Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7160993 | Nucleic acids encoding PRO4400 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 01/09/2007 |
| 7157248 | CDNA encoding the human α2 δ4 calcium channel subunit The present invention provides nucleic acid and polypeptide sequences describing a novel isoform of the α2δ subunit of a voltage gated calcium channel, herein named as α2δ-4. The isolated nucleic acid or polypeptide molecule of the invention can be used in diagn... | 01/02/2007 |
| 7153665 | Methods and compositions for screening for modulators of IgE synthesis, secretion and switch rearrangement The invention relates to methods and compositions useful in screening for modulators of IgE synthesis, secretion and switch rearrangement. ... | 12/26/2006 |
| 7122345 | Nucleic acid encoding a NOVX13 polypeptide Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm... | 10/17/2006 |
| 7122630 | SYK-UBP polypeptides and methods of making and isolating same The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molec... | 10/17/2006 |
| 7122332 | Modulators of leukocyte activation, compositions and methods of use The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of diso... | 10/17/2006 |
| 7109318 | Nucleic acids encoding PRO830 The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 09/19/2006 |
| 7101687 | Nucleic acids encoding PRO943 The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 09/05/2006 |
| 7094577 | Insulin and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 08/22/2006 |
| 7084106 | Application of a viral complement inhibitory protein in the treatment and diagnosis of Alzheimer's Disease The present invention provides a novel treatment for senile dementia (Alzheimer's Type), comprising administering an anti-complement protein to a patient in need of such treatment in an amount sufficient to inhibit the complement cascade and thereby inhibit the prod... | 08/01/2006 |
| 7083932 | Nucleic acid molecules encoding peptides having pronociceptive properties The present invention is related to nucleic acid molecules, the peptides encoded by said nucleic acid moleucles and the inhibitors direacted against said nucleic acid molecules or said peptides. The present invention concerns also the pharmaceutical composition, the... | 08/01/2006 |
| 7081354 | Interleukin and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 07/25/2006 |
| 7081241 | Extracellular rage binding protein (EN-RAGE) and uses thereof The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of an EN-RAGE peptide with a RAGE peptide, which comprises: (a) admixin... | 07/25/2006 |
| 7074910 | PRO4340 nucleic acids The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 07/11/2006 |
| 7074897 | Pro943 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 07/11/2006 |
| 7071305 | Isolated hOAT polypeptide This invention is concerned with human organic anion transporter (“hOAT”). Isolated nucleic acid encoding hOAT is provided, along with ioslated hOAT polypeptide. hOAT nucleic acid and/or hOAT polypeptide are employed in transgenic animals, recombinant cells, rep... | 07/04/2006 |
| 7071159 | Inhibitor of vascular endothelial cell growth factor The vascular endothelial cell growth factor (VEGF) inhibitors of the present invention are naturally occurring or recombinantly engineered soluble forms with or without a C-terminal transmembrane region of the receptor for VEGF, a very selective growth factor for en... | 07/04/2006 |
| 7070955 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 07/04/2006 |
| 7070946 | Bone metabolism related protein and gene thereof The present invention is directed to a novel method of detecting a function or activity of a polypeptide which is related to bone metabolism, in particular, differentiation (maturation) of osteoblast or morphological change (retraction), specifically relating to a p... | 07/04/2006 |
| 7071310 | Antibody against the human toll- like receptor 2 (tlr2) and uses thereof The present invention relates to an antibody capable of binding to human TLR2 and which (i) binds only to CD14+ cells in a normal human mononuclear cell population, and not to CD14− cells; (ii) does not inhibit LPS-induced activation of norma... | 07/04/2006 |
| 7067477 | Canine erythropoietin gene and recombinant protein One aspect of the present invention is an isolated nucleic acid molecule encoding canine erythropoietin. The present invention also relates to an isolated canine erythropoietin protein or polypeptide. Another aspect of the present invention is a method for providing... | 06/27/2006 |
| 7067277 | Chimeric G proteins and uses thereof This invention provides isolated nucleic acids encoding chimeric G proteins, vectors comprising nucleic acids encoding chimeric G proteins, cells comprising such vectors, processes of determining agonists and antagonists of mammalian G protein-coupled receptors util... | 06/27/2006 |
