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| Number | Title | Issue Date |
| 5420162 | Phorbol ester pharmaceutical compositions and their use for treating inflammation The present invention relates to a method of inhibiting the protein kinase C-mediated biological response inflammation. The method comprises administering to a mammal a non-tumor promoting 12-deoxyphorbol ester. Phorbol esters suitable for use in the meth... | 05/30/1995 |
| 5369111 | Modulator agent and use thereof Sensitizing tumoral cells to anticancerous drugs and/or inhibiting the tumoral cells resistance to antitumoral drugs employing as a modulator agent a vinca alkaloid dimer, analog to vinblastine or vincristine, with a low cytotoxicity or devoid of cytotoxi... | 11/29/1994 |
| 5334615 | Oil with bactericidal and virucidal properties A composition embraces an oil, for instance, a mineral oil, animal oil, or plant or vegetable oil, in combination with an acetal that can release aldehyde functionality on aqueous contact. It may be used in a method for kill or control of bacterium or vir... | 08/02/1994 |
| 5332567 | Detection and treatment of infections with immunoconjugates A method of targeting a diagnostic or therapeutic agent to a focus of infection comprises injecting a patient infected with a pathogen parenterally with an antibody conjugate which specifically binds to an accessible epitope of the pathogen or of a pathog... | 07/26/1994 |
| 5330993 | Immunosuppressive compounds This invention relates to a novel class of immunosuppressive compounds having an affinity for the FK-506 binding protein (FKBP). Once bound to this protein, the immunosuppressive compounds inhibit the prolyl peptidyl cis-trans isomerase (rotamass) activit... | 07/19/1994 |
| 5318992 | Inhibitors of nitric oxide biosynthesis The present invention is a method of treating hypotension and shock using select ornithine or NG -arginine derivatives.... | 06/07/1994 |
| 5317022 | Pharmaceutical composition and use A biologically active preparation for human or veterinary use for the selective blockade of opioid binding sites of the brain responsible for respiratory depression containing in a biologically active quantity the codeinone derivative of general formula (... | 05/31/1994 |
| 5312835 | Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension The present invention involves a method for prophylaxis or treatment of an animal for systemic hypotension induced by endotoxin and/or a biological response modifier such as the cytokines, IFN, TNF, IL-1 or IL-2 and the like. Said method involves administ... | 05/17/1994 |
| 5312818 | Method of protecting against and/or treating ulcerative gastrointestinal conditions using a thromboxane A2 receptor antagonist and combination useful in preventing and/or treating ulcers and/or inflammation A method is provided for protecting against and/or treating ulcerative gastrointestinal conditions, including anti-inflammatory drug-induced gastrointestinal ulcers, using a thromboxane A2 receptor antagonist. In addition, a combination is prov... | 05/17/1994 |
| 5310742 | Uses for thioureylenes This invention provides new uses for the drugs of the thioureylene class and thiabendazole. These new uses include methods of treatment for a variety of conditions and diseases, including psoriasis, other atopic dermatoses and inflammatory conditions havi... | 05/10/1994 |
| 5300493 | Ulcer treatment using choline esters of polysaccharides Acidic polysaccharide esters containing carboxylic groups are useful for protecting against and curing ulcers of the gastro-enteric system. These esters include choline esters with acidic polysaccharide selected from the group consisting of hyaluronic aci... | 04/05/1994 |
| 5298523 | Method for treating transplant patients using mycalamide compounds Mycalamide compounds are derived from marine sponges of the genus Mycale or prepared by synthetic methods. These compounds, and pharmaceutical compositions containing them as active ingredients, are useful as immunomodulatory agents.... | 03/29/1994 |
| 5296503 | Medicaments containing substituted 2-cyclohexene derivatives and their use for the control of candida infections The present invention relates to the use of known substituted 2-cyclohexene derivatives in the control of diseases, in particular bacterial infections and mycoses.... | 03/22/1994 |
