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| Number | Title | Issue Date |
| 7097827 | Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture c... | 08/29/2006 |
| 7078016 | Delivery of caffeine through an inhalation route The present invention relates to the delivery of caffeine through an inhalation route. Specifically, it relates to aerosols containing caffeine that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles com... | 07/18/2006 |
| 7066171 | Process and apparatus for producing inhalable medicaments A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segme... | 06/27/2006 |
| 6797259 | Delivery of muscle relaxants through an inhalation route The present invention relates to the delivery of muscle relaxants through an inhalation route. Specifically, it relates to aerosols containing a muscle relaxant that is used in inhalation therapy. In a composition aspect of the present invention, the aerosol compris... | 09/28/2004 |
| 6780400 | Delivery of antiemetics through an inhalation route The present invention relates to the delivery of antiemetics through an inhalation route. Specifically, it relates to aerosols containing antiemetics that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particl... | 08/24/2004 |
| 6743414 | Inhalation administration of biophosphonates The present invention relates to the treatment and prevention of bone diseases in humans, including osteoporosis in postmenopausal women, Paget's Disease and hypercalcemia, by administration of a bisphosphonate in an inhalation form. The invention also relates to ph... | 06/01/2004 |
| 6723345 | Topical drug preparations Topical gelled compositions comprising an optional drug dispersed within a polymer matrix, methods of producing the same and treatments with the complex. ... | 04/20/2004 |
| 6713047 | Pharmaceutical aerosol composition containing HFA 227 and HFA 134a In a solution composition for use in an aerosol inhaler which comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility compound the use of a mixture of HFA 134a and HFA 227 allows to modulate the m... | 03/30/2004 |
| 6702997 | Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma The present invention relates to an albuterol inhalation solution, system, kit and method for relieving bronchospasm in children suffering from asthma. In one alternative embodiment, the solution of the present invention is a sterile, premixed, premeasure... | 03/09/2004 |
| 6699459 | Methods of treating lung inflammation The present invention relates to a method of treating lung inflammation in a subject which includes administering butylated hydroxyanisol to the subject in an amount effective to treat lung inflammation. The invention also relates to methods of inhibiting... | 03/02/2004 |
| 6696041 | Treatment of colds, flu like infections and other general nasal based infections with a solution containing iodine and other broad spectrum microbicides and a method for its use The invention relates generally to a method which utilizes iodine as a broad spectrum microbicide wherein the active agent may be applied in nasal passages in the manner of a decongestant type nose spray. The spray is intended particularly for human use. ... | 02/24/2004 |
| 6682716 | Delivery of aerosols containing small particles through an inhalation route The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to the delivery of drug containing aerosols having particles with a mass median aerodynamic diameter less than 1μ for inhalation the... | 01/27/2004 |
| 6676931 | Buccal, polar and non-polar spray or capsule Buccal aerosol sprays or capsule using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the in... | 01/13/2004 |
| 6673335 | Compositions and methods for the pulmonary delivery of aerosolized medicaments According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a... | 01/06/2004 |
| 6652837 | Preparation of novel particles for inhalation Particles incorporating a surfactant and/or a hydrophilic or hydrophobic complex of a positively or negatively charged therapeutic agent and a charged molecule of opposite charge for drug delivery to the pulmonary system, and methods for their synthesis a... | 11/25/2003 |
| 6645468 | Medicinal aerosol formulation This invention relates to medicinal aerosol and more formulation and more particularly, to a medicinal aerosol formulation containing rosiglitazone maleate and a fluid carrier.... | 11/11/2003 |
| 6645466 | Dry powder for inhalation The aim of the invention is to improve the moisture resistance of dry powder formulations for inhalation which contain a pharmaceutically ineffective carrier of not-inhalable particle size and a finely divided pharmaceutically active compound of inhalable... | 11/11/2003 |
| 6638495 | Stabilized preparation for use in metered dose inhalers Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydr... | 10/28/2003 |
| 6635242 | Broad spectrum microbicidal and spermicidal compositions, devices, and methods Microbicidal and spermicidal devices, methods, and compositions containing sodium dodecyl sulfate or related anionic surfactants as active ingredients for the prevention and control of pregnancy and sexually transmitted disease, including conditions cause... | 10/21/2003 |
| 6630129 | Pharmaceutical formulation of fluticasone propionate There is provided according to the invention a pharmaceutical aerosol formulation which comprises: (i) fluticasone propionate and (ii) a hydrofluoroalkane (HFA) propellant, characterized in that the fluticasone propionate is completely dissolved in the... | 10/07/2003 |
| 6623723 | Method for treating bronchial constriction and bronchospasm The present invention is directed to a method for treating bronchial constriction in mammals. The method comprises contacting mammalian lung with a compound selected from the group consisting of pyruvate and pyruvate precursors. The compound is present in... | 09/23/2003 |
