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Maier, Leigh C.


Primary examiner statistics: 83 patents; average approval time: 112 days
Assistant examiner statistics: 218 patents; average approval time: 949 days

Patents as Primary Examiner

1      
NumberTitleIssue Date
RE41005Beads bound to a solid support and to nucleic acids
Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to “flat” surfaces, beads linked to a solid sup...
11/24/2009
7459549Composition for preparing nanoporous material
Disclosed herein is a composition for preparing a nanoporous material. The composition comprises i) a cyclodextrin derivative, ii) a thermostable matrix precursor, and iii) a solvent for dissolving the components i) and ii). The composition enables the preparation o...
12/02/2008
7446101Bioavailable carotenoid-cyclodextrin formulations for soft-gels and other encapsulation systems
The present invention describes an improved commercial process for the production of carotenoid-cyclodextrin complexes and formulation of the complex for human ingestion. Complexation with cyclodextrins (e.g., α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, or HP...
11/04/2008
7446100Methods for cell mobilization using in vivo treatment with hyaluronan (HA)
The use of forms of hyaluronic acid having a molecular weight less than about 750,000 daltons selected from the group consisting of hyaluronic acid and pharmaceutically acceptable salts thereof is provided for the same purposes known for using recombinant GM-CFS of ...
11/04/2008
7438931Methods and compositions for the treatment of angiogenic diseases
Provided are agents that can bind to copper, and form a tripartite complex with protein, and the use of these agents in the prevention and treatment of diseases with a vascular component, such as solid tumors. Compositions and methods for combination therapy of thes...
10/21/2008
7438722Method for treatment of restenosis
A method for inhibiting restenosis is described. The method comprises implanting a stent in a patient's vasculature and simultaneously delivering a restenosis-inhibiting medicine to the treatment site by adjuvant therapy. ...
10/21/2008
7425548Materials and methods for immune system stimulation
The subject invention concerns a novel polysaccharide. RR1 is an α-D-glucan polysaccharide composed of a (1→4) linked back bone and (1→6) linked branches, which has been isolated from a medicinal herb, Tinospora cordifolia. RR1 exhibits unique immune-sti...
09/16/2008
7423026Methylated cyclodextrin complexes
The present invention is directed to novel complexes of cyclodextrin. In particular the invention is directed to a complex of a cyclodextrin selected from the group consisting of RM-β-cyclodextrin, DM-β-cyclodextrin and TM-β-cyclodextrin, and a cannabinoid select...
09/09/2008
7422763Acid controlled induced viscosity fiber system and uses thereof
The present invention relates generally to a method of blunting the postprandial glycemic response to a meal by feeding an acid controlled induced viscosity fiber system. The first component of the induced viscosity fiber system is anionic soluble fiber. The second ...
09/09/2008
7422733Linkable sialyl Lewis X analogs
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLeX) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in preparing multimeric SLe
09/09/2008
7423028Injectable pharmaceutical compositions comprising sodium diclofenac and β-cyclodextrin
Injectable pharmaceutical compositions are described comprising sodium diclofenac, a β-cyclodextrin and a polysorbate, suitable for subcutaneous and intramuscular administration. ...
09/09/2008
7419655Skin care products
The invention provides compositions and methods for conditioning the skin and reversing the effects of aging on the skin. ...
09/02/2008
7414038Embolic materials
The object of the present invention is to provide an embolizing material which is easily handleable and stable in quality and is solved by providing an embolizing material comprising an ester derivative of a polysaccharide having a weight-average molecular weight of...
08/19/2008
7414039Interstitial therapy for immediate symptom relief and chronic therapy in interstitial cystitis
The present invention relates to a disorder of the lower urinary tract, and in particular, reducing the symptoms (including treatment) of interstitial cystitis in vivo. In a preferred embodiment, the present invention relates to treatment formulations and methods fo...
08/19/2008
7407945Use of sulfated glycosaminoglycans for establishing effective labor in women
The invention refers to the use of sulfated glycosaminoglycans having an anticoagulant activity of 100 BP units/mg or less for the manufacture of a pharmaceutical preparation for prophylactic priming or curative treatment of the cervix and the myometrium for establi...
08/05/2008
7405293Reduced malto-oligosaccharides
Disclosed are a method for the reduction of an oligosaccharide mixture and an oligosaccharide mixture prepared thereby. In accordance with the disclosed invention, a mixture of oligosaccharides having a given DP profile is reduced to a DE of essentially zero by cata...
07/29/2008
7375096Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the invention is described. A method of treatment by administering a thera...
05/20/2008
7354910Agent for treating inflammatory bowel diseases
An agent for treating inflammatory bowel diseases and an agent for preventing or improving symptoms accompanied by inflammatory bowel diseases, which each comprises hyaluronic acid or a pharmaceutically acceptable salt thereof as an active ingredient. ...
04/08/2008
7351408Glycoconjugates and methods
Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosacch...
04/01/2008
7348317Aqueous compositions containing metronidazole
An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta-cyclodextrin and the second is niacin or niacinamid...
03/25/2008
7345031Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
