Quotables
"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
Scientific American ; Jan. 2 edition, 1909
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8112229 | Method for determining the order of execution of assays of a sample in a laboratory automation system A method for arranging assays in an order for execution in a system that employs a plurality of clinical analyzers, typically automated clinical analyzers. The method comprises the steps of (a) prioritizing the order of execution of a number of individual assays in ... | 02/07/2012 |
| 7941434 | Efficiently compiling co-associating bioattributes A bioinformatics method, software, database and system are presented in which attribute profiles of query-attribute-positive individuals and query-attribute-negative individuals are compared, and combinations of pangenetic and non-pangenetic attributes that occur at... | 05/10/2011 |
| 7668662 | Patient-specific dosimetry A patient-specific optimally effective radiation dose for administration of a radiopharmaceutical to a patient for treatment of a disease may be established by basing the calculation of the appropriate therapeutic dose on factors such as the desired total body dose,... | 02/23/2010 |
| 7620501 | Artery-vein separation and vessel modeling A system and method for artery-vein separation and vessel modeling are provided, the system including an adapter unit, a centerline locating unit in signal communication with the adapter unit, and a deformable modeling unit in signal communication with the centerlin... | 11/17/2009 |
| 7565250 | Method and system for analyzing reactions using an information system A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amp... | 07/21/2009 |
| 7514209 | Diagnosis and prognosis of breast cancer patients The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as... | 04/07/2009 |
| 7457708 | Methods and devices for identifying related ions from chromatographic mass spectral datasets containing overlapping components Described are techniques for processing data sets produced by analyzing a sample. The input data set is represented as rows of intensities over time for a particular mass to charge (m/z) range. A correlation matrix is produced in which each row of the input data set... | 11/25/2008 |
| 7440855 | Identification of antibiotic targets and critical points in metabolic networks based on pathway analysis A computational approach to identifying potential antimicrobial drug targets based on the structural capabilities of the microbe's metabolic network, which may be reconstructed from genomic and biochemical information. Starting with a cellular metabolic network (i) ... | 10/21/2008 |
| 7430475 | Biological discovery using gene regulatory networks generated from multiple-disruption expression libraries Embodiments of this invention include application of new inferential methods to analysis of complex biological information, including gene networks. In some embodiments, disruptant data and/or drug induction/inhibition data are obtained simultaneously for a number o... | 09/30/2008 |
| 7424369 | Physical-chemical property based sequence motifs and methods regarding same A data analysis system, program, and/or method, e.g., a data mining/data exploration method, using physical-chemical property motifs. For example, a sequence database may be searched for identifying segments thereof having physical-chemical properties similar to the... | 09/09/2008 |
| 7416524 | System, method and computer program product for fast and efficient searching of large chemical libraries A system, method, and computer program product for fast and efficient searching of large virtual combinatorial libraries based on a fitness function. According to the method of the present invention, a first set of N reagent combinations are selected, for example, a... | 08/26/2008 |
| 7409296 | System and method for scoring peptide matches The present invention relates to a system and method for scoring peptide matches. Embodiments of the present invention improves identification of peptides and proteins by introducing an appropriate signal detection based scoring system and what is believed to be the... | 08/05/2008 |
| 7406385 | System and method for consensus-calling with per-base quality values for sample assemblies The present teachings disclose a method for evaluation of a polynucleotide sequence using a consensus-based analysis approach. The sequence analysis method utilizes quality values for a plurality of aligned sequence fragments to identify consensus basecalls and calc... | 07/29/2008 |
| 7400980 | Methods of detecting DNA variation in sequence data A method for detecting DNA variation. First, by aligning trace data of a sample DNA sequence to trace data of a reference DNA sequence to produce an aligned sample DNA sequence. Then, inputting the trace data of the bases of both the reference DNA sequence and the a... | 07/15/2008 |
| 7395160 | Quality assurance/quality control for electrospray ionization processes The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to t... | 07/01/2008 |
| 7392141 | Method of preparing a modified granulocyte colony stimulating factor (G-CSF) with reduced immunogenicity A method of preparing a modified granulocyte colony stimulating factor (G-CSF) protein having reduced immunogenicity relative to human G-CSF comprises the steps of (i) identifying one or more potential T-cell epitopes within the amino acid sequence of human G-CSF (S... | 06/24/2008 |
| 7379820 | Solution structure of RIP DD and uses thereof The present invention relates to the three dimensional solution structure of receptor interacting protein dead domain (RIP DD), as well as the identification and characterization of various binding active sites of RIP DD. Also provided for by the present invention a... | 05/27/2008 |
| 7363167 | Method and system for managing blood products A method and system for managing blood products and tracking their movement between a central blood test facility and a plurality of hospitals in which a database is provided for entering information pertaining to each patient, including but not limited to entering ... | 04/22/2008 |
| 7363165 | Significance analysis of microarrays Microarrays can measure the expression of thousands of genes and thus identify changes in expression between different biological states. Methods are needed to determine the significance of these changes, while accounting for the enormous number of genes. We describ... | 04/22/2008 |
