Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7264963 | Protein(poly)peptide libraries The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of ... | 09/04/2007 |
| 7209835 | Algorithmic testing in laboratory medicine A method of pipelining a disease specific diagnostic algorithm on an n-bit data word stored in a memory whereby the n-bit data word is divided into clinical tests describing ranges of normal values. Then, each of the clinical tests of the n-bit data word is read out... | 04/24/2007 |
| 7184893 | Method for selecting an optimally diverse library of small molecules based on validated molecular structural descriptors The use for biological screening purposes of a subset (library) of a large combinatorially accessible chemical universe increases the efficiency of the screening process only if the subset contains members representative of the total diversity of the universe. In or... | 02/27/2007 |
| 7181349 | Identification of compounds for modulating dimeric receptors The invention includes the fitted quaternary structure of insulin receptor. It also includes methods of identifying compounds that modulate insulin receptor activity by producing a compound that interacts with all or part of the fitted quaternary structure of insuli... | 02/20/2007 |
| 7177767 | Systems and methods for the detection of short and long samples Methods and systems are provided for detecting the accidental use of short and long samples in the clinical analysis of a sample, specimen, or assay. The systems can include a clinical analyzer for determining one or more values for one or more measurable characteri... | 02/13/2007 |
| 7167819 | Method of determining the three-dimensional shape of a macromolecule The present invention provides a fast and efficient method for determining the three-dimensional conformation of a protein. The steps of the method of the invention include: 1) formation of physical distance constraints, e.g., forming intramolecular chemical crossli... | 01/23/2007 |
| 7146277 | NMR assisted design of high affinity ligands for structurally uncharacterized proteins Methods of using NMR spectroscopy for identifying ligands that bind to structurally uncharacterized proteins, and improving the binding affinity of ligands for biological targets are disclosed. One aspect of the method includes preparing first NMR spectra of a first... | 12/05/2006 |
| 7127357 | Crystal structure of WW domains and methods of use thereof A WW domain crystal structure of Pin1 is provided. In addition, methods of using the crystal structure and atomic coordinates for the development of WW domain binding agents is also provided. Also provided are computer programs on computer readable medium for use in... | 10/24/2006 |
| 7092825 | Protein engineering A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains of the constituent amino acid residues of a framework protein. A que... | 08/15/2006 |
| 7067139 | Method for treating autoimmune diseases A method of treating patients having rheumatoid arthritis by administering Product R, a peptide-nucleic acid preparation, is disclosed. ... | 06/27/2006 |
| 7058616 | Method and system for predicting resistance of a disease to a therapeutic agent using a neural network A method and system for predicting the resistance of a disease to a therapeutic agent is provided. Further provided is a method and system for designing a therapeutic treatment agent for a patient afflicted with a disease. Specifically, the methods use a trained neu... | 06/06/2006 |
| 7054758 | Computer-assisted means for assessing lifestyle risk factors The present invention relates to methods of assessing disease susceptibility associated with dietary and lifestyle risk factors. The invention provides for analysis of alleles at loci of genes associated with lifestyle risk factors, and the disease susceptibility pr... | 05/30/2006 |
| 7034143 | Systems and methods for sequencing by hybridization The systems and methods described herein relate to nucleic acid probes comprising a a pattern of universal and designate nucleotides, or ‘gapped’ probes, and the use of sets of gapped probes in sequencing by hybridization to determine the sequence of nucleic aci... | 04/25/2006 |
| 7027930 | Reading chemical arrays Methods of using an addressable array of biopolymers which has been exposed to a sample, and apparatus and computer program products for use of the arrays. In one embodiment the method includes detecting signals from the exposed array to obtain a signal image of the... | 04/11/2006 |
| 7024311 | COMPUTER-AIDED METHOD FOR THE PROVISION, IDENTIFICATION AND DESCRIPTION OF MOLECULES CAPABLE OF EXHIBITING A DESIRED BEHAVIOR, MORE PARTICULARLY IN THE PHARMACEUTICAL SECTOR, AND MOLECULES OBTAINED BY SAID METHOD The present invention is concerned with a computer-aided method for the provision, identification and description of molecules exhibiting a desired behaviour, more particularly in the pharmaceutical sector, employing a molecular modelling step, a combinatorial libra... | 04/04/2006 |
| 7020561 | Methods and systems for efficient comparison, identification, processing, and importing of gene expression data The present invention provides systems and methods for analyzing gene expression, gene annotation, and sample information in a relational format supporting efficient exploration and analysis, including comparative differential expression analysis, expression pattern... | 03/28/2006 |
| 7018794 | Methods for monitoring multiple gene expression The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus ... | 03/28/2006 |
| 7016787 | Characterizing biological stimuli by response curves A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype for cell(s) at a particul... | 03/21/2006 |
| 7016786 | Statistical methods for analyzing biological sequences Statistical algorithms that are useful to aid in the identification of evolutionarily conserved amino acid positions within a family of proteins, and in the identification of interacting amino acid positions within a protein sequence are disclosed. The algorithms ma... | 03/21/2006 |
