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| Number | Title | Issue Date |
| 7078481 | Potassium channel interactors and uses therefor The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated activities. The invention also provides antisense nucleic acid molecules, reco... | 07/18/2006 |
| 7074589 | Nucleic acids encoding BDP-1 Nucleic acid molecules encoding full length PTP20, PCP-2, BDP1, mCLK2, mCLK3, mCLK4, and SIRP polypeptides, portions of such nucleic acid molecules, nucleic acid vectors containing such nucleic acid molecules, recombinant cells containing such nucleic acid vectors, ... | 07/11/2006 |
| 6989435 | Compounds and methods to inhibit or augment an inflammatory response Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided. ... | 01/24/2006 |
| 6955894 | Method for producing TNF receptor releasing enzyme The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are method for identifying... | 10/18/2005 |
| 6930084 | Treating arthritis with TNF receptor releasing enzyme The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifyin... | 08/16/2005 |
| 6911314 | Screening for drugs that affect TNF receptor releasing enzyme The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifyin... | 06/28/2005 |
| 6893858 | Human kcnq5 potassium channel, methods and compositions thereof An isolated polynucleotide encoding a novel potassium channel polypeptide, KCNQ5, that is expressed primarily in brain and skeletal muscle is described. The new polypeptide has been cloned and isolated from a human brain cDNA library and is a member the KCNQ family ... | 05/17/2005 |
| 6891028 | Nucleic acids encoding transferrin receptor-like proteins The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the nucleic acids of the present invention, host cells transformed therewi... | 05/10/2005 |
| 6884590 | Methods of screening for ulcerative colitis and crohn's disease A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-... | 04/26/2005 |
| 6867017 | ATP-binding transporter (ABC7) and methods for detection of anemia and ataxia Disclosed is a novel ATP-binding cassette gene (ABC7), polypeptide and methods of detecting mutations therein. Further, the disclosure provides methods of detecting ABC7 associated disease and treatments thereof. In particular, the disclosure provides methods of det... | 03/15/2005 |
| 6855507 | Method of screening for pharmaceuticals by detecting cross talk between intracellular signals and intranuclear receptors Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-β super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAK1, and the knowledge of interaction of Smad molecule with intranu... | 02/15/2005 |
| 6849727 | DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nu... | 02/01/2005 |
| 6835546 | Drosophila G protein coupled receptors, nucleic acids, and methods related to the same The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention a... | 12/28/2004 |
| 6833440 | Human Elk, a voltage-gated potassium channel subunit The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening fo... | 12/21/2004 |
| 6833240 | Very low density lipoprotein receptor polymorphisms and uses therefor Polymorphic nucleic acid molecules encoding the very low density lipoprotein receptor are described, as well as gene products encoded by these nucleic acid molecules. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are al... | 12/21/2004 |
| 6824777 | Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies that specifically bind such polypeptides, and uses therefor. ... | 11/30/2004 |
| 6825324 | Antibodies to receptor protein tyrosine kinases The protein tyrosine kinase receptors, designated Rse and HPTK6, have been purified from human and/or murine cell tissues. Rse and HPTK6 have been cloned from a cDNA library of a human liver carcinoma cell line (i.e., Hep 3B) using PCR amplification. Provided herein... | 11/30/2004 |
| 6818419 | IRAK-4: compositions and methods of use The present invention provides nucleic acids and polypeptides for IRAK-4, a novel member of the IRAK family of protein kinases. Members of the IRAK family are indispensable signal transducer for members of the IL-1R/Toll family of transmembrane receptors, including ... | 11/16/2004 |
| 6818758 | Estrogen receptor beta variants and methods of detection thereof The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor beta genes and novel polymorphism in the estrogen receptor gene/protein. Such polymorphism can lead to a variety of disord... | 11/16/2004 |
| 6806352 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 10/19/2004 |
| 6806061 | G protein-coupled receptor gene and methods of use therefor The present invention relates to isolated and/or recombinant nucleic acids which encode a mammalian (e.g., human) receptor protein designated C-C Chemokine Receptor 3 (CKR-3) or Eos L2, and to proteins or polypeptides, referred to herein as isolated, recombinant mam... | 10/19/2004 |
| 6803448 | GBS toxin receptor A novel GBS toxin receptor, and methods for its preparation and use are provided. GBS toxin receptor polynucleotides and polypeptides are provided as well as detection, screening, and therapeutic methods and pharmaceutical compositions involving such polynucleotides... | 10/12/2004 |