| 7354707 | Nucleic acid probes, method for determining concentrations of nucleic acid by using the probes, and method for analyzing data obtained by the method Nucleic acid probes are provided, each of which is formed of a single-stranded oligonucleotide which can hybridize to a target nucleic acid and is labeled with a fluorescent dye or with a fluorescent dye and a quencher substance. The nucleic acid probes can be easil... | 04/08/2008 |
| 7353117 | Computation of wall thickness A method for automatic vessel wall thickness measurement at any point along the perimeter of either luminal or outer vessel wall boundaries. The method employs both Delaunay triangulation and multiresolution tiling. The MaxMin angle property of the Delaunay triangul... | 04/01/2008 |
| 7352920 | Managing images of microscopic specimens A method for managing a digital image of a biological specimen is disclosed. The method includes storing image data in a storage device. The image data is data for showing the image on a display. The method also includes identifying a portion of the image to be proc... | 04/01/2008 |
| 7349811 | Gene mining system and method The present invention provides a system, method and apparatus for targeting gene sequences having one or more phenotypic characteristics using a computer. One or more phenotypic characteristics are selected. A gene sequence is then selected that is known to have the... | 03/25/2008 |
| 7332275 | Methods for detecting methylated nucleotides A method for detecting methylated nucleotides within a nucleic acid sample is provided. The method includes the steps of splitting a nucleic acid sample into separate reaction vessels; contacting nucleic acid in one reaction vessel with bisulfite; amplifying the nuc... | 02/19/2008 |
| 7333896 | Quality assurance/quality control for high throughput bioassay process The present invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method includes generating a bioassay process model, and then comparing spectral data based on a combination of a biochip and a test serum to t... | 02/19/2008 |
| 7333895 | Quality assurance for high-throughput bioassay methods The invention relates to a method of quality assurance/quality control for high-throughput bioassay processes. The method permits monitoring of an entire system for obtaining spectral data from biological samples. Generally, the method includes generating a bioassay... | 02/19/2008 |
| 7332272 | Method for screening and identifying pharmaceutical agents The present invention describes the use of molecular expression profiles in the primary screening of compounds for pharmacological activity. In some embodiments, the methods of the invention comprise characterizing a profile of expression levels of a number of disti... | 02/19/2008 |
| 7329222 | Comparative field analysis (CoMFA) utilizing topomeric alignment of molecular fragments The static and electrostatic interaction energy fields between probe atoms and the atoms of a topomerically aligned fragment placed in a three-dimensional grid may be used to derive a CoMFA model. The topomeric CoMFA model coefficients may be used to predict partial... | 02/12/2008 |
| 7330794 | Water monitoring system using bivalve mollusks A toxicant detection system comprises at least one watertight chamber containing a mollusk. Water to be screened is introduced into the chamber. The mollusk is preferably supported on a mounting structure which facilitates quick mounting of the mollusk in the device... | 02/12/2008 |
| 7324926 | Methods for predicting chemosensitivity or chemoresistance Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression. Methods, computer s... | 01/29/2008 |
| 7315787 | Multi-marker screening protocol for fetal abnormalities A method of assessing a pregnant woman's risk of having a fetus with a fetal abnormality by determining the fetus' BPD/OFD ratio and using the BPD/OFD ratio in conjunction with one or more other screening markers for the fetal abnormality. Also provided is a method ... | 01/01/2008 |
| 7315785 | Method and system for displaying dendrogram The present invention represents a global state of branches in a whole dendrogram as well as detail of states of individual subtrees, to aid focusing of groupings and selection of a clustering method. The present invention selects a branch/subtree in a dendrogram di... | 01/01/2008 |
| 7297479 | DNA-based analog neural networks This invention is an oligomer-based analog neural network (ANN) comprising weight and saturation oligomers, the concentrations of which are selected such that activation of the ANN by a set of input oligomers generates a set of output oligomers, the sequences and re... | 11/20/2007 |
| 7299134 | Method for correlating gene expression profiles with protein expression profiles The present invention relates to methods for correlating gene and protein expression in a cell. ... | 11/20/2007 |
| 7292944 | Establishment of biological cut-off values for predicting resistance to therapy The present invention concerns methods and systems for improving the accuracy of predicting resistance of a disease to a therapy. In one embodiment of the invention, mean and standard deviation (SD) values of fold change in normalized sensitivity, relative to a labo... | 11/06/2007 |
| 7286941 | Method for haplotype analysis The invention relates to a method for determining haplotypes. The method is capable of providing phase information from a set of unphased genotype observations in an efficient robust manner. The method is capable of handling large datasets that include missing data.... | 10/23/2007 |
| 7266458 | BioMAP analysis The involvement of an expression product in a cell in a pathway is determined by genetically modifying the cell, incubating the cell with predetermined factors in induce a physiological state and measuring parameters affected by the pathway. Changes in the levels of... | 09/04/2007 |
| 7225079 | System and method for automated matched ion polynucleotide chromatography In an extensive Matched Ion Polynucleotide Chromatography (MIPC) system and method, and the computer programs or software associated therewith, the system provides automated options for sample selection, mobile phase gradient selection and control, column and mobile... | 05/29/2007 |
| 7225083 | Crystallographic structure of the androgen receptor ligand binding domain The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonis... | 05/29/2007 |
| 7206699 | Methods for measuring therapy resistance The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sam... | 04/17/2007 |
