Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 8183355 | Method for the synthesis of oligonucleotide derivatives Method for the synthesis of nucleotide derivatives wherein molecules of interest are grafted on the oligonucleotide with the help of a “click chemistry” reaction between an azide function on the molecule of interest and an alkyne function on the oligonucleotide,... | 05/22/2012 |
| 8178704 | Inositol-phosphate derivatives and method of detecting inositol-1-phosphate The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being... | 05/15/2012 |
| 8178360 | Dye compounds and the use of their labelled conjugates Novel rhodamine dye compounds, labelled conjugates comprising the dyes are described, together with methods for their use. The dyes and labelled conjugates are useful as molecular probes in a variety of applications, such as in assays involving staining of cells, pr... | 05/15/2012 |
| 8173445 | DNA intercalating agents The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used, for example, to genotype and sequence a nucleic acid. In a preferred ... | 05/08/2012 |
| 8173198 | Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers Intermediates and methods for forming activated metal complexes bound to surfaces on oxide layers, immobilizing beads to the modified surface and articles produced thereby are described. Hydroxyl groups on the oxide surfaces are reacted with a metal reagent complex ... | 05/08/2012 |
| 8168381 | Template directed split and mix systhesis of small molecule libraries The present invention provides a method for combining the advantages of encoded molecule fragments made by split and mix synthesis with the advantages of template directed synthesis of molecules. The method provided in the invention comprises the steps of: Adding a ... | 05/01/2012 |
| 8168583 | 2-fluoronucleosides 2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: | 05/01/2012 |
| 8163897 | 5-bromo-2′-deoxy-uridine labeled nucleotide triphosphates and nucleic acid probes and methods of making and using the same 5-bromo-2′-deoxy-uridine (BrdU) labeled nucleotide triphosphates and nucleic acid probes are described herein. The BrdU labeled nucleotide triphosphates include a linker between the nucleotide triphosphate and the BrdU moiety. The linker can be cleavable or non-cl... | 04/24/2012 |
| 8158346 | Labelled nucleotides Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group. ... | 04/17/2012 |
| 8153361 | Dynamic and combinatorial synthesis of polymerase primers This invention relates to the field of nucleic acid chemistry, more specifically to compositions of matter that are nucleic acid analogs, and processes that use them. Still more specifically, these compositions comprise two fragments of DNA-like molecules, each havi... | 04/10/2012 |
| 8153780 | Reporter unit for detection of target molecules using polymerisable substrate The invention relates to a reporter unit for detecting a target molecule comprising at least one component attached to a target molecule specific probe, wherein said at least one component is liberated from said probe by the activity of a first enzyme thereby making... | 04/10/2012 |
| 8153365 | Oligonucleotide analogues The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to olig... | 04/10/2012 |
| 8153773 | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger RNA cap New RNA cap analogs are disclosed containing one or more phosphorothioates groups. The analogs also contain modifications at the 2′-O position of 7-methylguanosine that prevent them from being incorporated in the reverse orientation during in vitro synthesis of mR... | 04/10/2012 |
| 8148503 | Nucleotides and nucleosides and methods for their use in DNA sequencing The present invention relates generally to labeled and unlabled cleavable terminating groups and methods for DNA sequencing and other types of DNA analysis. More particularly, the invention relates in part to nucleotides and nucleosides with chemically cleavable, ph... | 04/03/2012 |
| 8148516 | Flowcell systems for single molecule detection The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In opera... | 04/03/2012 |
| 8148064 | Labelled nucleotides Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group. ... | 04/03/2012 |
| 8133669 | Chemically modified nucleoside 5′-triphosphates for thermally initiated amplification of nucleic acid Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods a... | 03/13/2012 |
| 8133701 | Detection and quantification of biomolecules using mass spectrometry The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleo... | 03/13/2012 |
| 8133987 | Primer array synthesis and validation Methods are presented for generating large sets for polymers. The methods employ high density oligonucleotide array. ... | 03/13/2012 |
