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| Number | Title | Issue Date |
| 7045638 | Pigment dispersants based on diketopyrrolopyrrole compounds and pigment preparations The invention provides novel pigment dispersants of the formula (I) in which is a radical of the formula (Ia) s is a number from 0.1 to 4.0 and n is a number fr... | 05/16/2006 |
| RE38963 | Pyrazoline derivatives, their preparation and application as medicaments The present invention relates to new pyazoline derivatives of formula and to physiologically acceptable salts thereof, to the method for their preparation and to their application as medicaments. ... | 01/31/2006 |
| 6989372 | Antioxidants, preparation methods and uses The invention concerns compounds of general formula (I) (wherein R and R′ represent an alkyl radical or an aryl group and R″ is hydrogen or a CO—R1 group wherein R1 is an alkyl radical or an aryl group; and the dimers formed by the disulp... | 01/24/2006 |
| 6933307 | Fungicidal phenylimine derivatives The invention provides fungicidal compounds of formula I and salts thereof: wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing them and method ... | 08/23/2005 |
| 6924283 | 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents The invention provides a compound of formula I: wherein R1, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof,... | 08/02/2005 |
| 6906093 | Indolinone combinatorial libraries and related products and methods for the treatment of disease The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. ... | 06/14/2005 |
| 6875787 | 10,10-dialkyl prostanoic acid derivatives as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 04/05/2005 |
| 6869951 | Method of changing conformation of a matrix metalloproteinase The present invention provides a matrix metalloproteinase inhibiting compound having structure (VIII) or a salt, an enantiomer, a diastereomer, a racemate, or a tautomer thereof. In other embodiments, the present invention provides a method of changing the conformat... | 03/22/2005 |
| 6838476 | Imidazoles with anti-inflammatory activity Compounds of formula I wherein: one of X or Y represents N and the other represents C; R1 represents hydrogen, methyl, halogen, cyano, nitro, —CHO, —COCH3 or —COOR4; PR2 represents optionally-substituted aryl or hete... | 01/04/2005 |
| 6821994 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a compound of formula (I) (wherein all symbols are as defined in the specification), or a salt thereof as active ingredient. Because of having a... | 11/23/2004 |
| 6818588 | NOx treated mixed metal oxide catalyst A catalyst comprising a mixed metal oxide is useful for the vapor phase oxidation of an alkane or a mixture of an alkane and an alkene to an unsaturated carboxylic acid and for the vapor phase ammoxidation of an alkane or a mixture of an alkane and an alkene to an u... | 11/16/2004 |
| 6809204 | Processes for the preparation of substituted isoxazoles and 2-isoxazolines Provided are compounds, processes and synthetic intermediates useful for the preparation of compounds of the formula I and IX wherein R1 is selected from the group consisting of hydrogen, trihalomethyl, C | 10/26/2004 |
| 6809111 | Prodrugs of COX-2 inhibitors A compound of Formula (I), or a pharmaceutically-acceptable salt thereof, suitable for use in the treatment of a cyclooxygenase-2 mediated disease is provided. Also provided is a pharmaceutical composition comprising a... | 10/26/2004 |
| 6806373 | Process for preparing leflunomide form I New leflunomide Form III is disclosed, along with processes for preparing it. The present invention also provides an economic process for preparing leflunomide Form II and a process for preparing leflunomide Form I from leflunomide Form III. Pharmaceutical compositi... | 10/19/2004 |
| 6806283 | Selective serotonin receptor antagonists and therapeutic applications thereof Spiro[9,10-dihydroanthracene]-9,3′-pyrrolidine (SPAN) and derivatives thereof are provided as selective serotonin receptor antagonists. The compounds are selective, high affinity antagonists of 5-HT2 serotonin receptors. The compounds are useful as anti... | 10/19/2004 |
| 6800778 | Process for producing optically active naphthalene derivative and optical resolver therefor The present invention provides a method of producing an optically active form of a compound represented by the formula (I) having a steroid C17,20-lyase inhibitory activity and is useful as an agent for the prophylaxis or treatment of prostatism, tumor su... | 10/05/2004 |
| 6797829 | Synthesis of a novel paramagnetic amino derivative (epm-5) for labelling chemical and biological macromolecules The present invention refers to the synthesis and application of 2,2,5,5-tetramethylpyrrolidine-N-oxyl-(9-fluorenylmethyloxycarbonyl)-3-amine-4-carboxylic acid, a novel paramagnetic amino acid derivative (spin label), denominated Fmoc-Poac. Fmoc-Poac can be coupled ... | 09/28/2004 |
| 6794084 | Alkali metal hydrogen phosphates as precursors for phosphate-containing electrochemical active materials The present invention relates general to a method for making an alkali metal hydrogen phosphate of the general formula AxH3−xPO4, wherein A is an alkali metal and 0≦x≦3, prepared by admixing an alkali metal-containing compound,... | 09/21/2004 |
| 6794516 | Synthesis of clasto-lactacystin β-lactone and analogs thereof The present invention is directed to an improved synthesis of clasto-lactacystin-β-lactone, and analogs thereof, that proceeds in fewer steps and in much greater overall yield than syntheses described in the prior art. The synthetic pathway relies upon a novel ster... | 09/21/2004 |
