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| Number | Title | Issue Date |
| 8173369 | Peripheral gene expression biomarkers for autism The disclosed invention comprises methods and materials for screening cells for genetic profiles associated with autism spectrum disorders. The methods typically involve isolating a cell from an individual and then observing the expression profile of one or more gen... | 05/08/2012 |
| 8173387 | Method of examining chemical using gene-disrupted strain A method having higher sensitivity in a bioassay method utilizing cell response of a microorganism, for detecting the presence of a chemical in a test specimen is provided. The method of the present invention is characterized in that it uses specified gene-disrupted... | 05/08/2012 |
| 8168385 | Methods and compositions for tagging and identifying polynucleotides The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subuni... | 05/01/2012 |
| 8163493 | Targets for use in diagnosis, prognosis and therapy of cancer Provided herein are targets that can be used for the diagnosis, prognosis and therapy of a variety of cancers. ... | 04/24/2012 |
| 8158360 | Effects of inhibitors of FGFR3 on gene transcription Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or ad... | 04/17/2012 |
| 8153378 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 04/10/2012 |
| 8153380 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 04/10/2012 |
| 8153379 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 04/10/2012 |
| 8153772 | Oligonucleotide probes and primers comprising universal bases for diagnostic purposes Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease. ... | 04/10/2012 |
| 8148115 | Device and method for extraction and analysis of nucleic acids from biological samples Device and methods for extracting and analyzing nucleic acids from biological samples. ... | 04/03/2012 |
| 8148067 | Methods for diagnosing and monitoring the status of systemic lupus erythematosus The invention presents a method of diagnosing or monitoring the status of systemic lupus erythematosus (SLE) in a subject or patient comprising detecting the expression of all genes of a diagnostic set in the subject or patient wherein the diagnostic set comprises t... | 04/03/2012 |
| 8148068 | Methods and compositions for tagging and identifying polynucleotides The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subuni... | 04/03/2012 |
| 8143388 | Method and test kit for quantitative determination of polynucleotides in a mixture The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solut... | 03/27/2012 |
| 8137919 | Method of determining the sensitivity of cancer cells to EGFR inhibitors including cetuximab, panitumumab and erlotinib A method of determining if a cancer patient is amenable to treatment with EGFR inhibitors including but not limited to cetuximab, panitumumab or erlotinib by the following steps: (a) Obtaining cells from a cancer patient's tumor; (b) Determ... | 03/20/2012 |
| 8129122 | Method of predicting metastasis of oral cavity cancer into cervical lymph node and diagnosis kit to be used in the prediction A method for objectively predicting possibility of metastasis to a cervical lymph node in an early stage for an individual case diagnosed as an oral cavity cancer, and a diagnosis kit to be used in the prediction are provided. The method includes a step of assaying ... | 03/06/2012 |
| 8119385 | Nucleic acids and proteins and methods for making and using them The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and... | 02/21/2012 |
| 8110364 | Methods and compositions for diagnosing or monitoring autoimmune and chronic inflammatory diseases Methods of diagnosing or monitoring an autoimmune or chronic inflammatory disease, particularly SLE in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diag... | 02/07/2012 |
| 8110362 | Method for determining a tongue cancer An object is to provide: a method for determining a tongue cancer in which the malignancy of tongue cancer can be objectively and accurately determined; a method for analyzing a tongue cancer tissue specimen; and a kit for analyzing a tongue cancer tissue specimen. ... | 02/07/2012 |
| 8110653 | Collections of repeat proteins comprising repeat modules A collection of repeat proteins, each repeat protein comprising a repeat domain, which comprises a set of consecutive repeat modules, wherein each of the repeat modules is derived from one or more repeat units and wherein the repeat units comprise framework residues... | 02/07/2012 |
| 8110363 | Expression profiles to predict relapse of prostate cancer The present invention provides a method for preparing a reference model for cancer relapse prediction that provides higher resolution grading than Gleason score alone. The method encompasses obtaining from different individuals a plurality of prostate carcinoma tiss... | 02/07/2012 |
| 8110361 | DNA methylation markers associated with the CpG island methylator phenotype (CIMP) in human colorectal cancer Particular aspects confirm the existence of a CpG island methylator phenotype (CIMP) in colorectal cancer, and provide novel validated DNA methylation markers associated with CIMP. Additional aspects provide novel methods and compositions for: determining CIMP statu... | 02/07/2012 |
