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| Number | Title | Issue Date |
| 7056735 | Mimetics and inhibitors of the interaction between Vpr (HIV viral protein of regulation) and ANT (Mitochondrial adenine nucleotide translocator) The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleot... | 06/06/2006 |
| 7033781 | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating An invention comprising cellular transformation, directed evolution, and screening methods for creating novel transgenic organisms having desirable properties. Thus in one aspect, this invention relates to a method of generating a transgenic organism, such as a micr... | 04/25/2006 |
| 7008790 | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae A method of immunization, and compositions therefor, are provided for substantially preventing or reducing the symptoms of at least one infectious disease and at least one chronic immune mediated disorder. An immunogenic challenge which supplements the normal childh... | 03/07/2006 |
| 6974686 | Recombinant tryptophan mutants of influenza Recombinant PB2 tryptophan variant influenza viruses, RNA, cDNA and vectors are provided. Also provided are immunogenic compositions containing the variant viruses, methods of producing such viruses and methods for the prophylactic treatment of influenza in humans. | 12/13/2005 |
| 6969598 | Methods for producing high titre vectors and compositions used in such methods A method for producing viral vectors is described using packaging and producer cell lines is described. The producer cell comprises: (i) a first nucleotide sequence (NS) encoding a toxic viral envelope protein operably linked to a promoter; wherein the promoter is o... | 11/29/2005 |
| 6964869 | Method and composition for skin grafts A chimeric skin comprising immortalized human keratinocyte cells cocultured with donor keratinocytes is disclosed. ... | 11/15/2005 |
| 6960431 | Therapeutic compositions and methods for treating viral infection Methods for inhibiting viral propagation and treating viral infection are provided which include administering to cells infected with viruses a therapeutic peptide or a derivative thereof. ... | 11/01/2005 |
| 6949337 | Cellular receptor for HIV-1 Vpr essential for G2/M phase transition of the cell cycle The present invention provides methods of identifying anti-HIV compound by contacting human Vpr Interacting Protein (hVIP), or a fragment thereof known to interact with Vpr, with Vpr, or a fragment thereof known to interact with hVIP in the presence of a test compou... | 09/27/2005 |
| 6939689 | Exonuclease-mediated nucleic acid reassembly in directed evolution This invention provides methods of obtaining novel polynucleotides and encoded polypeptides by the use of non-stochastic methods of directed evolution (DirectEvolution™). A particular advantage of exonuclease-mediated reassembly methods is the ability to reassembl... | 09/06/2005 |
| 6927031 | Methods for identifying polypeptide factors interacting with RNA The present invention relates to methods of screening for target polypeptides that bind to RNA, using affinity purification methods, and the use of such target polypeptide for drug discovery and in methods of treating and preventing disease, e.g., HCV infection.... | 08/09/2005 |
| 6924095 | Retrovirus isolated from mantle histiocytes in mantle cell lymphoma The present invention features an isolated, intact virus associated with human lymphoma, and originally isolated from a mantle cell lymphoma, referred to herein as a mantle histiocyte retrovirus (MHRV). The invention also features compositions and methods for detect... | 08/02/2005 |
| 6908734 | Sulfated CCR5 peptides for HIV-1 infection This invention provides a compound comprising the structure: θαYDINYYTSEβλ wherein each T represents a threonine, each S represents a serine, each E represents a glutamic acid, each Y represents a tyrosine; each D represents an aspartic acid, each I represents a... | 06/21/2005 |
| 6900035 | Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins This document describes compositions and methods for inducing an immune response (e.g., a cellular response such as a cell-mediated cytolytic immune response) to a human papillomavirus (HPV) antigen, which can be displayed by HPV or exhibited by infected cells (e.g.... | 05/31/2005 |
| 6893813 | Methods for treatment of HIV and other infections using a T cell or viral activator and anti-retroviral combination therapy Disclosed is a method for treating infection with a pathogen. The method involves administration of: (1) a substance which induces active pathogen replication in a cell latently infected with HIV and (2) an anti-pathogen drug. Also disclosed are methods for expandin... | 05/17/2005 |
| 6835372 | Compositions comprising an active agent The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention possesses superior aerosol properties and is thus preferred for aerosol... | 12/28/2004 |
| 6835536 | Antimicrobial cationic peptides and formulations thereof Compositions and methods for making and using therapeutic formulations of antimicrobial cationic peptides are provided. The antimicrobial cationic peptide formulations may be used, for example, in the treatment of microorganism-caused infections, which infections ma... | 12/28/2004 |
| 6833254 | Method to identify IRES elements A method to identify internal ribosome entry site (IRES) elements using a bicistronic expression system for reporter proteins is described. The IRES elements thus identified are useful in identifying trans-acting translation factors and as antiviral agents. ... | 12/21/2004 |
| 6828105 | Antisense antiviral agent and method for treating ssRNA viral infection The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds are substant... | 12/07/2004 |
| 6821778 | Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells This invention relates to methods of using human dendritic cells to present antigens for the induction of antigen-specific T cell-mediated immune responses. In particular, it relates to the isolation of dendritic cells from human blood, exposing the cells to antigen... | 11/23/2004 |
| 6821753 | Replication incompetent herpes viruses for use in gene therapy Use of a replication incompetent herpes virus capable of delivering a gene to multiple connected sites within the nervous system, which virus comprises: (a) a mutation which prevents or reduces the expression of at least two immediate early genes; and (b) a heterolo... | 11/23/2004 |
