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| Number | Title | Issue Date |
| 5633360 | Oligonucleotide analogs capable of passive cell membrane permeation Oligonucleotides that are capable of passive diffusion across cell membranes are disclosed. These oligonucleotides contain at least two nucleotide residues and show a log distribution coefficient in octanol:water of about 0.0-2.5 and a solubility in water... | 05/27/1997 |
| 5578582 | Methods of treating ischemia with C2, N6 -disubstituted adenosine derivatives This application relates to methods of treating myocardial or cerebral ischemia, comprising administering a compound of formula I: ##STR1## wherein X is halogen, perhalomethyl, cyano, C1-6 -alkoxy, C1-6 -alkylthio or C1-6 | 11/26/1996 |
| 5519129 | Complex of guanidine and AZT A composition of a 1:1 molar complex of guanidine and 3'-azido-3'-deoxythymidine (AZT) which is generated at about pH above 9 and disrupted by pH below about 9. This complex is a useful intermediate in the purification of AZT.... | 05/21/1996 |
| 5512672 | Curdlan sulfate A beta-1,3-glucan of sulfated curdlan having a sulfur content of 12.4 to 17% and an average molecular weight of 27,000 to 330,000 daltons. Sulfate curdlan exhibits strong HIV inhibitory activity with little anticoagulant activity and little toxicity.... | 04/30/1996 |
| 5503816 | Silicate compounds for DNA purification The present invention relates to a silicon-containing material which exhibits sufficient hydrophilicity and sufficient electropositivity to bind DNA from a suspension containing DNA and permit elution of the DNA from the material. Generally, the hydrophil... | 04/02/1996 |
| 5496809 | Stable solutions of rebeccamycin analog Stable solutions of rebeccamycin analog consist essentially of (a) water, (b) 8-N-(diethylaminoethyl)rebeccamycin in an effective dosage amount, and (c) pharmaceutically acceptable acid such that the presence of a molar equivalence thereof would solubiliz... | 03/05/1996 |
| 5484908 | Oligonucleotides containing 5-propynyl pyrimidines Oligonucleotides with enhanced hybridization binding possessing 5-propynyluracil and/or 5-propynylcytosine in place of uracil and cytosine, respectively. These oligonucleotides are useful in traditional hybridization assays for detection of a specific DNA... | 01/16/1996 |
| 5476931 | Process for preparing 3-deoxy-B-D-threo-pentofuranosyl nucleosides A process for preparing 3-deoxy-ଲ-D-threo-pentofuransyl nucleosides having the formula (II') shown below: ##STR1## wherein B is a purine, pyrimidine, a protected purine or a protected pyrimidine, and R4 is a hydroxyl protecting group... | 12/19/1995 |
| 5476930 | Non-enzymatic ligation of oligonucleotides A process for non-enzymatic convalent ligation of two oligonucleotides having the structure shown below: ##STR1## The spontaneous reaction of these above oligonucleotides produces a thiophosphorylacetylamino linkage as shown below: ##STR2## ... | 12/19/1995 |
| 5474986 | Method for treating galabiose-binding bacteria infections A method for treating infections caused by galabiose-binding bacteria using galabiose derivatives modified at the 3' and anomeric positions. The galabiose-derivatives and compositions of same are also disclosed.... | 12/12/1995 |
| 5470967 | Oligonucleotide analogs with sulfamate linkages Oligonucleotides possessing at least one sulfamate or sulfamide internucleotides linkages. These compounds can be used as specific hybridization probes to detect complementary nucleic acid sequences.... | 11/28/1995 |
| 5470838 | Method of delivering exogenous uridine or cytidine using acylated uridine or cytidine Methods of delivering exogenous uridine or cytidine to the tissue of an animal comprising the administration of acyl derivatives of uridine or cytidine, respectively, are disclosed. Also disclosed are methods for treating cardiac insufficiency, myocardial... | 11/28/1995 |
| 5468853 | Synthesis of 5-radiohalo-2'-deoxyuridine Method of synthesizing 5-radio-halogenated-2'-deoxyuridine from 5-trimethylstannyl-2'-deoxyuridine is described. The method consists of the steps of mixing 5-trimethylstannyl-2'-deoxyuridine with an aqueous solution consisting of a radiohalide and NaOH to... | 11/21/1995 |
