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| Number | Title | Issue Date |
| 5891840 | Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis Novel modified or derivatized recombinant animal somatotropins. Methods for stabilizing recombinant animal somatotropins by modification or deletion of the Cysteine residues utilizing site directed mutagenesis to replace from one to four of the cysteine a... | 04/06/1999 |
| 5691181 | DNA encoding lipase from human gastric mucosal tissue A human gastric lipase protein for use in the treatment of lipase deficiency. A process is described for producing gastric lipase using recombinant DNA technology to produce a host organism (for example E. coli) capable of producing a methionine-gastric l... | 11/25/1997 |
| 5639651 | Gap-related gene, human IQGAP1 A purified nucleic acid encoding the IQGAP1 protein, a novel member of the GTPase activating protein family, useful in the diagnosis and treatment of tumors.... | 06/17/1997 |
| 5631151 | Melanin production by transformed organisms The present invention is directed to a process for producing melanins, their precursors and their analogues, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 3.3 grams wet wei... | 05/20/1997 |
| 5616482 | Chimeric toxins A chimeric diptheria toxin comprising protein fragments joined together by peptide bonds.... | 04/01/1997 |
| 5610063 | cDNA for -N-acetyl-galactosaminidase from Gallus domesticus A purified and isolated cDNA clone, as set forth in SEQ ID No:1, encoding the mature chicken -N-acetylgalactosaminidase enzyme is disclosed.... | 03/11/1997 |
| 5607850 | Enzyme from microbial source: phthalyl amidase Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides said phthalyl amidase, means for producing it by culturing the natural organism from ... | 03/04/1997 |
| 5595903 | Genetically engineered human acetylcholinesterase Genetically engineered human acetylcholinesterase and antibodies that def the protein are described. These composition may be used in pharmaceutical preparations for treatment and prophylaxis of organo-phosphorous compound poisoning or post-operative apn... | 01/21/1997 |
| 5580757 | Cloning and expression of biologically active -galactosidase A as a fusion protein The present invention involves the production of large quantities of human -Gal A by cloning and expressing the -Gal A coding sequence in eukaryotic host cell expression systems. The eukaryotic expression systems, and in particular the mamma... | 12/03/1996 |
| 5578481 | Cloning and characterization of a cardiac adenylyl cyclase A DNA sequence encoding a novel effector enzyme referred to as a cardiac adenylyl cyclase is described. The amino acid sequence of the cardiac adenylyl cyclase encoded by that DNA sequence is also described.... | 11/26/1996 |
| 5554523 | Nucleic acid sequences encoding human leucine-zipper protein-kinase A novel protein kinase, leucine-zipper protein kinase, 668 amino acids in length is provided by the present invention. This protein kinase is localized to the human brain. Nucleic acid sequences encoding the protein kinase are also provided.... | 09/10/1996 |
| 5552299 | Plasmids and process for producing recombinant desulphatohirudin HV-1 peptides The present invention relates to a process for producing recombinant desulphatohirudin by means of culturing microorganisms. Concerning the codon usage of microorganisms the synthesized nucleotide sequences were joined downstream of and in reading frame with i... | 09/03/1996 |
| 5547871 | Heterologous signal sequences for secretion of insect controlling proteins Seven heterologous signal sequence are described for use with genes for insect controlling proteins, such that when the signal sequence and protein genes are inserted into an insect virus, that virus demonstrates an earlier onset of morbidity than a wild-... | 08/20/1996 |
| 5545548 | Thermally stable cytosine deaminase from saccharomyces Thermally stable cytosine deaminase (CDase), and the gene coding therefor, is disclosed as well as methods of isolating, purifying, and recombinantly producing the same. The thermally stable CDase can be isolated from Saccharomyces cerevisiae. The yeast i... | 08/13/1996 |
| 5543497 | Genes encoding and method of expressing a novel enzyme: phthalyl amidase Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides DNA compounds encoding the phthalyl amidase enzyme and methods for expressing such co... | 08/06/1996 |
| 5538876 | Stabilization of carboxyl esterase Carboxyl esterase is inactivated by several chemical compounds such as naproxen or diclofop. By substituting or modifying certain basic residues of the carboxyl esterase, this enzyme shows improved stability properties during application. In this way it i... | 07/23/1996 |
| 5529909 | Tyrosinase-activator protein fusion enzyme The present invention relates to a nucleic acid sequence that encodes a fusion enzyme of tyrosinase and a tyrosinase activator protein. Further, the present invention also relates to the amino acid sequence which is encoded by the nucleic acid sequence of... | 06/25/1996 |
| 5529925 | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma The present invention is based on the identification and sequence determination of fusion proteins generated by translocation which is present in t(2:5) lymphoma cells. Using either the amino acid or nucleic acid sequences of the fusion proteins disclosed... | 06/25/1996 |
| 5523393 | BCL-2 proteins The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes ... | 06/04/1996 |
| 5514779 | Biocidal proteins from plants Biocidal proteins capable of isolation from seeds have been characterized. The proteins have an amino acid sequence containing the common cysteine/glycine domain of Chitin-binding Plant Proteins but show substantially better activity against pathogenic fu... | 05/07/1996 |
| 5506139 | Analog of haemophilus Hin47 with reduced protease activity An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. ... | 04/09/1996 |