| 6616914 | Method for pulmonary and oral delivery of pharmaceuticals In a powder formulation for use in a dry powder inhaler, a pharmaceutical acts as its own carrier, so that use of lactose or other excipients are not needed. The dry powder formulation has a single active pharmaceutical compound having two major populatio... | 09/09/2003 |
| 6613308 | Pulmonary delivery in treating disorders of the central nervous system A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose... | 09/02/2003 |
| 6613307 | Aerosol formulations of salmeterol xinafoate The present invention relates to formulations comprising particulate products which may be prepared by methods and apparatus using supercritical fluids. More particularly, the invention relates to formulations comprising certain crystalline forms of ... | 09/02/2003 |
| 6610273 | Process for making chemically stable C-17/21 OH 20-ketosteroid aerosol products A medicinal aerosol steroid solution formulation product with enhanced chemical stability. The steroid is a 20-ketosteroid having an OH group at the C-17 or C-21 position and the aerosol container has a non-metal interior surface which has been found to r... | 08/26/2003 |
| 6610272 | Medicinal aerosol formulation A medicinal formulation is disclosed comprising pioglitazone or a derivative thereof. The formulation additionally comprises a fluid carrier and a stabilizer.... | 08/26/2003 |
| 6596262 | Modulated release particles for aerosol delivery A polymeric construct is disclosed. The construct comprises a polymer selected from silica gel, fumed silica gel, silicic acid, disilicic acid, trisilicic acid, metasilicic acid, and orthosilicic acid in their free or salt forms; silicon dioxide in either... | 07/22/2003 |
| 6596261 | Method of administering a medicinal aerosol formulation A method of treating in a human or animal a condition capable of treatment by oral or nasal inhalation has been found. The method comprises administering a medicinal aerosol formulation comprising a selected medicament under conditions where the amount of... | 07/22/2003 |
| 6592903 | Nanoparticulate dispersions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate Disclosed are solid dose nanoparticulate compositions comprising a poorly soluble active agent, at least one polymeric surface stabilizer, and dioctyl sodium sulfosuccinate (DOSS). The solid dose compositions exhibit superior redispersibility of the nanop... | 07/15/2003 |
| 6589508 | Methods and compositions for treating pulmonary disorders using optically pure (R,R) formoterol A method and composition are disclosed utilizing the pure (R,R) isomer of formoterol, which is a potent bronchodilator with reduced adverse effects, having a low incidence of the development of tolerance and having increased duration of action.... | 07/08/2003 |
| 6585958 | Medicinal aerosol formulations A pressure-liquefied propellant mixture for aerosols, comprising dinitrogen monoxide and a hydrofluoroalkane having 1 to 3 carbon atoms, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, makes possible an improvement in the ... | 07/01/2003 |
| 6569406 | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 -helix bun... | 05/27/2003 |
| 6565885 | Methods of spray drying pharmaceutical compositions Spray drying methods for forming powder compositions for pharmaceutical applications are disclosed. According to one aspect of the invention, the spray drying feed stock comprises a bioactive agent, surfactant, and a blowing agent. Another aspect of the i... | 05/20/2003 |
| 6565832 | Spray composition with reduced dripping An aqueous-based sprayable composition comprises a therapeutic or palliative agent, water and a mixture of microcrystalline cellulose and alkali metal carboxyalkylcellulose. In one embodiment, the composition is a non-Newtonian nasal spray exhibiting a ve... | 05/20/2003 |
| 6555132 | Soft gelatin capsule manufacture Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the... | 04/29/2003 |
| 6551578 | Modulated release particles for aerosol delivery A modulated release aerosol formulation is disclosed. The formulation comprises a polysaccharide polymer having a selected medicament associated therewith, a fluid carrier for carrying and delivering the construct and a stabilizer.... | 04/22/2003 |
| 6544497 | Modulated release particles for aerosol delivery A modulated release aerosol formulation is disclosed. The formulation comprises a polymer, e.g. silica gel, fumed silica gel, having a selected medicament associated therewith, a fluid carrier for carrying and delivering the construct and a stabilizer.... | 04/08/2003 |
| 6537533 | Hair conditioner composition that is non-irritating to the eyes The invention relates to hair conditioner compositions that are non-irritating to the eye and which comprise: a) a C20-C24 quaternary ammonium compound, which has ethosulfate or methosulfate as an anion; b) a second C20-C24 quaternary ammonium compound, which ... | 03/25/2003 |
| 6537524 | Combinations of formoterol and a tiotropium salt A medicament containing, separately or together, (A) formoterol or a pharmaceutically acceptable salt thereof or a solvate of formoterol or said salt and (B) a tiotropium salt of a pharmaceutically acceptable acid, for simultaneous, sequential or separate... | 03/25/2003 |
| 6534071 | Composition in the form of an oil-in-water emulsion containing cellulose fibrils, and its uses, especially cosmetic uses The present application relates to a composition in the form of an oil-in-water emulsion comprising an oily phase dispersed in an aqueous phase, characterized in that the composition is free of surfactant and in that it contains cellulose fibrils which ha... | 03/18/2003 |
