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| Number | Title | Issue Date |
| 5368860 | Preparation for transdermal drug administration A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anestheti... | 11/29/1994 |
| 5326571 | Dosage forms comprising polymers comprising different molecular weights A dosage form is disclosed comprising a wall surrounding a compartment, which comprises a first composition comprising a carboxymethylcellulose and a second composition comprising a higher molecular weight carboxymethylcellulose. The first composition com... | 07/05/1994 |
| 5318779 | Drug-impregnated ceramic A drug-impregnated ceramic to be embedded in a living body is disclosed, and includes a porous ceramic having pores with a pore size of 10 to 300 μm, a drug impregnating the porous ceramic via the pores, and a surface layer for controlling the release of... | 06/07/1994 |
| 5300291 | Method and device for the release of drugs to the skin A method of increasing the adhesiveness of a shaped pressure sensitive adhesive, comprising adding an adhesiveness and drug release increasing amount of a clay to said adhesive prior to casting of the adhesive. A dermal composition comprising a drug, a pressur... | 04/05/1994 |
| 5300299 | Silicone pressure sensitive adhesive containing alkylmethylsiloxane wax and related methods and devices Hot-melt silicone pressure sensitive adhesive compositions containing alkylmethylsiloxane waxes, methods of using the compositions and devices made using the compositions are disclosed. The hot-melt silicone pressure sensitive adhesive compositions includ... | 04/05/1994 |
| 5296222 | Percutaneous drug delivery system A percutaneous drug delivery method and enhancement composition are disclosed. The method comprises applying an enzyme preparation containing suitable amounts of non-enzyme permeation enhancers, such as lactam compounds (e.g. 1-substituted-azacycloheptan-... | 03/22/1994 |
| 5284662 | Oral osmotic system for slightly soluble active agents An oral sustained release composition for slightly soluble pharmaceutically active agents comprising a core, a wall around said core, and a bore through said wall connecting said core and the environment outside of said wall; wherein said core comprises a... | 02/08/1994 |
| 5273752 | Controlled release dispenser comprising beneficial agent A dispenser is disclosed for delivering a beneficial agent in a hydrophilic carrier formulation to an animal in a rate-controlled manner. The dispenser comprises (1) a semipermeable housing defining an internal space, (2) at least one composition comprisi... | 12/28/1993 |
| 5271940 | Transdermal delivery device having delayed onset A transdermal delivery device has a reservoir containing an active compound, which is kept separate from the delivery layers of the device until administration. At the time of administration, the reservoir is laminated to the delivery layers, or is ruptur... | 12/21/1993 |
| 5271942 | Agent for reducing the growth of or removing the hair on the human body An agent for reducing the growth of human hair comprising a basic substance for application to the skin which contains a urea and demineralized, sterilized water.... | 12/21/1993 |
| 5268176 | Method and compositions for the non-invasive treatment of telangiectasia This invention is directed to a non-invasive, topical treatment for telangiectasia, a dermatological condition commonly known as spider veins. The treatment preferably includes repeated applications of a composition having an effective amount of an inosit... | 12/07/1993 |
| 5264219 | Transdermal drug delivery backing Polymer blends containing a very low density polyethylene copolymer of ethylene and 1-butene, 1-hexene, or 1-octene and about 15 to about 600 parts by weight of a linear low density polyethylene copolymer of ethylene and 1-octene, based on 100 parts by we... | 11/23/1993 |
| 5264224 | Process for producing and administration and/or dosage form for medicinal active substances by means of a printing process The invention relates to a process for producing an administration and/or dosage form for medicament active substances using a printing process, in which the printing process used is a pad printing process.... | 11/23/1993 |
| 5264222 | Oral pharmaceutical compositions in unit dosage form Oral pharmaceutical compositions in unit dosage form, especially capsules, comprising solid Colloidal Bismuth Subcitrate (CBS), optionally one or more auxilliary medicaments and excipients, the dosage units having a packing density of between 0.06 and 0.6... | 11/23/1993 |
| 5260064 | Percutaneous-administration-type pharmaceutical preparation of nitroglycerin A percutaneous-administration-type pharmaceutical preparation of nitroglycerin is provided. The preparation comprises a backing that is impervious to medicines, and a pressure-sensitive adhesive layer that is placed on one surface of said backing, wherein... | 11/09/1993 |
| 5252334 | Solid matrix system for transdermal drug delivery A matrix for containing drugs for transdermal delivery systems is disclosed. The matrix, formed of a skin-adhesive acrylate copolymer, attains high rates of drug delivery without the addition of drug delivery rate enhancers. In preferred embodiments the m... | 10/12/1993 |
| 5244677 | Application system for drug containing microemulsions The invention deals with devices, in particular with bandage strips, for a transdermal delivery of drugs to patients, whereby the drug formulations include highly viscous preparations, topical solutions of a low viscosity and micro-emulsions of a low visc... | 09/14/1993 |
| 5240713 | Dual rate agent delivery device The present invention is directed to a long-term dispensing device for the controlled delivery of a beneficial agent in a hydrophilic carrier, which device quickly and continuously delivers an effective amount of agent followed by a continuous and sustain... | 08/31/1993 |
| 5240711 | Transdermal therapeutic system comprising as active component buprenorphine The controlled release of buprenorphine or the pharmaceutically acceptable salts thereof to the skin over a period of time of at least 24 hours is ensured by a transdermal therapeutic system consisting of a backing layer which is impermeable to the active... | 08/31/1993 |
| 5238933 | Skin permeation enhancer compositions Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The compositions contain a lower aliphatic ester of a lower aliphatic carboxylic acid such as ethyl a... | 08/24/1993 |