| 5466793 | Process for preparing 2', 3'- dideoxyinosine A process for preparing 2',3'-dideoxyinosine comprising reducing a nucleoside of the formula IIIa or IIIb ##STR1## wherein R2 is hydrogen, C1-12 acyl, C1-12 alkyl, C7-8 aralkyl or a silyl protecting group; ... | 11/14/1995 |
| 5466787 | Process for preparing AZT A process for preparing AZT and comprising the steps of: a) reacting a 2'-halo-5'-protected pyrimidinyl 2'-deoxyribonucleoside having a 3'-sulfonyl group with tributyl tin hydride and catalytic amount of azobisisobutyronitrile in an ether, ester, or ketone sol... | 11/14/1995 |
| 5464826 | Method of treating tumors in mammals with 2',2'-difluoronucleosides A method of treating susceptible neoplasms in mammals comprising administering to a mammal in need of such treatment a pharmaceutically effective amount of a compound of the formula ##STR1## wherein: R1 is hydrogen; R2 is a base... | 11/07/1995 |
| 5463035 | Process for purifying pentostatin A process for purifying pentostatin from a crude fermentation beer comprising the steps of 1) applying the fermentation beer to a strong cation exchange resin; 2) eluting with ammonium hydroxide; 3) concentrating the eluate; 4) applying the concentrated e... | 10/31/1995 |
| 5461036 | Spicamycin derivatives and their use as anticancer agents Spicamycin derivative represented by the formula (I) or a salt thereof: ##STR1## wherein R represents specific diverse substituents, for example, a linear alkadienyl having from 11 to 13 carbon atoms, and R1 and R2 respectively ... | 10/24/1995 |
| 5457187 | Oligonucleotides containing 5-fluorouracil A homo-oligonucleotide of between 2 and 26 monomers of 5-fluorouridine 5'-monophosphate or 5-fluorodeoxyuridine 5'-monophosphate covalently linked via 3'- to 5'-phosphodiester linkages, where at the 3'- or 5'- terminus there is covalently linked a molecul... | 10/10/1995 |
| 5455344 | Agarose compositions for nucleic acid sequencing A nucleic acid sequencing gel comprising 2 to 10% of a gelling polysaccharide, preferably agarose; a denaturing agent, a non-gelling additive, preferably glycerol, and electrophoretic buffers. This composition is capable of resolving nucleic acid fragment... | 10/03/1995 |
| 5453496 | Polynucleotide phosphorodithioate Oligonucleotides having at least one phosphorodithioate internucleotide linkage. Phosphorodithioate oligonucleotides exhibit stronger antiviral activity than the corresponding phoshorothioate derivatives.... | 09/26/1995 |
| 5451463 | Non-nucleoside 1,3-diol reagents for labeling synthetic oligonucleotides A trifunctional reagent possessing a primary hydroxyl, a secondary hydroxyl, and a primary amino group. This reagent is useful in solid phase oligonucleotide synthesis for the convenient labeling of the 3'-terminus. The secondary hydroxyl may be an phosph... | 09/19/1995 |
| 5449770 | Process for making N-alkylamino polyols N-alkylamino polyols substantially free from nickel contamination are prepared by reacting N-alkylamines with reducing sugars in the presence of hydrogen and nickel catalysts under defined conditions of temperature and pressure. The polyols are characteri... | 09/12/1995 |
| 5449773 | Platinum complexes of sucrose derivatives Bis(platinum) and tris(platinum) complexes derived from 6,6'-diamino-6,6'-dideoxy-1',2-anhydrosucrose and 1',6,6'-triamino-1',6,6'-trideoxy-2,3,3',4,4'-penta-O-methylsucrose are disclosed as possessing anti-tumor activity.... | 09/12/1995 |
| 5447848 | Detection of campylobacter with nucleic acid probes Nucleic acid probes capable of specifically hybridizing to rRNA of Campylobacter jejuni, C. coli and C. laridis and not to rRNA or rRNA genes of Pseudomonas aeuroginosa, E. coli or Salmonella typhimunium are described along with methods utilizing such pro... | 09/05/1995 |
| 5444053 | Method for treating symptoms of Alzheimer's with NADH and NADPH A method for improving the cognitive function, memory, and orientation abilities of persons having senile or presenile dementia of the Alzheimer's type wherein the reduced form of nicotinamide-adenine-dinucleotide (NADH), or the reduced form of nicot... | 08/22/1995 |
