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| Number | Title | Issue Date |
| 6489441 | Transcriptional co-repressor that interacts with nuclear hormone receptors In accordance with the present invention, there are provided novel receptor interacting factors, referred to herein as "SMRT", i.e., a silencing mediator (co-repressor) for retinoic acid receptor (RAR) and thyroid hormone receptor (TR). SMRT is a novel pr... | 12/03/2002 |
| 6310185 | Recombinant human anti-Lewis Y antibodies The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by murine atibodies specific for the Lewis Y antigen. The Lewis Y antigen is expressed in normal tissues but the level o... | 10/30/2001 |
| 6309846 | Diagnosis and monitoring of colon cancer patients by measurement of NCA 50/90 in blood A method for aiding in the diagnosis of, and monitoring the progression or course of, colon cancer in a patient by measuring the amount of NCA 50/90 in a blood sample, e.g., serum sample, obtained from the patient. Measurement in a single sample of an amo... | 10/30/2001 |
| 6270978 | Immunomethods for isolating and indentifying human influx peptide transporter Monoclonal antibodies which react with the human influx peptide transporter are provided. The human influx peptide transporter-reactive antibodies are useful in the purification of influx peptide transporter and in immunoassays to identify agents taken up... | 08/07/2001 |
| 6248712 | Urokinase-type plasminogen activator receptor Activation of plasminogen to plasmin is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminoge... | 06/19/2001 |
| 6245735 | Methods and products for treating pseudomonas infection Methods and products for upregulating cystic fibrosis transmembrane conductance regulators are provided, including methods and products for the treatment of P. aeruginosa infection. The products include polysaccharides that interact with the cystic fibros... | 06/12/2001 |
| 6183705 | Method of cleaning and disinfecting contact lens, and apparatus therefor A method of cleaning and disinfecting contact lenses, including the steps of a) transmitting a ultrasonic energy field toward a pair of contact lenses being suspended in a solution medium in a cleaning cup, causing a cavitation to be produced to remove di... | 02/06/2001 |
| 6156877 | Compounds for diagnosis and/or therapy of tumours Compounds are provided for use in the diagnosis and/or therapy of tumors and/or as immunosuppressive agent. The compounds are antibodies which bind to IL-4 receptors and IL-4 receptor-binding fragments thereof. A preferred compound is monoclonal antibody ... | 12/05/2000 |
| 6140464 | Nonapeptides that bind a HLA-A2.1 molecule The invention described methods for identifying a molecule of interest, as well as nucleic acid molecules which encode it, and binding partners for it. A cDNA library from a cell expressing the target is prepared, and expressed in host cells. Lysates of t... | 10/31/2000 |
| 6124116 | Rab proteins The present invention provides four human Rab and Rab-associated proteins (designated collectively as HRAB) and polynucleotides which identify and encode HRAB. The invention also provides genetically engineered expression vectors and host cells comprising... | 09/26/2000 |
| 6103525 | Hybridoma cell lines producing monoclonal antibodies that bind to human plasma hyaluronidase The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invent... | 08/15/2000 |
| 6100048 | Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals The present invention provides recombinant expression constructs comprising nucleic acid encoding mammalian melanocortin receptors, and mammalian cells into which said recombinant expression constructs have been introduced that express functional mammalia... | 08/08/2000 |
| 6093399 | Methods and compositions for the specific coagulation of vasculature Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor regression, through the site-specific delivery of a coagulant using... | 07/25/2000 |
| 6083387 | Apparatus for the disinfection of fluids This invention relates to apparatus and methods for the disinfection of fluids and, in particular, to the disinfection of industrial fluids with ultraviolet radiation. These fluids are typically used in manufacturing as coolants in both long and short ass... | 07/04/2000 |
| 6077947 | DNA encoding an intracellular chimeric receptor comprising Janus kinase The present invention is directed to novel chimeric proliferation receptor proteins and DNA sequences encoding these proteins where the chimeric proteins are characterized in three general categories. In one category, the novel chimeric proteins comprise ... | 06/20/2000 |
| 6077685 | Tumor suppressor merlin and antibodies thereof A novel tumor suppressor protein, merlin, is described, including DNA sequences encoding merlin, and recombinant vectors and hosts capable of expressing merlin. Method for the diagnosis and treatment of merlin-associated tumors, and for the diagnosis and ... | 06/20/2000 |
| 6074642 | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis The use of anti-C5 antibodies, e.g., monoclonal antibodies, to treat glomerulonephritis (GN) is disclosed. The administration of such antibodies at low dosage levels has been found to significantly reduce glomerular inflammation/enlargement and other path... | 06/13/2000 |
| 6074862 | Mitogen-activated protein kinase kinase MEK6 and variants thereof Compositions and methods are provide for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such c... | 06/13/2000 |
| 6071888 | Composition for treating cancer The present invention is directed to compositions containing beta-alanine which are useful for treating cancer. The composition preferably comprises a ribose compound, L-beta-alanine, ascorbic acid, and nicotinic acid. The present invention is particularl... | 06/06/2000 |