| 5501975 | DNA molecules encoding an ER-located endoprotease The invention concerns novel DNA molecules encoding a modified, endoplasmic reticulum-located "dibasic processing endoprotease" and the use of said endoplasmic reticulum-located "dibasic processing endoprotease" for the correct processing of heterologous ... | 03/26/1996 |
| 5500365 | Synthetic plant genes A method for modifying structural gene sequences to enhance the expression of the protein product is disclosed. Also disclosed are novel structural genes which encode insecticidal proteins of B.t.k. HD-1, B.t.k. HD-73, B.t. tenebrionis, B.t. entomocidus, ... | 03/19/1996 |
| 5500370 | Thermostable ribonuclease H and genetic constructs therefore An essentially pure preparation of thermostable RNase H isolated from Thermus flavus is disclosed. In one preferable form of the invention, the RNase H is capable of biological activity after incubation at temperatures equal to or greater than 70° C. for... | 03/19/1996 |
| 5498830 | Decreased oil content in plant seeds Promoters for enhanced expression of ADPglucose pyrophosphorylase in potato tubers and fruits such as tomato; methods of using them; DNA molecules, plant cells and plants containing them. A method of decreasing the oil content of seeds by expression of AD... | 03/12/1996 |
| 5492890 | Polypeptides for promoting cell attachment Novel polypeptides derived from human fibronectin, and fusion proteins containing those peptide sequences are described which define a receptor binding site on fibronectin that binds to the platelet receptor glycoprotein GPIIb-IIIa expressed by cells. The... | 02/20/1996 |
| 5491075 | Cloning and expression of biologically active -N-acetylgalactosaminidase The present invention involves the production of human -GalNAc by cloning and expressing the -GalNAc coding sequence in eukaryotic host cell expressions systems. The eukaryotic expression systems, and in particular the mammalian host cell ex... | 02/13/1996 |
| 5475086 | Cloned glutamic acid decarboxylase peptides Isolated polypeptides useful in ameliorating autoimmune disease.... | 12/12/1995 |
| 5474917 | Modified cyclodextrin glycosyltransferases for producing γ-cyclodextrins A cyclodextrin glycosyltransferase (CGTase) which, in the conversion of starch or starch-like substrates to CD, produces γ-CD in an increased amount, and whose protein sequence, in the region between amino acid position 180 and amino acid position 240, c... | 12/12/1995 |
| 5474928 | Arginine deiminase from a Mycoplasma arginini strain A novel arginine deiminase of an approximately 45,000 molecular weight derived from mycoplasma having an ability to decompose arginine, and the method of manufacturing this novel enzyme from mycoplasma. This enzyme is an effective anti-cancer agent, as it... | 12/12/1995 |
| 5474920 | Modified thermo-resistant DNA polymerases Novel, modified Taq DNA polymerases and genes encoding for them are disclosed. The modified Taq DNA polymerases of the invention are the same size, have the same heat stability and synthesis rate as the native enzyme, but lack the 5'-3' exonuclease activi... | 12/12/1995 |
| 5466598 | Deacetylcephalosporin C acetyltransferase from Acremonium chrysogenum A DNA is disclosed, which comprises a gene coding for deacetylcephalosporin C acetyltransferase, i.e., an enzyme capable of catalyzing the final step of the biosynthesis of cephalosporin C. The gene may be either a cDNA or a genomic DNA. Also disclosed is... | 11/14/1995 |
| 5466591 | 5' to 3' exonuclease mutations of thermostable DNA polymerases The present invention relates to thermostable DNA polymerases which have been mutated such that a lesser amount of 5' to 3' exonuclease activity is exhibited from that which is exhibited by the native enzyme.... | 11/14/1995 |
| 5459063 | Plasmodium falciparum ribonucleotide reductase DNA This invention relates to the ribonucleotide reductase of Plasmodium falciparum (Pf RR), to the subunits of Pf RR (Pf R1 and Pf R2), and to compounds comprising peptides derived from the Pf R2 C-terminus sequence that inhibit the action of protozoal RR. T... | 10/17/1995 |
| 5459251 | DNA molecules having human bcl-2 gene sequences The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes ... | 10/17/1995 |
| 5457048 | Eph-related tyrosine kinases, nucleotide sequences and methods of use The invention is directed to substantially purified Eph-related protein tyrosine kinases, or functional fragments thereof, having about 23 to 66 percent amino acid sequence identity in their carboxyl terminal variable regions compared to known members of ... | 10/10/1995 |
| 5455170 | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 A purified thermostable enzyme is derived from the eubacterium Thermus species Z05. The enzyme has DNA polymerase, activity reverse transcriptase activity, and optionally 5'.fwdarw.3' exonuclease activity. The enzyme can be native or recombinant, and may ... | 10/03/1995 |
| 5451522 | Genes encoding and method of expressing an enzyme: phthalyl amidase Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides DNA compounds encoding the phthalyl amidase enzyme and methods for expressing such co... | 09/19/1995 |
| 5445959 | Enzyme from microbial source: phthalyl amidase Phthalyl amidase is an enzyme previously unknown in the art that catalyzes removal of the phthalyl moiety from phthalyl-containing amides. The current invention provides said phthalyl amidase, means for producing it by culturing the natural organism from ... | 08/29/1995 |
| 5439881 | Gene encoding nematode-active toxin PS63B cloned from Bacillus thuringiensis isolate This invention concerns genes or gene fragments which have been cloned from novel Bacillus thuringiensis isolates which have nematicidal activity. These genes or gene fragments can be used to transform suitable hosts for controlling nematodes.... | 08/08/1995 |