| 5440025 | Process for separating nucleic acid polymers A method is disclosed for separating a nucleic acid polymer without substantially denaturing the nucleic acid polymer. The method includes contacting a liquid medium, in which the nucleic acid polymer is disposed, with an electrically conductive polymer s... | 08/08/1995 |
| 5438126 | Human thyroid hormone receptor DNA The DNA encoding human thyroid hormone receptor protein alpha-1 (hTR -1). This polynucleotide can be used as a probe to detect the presence of a third form of human thyroid hormone receptor protein.... | 08/01/1995 |
| 5438132 | Method for removing osmium from nucleosides A process for removing osmium from an aqueous solution of nucleosides comprising adding hydrogen sulfide, an aromatic pi base such as pyridine, and a mineral acid. The osmium is precipitated out of solution.... | 08/01/1995 |
| 5436231 | Adenophostins Compounds of formula (I): ##STR1## (wherein R represents a hydrogen atom or an acetyl group), which we have named "the adenophostins", and, have the ability to increase intracellular calcium ion concentrations by acting on the inositol 1,4,5-trisphos... | 07/25/1995 |
| 5436327 | Support-bound oligonucleotides A method for synthesizing oligonucleotides by solid-phase methodology wherein the linkage between the oligonucleotide and the solid phase support is a non-labile phosphodiester. The spacer arm between the support and the phosphodiester is a hydrophilic gr... | 07/25/1995 |
| 5436331 | Protection of hydroxy function with 1-N-aryl-4-alkoxy-piperidin-4-yl A process for protecting the 2'-hydroxyl of a nucleoside, which can then be used in the chemical synthesis of polyribonucleotides, comprising the reacting of a protected nucleoside of formula I ##STR1## wherein B is a nucleoside heterocyclic base and... | 07/25/1995 |
| 5432164 | C2,N6 -disubstituted adenosine derivatives A compound of formula (I), or a pharmaceutically acceptable salt thereof: ##STR1## wherein X is halogen, perhalomethyl, cyano, C1-6 -alkoxy, C1-6 -alkylthio, or C1-6 -alkylamino; and R1 is selected from N-bonded... | 07/11/1995 |
| 5432166 | Use of 1-(ଲ-D-arabinofuranosyl) -5-propynyluracil for lowering serum cholesterol The use of 1-(ଲ-D-arabinofuranosyl)-5-propynyluracil or a pharmaceutically acceptable salt or physiologically labile ester thereof for lowering serum cholesterol, particularly low density lipoprotein cholesterol levels in a human subject.... | 07/11/1995 |
| 5430136 | Oligonucleotides having selectably cleavable and/or abasic sites Polynucleotides containing abasic, cleavable sites are provided. These polynucleotides are useful in a variety of biochemical and chemical contexts, particularly in solid phase nucleic acid hybridization assays because a captured probe can be released fro... | 07/04/1995 |
| 5426101 | 2-substituted adenosines with A-2 receptor affinity The compound (R)-2-[(phenylisopropyl)amino]adenosine whose structure is given below: ##STR1## (R)-2-[(phenylisopropyl)amino]adenosine is about two orders of magnitude greater in its selectivity between the A-1 and A-2 adenosine receptors than it... | 06/20/1995 |
| 5424295 | 9-ଲ-D-arabinofuranasyl-2-amino-6-methaoxy-9H-purine The compound 9-B-D-arabinofuranosyl-2-amino-6-methoxy-9H-purine along with its 5'-acetyl and 5'-(4-methoxy-4-oxobutyryl derivatives are disclosed as inhibitors of Varicella Zoster virus (VZV).... | 06/13/1995 |
| 5424297 | Adenosine dextran conjugates Covalent conjugates of water soluble dextrans and adenosine agonists or antagonists wherein the dextran is coupled through the C6 or C8 positions of the purine ring. These compounds activate or block adenosine A1 or A2 receptors are ... | 06/13/1995 |
| 5422241 | Methods for the recovery of nucleic acids from reaction mixtures A method for the recovery of nucleic acids from a reaction mixture, such as nuclease protection assays, comprising the use of one reagent containing a) nuclease for digesting single-stranded RNA and b) a nucleic acid precipitating carrier agent, (sheared ... | 06/06/1995 |
| 5422345 | No-carrier added radiohalogenated nucleosides A composition comprising no-carrier-added 1-(B-D-arabinofuranosyl)-5-(E)-(2-halogenovinyl)uracil wherein the halogen is radioactive iodine or bromine. This composition can be used to diagnose or treat herpes viral infections.... | 06/06/1995 |
