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Berch, Mark L.


Primary examiner statistics: 2687 patents; average approval time: 2686 days
Assistant examiner statistics: 242 patents; average approval time: 711 days

Patents as Assistant Examiner


1              
NumberTitleIssue Date
4158004Process for antibiotic FR 1923 and related compounds
Process for 1-[଱-(carboxy)-4-hydroxy or protected-hydroxybenzyl]-3-acylamidoazetidin-2-one esters, useful intermediates for preparing antibiotic FR 1923, comprising the ring opening of a 2-acyl-3,3-dialkyl-7-oxo-଱-[4-(protected-hydroxyphe...
06/12/1979
4136176O-alkyl-O-[6-substituted-thio-pyridazin-3-yl]-(thiono) (thiol)-phosphoric (phosphonic) acid esters
O-alkyl-O-[6-substituted-thio-pyridazin-3-yl]-(thiono) (thiol)-phosphoric (phosphonic) acid esters of the formula ##STR1## in which R represents alkyl, R1 represents alkyl, alkylthio or alkylamino, R2 represents alkyl, alkenyl, alkyn...
01/23/1979
4134978O-Alkyl-O-[8-chloro-quinoxal-2-yl]-thionoalkanephosphonic acid esters
O-Alkyl-O-[8-chloro-quinoxal-2-yl]-thionoalkanephosphonic acid esters of the formula ##STR1## in which R and R1 each independently is alkyl with 1 to 6 carbon atoms, which possess arthropodicidal, especially insecticidal and acaricida...
01/16/1979
41338142-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
Derivatives of 2-phenyl-3-aroylbenzothiophenes and 2-phenyl-3-aroylbenzothiophene-1-oxides are useful as antifertility agents. Certain of these compounds also are useful in suppressing the growth of mammary tumors....
01/09/1979
4133881Azetidinyl acetonitrile and acetamide antiarrhythmia compositions and methods
଱-(1-R-3-Azetidinyl)-଱-phenyl-଱-substituted-acetamides and -acetonitriles represented by the following formula: ##STR1## wherein R represents hydrogen, lower alkyl, lower cycloalkyl or phenyllower alkyl, R1 represents phe...
01/09/1979
41338074-Thioxo-2-azetidinones
A method is disclosed for the preparation of a class of dehydropenicillins by irradiating substituted 4-acylmethylthio-2-azetidinones and subsequently subjecting the as-obtained product to cyclization. Processing conditions and analytical data are reporte...
01/09/1979
4132542Organic(thio) phosphoric acid ester compounds and herbicidal compositions
New organic (thio) phosphoric acid ester compounds of the formula ##STR1## wherein R1 is alkyl of from 1 to 6 carbon atoms, cyclohexyl or phenyl, R2 is alkyl of from 1 to 6 carbon atoms, R3 is alkylene of up to 6 carbon at...
01/02/1979
4132708Metal complexes of azomethines and process for their manufacture
Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties....
01/02/1979
4131610Iminodiimides of 3,3',4,4'-benzophenonetetracarboxylic dianhydride and compositions thereof
Iminodiimides of 3,3',4,4'-benzophenonetetracarboxylic dianhydride are novel compounds having utility as pour depressants and as UV stabilizers when incorporated into lubricant compositions....
12/26/1978
4130557Method for the hydrolysis of azetidinothiazoline compounds
A process for preparing compounds having the formula: ##STR1## WHEREIN R is phenoxymethyl or benzyl; R2 is 1-methoxyethylidene, 1-hydroxyethylidene, or 1,1-dimethoxyethylidene; and R3 is trichloroethyl, diphenylmethyl, p-nitrobenzyl,...
12/19/1978
41287164-Halo derivatives of pyrazolo[1,5-a]-quinoxaline-3-carboxylic acids and esters
New 4-halo derivatives of pyrazolo[1,5-a]quinoxaline-3-carboxylic acid, esters and their salts have the formula ##STR1## R1 is hydrogen, lower alkyl or a salt forming ion; R2 is hydrogen, lower alkyl, halogen or lower alkoxy; an...
12/05/1978
4128717Derivatives of 5,6-dihydrobenzo[5,6]cyclohepta[1,2-B]pyrazolo-[4,3-E]pyridin-11 (1H)-ones and 11 (1H)-imines
New derivatives of 5,6-dihydrobenzo[5,6]cyclohepta-[1,2-b]pyrazolo[4,3-e]pyridin-11 (1H)-ones and imines, respectively, have the general formula ##STR1## They and the salts thereof are useful as psychotropic and antiinflammatory agents....
12/05/1978
4128546Process for the purification of FR-1923 substance
Purification of Fr-1923 antibiotic substance by treatment with a macroporous non-ionic adsorption resin such as styrene-divinyl benzene copolymer or acrylic ester polymer....
