2-oxo-3-hydroxy-LSD The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indo... | 01/02/2007 |
| 7148029 | Immunoassay for neonicotinyl insecticides The present invention provides immunogens for generating anti-neonicotinoid antibodies as well as antibodies, methods, reagents and kits for determining the presence of one or more neonicotinoid insecticides in a sample by immunoassay. The present invention has part... | 12/12/2006 |
| 7141437 | Solid-state colorimetric biosensors comprised of dendritic polymer networks Solid-state colorimetric biosensors having sensory groups and interdendritic cross-linking segments of alternating conjugated double and triple bonds are prepared by intermolecular polymerization of diacetylene-functionalized dendritic polymer precursors. The polyme... | 11/28/2006 |
| 7141655 | Reagents and procedures for high-specificity labeling A molecule with two pendant phenylarsine moieties according to the general structural Formula (I) and tautomers, acids, and salts thereof: wherein: (i) R1 or R2, are each independently O | 11/28/2006 |
| 7138504 | Reagents and methods for mycophenolic acid immunoassay The invention teaches derivatives of mycophenolic alcohol and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of mycophenolic acid (MPA) and/or active metabolites of MPA in patient specimens. An... | 11/21/2006 |
| 7135343 | Biomolecule resistant and their methods of use in assays The present invention relates to bio-molecule resistant surfaces for use in assays, particularly in assay devices such as arrays and microfluidic devices. The biomolecule resistant surface of the present invention are prepared by coating a substrate with hydrophilic... | 11/14/2006 |
| 7132269 | Coupling agents, the active intermediates and the conjugates thereof and the use of said conjugates in diagnostic methods The present invention concerns coupling agents having the following general formula: activated intermediates consisting of a coupling agent such as defined above with either a molecule having on its surface at le... | 11/07/2006 |
| 7118899 | Detection of transmembrane potentials by optical methods Methods and compositions are provided for detecting changes in membrane potential in membranes biological systems. In one aspect, the method comprises; a) providing a living cell with a first reagent comprising a charged hydrophobi... | 10/10/2006 |
| 7118908 | On-spot selectively activated hydrophobic slide and preparation thereof An on-spot selectively activated hydrophobic slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic material and a compound bearing a functional group protected by a protecting... | 10/10/2006 |
| 7115383 | Assays for amphetamine and methamphetamine Methods, compositions and kits are disclosed. The compounds disclosed comprise an amphetamine moiety and a methamphetamine moiety linked together by a first linking group. A second linking group depends from the first linking group and comprises a functional group. ... | 10/03/2006 |
