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| Number | Title | Issue Date |
| 5322682 | Method for quantitatively measuring and mapping stored iron in tissue using MRI The invention provides a specific measure of iron stores in vivo using magnetic resonance imaging. T2 relaxation times in both lower-to-mid field strength magnetic resonance imaging instruments and a higher field strength instrument is evaluate... | 06/21/1994 |
| 5284646 | Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents A new class of magnetic resonance (MR) contrast agents are described whose in vivo biodistribution is based upon the ability of certain cells to recognize and internalize macromolecules, including the MR contrast agents of the present invention, via a pro... | 02/08/1994 |
| 5281599 | Method for treating ischemic oranoxic insult to neurons employing quinine A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, which neurons are prone to Parkinsonian degeneration by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.... | 01/25/1994 |
| 5277895 | Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives Tetraazacyclododecane compounds of general formula I ##STR1## in which E and Q are defined herein and their salts with inorganic and/or organic bases, amino acids or amino acid amides are valuable pharmaceutical agents.... | 01/11/1994 |
| 5277896 | Clay enclosed transition and rare earth metal ions as contrast agents for the gastrointestinal tract The invention relates to compositions and methods of using clay-enclosed paramagnetic ions as image brightening or image contrast agents. In particular, T1 relaxivity measurements on Hectorite and mortmorillonite clay-enclosed trivalent gadolin... | 01/11/1994 |
| 5277897 | In vivo enhancement of cellular accumulation of lipophilic cationic organometallic compounds by reduction of intramembrane potential The invention relates to compositions that comprise (1) lipophilic cationic organometallic complexes, particularly hexakis(2-methoxyisobutylisonitrile)technetium(I) complex, and (2) an agent that decreases the intramembrane potential of a living cell. Age... | 01/11/1994 |
| 5271929 | Nuclear magnetic resonance imaging agent comprising a di-aldehyde complex There is disclosed a nuclear magnetic resonance imaging agent comprising a complex compound composed of (a) a dialdehyde-saccharide having a molecular weight of from 500 to 10,000, at least one of the constituent monosaccharides of which is oxidation-clea... | 12/21/1993 |
| 5271924 | Low molecular weight polysaccharide complexes for nuclear magnetic resonance imaging There is disclosed an imaging agent for diagnosis comprising a compound composed of a polynuclear type compound of the formula I or II: ##STR1## wherein each X is a hydrogen atom or a bifunctional ligand, at least one of them are bifunctional ligand ... | 12/21/1993 |
| 5271925 | Method for protecting against the effects of radiation which is based on the administration of a selenium or tellurium based compound Methods for providing radioprotection to humans and other animals employing certain organic derivatives of tellurium and selenium are disclosed.... | 12/21/1993 |
| 5268164 | Increasing blood-brain barrier permeability with permeabilizer peptides Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in ca... | 12/07/1993 |
| 5268165 | Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging Compositions comprising a covalently bounded adduct of deferoxamine, ferric iron and polymer for image enhancement in magnetic resonance (MR) imaging are provided. A pharmaceutical composition comprising the adduct and method of using the composition in m... | 12/07/1993 |
| 5264204 | Hydrophilic free radicals for magnetic resonance imaging Methods and compositions are disclosed for enhancing magnetic resonance imaging which utilize hydrophilic free radical compounds as magnetic resonance contrast media. Typical magnetic resonance contrast media within the scope of the present invention incl... | 11/23/1993 |
| 5262176 | Synthesis of polysaccharide covered superparamagnetic oxide colloids In a method for the synthesis of a colloid including a superparamagnetic metal oxide coated with a polymer, an acidic solution of a metal salt and a polymer may be cooled, and then neutralized by the controlled addition of a cool solution of a base, and m... | 11/16/1993 |