Hydrophilic transportable N-linked glycosyl dopaminergic prodrug compounds according to FORMULA V and methods of their use, wherein, Ring 1 comprises an aryl or heteroaryl ring having 4 to...
03/18/2008
7338940Cancer treatment including glycolytic inhibitors
Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as having a natural selective toxicity toward anaerobic cells, and will sign...
03/04/2008
7329759Illudin analogs useful as antitumor agents
The present invention provides illudin analogs of the general formula (I): where R1 is (CH2)n—X—Y or H; n is 0 to 4; X is O or S or N or absent; and Y...
02/12/2008
7314860Heparin-like compounds, their preparation and use to prevent arterial thrombosis associated with vascular injury and interventions
The present invention is related to heparin-like compounds characterized by their capacity of inhibiting collagen-induced platelet aggregation in flowing whole blood and their use for prophylactic treatment of arterial thrombosis associated with vascular or microvas...
01/01/2008
7307102Method of preventing or treating estrogen-dependent diseases and disorders
The present invention relates, in general, to the treatment of estrogen-dependent diseases and disorders and, in particular, to a method of treating estrogen-dependent cancers, particularly breast cancer, with antiestrogens. ...
12/11/2007
7307150Dextran-hemoglobin conjugates as blood substitutes
An hemoglobin (Hb)-Dextran (Dx) conjugate having a molecular weight between 50 kd and 500 kD provides a blood substitute that results in acceptable erythrocyte sedimentation rate (ESR) and excretion rate (EXC) values. DxHb conjugates of the invention can be used for...
12/11/2007
7297343Bioactive medical films
A wound dressing, method of making, and method of use, utilizing a polymeric film having complexed thereto by hydrophobic interaction a construct including a polyanion covalently bonded to a hydrophobic prosthetic moiety, with one or more bioactive molecules directl...
11/20/2007
7294615Compounds that associate on the intermolecular level and aggregate bodies that contain them
Compound of the general formula (I) X(B)m  (I) wherein X is an m-valent unit and B are identical or different and denote K-R, wherein K is a bond or is A1—(A2...
11/13/2007
7282485Method of obtaining D-glucuronic acid
A method of obtaining D-glucuronic acid. The D-glucuronic acid and its derivatives (lactone, salts, amides, etc.) are biologically high-active compounds, which are widely used in medicine and pharmaceutical chemistry for the synthesis of modified drugs as well as us...
10/16/2007
7276486Compositions for vaginal treatment
The invention provides mannose phosphate and salts thereof for increasing vaginal cell growth, vaginal cell maturation and vaginal moisture, as well as compositions, articles and methods for treating and preventing vaginal conditions characterized by poor vaginal ce...
10/02/2007
7270808Cyclodextrin-based polymers for therapeutics delivery
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug...
09/18/2007
7271196CETP activity inhibitors
The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight cha...
09/18/2007
7271259Solid phase host compositions
A new family of silicon-based polymers has been prepared in which organic host components are bound covalently. The polymer is a polysilsesquioxane matrix comprising, for example, hosts such as cyclodextrins (CD) or calixarenes (CX). ...
09/18/2007
7265099Use of chemical chelators as reversal agents for drug-induced neuromuscular block
The invention relates to the use of chemical chelators for the preparation of a medicament for the reversal of drug-induced neuromuscular block, to a kit for providing neuromuscular block and its reversal, and to cyclophane derivatives having general formula (A) whe...
09/04/2007
7262171Use of rhamnolipids in wound healing, treating burn shock, atherosclerosis, organ transplants, depression, schizophrenia and cosmetics
Various methods are provided, including wound healing with reduced fibrosis, treatment of burn shock, treatment and prevention of atherosclerosis, prevention and treatment of organ transplant rejection, treatment of depression and schizophrenia and treatment of the ...
08/28/2007
7259257Process for producing particulate, water-soluble cellulose derivatives using a superheated gas mixture containing steam
The present invention relates to a new, particularly economical process for preparing particulate water-soluble cellulose derivatives. The process involves forming a feed composition of swollen and/or dissolved cellulose derivative, and water. The feed composition i...
08/21/2007
7250068Method of increasing photosynthesis in plants comprising an exposure thereof to lipochitooligosaccharides and compositions therefor
The present invention relates to agriculture. More particularly, the invention relates to a method of increasing photosynthesis of a plant and more particularly of crop plants. In addition, the invention relates to a method of increasing photosynthesis and/or yield ...
07/31/2007
7223570Branched cyclic tetrasaccharide, process for producing the same, and use
The object of the present invention is to provide a novel glycosyl derivative of cyclotetrasaccharide represented by cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→}, and it is solved by provi...
05/29/2007
7217817Agarobiose-containing composition
A material containing agarobiose; a method for preparing the material; and a food, a drink or a seasoning using the material, which is tasty and has the effect of alleviating a stimulant taste and of enhancing the depth of sweetness. ...
05/15/2007
7199111Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
The present invention provides aqueous Ifosfamide compositions and a process for their preparation, in which the compositions have a reduced toxicity over and above the concomitant use of the uroprotective agent, Mesna. Aqueous Ifosfamide compositions can be prepare...
04/03/2007
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