12/05/1978
4127568Process for 3ଲ-aminoazetidin-2-ones
1-[଱-(Carboxy)-4-hydroxybenzyl]-3ଲ-aminoazetidin-2-one esters are prepared by converting 2-acyl-3,3-dialkyl-7-oxo-଱-[4-(benzyloxy)phenyl]-4-thia-2,6-diazabic yclo[3.2.0]-heptane-6-acetic acid esters with mercuric acetate in an aqueou...
11/28/1978
4125609O-alkyl-O-[1,6-dihydro-1-substituted-6-thioxopyridazin(3)yl]-(thiono) (thiol) phosphoric (phosphonic) acid ester and esteramides
O-Alkyl-O-[1,6-dihydro-1-substituted-6-thioxopyridazin(3)yl]-(thiono) (thiol) phosphoric (phosphonic) acid esters and ester-amides of the formula ##STR1## in which R is alkyl with 1 to 6 carbon atoms, R' is alkyl, alkoxy, alkylmercapto or alkylamino ...
11/14/1978
4125725Phenylated carboxyquinoxalines
High molecular weight polyphenylamide-quinoxalines comprised essentially of nits of the formula ##STR1## or mixtures thereof, are prepared by heating bifunctional monomers of the formula ##STR2## or mixtures thereof, wherein R is COCH3
11/14/1978
4125536Pyrolysis product of N-substituted-1-cyclohexene-1,2-dicarboximides
Pyrolysis of N-substituted-1-cyclohexene-1,2-dicarboximide gives N,N'-substituted-pyromellitdiimides. Pyrolysis of N-substituted-1-cyclohexene-1,2-dicarboximide in the presence of N-substituted maleimides produces N,N'-substituted-3,4,5,6-tetrahydrop...
11/14/1978
4123527N-tricyclic derivatives of azetidine and process for their preparation
Novel N-tricyclic derivatives of azetidine are disclosed of the general formula ##STR1## where A is a C1 -C3 alkylene group, a C2 -C3 alkenylene group or a cyclopropylene group, the remaining substituents ...
10/31/1978
41221852-Phenyl- and 2-benzyl-N-[(trichloromethyl)thio]succinimides, and fungicidal compositions thereof
N-[(Trichloromethyl)thio]succinimides of the formula ##STR1## WHERE R1, R2 and R3 independently are hydrogen or alkyl having from 1 to 6 carbon atoms, and n is zero or the integer 1, having antifungal activity, a meth...
10/24/1978
4122258Process for producing desacetoxycephalosporin derivatives by heating a penicillin-1-oxide in presence of an organic sulfide
Penicillin-1-oxides are rearranged into the corresponding 3-desacetosycephalosporin derivatives in an inert organic solvent in the concomitant presence of an acid catalyst and an organic sulfide in a good yield and with a high purity....
10/24/1978
4119636Preparation of acyclic and alicyclic N-substituted halo-2-pyrrolidinones
Acyclic and alicyclic N-substituted halo-2-pyrrolidinones having the formula ##STR1## in which Q is oxygen or sulfur; R is lower alkyl, haloalkyl, alkenyl, cycloalkyl, cycloalkylalkyl, benzyl and chlorobenzyl; X is hydrogen or chlorine, Y is chl...
10/10/1978
411712211-Aminoalkylmorphanthridin-11-ols
The compounds are 11-aminoalkylmorphanthridin-11-ols which are useful as antidepressant agents. The compounds disclosed are 11-(3-dimethylaminopropyl)morphanthridin-11-ol and 2-chloro-11-(3-dimethylaminopropyl)-5,6-dihydromorphanthridin-11-ol....
09/26/1978
4116933Hindered piperidine carboxylic acids, metal salts thereof and stabilized compositions
Compounds having the formula ##STR1## WHEREIN R1 and R2 are lower alkyl or together lower alkylene, R3 is hydrogen, alkyl, methoxyethyl, alkenyl, propargyl, benzyl, alkyl substituted benzyl, or acyl, R4 is alkyl...
09/26/1978
41153823,3-Dichloro-2-azetidinone derivatives having basic substituents
Compounds having the formula ##STR1## wherein X is oxygen or sulfur; R1 is alkyl, cycloalkyl or aryl; R2 is dialkylamino or a nitrogen containing heterocyclic group; A1 is a saturated bond or an alkylene group having ...
09/19/1978
4115399Preparation of catalyst for the polymerization of 2-pyrrolidone
A catalyst solution for the anionic polymerization of 2-pyrrolidone is produced by contacting an alkali metal hydroxide and excess 2-pyrrolidone. The catalyst solution is dehydrated under stripping conditions....