| 7005128 | Enzyme feed additive and animal feed including it The use is provided of a composition as a feed additive which comprises one or more endoglucanases, and 0–20% by weight, based upon the content of cellulase proteins in the composition, of a cellobiohydrolase. The endoglycanases may be one or more of EGI, EGII, EG... | 02/28/2006 |
| 7003403 | Quantifying gene relatedness via nonlinear prediction of gene Relatedness between genes is quantified by constructing nonlinear models predicting gene expression. Effectiveness of the model is evaluated to provide a measurement of the relatedness of genes associated with the model. Various types of models, including full-logic... | 02/21/2006 |
| 6975943 | Clone-array pooled shotgun strategy for nucleic acid sequencing A simplified strategy for sequencing large genomes has been developed. Clone-Array Pooled Shotgun Sequencing (CAPSS) is based upon pooling rows and columns of arrayed genomic clones, for shotgun library construction. Random sequences are accumulated and the data are... | 12/13/2005 |
| 6951742 | Methods and vectors for generating antibodies in avian species and uses therefor The present invention relates to processes for producing polyclonal and monoclonal antibodies to an antigen in an avian species, preferably in a chicken, using polynucleotide vaccination. The present invention also relates to processes for determining the proteomics... | 10/04/2005 |
| 6951936 | Probe for detecting a highly ordered structural site of a single stranded nucleic acid of a gene, and a method and a device for detecting the same The invention provides a probe for detecting a highly ordered structural site of a nucleic acid of a gene by specifically binding with the structural site to generate an electrochemical response. The inventive probe comprises a cyclic ligand containing ferrocenyl gr... | 10/04/2005 |
| 6950755 | Genotype pattern recognition and classification Interpreting data obtained by analysis of nucleic acids (DNA) by obtaining nucleic acid data in a spatial domain, transforming the nucleic acid data from the spatial domain into a frequency domain, and obtaining sequence data of the nucleic acid data by executing a ... | 09/27/2005 |
| 6928368 | Gene mining system and method The present invention provides a system, method and apparatus for targeting gene sequences having one or more phenotypic characteristics using a computer. One or more phenotypic characteristics are selected. A gene sequence is then selected that is known to have the... | 08/09/2005 |
| 6902901 | Polypeptides useful for diagnosis of Aspergillus fumigatus and a process of preparing the same The present invention relates to novel peptide sequences from the immunodominant region of an 18 kD major allergen/antigen of Aspergillus fumigatus from aa 6-22, comprising aa 10-20, aa 6-20, aa 14-20, aa 10-22, aa 6-13 and the peptide sequence resulting from... | 06/07/2005 |
| 6890737 | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombinantly e... | 05/10/2005 |
| 6890752 | Synthases Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. ... | 05/10/2005 |
| 6892141 | Primer design system A primer design system in which DNA nucleotide sequences are obtained from a database comprising a plurality of different DNA nucleotide sequences, and the nucleotide sequences of primers capable of hybridizing specifically to the DNA thus obtained are determined. A... | 05/10/2005 |
| 6878530 | Methods for detecting polymorphisms in nucleic acids The present invention provides methods for determining the genotype of a nucleic acid at the site of a polymorphism. The methods achieve sensitivities great enough to detect the presence of any difference between the nucleic acids, even single nucleotide polymorphis... | 04/12/2005 |
| 6864052 | Enhanced sequencing by hybridization using pools of probes The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a t... | 03/08/2005 |
| 6828422 | Protein/(poly)peptide libraries The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of ... | 12/07/2004 |
| 6829540 | Drug discovery using multiple membrane mimetic affinities The measurement of multiple membrane affinities of test compounds, methods and compositions useful for acquiring data characteristic of such affinities, and a method and system for using such data alone or in combination with other molecular descriptors for the pred... | 12/07/2004 |
| 6809178 | Steroid-activated nuclear receptors and uses therefor A novel nuclear receptor, termed the steroid and xenobiotic receptor (SXR), a broad-specificity sensing receptor that is a novel branch of the nuclear receptor superfamily, has been discovered. SXR forms a heterodimer with RXR that can bind to and induce transcripti... | 10/26/2004 |
| 6795776 | Crystallographic structure of the androgen receptor ligand binding domain The first crystal structure of the androgen receptor ligand binding domain has been determined to 2.0 angstrom resolution. Disclosed are the coordinates for the crystal structure, and methods for determining agonists, partial agonists, antagonists, partial antagonis... | 09/21/2004 |
| 6787640 | Fibroblast growth factor 14 Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound ... | 09/07/2004 |
| 6789022 | Method for assaying clustered DNA damages Disclosed is a method for detecting and quantifying clustered damages in DNA. In this method, a first aliquot of the DNA to be tested for clustered damages with one or more lesion-specific cleaving reagents under conditions appropriate for cleavage of the DNA to pro... | 09/07/2004 |
| 6780598 | Method of identifying and locating immunobiologically-active linear peptides The present invention relates to identifying protein epitopes and more particularly to a novel method for identifying, determining the location, optimal length of amino acid residues and immunobiological potency of protein epitopes by fitting a hydrophilicity and/or... | 08/24/2004 |
| 6760668 | Method for alignment of DNA sequences with enhanced accuracy and read length In order to align DNA sequence data traces, an experimental data trace representing the positions of a first species of base within a target polynucleotide and a reference data trace representing the positions of a second species of base (which may be the same as or... | 07/06/2004 |
