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| Number | Title | Issue Date |
| 5844095 | CTLA4 Ig fusion proteins The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybri... | 12/01/1998 |
| 5837258 | Induction of tissue, bone or cartilage formation using connective tissue growth factor The present invention relates to novel methods and compositions related to the administration of connective tissue growth factor, alone or in combination with other growth factors, compositions or compounds, to induce the formation of connective tissue, i... | 11/17/1998 |
| 5837521 | Nucleic acids encoding the γ-MSH receptor MC3-R The present invention relates to a mammalian melanocortin receptor. The invention is directed toward the isolation, characterization and pharmacological use of a mammalian melanocortin receptor (MC3-R). The invention specifically provides a particular mel... | 11/17/1998 |
| 5786210 | Mammalian thymokine genes Nucleic acids encoding a thymokine from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.... | 07/28/1998 |
| 5770209 | Acceleration of wound healing using connective tissue growth factor The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides encoding CTGF, and including 5' and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diag... | 06/23/1998 |
| 5767251 | Recombinant heterodimeric human fertility hormones, and methods, cells, and vectors and DNA for the production thereof Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subun... | 06/16/1998 |
| 5750366 | Cloning and expression of gonadotropin-releasing hormone receptor The present invention relates to the GnRH-R genes and proteins. The DNA sequences disclosed herein may be engineered into expression systems designed for the production of GnRH-R and/or cell lines which express the GnRH-R and preferably respond to GnRH in... | 05/12/1998 |
| 5744448 | Human follicle stimulating hormone receptor The present invention embraces essentially pure human FSH receptor, or a fragment or mutant thereof which binds FSH, DNA encoding said receptor, fragment or mutant, expression vectors comprising said DNA, cells transfected with said expression vectors, an... | 04/28/1998 |
| 5728813 | Antibodies directed against elk ligand Antibodies to elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor fami... | 03/17/1998 |
| 5705478 | Covalently linked ଲ subunits of the glycoprotein hormones as antagonists Single-chain forms of the glycoprotein hormone quartet, at least some members of which are found in most vertebrates, are disclosed. The single chain compounds of the invention comprise two ଲ subunits of the glycoprotein hormones, which ଲ subu... | 01/06/1998 |
| 5688641 | Cancer diagnosis using nucleic acid hybridization A method of determining whether a test cell from a given human tissue type is (a) normal, or (b) cancerous or precancerous, by contacting the mRNA of the test cell with a nucleic acid probe which contains a nucleotide sequence at least 15 nucleotides in l... | 11/18/1997 |
| 5674704 | Cytokine designated 4-IBB ligand Novel 4-1BB ligand (4-1BB-L) polypeptides and a human cell surface receptor designated 4-1BB that binds 4-1BB-L are provided. Isolated 4-1BB-L-encoding and human 4-1BB-encoding DNA sequences, recombinant expression vectors comprising the isolated DNA sequ... | 10/07/1997 |
| 5670625 | Elk ligand fusion proteins elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.... | 09/23/1997 |
| 5656737 | DNA encoding macrophage migration inhibition factor from ocular lens Macrophage Migration Inhibition Factor (MIF) can be obtained from ocular lens of various birds and mammals. The amino acid sequences of lens MIF from mice, chickens and humans has been determined and the corresponding cDNA has been cloned.... | 08/12/1997 |
| 5654188 | Neuroblastoma-associated regulator gene Described is a gene situated in the region of the neuroblastoma consensus deletion 1p36.2-p36.1 and which codes for a helix-loop-helix protein with the designation HEIR-1. The gene is affected significantly by allelic tumor deletions in neuroblastomas and... | 08/05/1997 |
| 5652123 | Protein having interleukin 13 activity, recombinant DNA coding for this protein, transformed cells and microorganisms The subject of the present invention is a protein having cytokine type activity, or a precursor of this protein, which comprises the following amino acid sequence (a1): ##STR1## in which Xaa represents Asp or Gly.... | 07/29/1997 |
| 5652113 | DNA encoding a human 5-HT 1F receptor and uses thereof This invention provides an isolated nucleic acid molecule encoding a human 5-HT1F receptor, an isolated protein which is a human 5-HT1F receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT1F... | 07/29/1997 |
| 5643754 | Nucleic acids encoding a leptospira outer membrane protein An antigenic preparation is provided which contains a 63 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism. Also provided in the invention are polynucleotides encoding the pr... | 07/01/1997 |
| 5639652 | DNA encoding a human 5-HT1F receptor and uses thereof This invention provides an isolated nucleic acid molecule encoding a human 5-HT1F receptor, an isolated protein which is a human 5-HT1F receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT1F... | 06/17/1997 |
| 5639639 | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof Biologically active heterodimeric human fertility hormones composed of two different subunits, each subunit being synthesized in the same cell transformed by at least one cell expression vector having heterologous DNA encoding each subunit with each subun... | 06/17/1997 |