| 6790976 | Process for producing aliphatic tricarbonitriles The present invention relates to a process for producing tricarbonitriles corresponding to formula I wherein n is an integer from 2 to 11 by forming an intermediate in the presence of a strong base in a first stag... | 09/14/2004 |
| 6787564 | Optically active clausenamides, process of the preparation thereof, pharmaceutical composition containing the same and their medical use The present invention relates to some new optically active clausenamide derivatives, process of the preparation thereof, a pharmaceutical composition containing the same and their medical use, particularly their use in the respects of hypoxia protective, nootropic a... | 09/07/2004 |
| 6780878 | Antithrombotic amides This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.... | 08/24/2004 |
| 6777437 | Cyclopropylindole derivatives as selective serotonin reuptake inhibitors The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts or solvates thereof and pharmaceutically acceptable formulations comprising said compounds useful for the treatment of depre... | 08/17/2004 |
| 6774239 | Process for the preparation of N,N′-carbonyldiazoles and azolide salts This invention relates to the preparation of N,N′-carbonyldiazoles in a particularly advantageous manner by reacting corresponding azolide salts with phosgene in an aromatic compound or an ether as solvent. The azolide salts are preferably prepared by a novel proc... | 08/10/2004 |
| 6770644 | Hydroxamic acid derivatives, process for the production thereof and drug containing the same as the active ingredient Hydroxamic acid derivatives of the formula (I) (wherein all the symbols have the same meaning as defined in the specification.), non-toxic salt thereof or prodrugs thereof. The compounds of the formula (I) ... | 08/03/2004 |
| 6765106 | Process for preparing a branched olefin, a method of using the branched olefin for making a surfactant, and a surfactant A process for preparing branched olefins comprising 0.5% or less quaternary aliphatic carbon atoms, which process comprises dehydrogenating an isoparaffinic composition over a suitable catalyst which isoparaffinic composition comprises paraffins having a carbon numb... | 07/20/2004 |
| 6759409 | Inhibitors of papilloma virus A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as ... | 07/06/2004 |
| 6759429 | Pyrrole derivatives Pyrrole derivatives represented by the following formula: wherein Ring Z is an optionally substituted pyrrole ring, etc.; W2 is —CO—, —SO2—, an optionally substituted C1-C4 | 07/06/2004 |
| 6756499 | Process for the preparation of novel diol-functionalized UV absorbers The invention pertains to a process for the preparation of a novel UV absorbing diol of the general formula: wherein R1 is hydrogen, tert-butyl; X1 is selected the group consisting of hydrogen, halo... | 06/29/2004 |
| 6756384 | Imidazole compounds A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatm... | 06/29/2004 |
| 6756398 | Positive modulators of nicotinic receptor agonists Compounds of Formula I wherein R1a, R1b, R2b, R3b, R3a, R2a, B1, B2, Z, A2 and A1 are as defined in the specif... | 06/29/2004 |
| 6750243 | Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such a... | 06/15/2004 |
| 6750353 | Preparation of pharmaceutically acceptable atorvastatin salts in non-crystalline form Non-crystalline, in particular amorphous, pharmaceutically acceptable atorvastatin salts, especially the calcium salt, are prepared from atorvastatin lactone or from a compound of formula (I) where A denotes a common pro... | 06/15/2004 |
| 6750351 | Method of production of 2-cyanoimino-1, 3-thiazolidine A method for producing high purity 2-cyanoimino-1,3-thiazolidine comprising the steps of: reacting an alkali metal cyanide compound, an alkali metal hydroxide, a lower alcohol and chlorine in an aqueous solution to form an carboimidic acid ester solution, the... | 06/15/2004 |
| 6750230 | Pyrazole derivatives This invention relates to the use of pyrazole derivatives of the formula and pharmaceutically acceptable salts and solvates thereof, in the manufacture of a reverse transcriptase inhibitor or modulator, to certain novel ... | 06/15/2004 |
| 6750255 | Calcium receptor-active compounds A novel calcium receptor active compound having the formula is provided: Ar1—[CR1R2]p—X—[CR3R4]q—[CR5R6]—NR7—[CR8R | 06/15/2004 |
| 6747025 | Kinase inhibitors for the treatment of disease The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell poliferation. ... | 06/08/2004 |
| 6747145 | Photochromic bis-naphthopyran compounds and methods for their manufacture The invention provides photochromic bis-naphthopyran compounds as well as methods for their manufacture and their use. The bis-naphthopyran compounds of the invention exhibit a wide range of color, i.e., from pink to purple to blue gray, upon activation by a source ... | 06/08/2004 |
| 6747157 | Processes for the preparation of oxo-oxazoline or alloamino acid derivatives A method for producing a compound represented by the general formula (I-A) or the general formula (I-B), comprising the following step: wherein R1 is an optionally substituted lower alkyl, and the like; R... | 06/08/2004 |
| 6747051 | m-Amino-phenylimino-imidazolidine derivatives for treating urinary incontinence A compound of Formula I or of Formula II wherein: R1 is F, Cl, Br, CH2F, CF2H, or CF3; R2 is NR6R7, where R6 is Me, Et... | 06/08/2004 |
