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| Number | Title | Issue Date |
| 5929060 | Method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue The present invention is related to a method for enhancing or accelerating re-epithelialization or re-endothelialization of a tissue. Examples of re-epithelialization in which the invention is particularly suited include, but are not limited to, re-epithe... | 07/27/1999 |
| 5773640 | N-N-(3,3-dimethylbutyl)-L-A-aspartyl!-L-hexahydrophenylalanine 1-methyl ester useful as a sweetening agent, its method of preparation Novel sweetening compound characterized in that it is N-N-(3,3-dimethylbutyl)-L--aspartyl!-L-hexahydrophenylalanine 1-methyl ester of formula: ##STR1## and its method of preparation characterized in that an aqueous/alcohol solution of p... | 06/30/1998 |
| 5767304 | Catalytic asymmetric aminohydroxylation of olefins with carbamates ଲ-Hydroxyamines and ଲ-hydroxycarbamates are synthesized from olefin substrates by means on a catalyzed asymmetric addition reaction. The addition reaction is catalyzed by osmium and is co-catalyzed by chiral ligands. The chiral ligands, in add... | 06/16/1998 |
| 5756813 | Hindered aromatic ester compounds useful as anti-viral agents Y is O or S; R1 is hydrogen, halogen, C1 -C4 alkyl or C1 -C4 alkoxy; R2 is hydrogen, halogen, C1 -C4 alkyl, C1 -C4 alkoxy, C2 -C4 | 05/26/1998 |
| 5750709 | Method and apparatus for isolating therapeutic compositions from source materials Method and apparatus are described for isolating natural therapeutic compositions from source materials. The method and apparatus isolate natural therapeutic compositions from waxes, fats, oils and other constituents of the source material with the use of... | 05/12/1998 |
| 5739381 | Disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate, its preparation and pharmaceutical compositions in which it is present The present invention relates to disodium 4-chlorophenylthiomethylenebisphosphonate monohydrate. The invention further relates to the method of preparing this monohydrate. The invention further relates to the pharmaceutical compositions in which disodium tilud... | 04/14/1998 |
| 5723647 | N-(4-bromo-2-fluorobenzyl)carbamates and a process for their preparation N-(4-Bromo-2-fluorobenzyl)carbamates and a process for their preparation The invention relates to N-(4-bromo-2-fluorobenzyl)carbamates of the formula (I), ##STR1## where R is (C1 -C12)alkyl, benzyl or phenyl, where the benzyl an... | 03/03/1998 |
| 5714605 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/03/1998 |
| 5710320 | Diaryliodonium fluoroalkyl sulfonate salts and a method of making The present invention provides a convenient, simple, safe and efficient one-pot method for the synthesis of a number of diarlyiodonium triflate salts which does not involve sulfuric acid and which eliminates the need for any counter-ion exchange processes... | 01/20/1998 |
| 5708026 | Cyclohexane derivatives This invention concerns compounds of generic formula: ##STR1## or a pharmaceutically acceptable salt thereof, where the dotted line represents an optional bond, one of R1 and R5 represents hydrogen, C1 -C6 alkyl... | 01/13/1998 |
| 5703261 | Process for the production of sulfuric acid semi-esters The invention relates to a process for the production of sulfuric acid semi-esters of general formula I RO--SO2 --OH (I), in which R represents an organic radical, from hydroxy compounds of general formula II... | 12/30/1997 |
| 5698745 | Hydroformylation process A hydroformylation process for the production of linear aldehydes of an olefin, with hydrogen and carbon monoxide in a solvent containing a catalyst having a platinum component, a bidentate diaryl phosphine component where the bridging group is ferrocenyl... | 12/16/1997 |
| 5698732 | Oxanilide U-V absorbers Oxalic acid diarylamides are described as useful monomers and comonomers in the polymerization of polycarbonates. The resin products resist degradation by ultra-violet light radiation. They can also be incorporated as comonomer or monomer in the polyester... | 12/16/1997 |