| 7067117 | Compounds and methods to inhibit or augment an inflammatory response Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided. ... | 06/27/2006 |
| 7060793 | Circularly permuted fluorescent protein indicators Polynucleotides encoding fluorescent indicators, which contain a sensor polypeptide inserted within a fluorescent moiety, are provided, as are polypeptides encoded by such polynucleotides. Also provided are circularly permuted fluorescent polypeptides and polynucleo... | 06/13/2006 |
| 7057022 | Antibodies which specifically bind to TNF-R Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed. ... | 06/06/2006 |
| 7056687 | Methods and compositions for screening for altered cellular phenotypes The invention relates to methods and compositions useful for screening for altered cellular phenotypes using an inducible expression system to enrich for and detect the altered phenotypes and, more particularly, relates to screening libraries of candidate bioactive ... | 06/06/2006 |
| 7057015 | Hormone receptor functional dimers and methods of their use The invention provides chimeric proteins having at least two functional protein units, each containing the dimerization domain of a member of the steroid/thyroid hormone nuclear receptor superfamily. The chimeric proteins can fold under crystallization conditions to... | 06/06/2006 |
| 7056701 | Hormone and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 06/06/2006 |
| 7056688 | LDL receptor signaling assays The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction of a low density lipoprotein (LDL) receptor binding polypeptide with ... | 06/06/2006 |
| 7053121 | Compositions and methods for regulating circadian rhythms The present invention provides methods of effecting a change in the core circadian clock by modulating retinoid nuclear receptors. ... | 05/30/2006 |
| 7053184 | Purified human erythropoietin receptor protein fragment and antibodies derived therefrom A E. coli recombinant plasmid expressing a fusion protein having the human erythropoietin receptor extracellular domain is disclosed. A purified fusion protein produced from such a vector is also disclosed, the fusion protein having a cleavage site suitable f... | 05/30/2006 |
| 7052850 | Isolated human EDG-4 receptor A novel, isolated EDG receptor that upon activation results in increased induction of IL-8 or NF-κB. Preferably, the EDG receptor is a human EDG-4 receptor, which has an amino acid sequence shown in FIGS. 16A and 16B, or a variant of these sequences h... | 05/30/2006 |
| 7049425 | Methods and compositions utilizing an alternative splice variant of the sigma-1 receptor A new variant of the sigma-1 (σ1)receptor is useful in screening compounds useful in the imaging and treatment of proliferative masses (i.e., tumors). This new variant, named sigma—1β (σ1β) finds particular use in the non-invas... | 05/23/2006 |
| 7049094 | Methods for identifying modulators of N-type ion channel inactivation Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an α-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compoun... | 05/23/2006 |
| 7049083 | Methods for identifying modulators of N-type ion channel inactivation Methods and compositions for identifying compounds which disrupt the functional interaction of an intracellular receptor region of an α-subunit of a voltage-gated ion channel and an amino-terminal inactivation region of an ion channel protein are disclosed. Compoun... | 05/23/2006 |
| 7045595 | Hemopoietin receptor protein, NR12 A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and... | 05/16/2006 |
| 7045497 | Use of peptide The present invention relates to use of peptide to which G-protein coupled receptor protein recognizes as a ligand. Since the ligand polypeptide of the present invention has a stimulating action on oxytocin secretion, it is useful as a drug for ameliorating, preserv... | 05/16/2006 |
| 7045303 | Screening methods for compounds useful in the treatment of polycystic kidney disease The present invention provides cell-based screening assays designed to identify agents that regulate the activity of the polycystic kidney disease proteins encoded by the PKD-1 and PKD-2 genes and that may be useful in the treatment of polycystic kidney disease. The... | 05/16/2006 |
| 7045308 | Modulators of leukocyte activation, compositions and methods of use The present invention provides compositions and methods for modulating leukocyte activation. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating leukocyte activation are provided. Compositions and methods for the treatment of diso... | 05/16/2006 |
| 7041478 | G-CSF and albumin fusion protein Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucl... | 05/09/2006 |
