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| Number | Title | Issue Date |
| 7101667 | Lanthanide binding tags The present invention provides lanthanide binding tags (LBT) that selectively complex trivalent lanthanide (Ln) ions and afford stable complexes with desirable physical properties, including at least one of fluorescence and anomalous x-ray scattering. ... | 09/05/2006 |
| 7087401 | Culture medium and method for detecting thermonuclease-positive staphylococci The present invention provides a method of detecting thermonuclease-positive staphylococci that does not require inactivation of DNase-positive/TNase-negative bacteria with heat. The method includes (a) providing a culture medium selective for growing staphylococci;... | 08/08/2006 |
| 7083911 | Method for detection of ATP Methods and kits for detecting the presence of ATP, for measuring ATP concentrations, and for detecting viable cells using a composition comprising an ATP-dependent enzyme and one or more ATPase inhibitors. ... | 08/01/2006 |
| 7070948 | Method for assaying glycated protein Based on a principle that is different to that of a conventional enzymatic method, the present invention provides a novel method for assaying a glycated protein by a simple procedure, within a short period of time, and with high accuracy, and a reagent kit for assay... | 07/04/2006 |
| 7067276 | Method of using metaloporphyrins for treatment of arteriosclerotic lesions A method for treating arteriosclerotic lesions is provided wherein the method is characterized by administering a chemical compound to the patient, the compound being a porphyrin complexed with a radioactive metal. Cells which exhibit an affinity for the porphyrin e... | 06/27/2006 |
| 7045311 | Whole cell assay systems for cell surface proteases The activity of a cell surface protease, particularly an ADAM, is determined in a rapid and sensitive assay employing a whole cell system. The assays are effective to identify effector molecules that affect the activity of a cell surface protease directly or indirec... | 05/16/2006 |
| 7041468 | Blood glucose tracking apparatus and methods A measurement module for glucose testing includes a glucose testing measurement module housing, a test strip receptacle formed in the housing, and a connector portion formed in the housing and shaped to permit mechanical removable attachment of the housing to a hand... | 05/09/2006 |
| 7026136 | Methods of reducing microbial resistance to drugs The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of sc... | 04/11/2006 |
| 7001740 | Methods of arraying biological materials using peelable and resealable devices Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the f... | 02/21/2006 |
| 6994985 | Development of anti-sigma factor agents Sigma factors are a unique family of essential proteins found in bacterial, but not eukaryotic cells, which are responsible for recognition of promoter DNA and delivery of the catalytic domain of RNA polymerase to a gene signaled to be expressed. The present inventi... | 02/07/2006 |
| 6986998 | Method of analyzing components in biological samples There is provided a method for a selective assay of component, particularly cholesterol, in very low-density lipoprotein (VLDL) which is one of serum lipoproteins. In the assay, an enzymatic reaction of lipoprotein lipase (LPL) or cholesterol esterase (CE) wh... | 01/17/2006 |
| 6984498 | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques A cancer screening method is provided, wherein the method is characterized by administering a compound to a patient, the compound being a complex of a fluorescent marker and a radioactive marker, in a dose emitting between 5 Gy and 20 Gy radiation. Cells are then co... | 01/10/2006 |
| 6979549 | Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a CLLD8 protein The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of usi... | 12/27/2005 |
| 6979553 | Use of Nernstein voltage sensitive dyes in measuring transmembrane voltage Transmembrane potential measurement methods using cationic dyes, and anionic dyes are provided. Compositions of the cationic and anionic dyes and microfluidic systems which include the dyes and membranes are provided in conjunction with processing elements for trans... | 12/27/2005 |
| 6974679 | Support with collagen base for tissue engineering and manufacture of biomaterials The invention relates to a method of in vitro testing of the efficacy of a potentially active substance comprising monitoring the effect of said potentially active substance on an artificial skin, comprising a composite product forming a collagen support comprising ... | 12/13/2005 |
| 6958221 | Cell flow apparatus and method for real-time measurements of patient cellular responses The present invention is directed to a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents. ... | 10/25/2005 |
| 6955890 | Method for the identification and treatment of pathogenic microorganisms infections by inhibiting one or more enzymes in an essential metabolic pathway A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the acti... | 10/18/2005 |
| 6953671 | Plasma phospholipid transfer protein (PLTP) deficiency represents an anti-atherogenic state and PLTP inhibitor has anti-atherosclerosis action This invention provides methods of decreasing apolipoprotein B-containing lipoprotein and of treating atherosclerotic diseases and dyslipidemic diseases by reducing plasma phospholipid transfer protein activity, and methods of identifying chemical compounds for use ... | 10/11/2005 |
| 6949351 | Cell assay, method and reagents A method for detecting the presence of a lysed eukaryotic cell in a sample, said method comprising: (i) adding adenosine diphosphate (ADP) to said sample under conditions which allows the conversion of ADP to adenosine triphosphate (ATP) by cellular adenylate kinase... | 09/27/2005 |
| 6942962 | Computer monitoring and control of fermentation It is desirable to enhance reproducibility and control of batch fermentation processes. Some examples of these processes include: alcoholic beverage manufacture, and acetone and pharmaceutical production. A cellular yield curve defines the relationship between subst... | 09/13/2005 |