| 5296501 | 2,6-diamino-heptandedioic acids A compound selected from the group consisting of a compound of the formula ##STR1## wherein the dotted lines indicate an optionally endo or exo double bond, Y is selected from the group consisting of alkyl, alkenyl and alkynyl of 2 to 18 carbon atoms... | 03/22/1994 |
| 5294430 | Use of dithiocarbamates to treat myelosuppression A process for preventing or ameliorating the myelosuppression which can occur in a mammal such as a human cancer patient being treated with a platinum-free antineoplastic drug is provided, comprising administering an effective dosage of a dithiocarbamate ... | 03/15/1994 |
| 5292764 | Azole derivatives for protecting industrial materials from bacteria Disclosed herein is a method for preventing deterioration of an industrial material by using an azole derivative represented by the following formula ##STR1## wherein X means a halogen atom or a C1 -C5 alkyl, haloalkyl, phenyl, ... | 03/08/1994 |
| 5292497 | Method of reducing chemotherapy toxicity using (methylaminopropylamino)propyl dihydrogen phosphorothioate A method of decreasing the toxicity of chemical therapeutic agents administered in cancer chemotherapy including adminstration to a patient undergoing chemotherapy. This reduction in toxicity can be accomplished by administering an effective amount of S-3... | 03/08/1994 |
| 5290538 | Nephro protective infusion solutions The invention herein is a method of protecting against renal damage in a patient receiving carboplatin, cyclosporine A or cisplatin comprising administering to said patient the following mixture of amino acids consisting of glycine, L-alanine, L-serine, L... | 03/01/1994 |
| 5286718 | Method and composition for ameliorating tissue damage due to ischemia and reperfusion A method of inhibiting tissue damage in warm blooded animals related to reperfusion of tissues after extended periods of ischemia is presented. The method comprises treatment prior to a planned ischemic event or up to six hours after an unplanned ischemic... | 02/15/1994 |
| 5284872 | Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide followed by the reaction of the resulting product with an amino acid, N-acylamino acid, peptide or an N-acyl peptide to produce a th... | 02/08/1994 |
| 5270321 | Use of dicentrine and its derivatives for the treatment of arrhythmia A method of arrhythmia with an effective amount of dicentrine or other alkaloids extracted from Lindera oldhammii (megaphylla) Hemsl.... | 12/14/1993 |
| 5266566 | Method of treating fungal infections using sterodial ester compounds Compounds of the general formula (2): ##STR1## wherein X is a hydrogen atom or a hydroxyl group, Y is a hydrogen atom or a hydroxyl group and R is an alkyl group of 1 to 4 carbon atoms, have anti-fungal activity, especially against organisms selected... | 11/30/1993 |
| 5262180 | Method for treating acute alkali exposure with carbon dioxide The present invention provides a method for combatting damage to a body tissue contacted to an alkali. The method comprising administering CO2 to the subject in an amount sufficient to produce an acidotic state in the tissue, the acidotic state... | 11/16/1993 |
| 5262421 | Use of dicentrine and its derivatives for the treatment of hypertension, arrhythmia, thrombosis and atherosclerosis A method for the treatment of hypertension, arrhythmia, thrombosis or/and atherosclerosis with an effective amount of dicentrine or other alkaloids extracted from Lindera oldhammii (megaphylla) Hemsl.... | 11/16/1993 |
| 5260328 | Phenyl-indenopurazol 3-oxo-propanamide derivatives useful in the treatment of rheumatoid arthritis Heteroaryl-3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents an oxygen atom or a --CH(R4)--, --O--CH(R4)--, --S(O)n --CH(R4)--, --CH(R4)--O--, --CH(R4)--S(O... | 11/09/1993 |
| 5260284 | Methods employing unique mixtures of polar and neutral lipids and sterol for lung surfactant replacement therapy The present invention discloses unique methods employing mixtures of phospholipids and neutral lipids for surfactant replacement therapy in the treatment of the various forms of respiratory distress syndrome. These compositions are shown to greatly enhanc... | 11/09/1993 |
| 5254541 | (Quinolin-2-ylmethoxy)indole/cyclodextrin complex A complex of cyclodextrin and 3-[N-(p-chlorobenzyl)-3-(t-buthylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl] -2,2-dimethylpropanoic acid, sodium salt is more soluble in water than the sodium salt alone. The complex is useful as an anti-asthmatic, anti-all... | 10/19/1993 |