| 5696128 | Method of regulating immune function Disclosed are methods for rectifying or ameliorating abnormal responses of mammalian immune systems. Also disclosed are methods for modifying normal responses of the mammalian immune system. Further disclosed are methods for accomplishing the foregoing by... | 12/09/1997 |
| 5696286 | Process for the preparation of aromatic-substituted aliphatic carboxylic acids A process for the preparation of aromatic substituted carboxylic acids is disclosed. The process comprises i) forming an aromatic-substituted acrylonitrile by dehydrating a cyanohydrin of the formula ##STR1## where Ar is C6 to C10 | 12/09/1997 |
| 5693855 | Process for the synthesis of fluorinated sulfonic acids Process for the preparation of a fluorinated sulphonic acid compound by hydrolysis of a corresponding fluorinated sulphonyl fluoride in the presence of a tertiary amine, comprising steps of (a) recovering a mixture of a salt of the fluorinated sulphonic acid w... | 12/02/1997 |
| 5693854 | Ethylene dicysteate sequestrants and methods for preparation Novel compounds useful as sequestrants as well as builders for detergent compositions and methods for their preparation are disclosed.... | 12/02/1997 |
| 5691381 | Hydroxamic and carbocyclic acids as metalloprotease inhibitors The present invention provides novel hydroxamic acids and carbocyclic acids and derivatives thereof and to pharmaceutical compositions and methods of use of these novel compounds for the inhibition of matrix metalloproteinases, such as stromelysin, and in... | 11/25/1997 |
| 5688990 | Substituted azetidinone compounds useful as hypocholesterolemic agents Substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar1 is R3 -substituted aryl; Ar2 is R4 -substituted aryl; Ar3 is R | 11/18/1997 |
| 5688945 | Compounds The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I ##STR1## wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, ... | 11/18/1997 |
| 5688996 | Ethyene containing cysteate sequestrants and methods of manufacture Novel compounds useful as sequestrants as well as builders for detergent compositions and methods for their preparation are disclosed.... | 11/18/1997 |
| 5686646 | Chiral hydrazine derivatives Disclosed are chiral hydrazine derivatives of the formula (Ia), (Ib), (Ic) and (Id) ##STR1## wherein: R1 and R2 are independently C1 -C10 alkyl; R3 is H or R4 wherein R4 is a hyd... | 11/11/1997 |
| 5686438 | Methods for preventing progressive tissue necrosis, reperfusion injury, bacterial translocation and adult respiratory distress syndrome The present invention is directed to a method for preventing or reducing ischemia following injury, such as reperfusion injury following ischemia, cellular damage associated with ischemic episodes, such as infarctions or traumatic injuries, and thus to pr... | 11/11/1997 |
| 5686479 | Immunosuppressive drug An immunosuppressive drug, an autoimmune disease treating drug, an immunosuppression enhancing drug and a cell adhesion inhibitor, each containing a thienotriazolodiazepine compound wherein the 2-position of its diazepine ring is alkylated as an active in... | 11/11/1997 |
| 5684184 | Process for preparation of sulphonates Sulphonates are prepared by the neutralization of a sulphonic acid with a basic hydroxide or Oxide. The process requires the staged addition of sulphonic acid to a reaction mixture comprising basic hydroxide or oxide dispersed in water/diluent mixture; th... | 11/04/1997 |
| 5684182 | Sulfonated diphosphines and a process for their preparation The present invention relates to sulfonated diphosphines of the formula (I) ##STR1## where M is hydrogen, ammonium, a monovalent metal or the equivalent of a polyvalent metal, a, b, c and d are each 0 or 1, with the proviso that a+b+c+d is an integer... | 11/04/1997 |
| 5684175 | C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor The synthesis of paclitaxel obtained from the semi-synthesis of taxol using a protected baccatin III backbone which is esterified with a suitably protected side chain acid, thereby producing an intermediate which may be acylated and deprotected to produce... | 11/04/1997 |
