Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 6245319 | Colloidal dispersions of perfluoropentane Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the tempera... | 06/12/2001 |
| 6241966 | Magnetic resonance imaging using Hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 06/05/2001 |
| 6241968 | Compositions for increasing the MRI contrast in visualizing the digestive tract of patients The invention provides, as contrast signal generators in MR imaging of the digestive tract, paramagnetic metal chelates of novel acrylic compounds of formula C(R1 R2).dbd.CR3 --CO--Z--Z (1) and/or C(R1 R2 | 06/05/2001 |
| 6231834 | Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same Improved methods for providing an image of an internal region of a patient. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises, in an aqueous carrier, a lipid, protein, polymer or surfactant, and a g... | 05/15/2001 |
| 6210691 | Cosmetics of lipophilic derivatives of amino deoxyalditols, cosmetic compositions containing them, and novel alkyl carbamates The invention is characterized by the use in cosmetic compositions of one or more lipophilic derivatives of amino deoxyalditols corresponding to the general formula: ##STR1## in which: R1 is a saturated linear C14 -C40 ali... | 04/03/2001 |
| 6207133 | Anti-tumoral therapy agent containing a contrast agent The invention relates to a new anti-tumoral therapy agent based on liposome-encapsulated cytostatic agents and/or the metabolites thereof. The invention can be used in the pharmaceutical industry and in medicine. The aim of the invention is to build up dr... | 03/27/2001 |
| 6207134 | Ultrafine lightly coated superparamagnetic particles for MRI The invention relates to particulate contrast agents, especially contrast agents for MR imaging having a metal oxide core which is preferably superparamagnetic iron oxide. The particulate contrast agents are provided with a low coating density of a polyel... | 03/27/2001 |
| 6207135 | Gaseous microparticles for ultrasonic diagnosis and process for their production The invention relates to gaseous microparticles for ultrasonic diagnosis, whose wall material is built up from block copolymers of polyesters of -, ଲ- or γ-hydroxycarboxylic acids with linear or star-shaped polyethylene glycols and optionall... | 03/27/2001 |
| 6203777 | Method of contrast enhanced magnetic resonance imaging using carbohydrate particles In a method of contrast MR imaging, using parenterally administered contrast agents, the improvement comprising using as the contrast agent, e.g. to achieve a negative contrast effect, composite particles comprising a biotolerable, carbohydrate or carbohy... | 03/20/2001 |
| 6203778 | Particulate radiopaque contrast agent for diagnostic imaging and microvascular characterization The properties of a tissue extracellular space, particularly the microvascular component of that space can be characterized by the use of x-ray diagnostic modalities in conjunction with particulate contrast agents. The present invention provides a method ... | 03/20/2001 |
| 6200548 | Gas or air filled polymeric microballoons Microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interfacially deposited, synthetic polymer membrane which is both deformable and resilsient. These microballoons are used for ultrasonic ec... | 03/13/2001 |
| 6193950 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuab... | 02/27/2001 |
| 6193953 | Stabilized microparticles and their use as ultrasound contrast agents Microparticles useful for enhancing the ultrasound image of a tissue or organ consist of liquid and/or gas core material which is encapsulated by a biocompatible, tanned protein shell. These stabilized microparticles are useful as ultrasonic imaging agent... | 02/27/2001 |
| 6193951 | Microparticles useful as ultrasonic contrast agents Microparticles are provided comprising a shell of an outer layer of a biologically compatible material and an inner layer of biodegradable polymer. The core of the microparticles contain a gas, liquid or solid for use in drug delivery or as a contrast age... | 02/27/2001 |
| 6187285 | Metal chelates of substituted polyaminocarboxylic macrocycles and their use in diagnostic imaging Chelates of the compounds of formula I ##STR1## in which R is a hydrophilic group containing 3 or 4 successive phenyl rings and m is 1 or 2, with metal ions, for use in diagnostic imaging.... | 02/13/2001 |
| 6187288 | Stable microbubble suspensions as enhancement agents for ultrasonic echography Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a st... | 02/13/2001 |
| 6183724 | Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuab... | 02/06/2001 |
| 6183725 | Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method The invention relates to injectable media for ultrasonic echography in the form of microbubbles or microballoons comprising at least two biocompatible substances A and B (gaseous at the body temperature) forming a mixture which when in suspension with usu... | 02/06/2001 |
| 6177062 | Agents and methods for enhancing contrast in ultrasound imaging The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60° C., processes for the preparation thereof and their use as diagnostic an... | 01/23/2001 |
| 6177061 | Contrast agents comprising an azeotropic mixture of two gases for ultrasound investigations A contrast agent for use in diagnostic studies, particularly ultrasound imaging, comprising a dispersion in an injectable aqueous medium of a biocompatible azeotropic mixture which is in gaseous form at 37° C., at least one component of said mixture bein... | 01/23/2001 |