| 6797811 | Antibodies to chemokine receptor 88C The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the ide... | 09/28/2004 |
| 6794161 | Potassium channels and genes encoding these potassium channels This invention relates to novel potassium channels and genes encoding these channels. More specifically the invention provides isolated polynucleotides encoding the KCNQ4 potassium channel, cells transformed with these polynucleotides, transgenic animals comprising ... | 09/21/2004 |
| 6790626 | Human pyrimidine receptor The present invention concerns a new receptor having a preference for pyrimidine nucleotides, preferably UTP, or purine nucleotides and UDP, and which has an amino acid sequence having more than 60% homology with the amino acid sequence shown in FIG. 1. ... | 09/14/2004 |
| 6787355 | Multipotent neural stem cells from peripheral tissues and uses thereof This invention relates to multipotent neural stem cells, purified from the peripheral nervous system of mammals, capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, ... | 09/07/2004 |
| 6783952 | Secreted soluble α2δ-2, α2δ-3 or α2δ-4 calcium channel subunit polypeptides and screening assays using same Soluble α2δ sub-type polypeptides. Methods for cloning, expression and purification of freely soluble α2δ subtype polypeptides. A method for the screening of ligands which bind to soluble α2δ subtype polypeptides.... | 08/31/2004 |
| 6777536 | EPH receptor ligands, and uses related thereto The present invention relates to the discovery of a novel EPH receptor ligand, referred to hereinafter as “Elf-1”, which protein has apparently broad involvement in the formation and maintenance of ordered spatial arrangements of differentiated tissues in verteb... | 08/17/2004 |
| 6770742 | Use of inhibitors for the treatment of disorders related to RTK hyperfunction, especially cancer The present invention concerns the use of inhibitors for the treatment and/or prophylaxis of diseases which are the consequence of increased receptor tyrosine kinase activity, particularly cancer. The use is particularly directed towards inhibition or lowering of th... | 08/03/2004 |
| 6767995 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 07/27/2004 |
| 6762290 | High affinity vascular endothelial growth factor (VEGF) receptor nucleic acid ligands and inhibitors Methods are described for the identification and preparation of high-affinity nucleic acid ligands to a VEGF receptor. Included in the invention are specific RNA ligands to a VEGF receptor identified by the SELEX method. Also included are RNA ligands that inhibit th... | 07/13/2004 |
| 6750200 | M2GlyR derived channel forming peptides The present invention provides a family of peptides based upon the M2GlyR sequence. These peptides are derivatives of the M2GlyR sequence and can be modified at their ends to include a plurality of polar amino acid residues to enhance their solubility. Particularly ... | 06/15/2004 |
| 6723535 | Secreted and transmembrane polypeptides and nucleic acids encoding the same The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 04/20/2004 |
| 6723522 | Sodium bicarbonate cotransporter protein The present invention relates to a protein having a Na+—HCO3− cotransporter activity and a DNA encoding it. The present protein and the present DNA can be used as or for [1] obtaining an antibody and antiserum, [2] constru... | 04/20/2004 |
| 6716587 | Antibodies to interleukin-4 receptors and uses thereof Mammalian Interleukin-4 receptor proteins, DNAs and expression vectors encoding mammalian IL-4 receptors, and processes for producing mammalian IL-4 receptors as products of cell culture, are disclosed. A method for suppressing an IL-4-dependent immune or inflammato... | 04/06/2004 |
| 6713053 | Use of IL-7 for treating auto-immune diseases and insulin-dependent diabetes mellitus in particular The use of interleukin 7 or T cells pre-incubated in the presence of IL-7 for preparing a drug or pharmaceutical composition for treating an auto-immune disease, particularly an auto-immune disease induced by a defect in CD4+ T cell immunoregulation, is disclosed. | 03/30/2004 |
| 6709839 | SYK-UBP proteins, compositions and methods of use The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molec... | 03/23/2004 |
| 6709831 | DNA encoding mammalian neuropeptide FF (NPFF) receptors and uses thereof This invention provides isolated nucleic acids encoding mammalian NPFF receptors, purified mammalian NPFF receptors, vectors comprising nucleic acid encoding mammalian NPFF receptors, cells comprising such vectors, antibodies directed to mammalian NPFF receptors, nu... | 03/23/2004 |
| 6703222 | Soluble LDL receptor, its production and use DNA encoding a soluble LDL receptor protein, is provided, as are vectors, cell lines and processes for the production of the protein, mutein or fragment. The soluble LDL receptor protein, and its muteins and fragments, are useful in protection of mammals ... | 03/09/2004 |
| 6699687 | Circularly permuted fluorescent protein indicators The present invention provides polypeptide and polynucleotides encoding fluorescent indicators having inserted within a fluorescent moiety a sensor polypeptide. Also provided are methods of using the fluorescent indicator. Circularly permuted fluorescent ... | 03/02/2004 |
