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| Number | Title | Issue Date |
| 7459317 | Method for detecting an analyte in a sample Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label moiety. The mixing produces a first composition. Unbound labeled bind... | 12/02/2008 |
| 7455980 | Method for characterizing autoimmune disorders The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. ... | 11/25/2008 |
| 7445766 | Medical device and method for diagnostic sensing Devices are provided for use in medical diagnostics which include a substrate, a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening, at least one diagnostic substance contained in each reservoir, and at least one no... | 11/04/2008 |
| 7439026 | Methods and kits for detecting ITA in a biological sample Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnan... | 10/21/2008 |
| 7427490 | Diagnostic markers of stroke and cerebral injury and methods of use thereof The present invention relates to methods for the diagnosis and evaluation of stroke and transient ischemic attacks. In a particular aspect, patient samples are analyzed for the presence or amount of a panel of markers comprising one or more specific markers for cere... | 09/23/2008 |
| 7422864 | Method for measuring oxidized LDL-CRP complex and measurement kit The present invention provides a method for measuring a “complex of oxidized LDL and CRP” which comprises using an “anti-CRP antibody”. An “anti-apoB antibody and/or anti-β2-GPI antibody” is preferably used in the method of the present invention, which ... | 09/09/2008 |
| 7416850 | Cytochrome and leucine-rich alpha-2-glycoprotein-1 assays, methods and antibodies The present invention relates generally to assays and methods involving Cytochrome c (Cyt c) and leucine-rich alpha-2-glycoprotein-1 (LRG), and related antibodies. In an embodiment, the invention includes a method of detecting LRG in a sample, the method including d... | 08/26/2008 |
| 7411048 | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that sp... | 08/12/2008 |
| 7410616 | Device for the controlled exposure of reservoir-based sensors Devices are provided for the controlled exposure of a sensor or sensor component. The device may include a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reserv... | 08/12/2008 |
| 7410807 | Pregnancy and sex identification test based on saliva or other bodily fluids A method of testing an animal for pregnancy or sex identification comprising the steps of first, providing a first vessel containing a liquid and having a removable surface wherein said removable surface is at least partially coated with an antibody and then introdu... | 08/12/2008 |
| 7405084 | Analytical method using particles and test kit for performing the method A method for use in a flow matrix, which utilizes biospecific affinity reactions to detect an analyte in the sample, and which comprises allowing the sample comprising the analyte and an analytically detectable reactant (Reactant*) to migrate through flow channels i... | 07/29/2008 |
| 7399598 | Diagnosis method of endometriosis by detecting biochemical markers and usage of these biochemical markers The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometrio... | 07/15/2008 |
| 7399641 | Mass spectrometric immunoassay Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated... | 07/15/2008 |
| 7396688 | Mass spectrometric analysis of biopolymers The present invention makes use of unique tags of a specific biopolymer that can be exploited for determining the concentration the biopolymer in crude solutions. In preferred embodiments the biopolymer is either a protein or a polynucleotide. Particularly, the inve... | 07/08/2008 |
| 7396689 | Method of adjusting the working range of a multi-analyte assay The invention features a method of adjusting the concentration of at least one but not all of a plurality of analytes in a fluid sample to match a known working range of detection of an analyte assay system, where each of the plurality of analytes may or may not be ... | 07/08/2008 |
| 7396687 | Mass spectrometric immunoassay analysis of specific proteins and variants present in various biological fluids Presented herein is the construction of pipettor tips (termed MSIA-Tips) containing porous solid supports that are constructed, covalently derivatized with affinity ligand, and used to extract specific proteins and their variants from various biological fluids by re... | 07/08/2008 |
| 7387897 | Tetrameric antibody complexes for blocking non-specific labeling of antigens A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two mono... | 06/17/2008 |
| 7378056 | Circuits for in vivo detection of biomolecule concentrations using fluorescent tags Methods are disclosed wherein labeled antibodies can be provided in vivo to tissue having antigens that specifically bind the labeled antibody. A first optical radiation is emitted into the tissue in vivo to excite the labeled antibody bound to the antigen in vivo. ... | 05/27/2008 |
| 7361517 | Real time method of detecting acute inflammatory conditions This invention relates to the diagnosis and/or monitoring of patients with inflammatory diseases or conditions, including systemic lupus erythematosus, particularly for diagnosis of the acute stage of the disease, including methods and kits for carrying out this act... | 04/22/2008 |