| 5236714 | Abusable substance dosage form having reduced abuse potential Compositions and dosage forms for administering abusable substances are disclosed which have a reduced potential for abuse without diminishing the therapeutic or beneficial effects of the abusable substance. Topical compositions for application to the ski... | 08/17/1993 |
| 5234691 | Sustained-release prepararation of basic medical agent hydrochloride A preparation obtained by coating granules containing both a basic medical agent hydrochloride (e.g. allotinolol hydrochloride) and a polyanion the particles of which are present in the form of a discontinuous layer, with a film containing a slightly wate... | 08/10/1993 |
| 5234690 | Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset A delayed onset transdermal drug delivery device exhibiting a delay period of at least six hours comprising a laminated composite of (1) a top backing layer; (2) a pressure rupturable layer underlying (1); (3) a reservoir of a solution of drug in a liquid... | 08/10/1993 |
| 5232702 | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices A silicone pressure sensitive adhesive composition which is compatible with drugs, excipients, co-solvents and skin penetration enhancers is disclosed which includes a cohesive strengthening agent in combination with a silicone fluid and a silicate resin.... | 08/03/1993 |
| 5232705 | Dosage form for time-varying patterns of drug delivery A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior o... | 08/03/1993 |
| 5230897 | Transdermal pentamidine Pharmaceutical compositions and transdermal patches comprised of pentamidine and a penetration enhancing amount of a terpene selected from the group consisting of menthol, carvone, carveol, dihydrocarveol, dihydrocarvone, neomenthol, isopulegol, terpene-4... | 07/27/1993 |
| 5230896 | Transdermal nicotine delivery system A novel transdermal delivery system for nicotine to satisfy addicted smokers' cravings therefore is comprised of a nicotine base, an acrylate polymer adhesive, a stabilizer and a polyester film backing. The nicotine is absorbed through the skin at suffici... | 07/27/1993 |
| 5229132 | Non-absorbable gastrointestinal medicament provided for treating the two levels of the digestive tract at the same time A non-absorbable and soluble gastrointestinal medicine provided for treating the two levels of the digestive tract, i.e. the stomach and the intestines. The medicine is presented in a gastroresistant oral pharmaceutical form associated with a non-enterica... | 07/20/1993 |
| 5227168 | Method of treating a wound An antimicrobial wound dressing and method of wound treatment, the wound dressing having a layer of a collagen dressing material impregnated with lyophilized, stabilized chlorine-containing compounds which generate on activation chlorine dioxide, like a m... | 07/13/1993 |
| 5227157 | Delivery of therapeutic agents The present invention relates to a composition of matter for the time-dependent liberation of therapeutic agents. This composition of matter comprises a polymeric slab and a homogeneously dispersed enzyme which degrades the polymeric slab in the presence ... | 07/13/1993 |
| 5227169 | Sorbitan esters as skin permeation enhancers Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The compositions contain a sorbitan ester in addition to the selected pharmacologically active agent,... | 07/13/1993 |
| 5225192 | Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate A poorly soluble medicament is incorporated into particles of a crosslinked polymer which is swellable in water but insoluble in water, and the product obtained is brought into contact with a solvent able to swell the polymer. The product obtained by this... | 07/06/1993 |
| 5225198 | Transdermal administration of short or intermediate half-life benzodiazepines Method and laminated composite for administering short or intermediate half-life benzodiazepines such as alprazolamine or triazolam transdermally to treat conditions such as anxiety in the case of alprazolam and insomnia in the case of triazolam. The comp... | 07/06/1993 |
| 5225196 | Bioadhesive compositions and methods of treatment therewith A controlled release treatment composition method of use are disclosed. The composition includes a bioadhesive and an effective amount of a treating agent. The bioadhesive is a water-swellable, but water-insoluble, fibrous, cross-linked carboxy-functional... | 07/06/1993 |
| 5223261 | Transdermal estradiol delivery system A pressure-sensitive adhesive sheet material for delivering estradiol to skin, the sheet material comprising a backing with a layer of a pressure-sensitive adhesive adjacent thereto, said pressure-sensitive adhesive layer comprising a pressure-sensitive a... | 06/29/1993 |
| 5223262 | Transdermal delivery system utilizing one way membranes A system for transdermally delivering a hydrophobic alkanol soluble active agent to the skin at a constant rate utilizing a lower alkanol penetration enhancer. The system comprises an overlying solvent reservoir containing a lower alkanol solvent and a dr... | 06/29/1993 |
| 5221536 | Dosage form indicated for the management of abnormal posture, tremor and involuntary movement A dosage form is disclosed comprising an anti-Parkinson's disease drug for administering to a patient in need of anti-Parkinson's disease therapy.... | 06/22/1993 |
| 5219572 | Controlled release delivery device for macromolecular proteins A controlled release delivery device for macromolecular proteins which comprises a water-soluble outer capsule completely surrounding an inner compartment containing a plurality of non-uniform beadlets. The beadlets comprise a rupturable wax shell which c... | 06/15/1993 |
| 5217707 | Pharmaceutical composition and process for the preparation thereof The invention relates to a stabile, aqueous suspoemulsion containing as active ingredient 0.2-5 weight % of primycin, 5-25 weight % of propylene glycol, 0.5-5 weight % of non-ionic surface active agent, if desired 15 weight % of auxiliary agent and distil... | 06/08/1993 |
| 5215751 | Therapeutic system for the retarded and controlled transdermal or transmucous administration of active substances (I) The present invention relates to a therapeutic system for the retarded and controlled transdermal and transmucous administration of active substances via an impermeable backing layer, an active substance containing reservoir, a substantially drug-free but... | 06/01/1993 |