| 5681838 | Substituted amino compounds, their preparation and their use as inhibitors of thrombocyte-aggregation The present invention relates to novel substituted amino compounds of the formula I: R1 -(A)a -(B)b -(D)c -(CH2)m -N(R2)-(CH2)n -R3 as defined in the ... | 10/28/1997 |
| 5679842 | Process for the preparation of aminomethanephosphonic acid and aminomethylphosphinic acids Aminomethanephosphonic acid and aminomethylphosphinic acids are interesting as biologically active compounds or as intermediates for the preparation of biologically active compounds. According to the invention, such compounds of the formula I ##STR1#... | 10/21/1997 |
| 5676923 | Substituted DTPA monoamides of the central carboxylic acid group and their metal complexes Diethylenetriaminepentaacetic acid monoamide derivatives, their complexes and complex salts, containing an element of atomic numbers 21-29, 31, 32, 39, 42-44, 49 or 57-83, pharmaceutical agents containing these compounds, their use as contrast media and p... | 10/14/1997 |
| 5676926 | Process for the production of DTPA-tetraesters of terminal carboxylic acids The invention relates to a process for the production of diethylenetriaminepentacarboxylic acid tetraesters of general formula I ##STR1## in which R1 and Z have different meanings.... | 10/14/1997 |
| 5675041 | Direct hydroformylation of a multi-component synthesis gas containing carbon monoxide, hydrogen, ethylene, and acetylene The invention is a process for production of C3 to C6 aldehydes by hydroformylating a mixture containing: (a) C2 to C5 olefins and mixtures thereof, and (b) (i) C2 to C5 alkynes and mixtures ... | 10/07/1997 |
| 5672740 | Alkoxylated alkyl glyceryl ether sulfonates and method of preparing A process for preparing alkoxylated alkyl glyceryl ether sulfonates which comprises reacting in the presence of water and the absence of ethanol a mixture of alkoxylated glycidyl ethers having as the major quantity of alkoxylated material ##STR1## ... | 09/30/1997 |
| 5672739 | Class of three tail surfactants law388 The present invention comprises a novel composition of matter having the general formula: ##STR1## wherein R1 is H or an alkoxide of from 5 to about 20 carbon atoms; x is an integer of from about 8 to 22 when R1 =H and from about 2 t... | 09/30/1997 |
| 5672741 | Process for the hydrolysis of fluorinated sulphonyl fluorides A process for base hydrolysis of a fluorinated sulphonyl fluoride by treatment of the fluoride with at least one mole equivalent of water in a basic solvent for a sufficient time to obtain a salt of a corresponding fluorinated sulphonic acid with the basi... | 09/30/1997 |
| 5672708 | Process for the preparation of N-arylaminoacrylic acid derivatives and the use of N-arylaminoacrylic acid derivatives thus prepared for the preparation of 4-quinolone-3-carboxylic acid derivatives N-arylaminoacrylic acid derivatives are obtained in good yields and in high purities when benzoylacetic acid derivatives are reacted with N-arylimino ethers. The products thus prepared are used, in particular, for the preparation of 4-quinolone-3-carboxyl... | 09/30/1997 |
| 5672771 | Integrated process for the production of ter-amyl alkyl ethers Integrated process for the production of ter-amyl alkyl ethers which comprises the feeding of a C5 hydrocarbon stream to an etherification reactor and the recycling of the remaining stream to the same reactor, after treatment in an isomerizatio... | 09/30/1997 |
| 5670602 | Synthesis of tyrosine-derived diphenol monomers A method for preparing diphenol compounds, which method includes the steps of coupling a hydroxyphenyl carboxylic acid with a L-tyrosine ester in a water-miscible organic reaction solvent containing a carbodiimide capable of forming a water-soluble urea b... | 09/23/1997 |
| 5668121 | Glutamate (NMDA) receptor antagonists Novel naphthyl-substituted -amino acid derivatives, pharmaceutical compositions containing the same and a method of using the same, for the blockade of aspartate and glutamate receptors, are described. Novel intermediates of the napthyl-substituted... | 09/16/1997 |
| 5665777 | Biphenyl hydroxamate inhibitors of matrix metalloproteinases Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases a... | 09/09/1997 |