| 6069231 | PR domain peptides The present invention provides PR domain peptides, which are about 100 to about 120 amino acids in length and contain three highly conserved sequences of about 10 to about 12 amino acids, separated by less conserved sequences of about 20 to about 35 amino... | 05/30/2000 |
| 6066321 | Method for antagonizing vascular adhesion protein-1 (VAP-1)-mediated binding of endothelial cells to lymphocytes A novel endothelial cell molecule, VAP-1, is described that mediates lymphocyte binding in man. Further described are anti-VAP-1 monoclonal antibodies and methods for the diagnosis and treatment of inflammatory and autoimmune diseases by the administratio... | 05/23/2000 |
| 6063594 | DNA encoding a novel human anion channel The present invention provides a novel anion channel (NANCH) and polynucleotides which identify and encode NANCH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NANCH and... | 05/16/2000 |
| 6057428 | Variants of vascular endothelial cell growth factor The present invention involves the preparation of vascular endothelial growth factor (VEGF) variants which provide materials that are selective in respect to binding characteristics to the kinase domain region and the FMS-like tyrosine-kinase region, resp... | 05/02/2000 |
| 6057435 | Tie ligand homologues The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein mole... | 05/02/2000 |
| 6051692 | Human retinoid binding protein The present invention provides a human retinoid binding protein (Hu-RBP) and polynucleotides which identify and encode Hu-RBP. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides methods for ... | 04/18/2000 |
| 6046025 | Expression of heterologous proteins in drosophila cells The present invention provides a novel method for expression of high levels of heterologous proteins in Drosophila cells.... | 04/04/2000 |
| 6043345 | IgE isoforms and methods of use Methods and compositions are provided relating to novel IgE isoforms and their use in immune hypersensitivity diagnosis and treatment. The compositions include transcription and translation products of the immunoglobulin epsilon locus, specific probes for... | 03/28/2000 |
| 6036955 | Kits and methods for the specific coagulation of vasculature Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor regression, through the site-specific delivery of a coagulant using... | 03/14/2000 |
| 6037178 | Method for quality control of an analyzing system Quality control of an analyzing system that includes a portable analyzer with insertable single-use cartridges whose sample chamber contains optical and/or electrochemical sensors is accomplished by bringing the sensors in the single-use cartridge into co... | 03/14/2000 |
| 6033869 | Polynucleotide encoding a novel human cytokine/steroid receptor The present invention provides a human cytokine/steroid receptor protein (CYSTAR) and polynucleotides which identify and encode CYSTAR. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides met... | 03/07/2000 |
| 6033870 | Human transmembrane protein The invention provides a novel human integral membrane protein (TMP-2) and polynucleotides which encode TMP-2. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provid... | 03/07/2000 |
| 6027921 | Chimeric proteins for use in transport of a selected substance into cells and DNA encoding chimeric proteins Chimeric proteins, which comprise a ligand-binding domain of a first receptor and a carrier domain which binds a cell surface receptor other than the first receptor, useful in transporting a selected substance present in extracellular fluids, such as bloo... | 02/22/2000 |
| 6024957 | Immunomodulators and methods for the prevention and reversal of organ transplant rejection using same Compounds and methods are described for the differential inhibition of tyrosine phosphorylation of phospholipase C-γ1 for the prevention or reversal of transplant rejection as well as therapy for autoimmune diseases. Methods for the treating or preventin... | 02/15/2000 |
| 6025191 | Isolated nucleic acid molecules which encode a melanoma specific antigen and uses thereof The invention involves the isolation of a nucleic acid molecule which encodes a melanoma associated antigen. Cell lines and expression vectors which include this and related sequences, as well as uses of these molecules, are described.... | 02/15/2000 |
| 6022707 | Ras-like protein The invention provides a human Ras-like protein (PRAS) and polynucleotides which identify and encode PRAS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating d... | 02/08/2000 |
| 6020145 | Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96 The present invention relates to novel antibodies, antibody fragments and antibody conjugates and single-chain immunotoxins reactive with human carcinoma cells. More particularly, the antibodies, conjugates and single-chain immunotoxins of the invention i... | 02/01/2000 |
| 6019958 | Technetium-99m labeled peptides for imaging inflammation This invention relates to compositions that are radiolabeled scintigraphic imaging agents, comprising a polybasic compound covalently linked to a radiolabel binding moiety and the composition further comprising a polysulfated glycan. The invention also pr... | 02/01/2000 |
| 6018023 | Kainate-binding, human CNS receptors of the EAA3 family Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now been isolated and the receptor protein characterized. Her... | 01/25/2000 |
| 6018021 | Human transaldolase: an autoantigen with a function in metabolism Transaldolase is an enzyme which acts as an autoantigen in immune-related neurodegenerative diseases, particularly multiple sclerosis. Human transaldolase, the DNA coding therefore, peptides derived therefrom, and DNA control elements associated therewith... | 01/25/2000 |
| 6017727 | Syndecan enhancer element and syndecan stimulation of cellular differentiation A DNA enhancer element and the use of this syndecan enhancer element to regulate the expression of genes are provided.... | 01/25/2000 |