09/19/1978
4115383Alkoxycarbonyl-ethylthio-azetidinones and process for their preparation
2-Sulfinyl (or thio)-଱-isopropenyl (or isopropylidene)-3-amido(or imido)-4-oxo-1-azetidineacetic acids and esters are prepared directly or indirectly from the reaction of a penicillin sulfoxide ester with an ester of acrylic acid. These compounds ar...
09/19/1978
4115386Perylene-3,4,9,10-tetracarboxylic acid diimide pigment, its manufacture and its use
A new pigmentary form of perylene-3,4,9,10-tetracarboxylic acid diimide of the formula ##STR1## which has a specific surface area (measured by the BET method) of from 10 to 35 m2 /g and a maximum in the particle size distribution at from ...
09/19/1978
4115384N-cyanoaziridines
N-Cyanoaziridines containing the grouping ##STR1## are obtained by reacting an ethylenically unsaturated compound with cyanogen azide (N3 CN). Exemplary is 3-cyanoazatricyclo[3.2.1.02.4 ] octane of the formula ##STR2## ...
09/19/1978
4111947Novel metal complexes of azomethines and process for their manufacture
Metal complexes of azomethines of the formula ##STR1## are useful for coloring plastics and lacquers in yellow to red shades of excellent fastness properties....
09/05/1978
4112081O,O-Di-alkyl-O-(1-6-pyridazinon-3-yl)-(thiono)-phosphoric acid esters and their pesticidal use
O,O-Di-alkyl-O-(1-6-pyridazinon-3-yl)-(thiono)-phosphoric acid esters of the formula ##STR1## in which R is methyl or ethyl, R1 is alkyl with 3 to 5 carbon atoms or alkoxyalkyl with 1 to 3 carbon atoms in each alkoxy and alkyl moiety, R
09/05/1978
41120956-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
This disclosure describes novel substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines useful as hypotensive agents....
09/05/1978
41119353-Chloro-6-phenylpyridazine compounds
Substituted derivatives of 3-chloro-6-phenylpyridazine which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have ଲ-adrenergic blocking and vasodilator activity....
09/05/1978
4111937Iodinated anilic acids
3-Amino-2,4,6-triiodobenzoic acids optionally substituted in the 5-position by amino or carboxy or a derivative thereof react with dibasic acid anhydrides to give the corresponding cyclic imides (A), which can be hydrolyzed to the corresponding anilic aci...
09/05/1978
4112080O-alkyl-S-[1,6-dihydro-6-oxo-pyridazin(1)ylmethyl]-(thiono )-(di)-thiolphosphoric(phosphonic) acid esters
O-Alkyl-S-[1,6-dihydro-6-oxo-pyridazin(1)ylmethyl]-(thiono)-(di)-thiolphosp horic(phosphonic) acid esters of the formula ##STR1## in which R1 is alkyl or alkoxyalkyl with 1 to 6 carbon atoms per alkyl chain, R2 is alkyl, alkylmer...
09/05/1978
4111936Pyridazinethiones
Substituted phenyl pyridazinethiones which are useful intermediates in the preparation of substituted phenylhydrazinopyridazines which have ଲ-adrenergic blocking and vasodilator activity....
09/05/1978
41120887-Acyl-3-(sulfoalkyl substituted oxadiazolylthiomethyl) cephalosporins
The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a sulfoalkyl substituted oxadiazolylthiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acy...
09/05/1978
4110105Aromatic N-substituted halo-substituted-2-pyrrolidinones and their utility as herbicides
Monocyclic aromatic N-substituted halo-2-pyrrolidinones having the formula ##STR1## in which X is hydrogen, chlorine or methyl; Y is hydrogen, chlorine or bromine, Z is chlorine or bromine; R2 is alkyl or hydrogen; R is hydrogen, alkyl, ac...
08/29/1978
4110329Metallic derivatives of neopinone ketal
Certain mercury, lead, thallium, platinum or palladium derivatives of neopinone dimethyl ketal are provided which are useful as intermediates in the preparation of neopinone alkaloid, for example, 7-acetomercuri neopinone dimethyl ketal. Also provided are...
08/29/1978
4105657Production of N-alkyl derivatives of cyclic alkylenimines
Production of N-alkylated cyclic alkylenimines by reaction of cyclic alkylenimines with an alcohol or ether in the gas phase in the presence of a high-area SiO2 /P2 O5 catalyst....
08/08/1978
4105658Neothramycin antibiotics
There are disclosed two new antibiotics formerly denominated MC916-A and MC916-B and now called neothramycin A and neothramycin B which are potent inhibitors of the growth of leukemia cells, e.g. Leukemia L-1210 cells in mice. They are produced by control...
08/08/1978
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