| 6168780 | Marker for determining its position in a cavity inside the organism of a living being The invention provides a marker whose position in a cavity inside of a living organism can be determined, in particular for detecting local passage speeds of the marker through the gastro-intestinal tract, preferably in the small intestinal tract. The obj... | 01/02/2001 |
| 6159444 | NMR/MRI with hyperpolarized gas and high Tc SQUID A method and apparatus for the detection of nuclear magnetic resonance (NMR) signals and production of magnetic resonance imaging (MRI) from samples combines the use of hyperpolarized inert gases to enhance the NMR signals from target nuclei in a sample a... | 12/12/2000 |
| 6156292 | Gaseous ultrasound contrast media and method for selecting gases for use as ultrasound contrast media Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and ma... | 12/05/2000 |
| 6153172 | Reflective microspheres for ultrasonic imaging The present invention provides a method of contrast enhanced ultrasonic diagnostic imaging comprising administering to a subject a contrast enhancing amount of spheres or particles comprising a matrix enclosing a contrast agent which reflects sound waves,... | 11/28/2000 |
| 6146615 | Contrast agents for image enhancement in magnetic resonance imaging A compound of formula (I): ##STR1## wherein, R1, R2, R3 and R4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R1, R2 and ... | 11/14/2000 |
| 6143274 | Method for imaging and radiopharmaceutical therapy using 1-substituted-4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs A method for imaging mammalian tissue utilizing a non-ionic complex of a paramagnetic ion of lanthanide element and a macrocyclic chelating agent.... | 11/07/2000 |
| 6139818 | Method of making ultrasonic contrast agent Methods of making Ultrasonic contrast agents useful for echographic imaging body organs comprising a suspension of gas or air filled microballoons having a mean size in the range of 0.5 to 1000 microns bounded by a 50 to 500 nm thick biodegradable, interf... | 10/31/2000 |
| 6136292 | Determination of non-functioning areas of the g.i. tract using MRI of manganese composition The invention provides a method of functional imaging of a human or non-human animal body, which method comprises administering into the gastrointestinal tract of a said body an effective amount of a composition comprising (a) a first contrast agent compr... | 10/24/2000 |
| 6136293 | Stable microbubbles suspensions containing saturated lamellar phospholipids Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposo... | 10/24/2000 |
| 6132699 | Microencapsulated fluorinated gases for use as imaging agents It has been discovered that the incorporation of fluorinated gases, especially a perfluorocarbon such as octafluoropropane, into synthetic polymeric microparticles, significantly enhances echogenicity as compared with microparticles having air incorporate... | 10/17/2000 |
| 6123919 | Magnetic resonance imaging using hyperpolarized noble gases A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of th... | 09/26/2000 |
| 6123917 | Method for making cocaine receptor binding ligands and intermediates therefor An improved method for preparation of cocaine receptor binding ligands is provided. The method calls for the preparation of the silylaryl intermediate prepared from phenyl trimethylsilane and a anhydroecgonine methyl ester appropriately substituted. The i... | 09/26/2000 |
| 6123920 | Superparamagnetic contrast media coated with starch and polyalkylene oxides The invention relates to MR contrast media containing composite nanoparticles, preferably comprising a superparamagnetic iron oxide core provided with a coating comprising an oxidatively cleaved starch coating optionally together with a functionalized pol... | 09/26/2000 |
| 6113880 | Polyrotaxane derivatives for x-ray and nuclear magnetic resonance imaging The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.... | 09/05/2000 |
| 6110443 | Dry stable formation to produce microbubble suspension for ultrasound Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposo... | 08/29/2000 |
| 6099824 | Benzyloxy derivatives of DTPA for MRI Compounds which can chelate paramagnetic bi- and trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI), the compounds having formula (I) ##STR1## wherein R is a --(CH2 | 08/08/2000 |
| 6096874 | High affinity tamoxifen derivatives The synthesis of tamoxifen derivatives, most particularly halo, halo alkyl, hydroxy, and amino tamoxifen derivatives is disclosed. The native tamoxifen molecule includes a substituted chemical group positioned on the aliphatic chain of the tamoxifen molec... | 08/01/2000 |
| 6083484 | Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents Microparticles useful for enhancing the ultrasound image of a tissue or organ consist of liquid and/or gas core material which is encapsulated by a biocompatible, tanned protein shell. These stabilized microparticles are useful as ultrasonic imaging agent... | 07/04/2000 |
| 6083479 | Contrast media for infarction and necrosis imaging The invention relates to new compounds that are suitable as contrast media especially for infarction and necrosis imaging, process for their production and pharmaceutical agents that contain these compounds.... | 07/04/2000 |
| 6071496 | Polyalkylcyanoacrylate agents and methods for enhancing contrast in ultrasound imaging The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymer which is a polyalkylcyanoarylate and a gas and/or a fluid with a boiling point below 60° C., processes for the preparation thereo... | 06/06/2000 |