| 6936433 | Methods and devices for characterizing duplex nucleic acid molecules Methods and devices are provided for characterizing a duplex nucleic acid, e.g., a duplex DNA molecule. In the subject methods, a fluid conducting medium that includes a duplex nucleic acid molecule is contacted with a nanopore under the influence of an applied elec... | 08/30/2005 |
| 6936434 | Vapor phase decontamination process biological indicator evaluator resistomer (BIER) vessel A BIER vessel evaluates biological indicators for sterilization processes. By flowing gaseous sterilant, such as vaporized hydrogen peroxide, through a chamber (12) before, during, and after introducing the indicators, the indicators are instantaneously expos... | 08/30/2005 |
| 6929926 | Composition for the detection of gastrointestinal disorders A system and method for detecting bacterial infections in the gastrointestinal tract is disclosed. In one embodiment, the system includes a first composition separated from a second composition. The first composition contains urea in powdered form. The second compos... | 08/16/2005 |
| 6927039 | Enzymatic process A process is described for detecting modulation of NAD(P)H and/or a NAD(P)H dependent oxidoreductase (“NDO”) in or by a biological system which comprises NAD(P)H and an NDO. The process comprises generating a detectable marker of NAD(P)H modulation, and detectin... | 08/09/2005 |
| 6916604 | Uses of synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites Peptides synthesized to match the human α1 (I) and α2 (I) amino-telopeptide sequences of type I collagen degradation products in body fluids, preferably either Asp-GIu-Lys-Ser-Thr-Gly-Gly (SEQ ID NO:5) or Gln-Tyr-Asp-Gly-Lys-Gly-Val-Gly (SEQ ID NO:6). used as cali... | 07/12/2005 |
| 6911305 | Method for chemiluminescent detection The invention provides chemiluminescent assays that incorporate a film including at least one chemiluminescent precursor immobilized therewith which produces a triggerable chemiluminescent compound, the film being free of compounds which generate singlet oxygen and ... | 06/28/2005 |
| 6911319 | Methods and kits for detecting protein kinases A method for measuring protein kinase activity comprising: (a) providing a first solution comprising ATP and a protein kinase to be tested, and a second solution comprising ATP in the absence of said kinase to be tested; ... | 06/28/2005 |
| 6911318 | Bacterial transglycosylases: assays for monitoring the activity using Lipid II substrate analogs and methods for discovering new antibiotics This invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-polymeric products simultaneou... | 06/28/2005 |
| 6908744 | Methods of stimulating cartilage formation The disruption of the murine ROR2 gene leads to profound skeletal abnormalities, with essentially all endochondrally derived bones foreshortened and/or misshapen, albeit to differing degrees. ROR2 is selectively expressed in the chondrocytes of all developing cartil... | 06/21/2005 |
| 6908746 | Rapid method of detection and enumeration of sulfide-producing bacteria in food products A rapid method for detecting spoilage of a food sample, particularly a fish sample, by detecting and enumerating sulfide-producing bacteria (SPB). A growth medium containing iron and sulfur is combined with the food sample forming an incubation mixture which is incu... | 06/21/2005 |
| 6908740 | Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of peptides. The isolation is based on a specific chemical and/or enzymatic alter... | 06/21/2005 |
| 6905836 | Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of iκb Compounds that inhibit ubiquitin-mediated proteolysis of phosphorylated IκB by interfering, directly or indirectly, with the ability of β-TrCP/E3RS to engage in protein-protein association involving hnRNP-U, are useful as drugs for treating conditions associated w... | 06/14/2005 |
| 6905839 | In vivo phenotyping for human cytochrome P450 3A activity In a method for evaluating in vivo human cytochrome P450 3A (CYP3A), at least a 2-hour urine collection and one blood sample are obtained. Endogenous cortisol in plasma and 6β-hydroxycortisol in urine are measured. Metabolic clearance specific for the 6β-hydroxyla... | 06/14/2005 |
| 6897037 | Pre-treatment kit for saliva and pre-treatment method for saliva using the same To provide a pre-treatment kit for saliva and a pre-treatment method for saliva for identification and quantitation of mutans streptococci in human saliva by the immunochromatographic method, which can eliminate mucin in saliva and prevent mutans streptococci from c... | 05/24/2005 |
| 6897036 | Fluorescent detection of peroxidase enzymes Methods of producing fluorescence from fluorogenic substrates reactive with a peroxidase enzyme are disclosed. Use of the methods in assays for peroxidase enzymes, peroxidase-labeled analytes are provided. Fluorogenic compounds, compositions and kits for reaction wi... | 05/24/2005 |
| 6893825 | Microorganisms for use in the measurement of environmental factors A microorganism mixture consisting of a first microorganism that secretes a substance upon perception of an environmental factor and a second microorganism that expresses a marker gene upon perception of the secreted substance is disclosed. The present invention pro... | 05/17/2005 |
| 6887659 | Urinary assay for measuring bone resorption A method for assaying bone resorption rates which consists of quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid is disclosed. The method includes immunometric assay, fluorometric assay and electrochemical titration... | 05/03/2005 |
| 6881546 | Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor Methods and compositions are disclosed that are useful for the prevention and/or treatment of cardiovascular and cardiac diseases and disorders, or damage resulting from surgical or medical procedures that may cause ischemic or ischemic/reperfusion damage in humans;... | 04/19/2005 |
| 6881551 | Subcutaneous glucose electrode A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in th... | 04/19/2005 |
| 6875582 | Methods and targets of antibiotic resistance The present invention provides for a method of evolving and selecting cells resistant to a selective agent by inducing directed evolution in continuous culture while applying both a mutagenic and selective agent to the cells to determine the cells having resistance.... | 04/05/2005 |