| 5250442 | Method of treating rheumatoid arthritis using tetracycline A method of treating rheumatoid arthritis which includes first, taking a blood test to determine a rate of erythrocyte sedimentation and a rheumatoid factor, and then fasting for a 12-hour period prior to orally administering a 500 milligram dosage of tet... | 10/05/1993 |
| 5248668 | Use of purpurogallin and glycosides thereof in treating ischemia in mammals Purpurogallin and its mono- and di-glucosides are useful as cytoprotective agents. Patient-administrable compositions for addition to a patient's blood to minimize oxyradical damage caused by ischemia-reperfusion injury that may result in various surgical... | 09/28/1993 |
| 5244671 | Derivatives of porphycene for photodynamic therapy of cancer New porphycene compounds useful as photodynamic therapy agents. The porphycene compounds have an active group capable of binding to proteins and peptides and facilitating decomposition of the porphycenes following therapy.... | 09/14/1993 |
| 5238928 | Methods and materials for obtaining phenotypic females despite androgen administration Methods for producing phenotypic female mammals intended for human or animal consumption despite androgen administration to obtain the benefits thereof, which methods include prenatally exposing said female mammals to androgen by administering to the moth... | 08/24/1993 |
| 5234949 | Parenteral solutions containing amiodarone in acetate buffer solution Disclosed herein are parenteral solutions containing 3-diethylaminoethoxybenzoyl-benzofurans, such as amiodarone, in acetate buffer useful in the treatment of arrhythmias.... | 08/10/1993 |
| 5225432 | Control of micro-organisms on plants with 1-hydroxymethylpyrazoles A method of protecting plants and seeds thereof which are susceptible to attack by microorganisms. To the plant or seed is applied a compound having the formula ##STR1## wherein R and R' are independently selected from hydrogen and alkyl of 1 to... | 07/06/1993 |
| 5223537 | Method and composition for treatment of gastric and duodenal disorders The invention is related to the field of treating gastric and duodenal disorders and more specifically to the use of certain 13,14-dihydro-prostaglandin E derivatives, especially of PGE2, which are modified to contain a ring structure in the om... | 06/29/1993 |
| 5219875 | Antimicrobial compositions comprising iodopropargyl butylcarbamate and 1,2-benzisothiazolin-3-one and methods of controlling microbes A synergistic antimicrobial composition comprising 1,2-benzisothiazolin-3-one and iodopropargyl butylcarbamate in a ratio to each other which exhibits synergism is disclosed.... | 06/15/1993 |
| 5216032 | Selective aortic arch perfusion using perfluorochemical and alpha adrenergic agonist to treat cardiac arrest A method of treating a subject in cardiac arrest, comprises blocking the descending aorta of the subject and then perfusing the aortic arch of the subject with a protective solution. The protective solution is one capable of delivering oxygen to the heart... | 06/01/1993 |
| 5208020 | Cytotoxic agents comprising maytansinoids and their therapeutic use A cytotoxic agent comprising one or more maytansinoids linked to a cell binding agent. A therapeutic agent for killing selected cell populations comprising: (a) a cytotoxic amount of one or more maytansinoids linked to a cell binding agent, and (b) a phar... | 05/04/1993 |
| 5204368 | Bacteriostatic and bacteriocidal method using fulvic acid derivatives The present invention relates to compounds of the class of coal-derived fulvic acid or a salt or a derivative thereof as active ingredient in a suitable carrier, useful as a bactericidal or bacteriostatic agent. The carrier is preferably water.... | 04/20/1993 |
| 5202355 | Method of inhibiting aldose reductase in diabetic hosts using phenol derivatives The use of alkyl or alkenyl phenols or pharmaceutical acceptable salts thereof as aldose reductase inhibitors, and hence, as an agent for preventing or alleviating chronic diabetic complications.... | 04/13/1993 |
| 5202325 | Use of ergoline derivatives in treating emesis Compounds of the formula I ##STR1## wherein n is 1 or 2, R1 represents a hydrogen atom or a C1 -C4 alkyl group, R2 represents a hydrogen atom and R3 represents a hydrogen atom or a hydroxy group ... | 04/13/1993 |
