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| Number | Title | Issue Date |
| 8026264 | Triazole derivatives as inhibitors of 11-β hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dysli... | 09/27/2011 |
| 7846932 | Methods for the use of pyrimidine derivatives which are antagonists of vitronectin receptor A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparatio... | 12/07/2010 |
| 7566734 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors. ... | 07/28/2009 |
| 7541475 | Substituted thiazoles This invention is directed to processes for making substituted thiazoles. The substituted thiazole, ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate, also known as TEI-6720, is useful for treatment of gout and hyperuricemia. This compound belongs to a c... | 06/02/2009 |
| 7534805 | Imidazole derivatives, their preparation and their use as medicaments Novel imidazole compounds of the formula wherein the substituents are as defined in the application having antitumoral activity and use thereof. ... | 05/19/2009 |
| 7534793 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man ... | 05/19/2009 |
| 7511152 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 03/31/2009 |
| 7507831 | Tetra- and penta-o-benzyl-protected, C-4 activated-epicatechin and -catechin monomers and processes for their preparation and use Various processes are disclosed for preparing protected epicatechin oligomers having (4β,8)-interflavan linkages. In one process, a tetra-O-protected epicatechin monomer or oligomer is coupled with a protected, C-4 activated epicatechin monomer in the presence of a... | 03/24/2009 |
| 7462629 | Immunosuppressant compounds and compositions The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by... | 12/09/2008 |
| 7462717 | C6-and C9-substituted chromeno[4,3-c]isoxazoline derivatives and their use as anti-depressants The invention concerns substituted tricyclic isoxazoline derivatives, more in particular tricyclic dihydrobenzopyranoisoxazoline, dihydroquinolinoisoxazoline, dihydronaphthalenoisoxazoline and dihydrobenzothiopyranoisoxazoline derivatives substituted on at least one... | 12/09/2008 |
| 7462726 | Conjugated thiophene compound comprising perfluorinated and alkylated sidechains, conductive organic thin film containing the compound, and field-effect type organic transistor employing the thin film A π-conjugated compound has rings represented by Formulae (I) and (II), an odd number of rings being interposed between the rings of Formula (I), and an odd number of rings being interposed between the rings of Formula (II): | 12/09/2008 |
| 7462336 | Apparatus for preparing a dialkyl carbonate An apparatus for preparing a dialkyl carbonate comprises means for reacting an alkanol, oxygen, carbon monoxide, and a catalyst to form a mixture comprising a dialkyl carbonate, an alkyl chloroformate, hydrochloric acid, water, carbon dioxide, and carbon monoxide; m... | 12/09/2008 |
| 7459568 | Alpha crystalline form of strontium ranelate Alpha crystalline form of strontium ranelate of formula (I): characterized by its powder X-ray diffraction diagram and by a water content of from 22 to 24%. Medicinal products containing the same which are useful in... | 12/02/2008 |
| 7459567 | Substituted thienyl and furyl acylguanidines and methods of their use as beta-secretase modulators The present invention provides a substituted thienyl or furyl acylguanidine compound of formula I The present invention also provides methods for the inhibition of β-secretase (BACE) and for the treatment of β-amyloid dep... | 12/02/2008 |
| 7459564 | Substituted biaryl compounds as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein.... | 12/02/2008 |
| 7456316 | Anthraquinone dyes The present invention relates to a compound of formula (I) wherein R1 is a radical of formula (II) R2 is —NH2 or a radical of formula (II), R3 and R4 are each independently of the other hydrogen, hydroxy, —N... | 11/25/2008 |
| 7456296 | Method for preparation of crystalline perindopril erbumine A process for preparation of crystalline perindopril erbumine of formula (II) which exhibits the X-ray (powder) diffraction pattern like that shown in FIG. 2 The process comprises reacting a solution of peri... | 11/25/2008 |
| 7456221 | Prodrugs of excitatory amino acids This invention relates to synthetic excitatory amino acid prodrugs and processes for their preparation. The invention further relates to methods of using, and pharmaceutical compositions comprising, the compounds for the treatment of neurological disorders and psych... | 11/25/2008 |
| 7456211 | Peptide deformylase inhibitors The present invention involves novel anti-bacterial compounds represented by Formula (I), pharmaceutical compositions thereof, their use as PDF inhibitors, and their use in the treatment of bacterial infections. ... | 11/25/2008 |
| 7453001 | Isoxazole derivatives and process for producing the same The present invention provides isoxazole derivatives represented by the following formula (I): (wherein R1 represents a hydrogen atom, C1-C20 hydrocarbon group or —C(═O)OR1a (... | 11/18/2008 |