| 7358096 | Immobilisation of proteins The immobilization of proteins at solid surfaces facilitated by incorporation of a polypeptide segment which is capable of adopting a folded structure is described. Materials comprising proteins so immobilized and uses thereof are also described. ... | 04/15/2008 |
| 7341696 | Nanoporous membrane immunosensor A sensor for a selected analyte in a test sample has (a) a semipermeable membrane with pores for retaining the analyte, where the membrane has been chemically modified by attachment of membrane modifiers; (b) immunoassay labels which have label binding ligands where... | 03/11/2008 |
| 7320894 | Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that sp... | 01/22/2008 |
| 7303888 | Mass spectrometric immunoassay Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated... | 12/04/2007 |
| 7303884 | Method for indirectly determining the blood-clotting status The invention relates to a method for indirectly determining the blood-clotting status. The inventive method comprises the following steps: a) collecting body fluids which contain a protein that can be modified by a vitamin K-dependent γ-carboxylase, b) determining... | 12/04/2007 |
| 7300633 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 11/27/2007 |
| 7297556 | Method of diagnosing nephrotic syndrome This invention provides organic biomolecule markers (e.g., proteins) useful for differentiating minimal change nephrotic syndrome (MCNS) from focal segmental glomerulosclerosis (FCS), membranous nephrothropy (MN), and membranoproliferative glomerulonephritis (MPGN).... | 11/20/2007 |
| 7270959 | Specimen collection container The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ... | 09/18/2007 |
| 7256050 | High fluorescent intensity cross-linked allophycocyanin In a method for quantitating an analyte by measuring time resolved transfer of fluorescence energy to or from a label quantitatively associated with the analyte, the present invention provides an improvement comprising measuring the energy transferred from donor com... | 08/14/2007 |
| 7256008 | Determination of concentration of FK778 by competitive immunoassay Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridini... | 08/14/2007 |
| 7250489 | Purified linear polypeptide epitope from walnuts and associated methods A purified Ig-E binding immunogenic polypeptide the amino acid sequence of which consists of SEQ ID NO:1 is disclosed. The purified amino acid sequence is a major allergen of the walnut Juglans regia. Also described are a diagnostic test kit and use of the pu... | 07/31/2007 |
| 7238490 | Real time detection of intermolecular interaction Intermolecular binding can be detected by formation of a “paratope” which results in an immediate generation of a signal. The substances to be tested for interaction are bound to demitopes, wherein said demitopes are components of a paratope which binds a report... | 07/03/2007 |
| 7226752 | Methods for detecting an analyte in a sample Methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include mixing a sample with an indirectly-detectable labeled binding member that includes a label moiety. The mixing produces a first composition. Unbound labeled bind... | 06/05/2007 |
| 7220596 | Real time detection of antigens Antigens can be captured and detected from complex samples, such as food and environmental samples, in about 30 minutes using apparatus and methods that include flow of the samples through a module containing antibodies coupled to beads. The samples flow through the... | 05/22/2007 |
| 7220389 | Biochemical analysis unit and method of producing thereof The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the absorptive regions are applied and absorbed specific binding substan... | 05/22/2007 |
| 7211441 | Lipoprotein assay A method of assaying to determine the identity and/or concentration or relative concentration in a sample solution of a particular one of a number of different target molecule types, comprise the steps of: i) adding to the sample a probe substance which binds to the... | 05/01/2007 |
| 7201872 | System and method for determining the presence of a substance in-vivo The present invention relates to a method and system for the in vivo determination of the presence and/or concentration of biological and/or chemical substances in body lumens. The system of the invention comprises a solid support, the support being inserted into a ... | 04/10/2007 |
| 7192716 | Organ transplant rejection and associated conditions Protein markers associated with organ transplant rejection and associated conditions are disclosed, and in particular materials and methods relating to the diagnosis and treatment of acute rejection. Examples of markers include a-Crystallin b-chain Tropomyosin a-cha... | 03/20/2007 |
| 7189520 | Compositions and methods for detecting animal byproduct in feed Analytes and ligands for detecting animal byproduct in agricultural samples such as animal feed to minimize the transmission of prion pathogens into food products consumed by humans. The analyte is a component of rendered animal byproduct such as meat and bone meal ... | 03/13/2007 |
| 7189516 | Method for characterizing autoimmune disorders The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. ... | 03/13/2007 |
| 7183118 | Methods for quantitative proteome analysis of glycoproteins The invention provides a method for identifying and quantifying polyglycopeptides in a sample. The method can include the steps of immobilizing glycopolypeptides to a solid support; cleaving the immobilized glycopolypeptides, thereby releasing non-glycosylated pepti... | 02/27/2007 |