| 8105785 | Mylks as modifiers of branching morphogenesis and methods of use Human MYLK genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening f... | 01/31/2012 |
| 8101577 | Oxidative DNA damage protection Provided herein are methods of screening compounds, gene sequences, and gene products in bacteria for agents that are protective against oxidative DNA damage in a human or animal. Gene sequences identified by these screens can also be used in diagnostic assays that ... | 01/24/2012 |
| 8092998 | Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders The invention provides methods for predicting responsiveness to TNFα inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictiv... | 01/10/2012 |
| 8084209 | HMGCR isoforms in prediction of efficacy and identification of cholesterol-modulating compounds The present invention provides methods for assessing a subject's responsiveness to a HMGCR inhibitor therapy, and selection of a HMGCR inhibitor therapy based upon such methods. The invention further provides methods for identifying agents that modulate HMGCR activi... | 12/27/2011 |
| 8076084 | Method of predicting metastatic potential prognosis or overall survival of cancer patients A method of predicting metastatic potential, prognosis or overall survival of cancer patients is provided. The method utilizes reliable markers, HIF-1α, TWIST or Snail, to predict the probability of the metastatic potential, prognosis situation or overall survival ... | 12/13/2011 |
| 8076138 | Evolution of whole cells and organisms by recursive sequence recombination The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number... | 12/13/2011 |
| 8071305 | Microarray-mediated diagnosis of herpes virus infection by monitoring host's differential gene expression upon infection The present invention discloses disease-associated molecules and assays, which are useful for diagnosing and assessing those animals with herpes virus infection, and determining those animals at risk of developing an herpes virus infection or its sequelae. The inven... | 12/06/2011 |
| 8071307 | Method of detecting relative risk for the onset of atopic dermatitis by gene single nucleotide polymorphism analysis The present invention provides a method of discriminating a relative risk for the morbidity of atopic dermatitis of a test subject comprising: analyzing gene polymorphism of two or more of genes related to onset of atopic dermatitis using a sample isolated from a st... | 12/06/2011 |
| 8067178 | Gene expression markers for prediction of patient response to chemotherapy The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment ... | 11/29/2011 |
| 8067184 | Optoelectronic detection system The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sampl... | 11/29/2011 |
| 8058005 | Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray A method and apparatus for real-time, simultaneous, qualitative measurement of one or more single nucleotide polymorphisms in one or more target nucleic acids is provided. This method involves combining a polymerase chain reaction (PCR) technique with an evanescent ... | 11/15/2011 |
| 8053193 | Method and apparatus for judging the presence or absence of cancer cell The invention provides a method for judging whether cancer cells are present or not in a sample, comprising a obtaining step of obtaining values related to an expression level of a caner marker gene and a housekeeping gene; a first comparing step of comparing the va... | 11/08/2011 |
| 8048634 | Cancer screening method A method for screening cancer comprises the following steps: (1) providing a test specimen; (2) detecting the methylation rate of the CpG sequence in at least one target gene of the test specimen, wherein the target genes is consisted of PTPRR, ZNF582, PDE8B and DBC... | 11/01/2011 |
| 8039690 | Stress-regulated genes of plants, transgenic plants containing same, and methods of use Clusters of plant genes that are regulated in response to one or more stress conditions are provided, as are isolated plant stress-regulated genes, including portions thereof comprising a coding sequence or a regulatory element, and to consensus sequences comprising... | 10/18/2011 |
| 8034566 | Enhanced sequencing by hybridization using pools of probes The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a t... | 10/11/2011 |
| 8029995 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 10/04/2011 |
| 8026060 | Gene expression markers for colorectal cancer prognosis A method of predicting clinical outcome in a subject diagnosed with colorectal cancer comprising determining evidence of the expression of one or more predictive RNA transcripts or their expression products in a biological sample of cancer cells obtained from the su... | 09/27/2011 |
| 8021840 | Diagnostic marker for interferon responsiveness in multiple sclerosis Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon the... | 09/20/2011 |
| 8017327 | Single nucleotide polymorphism genotyping detection via the real-time invader assay microarray platform A method and apparatus for real-time, simultaneous, quantitative measurement for detecting a single nucleotide polymorphism in a target nucleic acid is provided. This method involves combining a polymerase chain reaction (PCR) technique with invader assay technique.... | 09/13/2011 |