| 5260049 | X-ray contrast compositions comprising alkoxyphenols Disclosed are aqueous compositions containing a contrast agent of the formula ##STR1## and methods for their use in diagnostic radiology of the gastrointestinal tract, wherein R is a substituted or unsubstituted alkyl group containing from 2 to ... | 11/09/1993 |
| 5260050 | Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for nuclear magnetic resonance imaging. A polyatomic complex which... | 11/09/1993 |
| 5258172 | Iodinated aliphatic emulsions for X-ray contrast Contrast agents comprising stable aqueous emulsions of iophendylate and their use in radiological examination of the small and large intestine after oral administration are described.... | 11/02/1993 |
| 5256397 | 2,2,5,5-tetrasubstituted-pyrrolidine-1-oxyl compounds useful as MRI agents Nitroxides useful as MRI enhancing agents are of the formula ##STR1## wherein R1, R2, R3 and R4 each are alkyl of 1-4 carbon atoms; and R is --alk--COO- M+ or --B--N+ (Alk)... | 10/26/1993 |
| 5256399 | Aromatic pentadentate expanded porphyrins in magnetic resonance imaging The present invention involves a novel tripyrrole dimethine-derived "expanded porphyrin" (texaphyrin), the synthesis of such compounds, their analogs or derivatives and their uses. These expanded porphyrin-like macrocycles are efficient chelators of dival... | 10/26/1993 |
| 5250284 | Method for increasing nuclear magnetic resonance signals in living biological tissue using zinc A method of enhancing a magnetic resonance signal comprising the steps of administering a quantity of a selected magnetic isotope to a living biological tissue at a concentration greater than the naturally occurring concentration of such isotope and detec... | 10/05/1993 |
| 5248492 | Low molecular weight carbohydrates as additives to stabilize metal oxide compositions This invention relates to compositions comprising a colloidal or particulate metal oxide which are stabilized by low molecular weight carbohydrates. The carbohydrates are characterized by the fact that a) they are not retained on the surface of the metal ... | 09/28/1993 |
| 5248498 | Fullerene compositions for magnetic resonance spectroscopy and imaging Methods and compositions are disclosed for enhancing magnetic resonance imaging and spectroscopy which utilize derivatives of the even-numbered carbon clusters, known as "fullerenes." Perfluorinated carbon clusters of the formula Cn Fm | 09/28/1993 |
| 5246696 | Compositions for enhancing magnetic resonance imaging Substantially nontoxic manganese or gadolinium complexes of compounds of the formula: ##STR1## wherein n and m=1, 2, 3 or 4, y=1, 2 or 3, and x is selected from the group consisting of S, CHOH and CHSH, are useful for enhancing magnetic resonanc... | 09/21/1993 |
| 5242683 | Contrast media comprising a paramagnetic agent and an iodinated agent for X-ray and MRI There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent. The contrast medium can be used for both X-ray and magnetic resonance ... | 09/07/1993 |
| 5242681 | Lipophilic contrast agents for diagnostic image analysis The present invention relates to contrast enhancing agents, conjugates thereof, pharmaceutical compositions thereof, and methods for diagnostic analysis, particularly NMR image analysis using these agents. The contrast enhancing agents are chelates of par... | 09/07/1993 |
| 5238945 | Method of treating psychoses Disclosed is a method of treating psychoses in human beings, comprising the step of administering an effective amount of the compound, ##STR1## or a pharmaceutically acceptable salt thereof, to a patient in need thereof. Said compound selectively blo... | 08/24/1993 |
| 5234680 | Perfluoro-t-butyl-containing compounds for use in fluorine-19 NMR and/or MRI The present invention is directed to biological compounds derivatized so as to contain at least one perfluoro-t-butyl moiety for use in fluorine-19 NMR and/or MRI studies. The perfluoro-t-butyl (PFTB) moiety, ##STR1## is an excellent reporter group f... | 08/10/1993 |
| 5234940 | Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof A method of detecting and treating malignant and non-malignant tissue abnormalities and lesions of the skin; conjunctiva; respiratory, digestive and vaginal mucosa; endometrium and urothelium; and for ablating the endometrial tissue and treating body flui... | 08/10/1993 |
