Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 6177549 | Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates, and uses thereof This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclid... | 01/23/2001 |
| 6114507 | Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody An anti-Fas ligand antibody capable of suppressing Fas ligand-induced apoptosis to a high degree, especially humanized antibodies having less antigenecity to human, and a method for assaying the Fas ligand in human body fluid utilizing such an antibody. M... | 09/05/2000 |
| 6113918 | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors Aminoalkyl glucosamine phosphate compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 ... | 09/05/2000 |
| 6083478 | Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 Immunoconjugates, and uses thereof An immunoconjugate which consists of a cytotoxic radionuclide and a homodimer comprising two heavy chains, the cytotoxic radionuclide being linked to the heavy chains dirctly or using a bifunctional chelator and a composition which comprises the immunocon... | 07/04/2000 |
| 6077662 | Virus-like particles, methods and immunogenic compositions The present disclosure provides retrovirus-like particles which comprise retrovirus env proteins, immunogenic compositions comprising retrovirus-like particles, methods for the production of retrovirus-like particles and methods for the protection of an a... | 06/20/2000 |
| 6060587 | Cellular receptor for HIV-1 VPR essential for G2/M phase transition of the cell cycle The present invention is directed to substantially pure human Vpr Interacting Protein (hVIP), and fragments thereof. Also disclosed are isolated nucleic acid molecules that encode hVIP, or a fragment thereof; nucleic acid probes and primers directed to nu... | 05/09/2000 |
| 6051410 | Self-assembled, defective, nonself-propagating viral particles Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted deliver... | 04/18/2000 |
| 6033886 | Recombinant infectious non-segmented negative strand RNA virus The present invention provides the generation of infectious replicating non-segmented negative-stranded RNA virus, entirely from cloned cDNA. This process offers the possibility to introduce mutations into the virus genome by means of recombinant DNA tech... | 03/07/2000 |
| 6034223 | Non-peptidyl moiety-conjugated CD4-gamma2 and CD4-IgG2 immunoconjugates, and uses thereof This invention provides an immunoconjugate which comprises 1) a non-peptidyl toxin and 2) a CD4-gamma2 chimeric heavy chain homodimer linked thereto. This invention also provides an immunoconjugate which comprises 1) a gamma radiation-emitting radionuclid... | 03/07/2000 |
| 6033885 | Integrative recombinant adenoviruses, preparation thereof and therapeutical uses thereof The present invention relates to recombinant adenoviruses having a cassette capable of integrating into the genome of infected cells, their preparation, pharmaceutical compositions containing them, and their use. In particular, the cassette contains at le... | 03/07/2000 |
| 6030769 | Group O HIV-1, fragments of such viruses, and uses thereof Group HIV-1 retrovirus strains, particularly the strains known as BCF02, BCF01, BCF06, BCF07, BCF08, BCF11, BCF03, BCF09, BCF12, BCF13 and BCF14, fragments of said retroviruses, and the uses thereof as a diagnostic reagent and as an immunogen, are disclos... | 02/29/2000 |
| 6020468 | Antibodies directed against binding-associated epitopes Binding of two members of a binding couple reveals epitopes which are revealed only after binding and the monoclonal antibody secreted from the hybridoma cell line CG-10 directed against these epitopes bind to the bound couple at a significantly higher af... | 02/01/2000 |
| 6015564 | Cytotoxic T lymphocyte-inducing lipopeptides and use as vaccines Cytotoxic lymphocyte-inducing lipopeptides comprising a peptide part having between 10 and 40 amino acids approximately and comprising at least one tigenic determinant. The lipopeptides also comprise one or more chains derived from fatty acids and one or... | 01/18/2000 |
| 6015665 | Method and composition for regulating apoptosis Methods and compositions for preventing or inhibiting apoptosis are provided by this invention. The methods require introducing into a cell which may undergo apoptosis a nucleic acid molecule coding for a gene product having crmA biological activity or a ... | 01/18/2000 |