| 7452913 | Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors The present invention relates to polymorphs of the 3-pyrrole substituted 2-indolinone compound 5-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-pyrrolidin-1-yl-ethyl)-amide. ... | 11/18/2008 |
| 7452915 | Antiparasitic artemisinin derivatives (endoperoxides) This invention relates to the use of certain C-10 substituted derivatives of artemisinin of general formula (I) in the treatment and/or prophylaxis of diseases caused by infection with a parasite, certain novel C-10 substituted derivatives of artemisinin, processes ... | 11/18/2008 |
| 7452999 | Chemical process for the preparation of intermediates to obtain -formyl hydroxy-lamine compounds Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) m... | 11/18/2008 |
| 7452997 | Tetrahydro-indazole cannabinoid modulators This invention is directed to a tetrahydro-indazole cannabinoid modulator compound of formula I: and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease. | 11/18/2008 |
| 7453000 | Substituted oxazolobenzoisothiazole dioxide derivatives method for production and use thereof The invention relates to compounds of formula (I), where the groups have the meanings set forth herein and the physiologically-acceptable salts thereof. The compounds are suitable as medicaments for lowering blood sugar levels and for prevention and treatment of dia... | 11/18/2008 |
| 7452992 | Heterocyclic compounds as CCR5 antagonists The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an... | 11/18/2008 |
| 7449585 | Indazol-3-ones and analogues and derivatives thereof which modulate the function of the vanilloid-1 receptor (VR1) Compounds of formula (I), which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1). ... | 11/11/2008 |
| 7449486 | Mitotic kinesin inhibitors and methods of use thereof This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pha... | 11/11/2008 |
| 7449459 | Inhibitors of soluble adenylate cyclase The invention relates to compounds of general formula I as well as the production and use thereof as a medication. ... | 11/11/2008 |
| 7449426 | Catalyst composition without antimony or molybdenum for ammoxidation of alkanes, a process of making and a process of using thereof Disclosed is a catalyst composition which does not contain antimony or molybdenum for the vapor phase ammoxidation of alkanes of the general empirical formula: VWaBibMcOx wherein M is one or more elemen... | 11/11/2008 |
| 7449715 | Poly[bis(ethynyl)heteroacene]s and electronic devices generated therefrom An electronic device comprising a polymer of Formula or structure (I) wherein R1 is hydrogen, halogen, a suitable hydrocarbon, or a heteroatom containing group; R2 is hydrogen, a suitable hydrocarbon, ... | 11/11/2008 |
| 7446120 | Peptidomimetic modulators of cell adhesion Peptidomimetics of cyclic peptides, and compositions comprising such peptidomimetics are provided. The peptidomimetics have a three-dimensional structure that is substantially similar to a three-dimensional structure of a cyclic peptide that comprises a cadherin cel... | 11/04/2008 |
| 7446214 | Method for purifying oxybisphthalic anhydrides A method for purifying dianhydrides is provided. In one aspect, purified oxybisphthalic anhydrides, intermediates useful in the preparation of polyetherimides are provided. In one embodiment, a first solution containing a dianhydride compound, a solvent, and a phase... | 11/04/2008 |
| 7446204 | Amino substituted aryloxybenzylpiperidine derivatives This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmac... | 11/04/2008 |
| 7442808 | Antidiabetic bicyclic compounds Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful a... | 10/28/2008 |
| 7442806 | Processes for preparing darifenacin hydrobromide The invention encompasses processes for the preparation of darifenacin hydrobromide. ... | 10/28/2008 |
| 7442804 | Process for the preparation of furopyrroles The present invention relates to a process for the preparation of furopyrroles of general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein A1 and A2... | 10/28/2008 |
| 7442801 | Pyrazole compound A pyrazole compound of formula (a): wherein R1 represents C1-C4 alkyl or trifluoromethyl, R2 represents C1-C4 alkyl, R3 represents hydrogen or C1-C6 alkyl; R4 represents halogen a... | 10/28/2008 |
| 7442717 | Substituted 2-aminoimidazoles, process for their preparation, their use as medicament or diagnostic aid Novel substituted 2-aminoimidazoles of formula I, process for their preparation, their use as medicament or diagnostic aid, and medicament containing them. The compounds of this type are useful in the prevention or treatment of various disorders and can be employed ... | 10/28/2008 |
| 7442704 | Amide derivatives The invention concerns amide derivatives of Formula (Ia) wherein X is —NHCO— or —CONH—; m is 0-3; R1 is a group such as hydroxy, halogeno, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; n is 0-2; R2 is a group su... | 10/28/2008 |