| 6821744 | Method, assay, and kit for quantifying HIV protease inhibitors A method for quantifying an HIV protease inhibitor in a sample includes combining HIV protease, a conjugate comprising an HIV protease inhibitor analog, and a sample suspected of containing an HIV protease inhibitor. The HIV protease and the conjugate are capable of... | 11/23/2004 |
| 6821723 | GP41 antigen The present invention comprises novel polypeptide antigens that can be used for therapeutic and prophylactic immunization against HIV-related infections. The polypeptide of the invention mimics the intermediate state of gp41 and is capable of inducing antibodies whi... | 11/23/2004 |
| 6818199 | Media and methods for enhanced medical imaging Metal nanoparticles are described that are useful for enhancing the contrast of x-rays or other radiation sources. A method is disclosed whereby the agents are administered intravenously or intra-arterially to detect coronary senses and other vascular features. It i... | 11/16/2004 |
| 6818748 | Cloning, expression, sequencing, and functional enhancement of monoclonal ScFv antibody against Venezuelan equine encephalitis virus (VEE) A single chain variable fragment (ScFv) antibody from a monoclonal antibody (Mab) against Venezuelan equine encephalitis (VEE) virus, is generated by cloning linked variable regions of the heavy (VH) and the light (VL) chain antibody genes. Mab... | 11/16/2004 |
| 6815201 | HIV-1 gp120 V1/V2 domain epitopes capable of generating neutralizing antibodies The invention features a protein which includes a gp120 V1/V2 domain of an HIV-1 strain and not a gp120 V3 domain of an HIV-1 strain, which protein does not substantially bind CD4. The gp120 V1/V2 domain of the protein displays an epitope which is recognized by an a... | 11/09/2004 |
| 6815158 | Methods for judging resistance to the onset of bovine leukemia A method for judging a resistance to the onset of bovine leukemia caused by bovine leukemia virus BLV, wherein a bovine individual, in which amino acids specified by the amino acid numbers 74, 77 and 78 of β1 domain of bovine MHC Class II DRβ chain are Glu, Arg an... | 11/09/2004 |
| 6811971 | Method for the detection of influenza A/B viruses The invention concerns a method for the detection of an infection with influenza A and/or influenza B virus comprising the steps: i) obtaining a saliva sample, ii) preparing the saliva sample for a detection reaction and iii) detecting the influenza A and/or influen... | 11/02/2004 |
| 6812025 | Two hybrid assay that detects HIV-1 reverse transcriptase dimerization This invention provides methods of determining whether a compound inhibits HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse tran... | 11/02/2004 |
| 6812026 | Antibodies directed against binding-associated epitopes Binding of two members of a binding couple reveal epitopes which are revealed only after binding and the monoclonal antibody secreted from the hybridoma cell line CG-10 directed against these epitopes bind to the bound couple at a significantly higher affinit... | 11/02/2004 |
| 6808877 | Ligands for FPR class receptors that induce a host immune response to a pathogen or inhibit HIV infection The present invention relates to the discovery of molecules that inhibit viral infection and promote a host immune response to a pathogen. More specifically, the invention disclosed herein concerns molecules that interact with a FPR class receptor, inhibit HIV infec... | 10/26/2004 |
| 6806055 | HIV envelopolype peptides A method for the rational design and preparation of vaccines based on HIV envelope polypeptides is described. In one embodiment, the method for making an HIV gp120 subunit vaccine for a geographic region comprises determining neutralizing epitopes in the V2 and/or C... | 10/19/2004 |
| 6806045 | Method for the identification of a receptor A method for the identification and characterization of a receptor in target tissue for which a selected vector has affinity, wherein a transfected cell line expressing the receptor is added to a suspension of encapsulated microbubbles to which the selected vector i... | 10/19/2004 |
| 6806046 | Methods for HIV sequencing and genotyping Methods are provided for amplifying regions of the HIV pol gene amplifying double-stranded nucleic acid template derived from HIV tube RT-PCR with novel PCR primers to produce amplified target sequences. Methods are also provided for analyzing the nucleotide sequenc... | 10/19/2004 |
| 6794174 | Full-length infectious cDNA clones of tick borne flavivirus Embodiments described herein include full-length infectious cDNA clones of Langat tick-borne flavivirus. ... | 09/21/2004 |
| 6790641 | Lentiviral vector particles resistant to complement inactivation The present invention provides a retroviral gene delivery system that resists complement inactivation through the incorporation of a complement regulatory protein into retroviral particles. In particular, the present invention provides a lentiviral packaging system ... | 09/14/2004 |
| 6787333 | Retrovirus isolated from humans The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spum... | 09/07/2004 |
| 6787351 | Adenovirus carrying gag gene HIV vaccine An adenoviral vector is described which carries a codon-optimized gag gene, along with a heterologous promoter and transcription terminator. This viral vaccine can effectively prevent HIV infection when administered to humans either alone or as part of a prime and b... | 09/07/2004 |
| 6783981 | Anti-viral vectors A viral vector production system is provided which system comprises: (i) a viral genome comprising at least one first nucleotide sequence encoding a gene product capable of binding to and effecting the cleavage, directly or indirectly, of a second nucleotide sequenc... | 08/31/2004 |
| 6783939 | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines The present invention provides methods and compositions comprising a population of alphavirus replicon particles comprising two or more isolated nucleic acids selected from 1) an isolated nucleic acid encoding an env gene product or an immunogenic fragment thereof o... | 08/31/2004 |
| 6777178 | Antibodies for judging possibility of the onset of bovine leukemia A c143 monoclonal antibody which is used for detecting a bovine individual having a possibility of onset of bovine leukemia; a monoclonal antibody which is used for detecting a bovine individual having a possibility of onset of bovine leukemia, wherein the monoclona... | 08/17/2004 |