| 5639640 | DNA encoding the beta subunit of human follide stimulating hormone and expression vectors and cells containing same The correct sequence is disclosed for the beta subunit of human follicle stimulating hormone which, when present in a recombinant heterodimeric human fertility hormone allows the production of biologically active hormone. DNA coding for such beta subunit ... | 06/17/1997 |
| 5627267 | Cytokine designated elk ligand elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.... | 05/06/1997 |
| 5624816 | Transmembrane glycoprotein ASGP-2: nucleotide sequences and recombinant production of proteins The present invention relates, in general, to a glycoprotein that is a member of the epidermal growth factor superfamily ASGP-2. In particular, the present invention relates to a DNA segment encoding the glycoprotein; to a recombinant DNA molecule contain... | 04/29/1997 |
| 5623053 | Soluble mammal-derived Fc receptor which binds at a pH ranging from about 5.5 to 6.5 and releases at a pH ranging from about 7.5 to 8.5 The present invention pertains to a new composition of matter in the form of a soluble Fc receptor (pHsFcR) is created. The pHsFcR has a pH-determinable binding capability for at least one antibody or complex thereof. The pHsFcR is produced using the cDNA... | 04/22/1997 |
| 5616494 | Thermus aquaticus DNA polymerase lacking the n-terminal 235 amino acids of taq DNA polymerase A vector which includes nucleic acid which encodes a DNA polymerase having an identical amino acid sequence to that of the DNA polymerase of Thermus aquaticus termed Taq DNA polymerase, except that it lacks the N-terminal 235 amino acids of Taq DNA polyme... | 04/01/1997 |
| 5605815 | Nucleic acids encoding and expression of parathyroid hormone-like peptide There is disclosed the nucleic acid and amino acid sequences for the human PTH-Like Peptide and derivatives. PTH-Like Peptide is the humoral mediator of humoral hypercalcemia of malignany or HHM which is common in patients with squamous carcinomas or rena... | 02/25/1997 |
| 5596072 | Method of refolding human IL-13 Nucleic acids encoding human IL-13, and purified IL-13 proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.... | 01/21/1997 |
| 5593882 | Selectin variants This invention concerns selectin variants having an amino acid alteration at a site or sites of a selectin lectin domain amino acid sequence within a region defined by binding sites recognized by blocking monoclonal antibodies to the corresponding selecti... | 01/14/1997 |
| 5594107 | Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of an... | 01/14/1997 |
| 5589570 | Integrin alpha subunit cytoplasmic domain polypeptides and methods Diagnostic systems, methods, polypeptides and antibodies for detecting the presence of the cytoplasmic domain of the integrin or subunit in a body sample are disclosed.... | 12/31/1996 |
| 5589358 | Ileal bile acid transporter compositions and methods Bile acids are absorbed from the small intestine by an passive and an active mechanism. The active mechanism involves a Na+ /bile acid cotransporter. A cDNA encoding the ileal bile acid cotransporter has been isolated and sequenced. The amino a... | 12/31/1996 |
| 5585270 | Polynucleotides encoding connective tissue growth factor Polynucleotides encoding connective tissue growth factor (CTGF) are provided. An exemplary polynucleotide of the invention is shown in SEQ ID NO:1. Expression vectors containing CTGF polynucleotide and host cells containing such expression vectors are als... | 12/17/1996 |
| 5583199 | Hemopoietic growth-regulatory calmodulin-binding protein and methods of using the same A 68 kDa a calmodulin-binding protein obtained from cytoplasmic or nuclear eukaryotic cell fractions, which is induced in hemopoietic factor-dependent cell lines by at least one of the following cytokines: granulocyte-macrophage colony stimulating factor,... | 12/10/1996 |
| 5576191 | Cytokine that binds ST2 ST2 ligand polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing ST2 ligand polypeptides. The ST2 ligand polypeptide binds to a receptor that is expressed on cell types that include certain ... | 11/19/1996 |
| 5573924 | CD27 ligand CD27 ligand (CD27L) polypeptide and DNA sequences, vectors and transformed host cells useful in providing CD27L polypeptides. The CD27L polypeptide binds to the CD27 receptor.... | 11/12/1996 |
| 5554512 | Ligands for flt3 receptors Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding ... | 09/10/1996 |
| 5536637 | Method of screening for cDNA encoding novel secreted mammalian proteins in yeast A novel method of screening for novel secreted mammalian proteins is described in which mammalian secretory leader sequences are detected using the yeast invertase gene as a reporter system.... | 07/16/1996 |
| 5536648 | Amplified DNA assay using a double stranded DNA binding protein A method for capturing amplified target DNA on a solid substrate comprising incorporating a ligand into said DNA by a polymerase chain reaction using a set of primers wherein one of the primers bears the ligand, and contacting the so treated DNA with a so... | 07/16/1996 |
| 5512457 | Cytokine designated elk ligand elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.... | 04/30/1996 |
| 5494663 | Treatment of microbial infection with interleukin 1 polypeptides DNAs encoding polypeptides having interleukin 1, vectors inserted with said DNAs, hosts transformed with said recombinant vectors, polypeptides having interleukin 1 activity which are produced by cultivation of the transformed hosts, derivatives of the po... | 02/27/1996 |