| 6013506 | Feline leukemia virus vaccines Disclosed are recombinant baculovirus expressing the gag, gp70, and gp85 genes of feline leukemia virus. Also disclosed are vaccines based on protein expressed from these recombinants. Also disclosed is a combined mucosal/parenteral inoculation method.... | 01/11/2000 |
| 6007817 | Vasopermeability enhancing immunoconjugates Conjugates having a clinically useful delivery vehicle linked to a biologically active species which acts to increase vascular permeability and expand blood volume at or in proximity to the tumor site are disclosed. The vehicle-linked species may be, for ... | 12/28/1999 |
| 6008044 | Human monoclonal antibodies directed against the transmembrane glycoprotein (gp41) of human immunodeficiency virus-1 (HIV-1) and detection of antibodies against epitope (GCSGKLIC) A method for neutralizing the retrovirus Human Immunodeficiency Virus-1 (HIV-1) through free virus neutralization or fusion inhibition, comprises adding to a cell mixture of HIV-infected and uninfected cells, a neutralizing agent which specifically binds ... | 12/28/1999 |
| 6004799 | Recombinant live feline immunodeficiency virus and proviral DNA vaccines This invention discloses live-attenuated feline immunodeficiency virus (FIV), and recombinant vectors for producing them, useful as vaccines and therapeutic agents against FIV and diseases associated with virulent FIV infection. In the recombinant vectors... | 12/21/1999 |
| 6004763 | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses The invention concerns the use, in the induction of an immune response, of a synthetic microparticle polymer carrying on the surface one or more covalently bonded proteins capable of carrying one or more epitopes, the molecular weight of the protein(s) on... | 12/21/1999 |
| 5997866 | Panel of antibodies for detecting cadherins, catenins and plaque proteins in tissues and method of using the panel There is provided an antibody-based panel for detecting the cadherin family of proteins, the catenin family of proteins and the plaque family of proteins in tissues for the diagnosis and prognostic assessment of human tumors. The panel includes a set of a... | 12/07/1999 |
| 5994516 | Mutated proteins encoded by a lentivirus mutated env gene, peptide fragments and expression vectors Mutated proteins coded by a mutated env gene of a lentivirus, particularly FIV, HIV or CAEV, peptide fragments contained in said mutated proteins and expression vectors expressing said mutaded proteins as well as the applications thereof are described. Th... | 11/30/1999 |
| 5994055 | HIV trans-activator Tat binding to CDK7 and activation of CTD phosphorylation The present invention relates to methods of inhibiting Tat trans-activation in a cell and methods of assaying for inhibitors of Tat trans-activation.... | 11/30/1999 |
| 5989688 | Composite nonwovens and methods for the preparation thereof A composite nonwoven for controlled acquisition and distribution of liquid, comprising at least a first support layer and a first bulky layer, the bulky layer functioning to acquire and distribute liquid and the support layer being suitable for use either... | 11/23/1999 |
| 5989562 | Recombinant raccoon pox viruses and their use as an effective vaccine against feline immunodeficiency virus infection The present invention provides recombinant raccoon poxviruses (RRPVs) useful in vaccines for the prophylaxis of disease caused by feline immunodeficiency virus (FIV). RRPVs according to the invention have at least one internal gene comprising a DNA sequen... | 11/23/1999 |
| 5985636 | Method and compositions for inhibiting oxidation Anthocyanin containing fractions isolated from tart cherries and exhibiting inhibition of oxidation when introduced into various materials is described. The fractions are particularly useful in high and low moisture foods.... | 11/16/1999 |
| 5985318 | Fusogenic liposomes that are free of active neuraminidase Liposomes which have present on their surface a polypeptide capable of binding to a mucosal cell surface of a human or animal and which are substantially free of active neuraminidase are useful as vaccines.... | 11/16/1999 |
| 5981040 | Holographic imaging A holographic image produced by the impression of a shim onto a metallic ink coating comprising a plurality of metallic particles suspended in a resinous ink binder. A resinous or substantially tactile and nonresilient undercoat can be applied to the subs... | 11/09/1999 |