| 8133702 | Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing Engineered nucleotide compositions, having polymerase interacting components that improve the interactivity of the polymerase and the nucleotide, particularly for nucleic acid sequencing applications. Compositions include the interactive polymerases along with the n... | 03/13/2012 |
| 8129159 | Attachment of molecules to surfaces The present invention relates to methods, reagents, and substrates that can be used for, for example, immobilizing biomolecules, such as nucleic acids and proteins. In an embodiment, the present invention relates to surfaces coated with a polymer according to the pr... | 03/06/2012 |
| 8129529 | UV excitable fluorescent energy transfer dyes Novel energy transfer dyes which can be used with shorter wavelength light sources are provided. These dyes include a donor dye with an absorption maxima at a wavelength between about 250 to 450 nm and an acceptor dye which is capable of absorbing energy emitted fro... | 03/06/2012 |
| 8129517 | Labeled solid supports for organic synthesis The disclosed invention pertains to improved oligonucleotide manufacturing methods, including novel support compositions that are optionally labeled, their methods of preparation and use. The compositions and methods are particularly well suited for high throughput ... | 03/06/2012 |
| 8129111 | Fluorescent water-soluable conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric microparticles and/or nanoparticles comprising the water-soluble conju... | 03/06/2012 |
| 8129106 | Sequence-specific detection of methylation in biomolecules A method for detecting sequence specific methylation in a biomolecule, comprising: (a) contacting the biomolecule with an S-adenosyl-L-methionine-dependent methyltransferase in the presence of a detectable cofactor of said methyltransferase; and (b) detecting whethe... | 03/06/2012 |
| 8129107 | Bisulfite conversion of DNA The present invention relates to an improved method for the bisulfite conversion of DNA. In certain time-temperature ranges the efficacy of the bisulfite conversion is clearly improved. By combination with denaturating solvents, new reaction conditions and new purif... | 03/06/2012 |
| 8124333 | Methods for covalent linking of optical reporters A method to link a light emitting reporter to biomolecules with nucleotide oligomers is described. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light re... | 02/28/2012 |
| 8114636 | Labeling and detection of nucleic acids Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling nucleic acids with an azide group. ... | 02/14/2012 |
| 8114973 | Nucleotide analogs The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids. ... | 02/14/2012 |
| 8105770 | Method of detecting amplification or deletion in genomic DNA Fragment [PROBLEMS] To provide a CGH method, in particular a CGH microarray method, enabling detection at an elevated accuracy and elevated sensitivity. [MEANS FOR SOLVING PROBLEMS] A method which comprises: (a) labeling a test genomic DNA fragment that is a cell-orig... | 01/31/2012 |
| 8101737 | Parallel preparation of high fidelity probes in an array format The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from about 101 to about 105 different sequences, gener... | 01/24/2012 |
| 8093367 | Preparation and isolation of 5′ capped mRNA The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool ... | 01/10/2012 |
| 8093186 | Biopolymeric arrays having replicate elements A method for designing an array is provided. In certain embodiments, this method includes grouping probes into a plurality of ranked groups of probes; and designing an array comprising the ranked groups of probes, wherein the array contains more replicates of probes... | 01/10/2012 |
| 8088904 | Tetrahydropyran nucleic acid analogs The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, th... | 01/03/2012 |
| 8088575 | Massive parallel method for decoding DNA and RNA This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction.... | 01/03/2012 |
| 8084590 | Labelled nucleotides The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group ... | 12/27/2011 |
| 8084589 | Phosphoramidite nucleoside analogs Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or severa... | 12/27/2011 |
| 8084201 | Fluorescent molecule It is an object of the present invention to provide an on-off type fluorescent compound (a fluorescence-producing molecule system) used in gene analyses, which is highly stable (namely, being active for a long period of time) and highly sensitive, and which enables ... | 12/27/2011 |
| 8080644 | Oligonucleotide analogues The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs (Locked Nucleoside Analogues), are able to provide valuable improvements to olig... | 12/20/2011 |
| 8071739 | Modified nucleotides The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a gro... | 12/06/2011 |
