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| Number | Title | Issue Date |
| 7226758 | Nucleic acids encoding glial cell line-derived neurotrophic factor (GDNF) A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A ge... | 06/05/2007 |
| 7138251 | Polynucleotides encoding a neurotrophic factor receptor The present invention relates to glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophin that exhibits a broad spectrum of biological activities on a variety of cell types from both the central and peripheral nervous systems. The present invention ... | 11/21/2006 |
| 7115250 | Delivery of erectile dysfunction drugs through an inhalation route The present invention relates to the delivery of erectile dysfunction drugs through an inhalation route. Specifically, it relates to aerosols containing erectile dysfunction drugs that are used in inhalation therapy. In a method aspect of the present invention, an e... | 10/03/2006 |
| 7101569 | Methods of administering levothyroxine pharmaceutical compositions The present invention generally relates to stable pharmaceutical compositions, and methods of making and administering such compositions. In one aspect, the invention features stabilized pharmaceutical compositions that include pharmaceutically active ingredients su... | 09/05/2006 |
| 7101837 | Recombinant human alpha-fetoprotein as a cell proliferative agent A method of promoting bone marrow cell proliferation in a mammal by administering unglycosylated recombinant human alpha-fetoprotein is disclosed. ... | 09/05/2006 |
| 7097827 | Devices, compositions and methods for the pulmonary delivery of aerosolized medicaments According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture c... | 08/29/2006 |
| 7094392 | Delivery of antihistamines through an inhalation route The present invention relates to the delivery of antihistamines through an inhalation route. Specifically, it relates to aerosols containing antihistamines that are used in inhalation therapy. In a method aspect of the present invention, an antihistamine is delivere... | 08/22/2006 |
| 7070782 | Prostate-specific membrane antigen The invention provides a purified prostate-specific membrane antigen. ... | 07/04/2006 |
| 7067145 | Use of arachidonic acid for enhanced culturing of fish larvae and broodstock A method of enhancing a culturing characteristic of fish larvae, including administering to said larvae in a nutritional diet essential fatty acids including DHA and AA in a ratio effective to enhance the culturing characteristic of such fish larvae relative to a co... | 06/27/2006 |
| 7066171 | Process and apparatus for producing inhalable medicaments A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segme... | 06/27/2006 |
| 7049401 | Human histamine receptor of the H3 subtype DNAs encoding the human histamine H3 receptor have been cloned and characterized. The recombinant protein is capable of forming biologically active histamine H3 receptor protein. The cDNA's have been expressed in recombinant host cells which produce active recombina... | 05/23/2006 |
| 7045119 | Delivery of diazepam through an inhalation route The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of t... | 05/16/2006 |
| 7041473 | Alzheimer's disease secretase, APP substrates therefor, and uses thereof The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cell and cell isolates and assays. The invention further provides a modified APP protei... | 05/09/2006 |
| 7037662 | Receptor-ligand system and assay An Eph family RTK (receptor tyrosine kinase) ligand-binding domain as well as a method of identifying Eph family RTK agonists or antagonist. The ligand-binding domain is suitably encoded by exon III of a gone encoding the RTK of the Eph family and may additionally i... | 05/02/2006 |
| 7038022 | Multimeric forms of members of the steroid/thyroid superfamily of receptors In accordance with the present invention, it has been discovered that various members of the steroid/thyroid superfamily of receptors can interact to form multimeric species comprising a complex of more than one receptor. Accordingly, the interaction of a first rece... | 05/02/2006 |
| 7037647 | Prostate-specific membrane antigen and uses thereof This invention provides an isolated mammalian nucleic acid molecule encoding an alternatively spliced prostate-specific membrane (PSM′) antigen. This invention provides an isolated nucleic acid molecule encoding a prostate-specific membrane antigen promoter. This ... | 05/02/2006 |
| 7037677 | Megakaryocytic protein tyrosine kinase I The present invention relates to novel cytoplasmic tyrosine kinases isolated from megakaryoctyes (megakaryocyte kinases or MKKs) which are involved in cellular signal transduction pathways and to the use of these novel proteins in the diagnosis and treatment of dise... | 05/02/2006 |
| 7033783 | Polynucleotide encoding IL-1 zeta polypeptide The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these pol... | 04/25/2006 |
| 7029658 | Delivery of antidepressants through an inhalation route The present invention relates to the delivery of antidepressants through an inhalation route. Specifically, it relates to aerosols containing an antidepressant that are used in inhalation therapy. In a method aspect of the present invention, an antidepressant is adm... | 04/18/2006 |
| 7022651 | Composition, method, and apparatus for protecting plants from injury caused by frost or freezing temperatures The present invention is directed to a composition, method, and apparatus for protecting plants from injury caused by frost or freezing temperatures by applying an insulating foam to the surface of plants. Plants are sprayed with a foam formed from a pre-emulsion co... | 04/04/2006 |
| 7018618 | Stable pharmaceutical solution formulations for pressurized metered dose inhalers An aerosol solution composition for use in an aerosol inhaler comprises an active material, a propellant containing a hydrofluoroalkane, a cosolvent and optionally a low volatility component to increase the mass median aerodynamic diameter (MMAD) of the aerosol part... | 03/28/2006 |