| 5232947 | Oxamic acid compounds and pharmaceutical composition for use in improvement of damaged cerebral functions of brain New N,N-di-alkyl- or alkenyl-substituted derivatives of oxamic acid of which the two alkyl or alkenyl groups are different from each other are now produced and found to exhibit the cerebral protective effect against cerebral anoxia in the brain of a mamma... | 08/03/1993 |
| 5230883 | Method for localization and treatment of tumors using polylysine complexes Improved methods of selectively localizing, imaging and/or treating tumors, which have a net negative charge, employ novel compositions containing non-immunogenic complexes having a net positive charge in a sterile solution. The complexes contain polylysi... | 07/27/1993 |
| 5229394 | Method for treatment of amyotrophic lateral sclerosis comprising administration of DMP A method for treating ALS (Amyotrophic Lateral Sclerosis) is disclosed. The inventive method comprises the administration of controlled dosages of dextromethorphan in therapeutically effective amounts in a pharmaceutically acceptable vehicle Dextromethorp... | 07/20/1993 |
| 5229422 | Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion An extemporaneous kit of pharmaceutical substance-containing fat emulsion which consists of a fat emulsion and (a) a pharmaceutical substance composition containing pharmaceutical substance and at least one solvent selected from the group consisting of wa... | 07/20/1993 |
| 5223515 | Injectable solution containing a pyridyl methylsulfinylbenzimidazole An injectable solution of a compound useful as an anti-ulcer agent of the formula; ##STR1## wherein R1 represents hydrogen, methoxy or trifluoromethyl group; R2 and R3, being the same as or different from each other, ... | 06/29/1993 |
| 5219553 | Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI Magnetic resonance imaging contrast media used to affect the relaxation times of atoms in body tissues undergoing NMR diagnosis are disclosed. Such media comprise (1) a paramagnetic, physiologically compatible complex of (a) a chelant consisting of a N-ca... | 06/15/1993 |
| 5217706 | Complexes and compositions for magnetic resonance imaging Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high... | 06/08/1993 |
| 5215985 | Method for treating ischemic insult to neurons employing an ATP-sensitive potassium channel blocker A method is provided for treatment of neuronal insult, such as caused by lack of oxygen, by administering an ATP-sensitive potassium channel blocker, such as a sulfonyl urea, for example, tolbutamide.... | 06/01/1993 |
| 5216025 | Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients A method for treatment of an animal for systemic hypotension induced by internal nitric oxide production caused by endotoxin or cytokines. The method involves administering an 댑 adrenergic agonist and an amount of an inhibitor of nitric ... | 06/01/1993 |
| 5213788 | Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement Improved compositions and methods for selective access to tumor regions (or other regions of abnormal endothelial properties). This capability provides powerful contrast-enhancement agents for nuclear magnetic resonance imaging. A polyatomic complex which... | 05/25/1993 |
| 5211938 | Method of detection of malignant and non-malignant lesions by photochemotherapy of protoporphyrin IX percursors A method of detecting and treating malignant and nonmalignant tissue abnormalities and lesions of the skin, conjunctives, respiratory, digestive and vaginal mucosa; endometrium and urothelium in which 5-aminolevulinic acid is administered to the patient i... | 05/18/1993 |
| 5206006 | Stabilized trinder reagent Spontaneous aspecific coloration in so-called Trinder reagents which can alter subsequent colorimetric determinations is inhibited by adding compounds of the chelating agent class to the solution. The resultant compositions contain a peroxidase enzyme, a ... | 04/27/1993 |
| 5204085 | Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents Paramagnetic chelates, as for example, Gadolinium diethylenetriaminepentaacetic acid (DTPA), manganese, ethylenediaminetetraacetic acid (EDTA), and others used as X-ray contrast agents are more toxic acutely when injected in high concentration or at ... | 04/20/1993 |