| 5972666 | Assembly-deficient herpesvirus vaccine A vaccine is described which comprises an assembly-deficient herpesvirus. The mutant herpesvirus is capable of infecting and undergoing DNA replication in the cells of a susceptible mammal, but is defective in capsid assembly and formation of mature virio... | 10/26/1999 |
| 5972448 | Nanocomposite polymer container The container of the present invention is composed of a polymer material integrated with a plurality of nanosize particles of a clay mineral which act to enhance the barrier properties of the container. The polymer material may be PET, COPET or any mixtur... | 10/26/1999 |
| 5972511 | Process for forming low thermal expansion pyrolytic nitride coatings on low thermal expansion materials and coated article A coated article of a stoichiometric coating composition of pyrolytic PB(Si)N on low thermal expansion carbon, graphite or ceramic materials and process of forming the coated article. The process involves introducing reactant vapors, under appropriate dep... | 10/26/1999 |
| 5968542 | High viscosity liquid controlled delivery system as a device A composition as a medical or surgical device is provided that includes: (i) a non-polymeric, non-water soluble liquid carrier material (HVLCM) of viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological cond... | 10/19/1999 |
| 5961984 | Human T-cell lymphotropic virus type I envelope protein and human monoclonal antibodies specific therefor Isolated and purified envelope protein of HTLV-I is provided devoid of non-envelope protein of HTLV-I and having substantially the same conformation as the envelope protein in native HTLV-I. The protein is produced recombinantly using a dual vaccinia/T7 p... | 10/05/1999 |
| 5962325 | Three-dimensional stromal tissue cultures The present invention relates to a method of stimulating the proliferation and appropriate cell maturation of a variety of different cells and tissues in three-dimensional cultures in vitro using TGF-ଲ in the culture medium. In accordance with the i... | 10/05/1999 |
| 5962635 | Therapeutic compounds A biologically-active peptide fragment of the Nef protein of human immunodeficiency virus is provided, pharmaceutical compositions comprising the peptide, analogs or derivatives of the peptide and therepeutic and screening methods which utilize the peptid... | 10/05/1999 |
| 5962637 | Toxin assay A toxin assay that uses a substrate for cleavage by the toxin and antibodies that do not recognise the substrate but recognise and bind to the product of cleavage of the substrate by the toxin. The substrate can be a nerve cell peptide when the assay is f... | 10/05/1999 |
| 5958765 | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof A highly efficient method for generating human antibodies in particular which are specific to be RSV fusion protein which combines in vitro priming of human spleen cells and antigen boosting in SCID mice is taught. This method provides for very high human... | 09/28/1999 |
| 5955364 | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof Novel human monoclonal antibodies, and their corresponding nucleic acid sequences having high affinity for the human RSV-F protein are provided.... | 09/21/1999 |
| 5948369 | Method and apparatus for exhausting gases from processing tank An exhaust system for a liquid processing vessel or tank including a port provided in a cover of the tank and a closure fixed in the tank to close the port when the cover in a closed position closing the space enclosed by the tank. The cover is movable to... | 09/07/1999 |
| 5942401 | Method of determining favorable prognosis against progressing from an asymptomatic condition to AIDS in an human immunodeficiency virus (HIV) positive subject The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease condition and a favourable prognosis of lack of progression to... | 08/24/1999 |
| 5942390 | Method of diagnosing predisposition for ulcerative colitis in Jewish population by detection of interleukin-1 receptor antagonist polymorphism A novel, differential association between allele 2 of the variable number of tandem repeats polymorphism at intron 2 of the human IL-1 receptor antagonist gene and ulcerative colitis in humans of Jewish ancestry has been discovered. In accordance with the... | 08/24/1999 |