| 7018648 | Transdermal device for administering testosterone or one of the derivatives thereof The invention relates to a self-adhesive transdermal device for the administration of testosterone and/or at least one of the derivatives thereof, comprising successively at least one support layer, a self-adhesive matrix layer and a detachable protective layer, whe... | 03/28/2006 |
| 7014841 | Delivery of antiemetics through an inhalation route The present invention relates to the delivery of antiemetics through an inhalation route. Specifically, it relates to aerosols containing antiemetics that are used in inhalation therapy. In a method aspect of the present invention, an antiemetic is delivered to a pa... | 03/21/2006 |
| 7011844 | Formulations for the administration of fluoxetine Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination wi... | 03/14/2006 |
| 7011818 | Carrier particles for use in dry powder inhalers A powder for use in a dry powder inhaler includes active particles and carrier particles for carrying the active particles. The powder further includes additive material (4) on the surfaces of the carrier particles to promote the release of the active particl... | 03/14/2006 |
| 7012134 | Dendritic enriched secreted lymphocyte activation molecule The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing thi... | 03/14/2006 |
| 7008645 | Method of inhibiting restenosis using bisphosphonates A method of inhibiting the activity or production of cytokines or growth factors associated with vascular restenosis, by administering to an individual an effective amount of an active ingredient comprising a bisphosphonate particle or a bisphosphonate particulate. ... | 03/07/2006 |
| 7008616 | Delivery of stimulants through an inhalation route The present invention relates to the delivery of stimulants through an inhalation route. Specifically, it relates to aerosols containing stimulants that are used in inhalation therapy. In a method aspect of the present invention, a stimulant is delivered to a patien... | 03/07/2006 |
| 7005135 | Glass scaffolds with controlled resorption rates and methods for making same The present invention relates to resorbable glass scaffolds for use in biological applications and methods for making same. Specifically, these scaffolds are composed of phosphate glass fibers, where the rate of dissolution into biological fluids is controlled by th... | 02/28/2006 |
| 6998110 | Buccal, polar and non-polar spray or capsule Buccal aerosol sprays or capsule using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention com... | 02/14/2006 |
| 6994863 | Pharmaceutical and cosmetic carrier and composition for topical application A pharmaceutical or cosmetic carrier or composition for topical application characterized by rheological properties which render the carrier or composition semi-solid at rest and a liquid upon application of shear forces thereto. The composition or carrier are prepa... | 02/07/2006 |
| 6994870 | Local nasal immunotherapy with allergen strip for allergic rhinitis A method and strip for treating allergen-induced airway inflammation. The method includes applying a nasal or skin strip containing a mixture of an allergen and a pharmaceutically acceptable carrier to an individual having allergen-induced airway inflammation in a m... | 02/07/2006 |
| 6994872 | Monolayer sugar-coated tablet and process for preparation thereof This invention relates to a monolayer sugar-coated tablet which is coated with a sugar-coating liquid containing 30–54% by weight of saccharide, 2–10% by weight of polyethylene glycol and 0.2–2% by weight of polyvinylpyrrolidone, and a process for preparing th... | 02/07/2006 |
| 6989368 | Use of calmodulin to promote bone regeneration The present invention provides methods and compositions for promoting bone regeneration, comprising administration of calmodulin. The method of bone regeneration is applied to subjects having bone disorders characterized by decreased bone mass such as osteopenia and... | 01/24/2006 |
| 6989151 | Emulsifier-free finely disperse systems of the oil-in-water and water-in-oil type Pickering emulsions, which are finely disperse systems of the water-in-oil or oil-in-water type, comprising (1) an oil phase, (2) a water phase, (3) at least one type of microfine particles which a) have an... | 01/24/2006 |
| 6986885 | Stable and efficacious soft solid product A low residue antiperspirant and/or deodorant composition in the form of an anhydrous, surfactant-free and antiseptic alcohol-free suspension exhibiting a syneresis of less than 8% is disclosed which comprises: (a) a dimethicone/vinyldimethicone crosspolymer composi... | 01/17/2006 |
| 6984402 | Chrono delivery formulations and method of treating atrial fibrillation A dosage formulation for once daily administration prior to sleeping is described that provides an initial delay in pharmaceutical release followed by controlled release of the pharmaceutical. There is also provided a method for preparing a time specific delayed, co... | 01/10/2006 |
| 6984400 | Method of treating restenosis using bisphosphonate nanoparticles A method of treating or preventing restenosis by administering to an individual an effective amount of an active ingredient comprising a bisphosphonate particle or a bisphosphonate particulate. The bisphosphonate may be encapsulated, embedded or adsorbed within the ... | 01/10/2006 |
| 6984390 | Silicone compound and cosmetic preparation This invention provides a sterol-modified silicone compound which is low melting, hydrophilic and very suitable for emulsifying, represented by the general formula R1aR2bSiO(4−a−b)/2, and having a melting po... | 01/10/2006 |
| 6979437 | Pulmonary delivery in treating disorders of the central nervous system A method for treating a disorder of the central nervous system includes administering to the respiratory tract of a patient a drug which is delivered to the pulmonary system, for instance to the alveoli or the deep lung. The drug is administered at a dose which is a... | 12/27/2005 |
